Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 165 (07 Apr 2021)
Sequence version 2 (27 Jul 2011)
Previous versions | rss
Add a publicationFeedback
Protein

RE1-silencing transcription factor

Gene

Rest

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (PubMed:29961578, PubMed:9771705). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (By similarity). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (By similarity). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 2 (PubMed:21884984). Repressor activity may be inhibited by forming heterodimers with isoform 2, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (PubMed:10490617, PubMed:11039732). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (PubMed:15907476). Thereby is involved in maintaining the quiescent state of adult neural stem cells and preventing premature differentiation into mature neurons (PubMed:27819263). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (By similarity). Acts as a regulator of osteoblast differentiation (PubMed:25727884). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (By similarity). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (PubMed:24670762). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (By similarity). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (By similarity).By similarity9 Publications
Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than isoform 1 (PubMed:11039732). Exhibits weaker repressor activity compared to isoform 1 (By similarity). May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (PubMed:11039732, PubMed:10490617). However, in another study, does not appear to be implicated in repressor activity of a NRSE motif-containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity (By similarity). Post-transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 2 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes, maintenance of hair cells and hearing (PubMed:29961578).By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri154 – 176C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri211 – 235C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri243 – 265C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 350C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri356 – 378C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 407C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1036 – 1058C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3214815, HDACs deacetylate histones

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RE1-silencing transcription factor
Alternative name(s):
Neural-restrictive silencer factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rest
Synonyms:Nrsf
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:104897, Rest

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethality by embryonic day 11.5 dpc (PubMed:9771705). At 9.25 dpc, disorganization of the head mesenchyme in the midbrain region with separation of myotomal cells from the dermomyotome and widespread apoptotic cell death (PubMed:9771705). Forebrain malformation and widening of the mesencephalic flexure at 9.5 dpc and 10.5 dpc, and growth retardation by 10.5 dpc (PubMed:9771705). Conditional knockout in the nervous system results in a progressive age-related neurodegenerative phenotype (PubMed:24670762). At the age of 1 month, no change of neuronal numbers in the cortex and hippocampus, but at the age of 8 months, neuronal degeneration and apoptosis, accompanied by significant neuronal loss in the cerebral cortex and hippocampus, and pronounced gliosis (PubMed:24670762). In primary 16 dpc cortical neurons, increased degeneration and cell death upon oxidative stress or exposure to oligomeric amyloid-beta 42 (PubMed:24670762). Conditional knockout in QNP cells leads to a higher number of proliferating QNP cells, an increased transition to TAP cells and increased differentiation into mature neurons (PubMed:27819263). Conditional knockdout in proliferating cells leads to a decreased number of proliferating TAP cells and an increase in immature and mature neurons (PubMed:27819263).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1 – 209Missing : Abolished binding to neuron-restrictive silencer element. 1 PublicationAdd BLAST209
Mutagenesisi1 – 194Missing : Decreased binding to neuron-restrictive silencer element. 1 PublicationAdd BLAST194
Mutagenesisi1 – 176Missing : Decreased binding to neuron-restrictive silencer element. 1 PublicationAdd BLAST176
Mutagenesisi1 – 152Missing : Decreased binding to neuron-restrictive silencer element. 1 PublicationAdd BLAST152
Mutagenesisi1 – 86Missing : Increased binding to neuron-restrictive silencer element. 1 PublicationAdd BLAST86
Mutagenesisi196 – 207Missing : Abolished binding to neuron-restrictive silencer element. 1 PublicationAdd BLAST12
Mutagenesisi243 – 265Missing : Abolished binding to neuron-restrictive silencer element. 1 PublicationAdd BLAST23

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002695481 – 1082RE1-silencing transcription factorAdd BLAST1082

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei950PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated.1 Publication
Phosphorylated; phosphorylation is required for ubiquitination.By similarity
Ubiquitinated; ubiquitination is mediated by BTRC and leads to proteasomal degradation in G2 phase (By similarity). Ubiquitination increases during neuronal differentiation (By similarity). Deubiquitinated by USP7; leading to its stabilization and promoting the maintenance of neural progenitor cells (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8VIG1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8VIG1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8VIG1

