Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BarH-like 2 homeobox protein

Gene

Barhl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential regulator of neural basic helix-loop-helix genes. It may down-regulate expression of ASCL1 and, within the thalamus, up-regulate NGN2, thereby regulating distinct patterns of neuronal differentiation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi229 – 288HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
BarH-like 2 homeobox protein
Alternative name(s):
Bar-class homeodomain protein MBH1
Homeobox protein B-H1
Gene namesi
Name:Barhl2
Synonyms:Barh1, Mbh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1859314 Barhl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488301 – 384BarH-like 2 homeobox proteinAdd BLAST384

Proteomic databases

PaxDbiQ8VIB5
PRIDEiQ8VIB5

PTM databases

iPTMnetiQ8VIB5
PhosphoSitePlusiQ8VIB5

Expressioni

Gene expression databases

BgeeiENSMUSG00000034384 Expressed in 190 organ(s), highest expression level in diencephalon ventricular layer (mouse)
CleanExiMM_BARHL2
GenevisibleiQ8VIB5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084005

Structurei

3D structure databases

ProteinModelPortaliQ8VIB5
SMRiQ8VIB5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 118Pro-richAdd BLAST56
Compositional biasi85 – 91His-rich7
Compositional biasi128 – 131Ala-rich4
Compositional biasi327 – 333Poly-Ala7

Sequence similaritiesi

Belongs to the BAR homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000231533
HOVERGENiHBG050663
InParanoidiQ8VIB5
KOiK09360
OMAiMTTMEGA
OrthoDBiEOG091G13SM
PhylomeDBiQ8VIB5
TreeFamiTF316128

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VIB5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAMEGASGS SFGIDTILSG AGSGSPGMMN GDFRSLGEAR TTDFRSQATP
60 70 80 90 100
SPCSEIDTVG TAPSSPISVT LEPPEPHLVT DGPQHHHHLH HSQQPPPPSA
110 120 130 140 150
VPAQSLQPSP QQQPPPQPQS AAQQLGSAAA APRTSTSSFL IKDILGDSKP
160 170 180 190 200
LAACAPYSTS VSSPHHTPKQ ESNAAHESFR PKLEQEDGKT KLDKREDPQS
210 220 230 240 250
DIKCHGTKEE GDREITSSRE SPPVRAKKPR KARTAFSDHQ LNQLERSFER
260 270 280 290 300
QKYLSVQDRM DLAAALNLTD TQVKTWYQNR RTKWKRQTAV GLELLAEAGN
310 320 330 340 350
YSALQRMFPS PYFYHPSLLG SMDSTTAAAA AAAMYSSMYR TPPAPHPQLQ
360 370 380
RPLVPRVLIH GLGPGGQPAL NPLSNPIPGT PHPR
Length:384
Mass (Da):41,459
Last modified:August 2, 2005 - v2
Checksum:i0ECD1F92E8C22B7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078444 mRNA Translation: AAH78444.1
AB063281 Genomic DNA Translation: BAB79292.1
CCDSiCCDS19497.1
RefSeqiNP_001005477.1, NM_001005477.1
UniGeneiMm.271593

Genome annotation databases

EnsembliENSMUST00000086795; ENSMUSP00000084005; ENSMUSG00000034384
GeneIDi104382
KEGGimmu:104382
UCSCiuc008ylm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078444 mRNA Translation: AAH78444.1
AB063281 Genomic DNA Translation: BAB79292.1
CCDSiCCDS19497.1
RefSeqiNP_001005477.1, NM_001005477.1
UniGeneiMm.271593

3D structure databases

ProteinModelPortaliQ8VIB5
SMRiQ8VIB5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084005

PTM databases

iPTMnetiQ8VIB5
PhosphoSitePlusiQ8VIB5

Proteomic databases

PaxDbiQ8VIB5
PRIDEiQ8VIB5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000086795; ENSMUSP00000084005; ENSMUSG00000034384
GeneIDi104382
KEGGimmu:104382
UCSCiuc008ylm.1 mouse

Organism-specific databases

CTDi343472
MGIiMGI:1859314 Barhl2

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000231533
HOVERGENiHBG050663
InParanoidiQ8VIB5
KOiK09360
OMAiMTTMEGA
OrthoDBiEOG091G13SM
PhylomeDBiQ8VIB5
TreeFamiTF316128

Miscellaneous databases

ChiTaRSiCapg mouse
PROiPR:Q8VIB5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034384 Expressed in 190 organ(s), highest expression level in diencephalon ventricular layer (mouse)
CleanExiMM_BARHL2
GenevisibleiQ8VIB5 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBARH2_MOUSE
AccessioniPrimary (citable) accession number: Q8VIB5
Secondary accession number(s): Q66L43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: August 2, 2005
Last modified: November 7, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again