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Protein

Importin-4

Gene

Ipo4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. Acts as chaperone for exposed basic domains.By similarity1 Publication

GO - Molecular functioni

  • nuclear localization sequence binding Source: GO_Central
  • Ran GTPase binding Source: InterPro

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Importin-4
Short name:
Imp4
Alternative name(s):
Importin-4a
Short name:
Imp4a
Ran-binding protein 4
Short name:
RanBP4
Gene namesi
Name:Ipo4
Synonyms:Imp4a, Ranbp4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1923001 Ipo4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207491 – 1082Importin-4Add BLAST1082

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8VI75
MaxQBiQ8VI75
PaxDbiQ8VI75
PeptideAtlasiQ8VI75
PRIDEiQ8VI75

PTM databases

iPTMnetiQ8VI75
PhosphoSitePlusiQ8VI75

Expressioni

Gene expression databases

BgeeiENSMUSG00000002319 Expressed in 290 organ(s), highest expression level in internal carotid artery
CleanExiMM_IPO4
ExpressionAtlasiQ8VI75 baseline and differential
GenevisibleiQ8VI75 MM

Interactioni

Subunit structurei

Binds with high affinity to RPS3A. The binding is coupled to RanGTP cycles. Found in a cytosolic complex with ASF1A, ASF1B, CDAN1 and histones H3.1 and H4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi217713, 3 interactors
IntActiQ8VI75, 2 interactors
MINTiQ8VI75
STRINGi10090.ENSMUSP00000036555

Structurei

3D structure databases

ProteinModelPortaliQ8VI75
SMRiQ8VI75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 90Importin N-terminalPROSITE-ProRule annotationAdd BLAST67
Repeati348 – 385HEAT 1Add BLAST38
Repeati390 – 427HEAT 2Add BLAST38
Repeati431 – 471HEAT 3Add BLAST41
Repeati475 – 513HEAT 4Add BLAST39
Repeati896 – 933HEAT 5Add BLAST38
Repeati937 – 975HEAT 6Add BLAST39

Sequence similaritiesi

Belongs to the importin beta family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KD6C Eukaryota
ENOG410XP2Z LUCA
GeneTreeiENSGT00550000075074
HOGENOMiHOG000008166
HOVERGENiHBG049052
InParanoidiQ8VI75
KOiK20221
OMAiLCKTKQG
OrthoDBiEOG091G012W
PhylomeDBiQ8VI75
TreeFamiTF323157

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000357 HEAT
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF02985 HEAT, 1 hit
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8VI75-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPAGLEQIL KELLLPDTER IRRATEQLQT ILRDPAALPA LFDLLATATD
60 70 80 90 100
SQIRQFAAVL TRRRLNNRWR RLAPEQRESL KSLVLTALQK ETVHSVSVSL
110 120 130 140 150
AQLSATIFRK EGLQGWPQFM NLLQHSTHSS HSPEKEVGLL LLSVVVSSQP
160 170 180 190 200
EAFHAHQHEL LQLLNETLSD VSFPGVLFYS LRTLTAIARY VRPDDVSLAR
210 220 230 240 250
MLVPKVVTAL RTLIPLDEVK ACEALEALDE MLETELPIIN PHLSEVLTFC
260 270 280 290 300
LEVAKNVALG EPLRVRVLCC LTFLVKVKSK ALLKNRLVPP LLHALFPLMA
310 320 330 340 350
AEPPMGQLDP EDQDSDDDDL EIGLMGETPK HFAVQVVDML ALHLPPEKLC
360 370 380 390 400
PHVMPMLEEA LRSEDPYQRK AGFLVLAVLS DGAGDHIRQR LLYPLLQIVC
410 420 430 440 450
KGLDDPSQIV RNAALFALGQ FSENLQPHIS SYSEEVMPLL LSYLKSVPMG
460 470 480 490 500
NTHHLAKACY ALENFVENLG PKVQPYLPEL MECMLQPLKN PSKARTKELA
510 520 530 540 550
VSAIGAIATA AQDSLLPYFP TIMDLLREFL LTGHEDFHLV QIQSLETLGV
560 570 580 590 600
LARALGESMK PLAEECCQLG LGLCIHIDDP DVRRCTYSLF AALSGLMGEG
610 620 630 640 650
LGPYLPQITT LMLLSLRSTE GIVPQYDGIS SFLLFDDDSE AEEEEELMDE
660 670 680 690 700
DMEEEGDDSE ISGYSVENAF FDEKEDTCTA LGEISMNTCV AFLPFMDATF
710 720 730 740 750
DEVYKLLECP HMNVRKSAYE ALGQFCCALH KASQRSSSDP SSSPVLQTSL
760 770 780 790 800
ARVMPAYMQA VKVERERPVV MAVLESLTGV LRTCGSLALQ PPGRLSELCN
810 820 830 840 850
VLKAVLQKKT ACQDAEEDDD EDDDQAEYDA MLLEHAGEAI PVLAATAGGH
860 870 880 890 900
AFAPFFATFL PLLLCKTKQS CTVAEKSFAV GTLAESIQGL GTASAQFVSR
910 920 930 940 950
LFPVLLNNAR EADPEVRSNA IFGLGVLAEH GGCPAQDHFP KLLGLLLPLL
960 970 980 990 1000
ARERHDRVRD NICGALARVL MASPVGKTEP QVLATLLRAL PLKEDMEEWL
1010 1020 1030 1040 1050
TIGHLFSFLH QNNPEQVVDV ASELLRICSL ILPDNRIPPD TKAALLLLLT
1060 1070 1080
FLAKQHTDSF HTALGSLPND KAQELQAMMG LT
Length:1,082
Mass (Da):119,275
Last modified:March 1, 2002 - v1
Checksum:iBF78D395A3111FF3
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5U4C5Q5U4C5_MOUSE
Importin-4
Ipo4
818Annotation score:
D6RES6D6RES6_MOUSE
Importin 4, isoform CRA_a
Ipo4 mCG_22060
98Annotation score:
A0A2I3BRV3A0A2I3BRV3_MOUSE
Importin-4
Ipo4
188Annotation score:
A0A2I3BQQ0A0A2I3BQQ0_MOUSE
Importin-4
Ipo4
74Annotation score:

Sequence cautioni

The sequence AAH03469 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC26988 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123388 mRNA Translation: AAL55522.1
AK030490 mRNA Translation: BAC26988.1 Different initiation.
AK147086 mRNA Translation: BAE27666.1
AK171031 mRNA Translation: BAE42197.1
BC003469 mRNA Translation: AAH03469.1 Different initiation.
CCDSiCCDS27121.1
RefSeqiNP_077229.4, NM_024267.6
UniGeneiMm.27546

Genome annotation databases

EnsembliENSMUST00000047131; ENSMUSP00000036555; ENSMUSG00000002319
GeneIDi75751
KEGGimmu:75751
UCSCiuc007tzp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123388 mRNA Translation: AAL55522.1
AK030490 mRNA Translation: BAC26988.1 Different initiation.
AK147086 mRNA Translation: BAE27666.1
AK171031 mRNA Translation: BAE42197.1
BC003469 mRNA Translation: AAH03469.1 Different initiation.
CCDSiCCDS27121.1
RefSeqiNP_077229.4, NM_024267.6
UniGeneiMm.27546

3D structure databases

ProteinModelPortaliQ8VI75
SMRiQ8VI75
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217713, 3 interactors
IntActiQ8VI75, 2 interactors
MINTiQ8VI75
STRINGi10090.ENSMUSP00000036555

PTM databases

iPTMnetiQ8VI75
PhosphoSitePlusiQ8VI75

Proteomic databases

EPDiQ8VI75
MaxQBiQ8VI75
PaxDbiQ8VI75
PeptideAtlasiQ8VI75
PRIDEiQ8VI75

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047131; ENSMUSP00000036555; ENSMUSG00000002319
GeneIDi75751
KEGGimmu:75751
UCSCiuc007tzp.1 mouse

Organism-specific databases

CTDi79711
MGIiMGI:1923001 Ipo4

Phylogenomic databases

eggNOGiENOG410KD6C Eukaryota
ENOG410XP2Z LUCA
GeneTreeiENSGT00550000075074
HOGENOMiHOG000008166
HOVERGENiHBG049052
InParanoidiQ8VI75
KOiK20221
OMAiLCKTKQG
OrthoDBiEOG091G012W
PhylomeDBiQ8VI75
TreeFamiTF323157

Miscellaneous databases

ChiTaRSiIpo4 mouse
PROiPR:Q8VI75
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002319 Expressed in 290 organ(s), highest expression level in internal carotid artery
CleanExiMM_IPO4
ExpressionAtlasiQ8VI75 baseline and differential
GenevisibleiQ8VI75 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000357 HEAT
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF02985 HEAT, 1 hit
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIPO4_MOUSE
AccessioniPrimary (citable) accession number: Q8VI75
Secondary accession number(s): Q3TBW0, Q99J52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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