PeptideAtlas

More...
PeptideAtlasi
Q8VIG1

PRoteomics IDEntifications database

More...
PRIDEi
Q8VIG1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
254914 [Q8VIG1-1]
254915 [Q8VIG1-2]
254916 [Q8VIG1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8VIG1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8VIG1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the hippocampus, including quiescent neuronal progenitor (QNP) cells, transient-amplifying progenitor (TAP) cells, neuroblasts and mature neurons (at protein level) (PubMed:27819263). Expressed in embryonic stem cells (at protein level) (PubMed:15907476). Expressed in many non-neuronal tissues including the heart and liver (PubMed:7871435). Abundantly expressed in osteoblastic lineage cells (PubMed:25727884). Expressed in the spleen, kidney, blood cells, cortex, neocortex and in the utricle, saccule and organ of Corti of the inner ear (PubMed:29961578). Isoform 2: Expressed in the cortex, neocortex and in the utricle, saccule and organ of Corti of the inner ear (PubMed:29961578).5 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Ubiquitously expressed in 8.5 dpc and 9.5 dpc embryos (PubMed:9771705). During embryogenesis, expressed at high levels in non-neuronal and differentiated peripheral nervous tissues, but is not expressed in differentiating neurons in the CNS (PubMed:7697725, PubMed:7871435). Expressed in the neocortex at embryonic stage 14.5 dpc and 16 dpc and in the utricle at 15.5 dpc (PubMed:29961578). Isoform 2: Expressed in the neocortex at embryonic stage 14.5 dpc and 16 dpc and in the utricle and saccule at 16 dpc (PubMed:29961578).4 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated in differentiating neurons and mature neurons.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000029249, Expressed in embryo and 301 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8VIG1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1 and isoform 2 form heterodimers (PubMed:10490617). Isoform 2: Forms homodimers and homooligomers; binds to the neuron-restrictive silencer element (NRSE) as monomer (PubMed:11039732).

Interacts with SIN3A, SIN3B and RCOR1 (By similarity).

Interacts with CDYL (By similarity).

Interacts with EHMT1 and EHMT2 only in the presence of CDYL (By similarity).

Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2 (By similarity).

Interacts (via zinc-finger DNA-binding domain) with ZFP90 (via N- and C-termini); the interaction inhibits REST repressor activity (PubMed:21284946).

Interacts (via C2H2-type zinc finger 5) with PRICKLE1 (By similarity).

Interacts with FBXW11 and BTRC (By similarity).

Interacts with USP7 (By similarity).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
202864, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q8VIG1, 3 interactors

Molecular INTeraction database

More...
MINTi
Q8VIG1

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000079231

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8VIG1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q8VIG1

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni32 – 117Interaction with SIN3ABy similarityAdd BLAST86
Regioni43 – 57Interaction with SIN3BBy similarityAdd BLAST15
Regioni140 – 413Interaction with ZFP90By similarityAdd BLAST274
Regioni196 – 207Required for binding to the neuron-restrictive silencer element1 PublicationAdd BLAST12
Regioni985 – 1063Interaction with RCOR1By similarityAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi395 – 602Lys-richAdd BLAST208
Compositional biasi661 – 792Pro-richAdd BLAST132

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C2H2-type zinc finger 5 is required for nuclear localization.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri154 – 176C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri211 – 235C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri243 – 265C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 350C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri356 – 378C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 407C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1036 – 1058C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155341

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009801_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8VIG1

