Barhl2

Functionⁱ

Potential regulator of neural basic helix-loop-helix genes. It may down-regulate expression of ASCL1 and, within the thalamus, up-regulate NGN2, thereby regulating distinct patterns of neuronal differentiation (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	229 – 288	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA-binding transcription factor activity Source: MGI
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: MGI
Inferred from direct assayⁱ
- 18212062
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

animal organ development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell fate commitment
Source: MGI
Inferred from direct assayⁱ
- 14998930
cell fate determination
Source: MGI
Inferred from mutant phenotypeⁱ
- 12657654
nervous system development Source: MGI
neuron differentiation
Source: MGI
Inferred from direct assayⁱ
- 14998930
neuron migration
Source: MGI
Inferred from mutant phenotypeⁱ
- 12657654
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 18212062
positive regulation of translation
Source: MGI
Inferred from mutant phenotypeⁱ
- 12657654
regulation of axon extension
Source: MGI
Inferred from mutant phenotypeⁱ
- 12657654
regulation of transcription by RNA polymerase II Source: MGI
tissue development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: BarH-like 2 homeobox protein Alternative name(s): Bar-class homeodomain protein MBH1 Homeobox protein B-H1
Gene namesⁱ	Name:Barhl2 Synonyms:Barh1, Mbh1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:1859314 Barhl2

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000048830	1 – 384	BarH-like 2 homeobox proteinAdd BLAST		384

Proteomic databases

PaxDbⁱ	Q8VIB5
PRIDEⁱ	Q8VIB5

PTM databases

iPTMnetⁱ	Q8VIB5
PhosphoSitePlusⁱ	Q8VIB5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000034384 Expressed in 190 organ(s), highest expression level in diencephalon ventricular layer (mouse)
CleanExⁱ	MM_BARHL2
Genevisibleⁱ	Q8VIB5 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000084005

STRINGⁱ

10090.ENSMUSP00000084005

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8VIB5
SMRⁱ	Q8VIB5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	63 – 118	Pro-richAdd BLAST	56
Compositional biasⁱ	85 – 91	His-rich	7
Compositional biasⁱ	128 – 131	Ala-rich	4
Compositional biasⁱ	327 – 333	Poly-Ala	7

Sequence similaritiesⁱ

Belongs to the BAR homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0488 Eukaryota ENOG411188D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143996
HOGENOMⁱ	HOG000231533
HOVERGENⁱ	HBG050663
InParanoidⁱ	Q8VIB5
KEGG Orthology (KO) More...KOⁱ	K09360
OMAⁱ	MTTMEGA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G13SM
PhylomeDBⁱ	Q8VIB5
TreeFamⁱ	TF316128

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8VIB5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTAMEGASGS SFGIDTILSG AGSGSPGMMN GDFRSLGEAR TTDFRSQATP 
        60         70         80         90        100
SPCSEIDTVG TAPSSPISVT LEPPEPHLVT DGPQHHHHLH HSQQPPPPSA 
       110        120        130        140        150
VPAQSLQPSP QQQPPPQPQS AAQQLGSAAA APRTSTSSFL IKDILGDSKP 
       160        170        180        190        200
LAACAPYSTS VSSPHHTPKQ ESNAAHESFR PKLEQEDGKT KLDKREDPQS 
       210        220        230        240        250
DIKCHGTKEE GDREITSSRE SPPVRAKKPR KARTAFSDHQ LNQLERSFER 
       260        270        280        290        300
QKYLSVQDRM DLAAALNLTD TQVKTWYQNR RTKWKRQTAV GLELLAEAGN 
       310        320        330        340        350
YSALQRMFPS PYFYHPSLLG SMDSTTAAAA AAAMYSSMYR TPPAPHPQLQ 
       360        370        380 
RPLVPRVLIH GLGPGGQPAL NPLSNPIPGT PHPR

Length:384

Mass (Da):41,459

Last modified:August 2, 2005 - v2

Checksum:ⁱ0ECD1F92E8C22B7B

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC078444 mRNA Translation: AAH78444.1 AB063281 Genomic DNA Translation: BAB79292.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19497.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001005477.1, NM_001005477.1
UniGeneⁱ	Mm.271593

Genome annotation databases

Ensemblⁱ	ENSMUST00000086795; ENSMUSP00000084005; ENSMUSG00000034384
GeneIDⁱ	104382
KEGGⁱ	mmu:104382
UCSC genome browser More...UCSCⁱ	uc008ylm.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8VIB5	BarH-like 2 homeobox protein		HUMAN		387	UniRef90_Q8VIB5
BarH-like 2 homeobox protein		RAT		384
BarH like homeobox 2		CANLF		397
Uncharacterized protein		CALJA		390
Uncharacterized protein		MACMU		264
+99

Protein	Similar proteins		Species	Score	Length	Source
Q8VIB5	BarH-like 2 homeobox protein		HUMAN		387	UniRef50_Q8VIB5
BarH-like 2 homeobox protein		RAT		384
BarH like homeobox 2		CANLF		397
barH-like 2 homeobox protein		DIPOR		390
Uncharacterized protein		CALJA		390
+189

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC078444 mRNA Translation: AAH78444.1 AB063281 Genomic DNA Translation: BAB79292.1
CCDSⁱ	CCDS19497.1
RefSeqⁱ	NP_001005477.1, NM_001005477.1
UniGeneⁱ	Mm.271593

3D structure databases

ProteinModelPortalⁱ	Q8VIB5
SMRⁱ	Q8VIB5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000084005

STRINGⁱ

10090.ENSMUSP00000084005

PTM databases

iPTMnetⁱ	Q8VIB5
PhosphoSitePlusⁱ	Q8VIB5

Proteomic databases

PaxDbⁱ	Q8VIB5
PRIDEⁱ	Q8VIB5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000086795; ENSMUSP00000084005; ENSMUSG00000034384
GeneIDⁱ	104382
KEGGⁱ	mmu:104382
UCSCⁱ	uc008ylm.1 mouse

Organism-specific databases

CTDⁱ	343472
MGIⁱ	MGI:1859314 Barhl2

Phylogenomic databases

eggNOGⁱ	KOG0488 Eukaryota ENOG411188D LUCA
GeneTreeⁱ	ENSGT00910000143996
HOGENOMⁱ	HOG000231533
HOVERGENⁱ	HBG050663
InParanoidⁱ	Q8VIB5
KOⁱ	K09360
OMAⁱ	MTTMEGA
OrthoDBⁱ	EOG091G13SM
PhylomeDBⁱ	Q8VIB5
TreeFamⁱ	TF316128

Miscellaneous databases

ChiTaRSⁱ	Capg mouse
Protein Ontology More...PROⁱ	PR:Q8VIB5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000034384 Expressed in 190 organ(s), highest expression level in diencephalon ventricular layer (mouse)
CleanExⁱ	MM_BARHL2
Genevisibleⁱ	Q8VIB5 MM

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BARH2_MOUSE
Accessionⁱ	Q8VIB5Primary (citable) accession number: Q8VIB5 Secondary accession number(s): Q66L43
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
	Last sequence update:	August 2, 2005
	Last modified:	November 7, 2018
	This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8VIB5 (BARH2_MOUSE)

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BarH-like 2 homeobox protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