We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q8VIB5 (BARH2_MOUSE)
Protein
BarH-like 2 homeobox protein
Gene
Barhl2
Organism
Mus musculus (Mouse)
Status
Functioni
Potential regulator of neural basic helix-loop-helix genes. It may down-regulate expression of ASCL1 and, within the thalamus, up-regulate NGN2, thereby regulating distinct patterns of neuronal differentiation (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 229 – 288 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- cell fate commitment Source: MGI
- cell fate determination Source: MGI
- nervous system development Source: MGI
- neuron differentiation Source: MGI
- neuron migration Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of translation Source: MGI
- regulation of axon extension Source: MGI
- regulation of transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: BarH-like 2 homeobox proteinAlternative name(s): Bar-class homeodomain protein MBH1 Homeobox protein B-H1 |
Gene namesi | Name:Barhl2 Synonyms:Barh1, Mbh1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1859314, Barhl2 |
VEuPathDBi | HostDB:ENSMUSG00000034384 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048830 | 1 – 384 | BarH-like 2 homeobox proteinAdd BLAST | 384 |
Proteomic databases
PaxDbi | Q8VIB5 |
PRIDEi | Q8VIB5 |
ProteomicsDBi | 277162 |
PTM databases
iPTMneti | Q8VIB5 |
PhosphoSitePlusi | Q8VIB5 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000034384, Expressed in diencephalon ventricular layer (mouse) and 203 other tissues |
Genevisiblei | Q8VIB5, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000084005 |
Miscellaneous databases
RNActi | Q8VIB5, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 134 | DisorderedSequence analysisAdd BLAST | 134 | |
Regioni | 154 – 235 | DisorderedSequence analysisAdd BLAST | 82 | |
Regioni | 364 – 384 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 18 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 40 – 68 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 95 – 117 | Pro residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 118 – 134 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 155 – 169 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 170 – 235 | Basic and acidic residuesSequence analysisAdd BLAST | 66 |
Sequence similaritiesi
Belongs to the BAR homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0488, Eukaryota |
GeneTreei | ENSGT00940000158611 |
HOGENOMi | CLU_074592_0_0_1 |
InParanoidi | Q8VIB5 |
OMAi | LDKRDDT |
OrthoDBi | 1353352at2759 |
PhylomeDBi | Q8VIB5 |
TreeFami | TF316128 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8VIB5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTAMEGASGS SFGIDTILSG AGSGSPGMMN GDFRSLGEAR TTDFRSQATP
60 70 80 90 100
SPCSEIDTVG TAPSSPISVT LEPPEPHLVT DGPQHHHHLH HSQQPPPPSA
110 120 130 140 150
VPAQSLQPSP QQQPPPQPQS AAQQLGSAAA APRTSTSSFL IKDILGDSKP
160 170 180 190 200
LAACAPYSTS VSSPHHTPKQ ESNAAHESFR PKLEQEDGKT KLDKREDPQS
210 220 230 240 250
DIKCHGTKEE GDREITSSRE SPPVRAKKPR KARTAFSDHQ LNQLERSFER
260 270 280 290 300
QKYLSVQDRM DLAAALNLTD TQVKTWYQNR RTKWKRQTAV GLELLAEAGN
310 320 330 340 350
YSALQRMFPS PYFYHPSLLG SMDSTTAAAA AAAMYSSMYR TPPAPHPQLQ
360 370 380
RPLVPRVLIH GLGPGGQPAL NPLSNPIPGT PHPR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC078444 mRNA Translation: AAH78444.1 AB063281 Genomic DNA Translation: BAB79292.1 |
CCDSi | CCDS19497.1 |
RefSeqi | NP_001005477.1, NM_001005477.1 |
Genome annotation databases
Ensembli | ENSMUST00000086795; ENSMUSP00000084005; ENSMUSG00000034384 |
GeneIDi | 104382 |
KEGGi | mmu:104382 |
UCSCi | uc008ylm.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC078444 mRNA Translation: AAH78444.1 AB063281 Genomic DNA Translation: BAB79292.1 |
CCDSi | CCDS19497.1 |
RefSeqi | NP_001005477.1, NM_001005477.1 |
3D structure databases
SMRi | Q8VIB5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000084005 |
PTM databases
iPTMneti | Q8VIB5 |
PhosphoSitePlusi | Q8VIB5 |
Proteomic databases
PaxDbi | Q8VIB5 |
PRIDEi | Q8VIB5 |
ProteomicsDBi | 277162 |
Protocols and materials databases
Antibodypediai | 19858, 80 antibodies from 24 providers |
DNASUi | 104382 |
Genome annotation databases
Ensembli | ENSMUST00000086795; ENSMUSP00000084005; ENSMUSG00000034384 |
GeneIDi | 104382 |
KEGGi | mmu:104382 |
UCSCi | uc008ylm.1, mouse |
Organism-specific databases
CTDi | 343472 |
MGIi | MGI:1859314, Barhl2 |
VEuPathDBi | HostDB:ENSMUSG00000034384 |
Phylogenomic databases
eggNOGi | KOG0488, Eukaryota |
GeneTreei | ENSGT00940000158611 |
HOGENOMi | CLU_074592_0_0_1 |
InParanoidi | Q8VIB5 |
OMAi | LDKRDDT |
OrthoDBi | 1353352at2759 |
PhylomeDBi | Q8VIB5 |
TreeFami | TF316128 |
Miscellaneous databases
BioGRID-ORCSi | 104382, 2 hits in 65 CRISPR screens |
ChiTaRSi | Barhl2, mouse |
PROi | PR:Q8VIB5 |
RNActi | Q8VIB5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000034384, Expressed in diencephalon ventricular layer (mouse) and 203 other tissues |
Genevisiblei | Q8VIB5, MM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BARH2_MOUSE | |
Accessioni | Q8VIB5Primary (citable) accession number: Q8VIB5 Secondary accession number(s): Q66L43 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2004 |
Last sequence update: | August 2, 2005 | |
Last modified: | February 23, 2022 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families