Identification of Orthologs from Complete Genome Data

More...
OMAi
PCHFQAQ

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

TreeFam database of animal gene trees

More...
TreeFami
TF332861

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027757, REST
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...
PANTHERi
PTHR24403:SF64, PTHR24403:SF64, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8VIG1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATQVMGQSS GGGSLFNNSA NMGMALTNDM YDLHELSKAE LAAPQLIMLA
60 70 80 90 100
NVALTGEASG SCCDYLVGEE RQMAELMPVG DNHFSESEGE GLEESADLKG
110 120 130 140 150
LENMELGSLE LSAVEPQPVF EASAAPEIYS ANKDPAPETP VAEDKCRSSK
160 170 180 190 200
AKPFRCKPCQ YEAESEEQFV HHIRIHSAKK FFVEESAEKQ AKAWESGSSP
210 220 230 240 250
AEEGEFSKGP IRCDRCGYNT NRYDHYMAHL KHHLRAGENE RIYKCIICTY
260 270 280 290 300
TTVSEYHWRK HLRNHFPRKV YTCSKCNYFS DRKNNYVQHV RTHTGERPYK
310 320 330 340 350
CELCPYSSSQ KTHLTRHMRT HSGEKPFKCD QCNYVASNQH EVTRHARQVH
360 370 380 390 400
NGPKPLNCPH CDYKTADRSN FKKHVELHVN PRQFNCPVCD YAASKKCNLQ
410 420 430 440 450
YHFKSKHPTC PSKTMDVSKV KLKKTKKREA DLLNNAVSNE KMENEQTKTK
460 470 480 490 500
GDVSGKKNEK PVKAVGKDAS KEKKPGSSVS VVQVTTRTRK SAVAAETKAA
510 520 530 540 550
EVKHTDGQTG NNPEKPCKAK KNKRKKDAEA HPSEEPVNEG PVTKKKKKSE
560 570 580 590 600
CKSKIGTNVP KGGGRAEERP GVKKQSASLK KGTKKTPPKT KTSKKGGKLA
610 620 630 640 650
PKGMGQTEPS SGALAQVGVS PDPALIQAEV TGSGSSQTEL PSPMDIAKSE
660 670 680 690 700
PAQMEVSLTG PPPVEPAQME PSPAKPPQVE APTYPQPPQR GPAPPTGPAP
710 720 730 740 750
PTGPAPPTEP APPTGLAEME PSPTEPSQKE PPPSMEPPCP EELPQAEPPP
760 770 780 790 800
MEDCQKELPS PVEPAQIEVA QTAPTQVQEE PPPVSEPPRV KPTKRSSLRK
810 820 830 840 850
DRAEKELSLL SEMARQEQVL MGVGLVPVRD SKLLKGNKSA QDPPAPPSPS
860 870 880 890 900
PKGNSREETP KDQEMVSDGE GTIVFPLKKG GPEEAGESPA ELAALKESAR
910 920 930 940 950
VSSSEQNSAM PEGGASHSKC QTGSSGLCDV DTEQKTDTVP MKDSAAEPVS
960 970 980 990 1000
PPTPTVDRDA GSPAVVASPP ITLAENESQE IDEDEGIHSH DGSDLSDNMS
1010 1020 1030 1040 1050
EGSDDSGLHG ARPTPPEATS KNGKAGLAGK VTEGEFVCIF CDRSFRKEKD
1060 1070 1080
YSKHLNRHLV NVYFLEEAAE EQEEQEEREE QE
Length:1,082
Mass (Da):117,784
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D3616BC0820BC2F
GO
Isoform 2 (identifier: Q8VIG1-2) [UniParc]FASTAAdd to basket
Also known as: N16, REST4

The sequence of this isoform differs from the canonical sequence as follows:
     323-328: GEKPFK → ECDLAG
     329-1082: Missing.

Note: Produced by SRRM4-dependent alternative splicing in neurons and inner ear hair cells (PubMed:11039732, PubMed:29961578). Lacks the four C-terminal zinc fingers and the RCOR1 corepressor interaction site found in full length REST isoform 1, which are required for full DNA-binding and repressive activity (PubMed:11039732, PubMed:29961578).2 Publications Controversial data exists concerning the repressor activity of isoform 2. A study in human showed that human isoform 3 exhibits weak repressor activity of a NRSE motif-containing reporter construct (By similarity). Another report, however, does not observe any isoform 3 transcriptional repressor activity of a NRSE motif-containing reporter construct (By similarity). Controversial data also exists regarding the function of isoform 2 on the negative regulation of full-length REST. It was shown that isoform 2 negatively regulates the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (PubMed:10490617, PubMed:11039732). Another study in human, however, did not observe any inhibitory activity of human isoform 3 on the isoform 1 repressor activity (By similarity).By similarity2 Publications
Show »
Length:328
Mass (Da):36,953
Checksum:iF47E141348260843
GO
Isoform 3 (identifier: Q8VIG1-3) [UniParc]FASTAAdd to basket
Also known as: N28

The sequence of this isoform differs from the canonical sequence as follows:
     324-332: EKPFKCDQC → CDLVGYVFR
     333-1082: Missing.

Show »
Length:332
Mass (Da):37,475
Checksum:i15B8F53514610413
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH96434 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti414T → R in BAB82460 (Ref. 1) Curated1
Sequence conflicti485T → S in BAB82460 (Ref. 1) Curated1
Sequence conflicti556G → S in BAB82460 (Ref. 1) Curated1
Sequence conflicti584K → N in BAB82460 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_022069323 – 328GEKPFK → ECDLAG in isoform 2. 1 Publication6
Alternative sequenceiVSP_022070324 – 332EKPFKCDQC → CDLVGYVFR in isoform 3. Curated9
Alternative sequenceiVSP_022071329 – 1082Missing in isoform 2. 1 PublicationAdd BLAST754
Alternative sequenceiVSP_022072333 – 1082Missing in isoform 3. CuratedAdd BLAST750

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB024496 mRNA Translation: BAB82460.1
DQ644039 mRNA Translation: ABG35129.1
BC127065 mRNA Translation: AAI27066.1
BC096434 mRNA Translation: AAH96434.1 Sequence problems.
AK004945 mRNA Translation: BAB23689.3
AK156514 mRNA Translation: BAE33741.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS19372.1 [Q8VIG1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_035393.2, NM_011263.2 [Q8VIG1-1]
XP_006534905.1, XM_006534842.3 [Q8VIG1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000080359; ENSMUSP00000079231; ENSMUSG00000029249 [Q8VIG1-1]
ENSMUST00000113449; ENSMUSP00000109076; ENSMUSG00000029249 [Q8VIG1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
19712

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:19712

UCSC genome browser

More...
UCSCi
uc008xvz.2, mouse [Q8VIG1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024496 mRNA Translation: BAB82460.1
DQ644039 mRNA Translation: ABG35129.1
BC127065 mRNA Translation: AAI27066.1
BC096434 mRNA Translation: AAH96434.1 Sequence problems.
AK004945 mRNA Translation: BAB23689.3
AK156514 mRNA Translation: BAE33741.1
CCDSiCCDS19372.1 [Q8VIG1-1]
RefSeqiNP_035393.2, NM_011263.2 [Q8VIG1-1]
XP_006534905.1, XM_006534842.3 [Q8VIG1-1]

3D structure databases

BMRBiQ8VIG1
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi202864, 7 interactors
IntActiQ8VIG1, 3 interactors
MINTiQ8VIG1
STRINGi10090.ENSMUSP00000079231

PTM databases

iPTMnetiQ8VIG1
PhosphoSitePlusiQ8VIG1

Proteomic databases

EPDiQ8VIG1
jPOSTiQ8VIG1
PaxDbiQ8VIG1
PeptideAtlasiQ8VIG1
PRIDEiQ8VIG1
ProteomicsDBi254914 [Q8VIG1-1]
254915 [Q8VIG1-2]
254916 [Q8VIG1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1755, 273 antibodies

Genome annotation databases

EnsembliENSMUST00000080359; ENSMUSP00000079231; ENSMUSG00000029249 [Q8VIG1-1]
ENSMUST00000113449; ENSMUSP00000109076; ENSMUSG00000029249 [Q8VIG1-1]
GeneIDi19712
KEGGimmu:19712
UCSCiuc008xvz.2, mouse [Q8VIG1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5978
MGIiMGI:104897, Rest

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000155341
HOGENOMiCLU_009801_2_0_1
InParanoidiQ8VIG1
OMAiPCHFQAQ
OrthoDBi1318335at2759
TreeFamiTF332861

Enzyme and pathway databases

ReactomeiR-MMU-3214815, HDACs deacetylate histones

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
19712, 5 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Rest, mouse

Protein Ontology

More...
PROi
PR:Q8VIG1
RNActiQ8VIG1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000029249, Expressed in embryo and 301 other tissues
GenevisibleiQ8VIG1, MM

Family and domain databases

InterProiView protein in InterPro
IPR027757, REST
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PANTHERiPTHR24403:SF64, PTHR24403:SF64, 1 hit
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 9 hits
SUPFAMiSSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiREST_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VIG1
Secondary accession number(s): A0JNY8
, Q155C6, Q3U0W0, Q4VAD6, Q9CW43
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 27, 2011
Last modified: April 7, 2021
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again