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Protein

Solute carrier family 12 member 8

Gene

Slc12a8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation.By similarity

GO - Molecular functioni

  • potassium:chloride symporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processIon transport, Potassium transport, Symport, Transport
LigandChloride, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 12 member 8
Alternative name(s):
Cation-chloride cotransporter 9
Gene namesi
Name:Slc12a8
Synonyms:Ccc9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2443672 Slc12a8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Transmembranei390 – 410HelicalSequence analysisAdd BLAST21
Transmembranei587 – 607HelicalSequence analysisAdd BLAST21
Transmembranei612 – 632HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003052881 – 705Solute carrier family 12 member 8Add BLAST705

Proteomic databases

PaxDbiQ8VI23
PRIDEiQ8VI23

PTM databases

iPTMnetiQ8VI23
PhosphoSitePlusiQ8VI23

Expressioni

Gene expression databases

BgeeiENSMUSG00000035506 Expressed in 90 organ(s), highest expression level in submandibular gland
ExpressionAtlasiQ8VI23 baseline and differential
GenevisibleiQ8VI23 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062337

Structurei

3D structure databases

ProteinModelPortaliQ8VI23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC12A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2083 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00760000119053
HOGENOMiHOG000045198
HOVERGENiHBG108430
InParanoidiQ8VI23
KOiK14428
OMAiCNRWFSL
OrthoDBiEOG091G02VO
PhylomeDBiQ8VI23
TreeFamiTF313191

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8VI23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQRSPQELF HEAAQQGILA QPQPWWKIQL FMWEPVLFGT WDGVFTSCMI
60 70 80 90 100
NIFGVVLFLR TGWLVGNTGV LLGLLLVSFV VLVALITVLS GIGVAEHGGI
110 120 130 140 150
SSGGVYSMIS SVLGGQMGGT VGLLYVFGQC VAGAMYITGF AESISDLLGL
160 170 180 190 200
GDIWAVRGIS VAVLLALLGI NLAGVKWIIR LQLLLLLLLA VSTLDFVVGS
210 220 230 240 250
FTHLDPEHGF IGYSPELLQS NILPEYSPGE SFFTVFGVFF PAATGVMAGF
260 270 280 290 300
NMGGDLRDPA DSVPLGSLAA VGVSWFLYII FAFLLGAVCT REALRSDFLI
310 320 330 340 350
AEKVSLVGFL FLLGLYISSL ASCMGGLYGA PRILQCIAQD KVIPALAFLA
360 370 380 390 400
NGKGPNKTPV AAICLTSLVT MAFVLVGQVN VLAPVVTINF MLTYIMVDYS
410 420 430 440 450
YFALSMAHCG LAPSPEPVPR QGPDTLHCSE HLLQDRAPSY GSDVPARSLS
460 470 480 490 500
EGTLLEFTKD MDQFLQPIEE LESRQLGSRE GNNPKNQKRK GKKGAKQTLQ
510 520 530 540 550
DSFLLDPGSP LSFPTRTSER LSVAFCGEQE SYQKQQTSRS ESHDHLVPDL
560 570 580 590 600
RNQPRVNRED FFLKCRLQEQ EIQRRPSVFY ACMCNPWVSL LGALASLLIM
610 620 630 640 650
FVIQWLYTLA SMGVAALVYF YIGQASPGLY LGSASNFSFF QWMKSFLVPS
660 670 680 690 700
CRSLRSAQEQ IILAPSPAKV DMAMTQLTQD NADFATRDRY HHSSFLSREQ

LMPPY
Length:705
Mass (Da):77,020
Last modified:October 2, 2007 - v2
Checksum:i0AF9193CB067D315
GO
Isoform 2 (identifier: Q8VI23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAQRSP → MSQV

Show »
Length:703
Mass (Da):76,794
Checksum:i90FCDF8BF7ADF11E
GO
Isoform 3 (identifier: Q8VI23-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.
     304-352: Missing.

Note: No experimental confirmation available.
Show »
Length:625
Mass (Da):68,291
Checksum:iD0C2AED2F5DEBE7B
GO
Isoform 4 (identifier: Q8VI23-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-246: Missing.
     304-352: Missing.

Note: No experimental confirmation available.
Show »
Length:410
Mass (Da):45,717
Checksum:iCF8D2962EAAC808F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z3V1D3Z3V1_MOUSE
Solute carrier family 12 member 8
Slc12a8
459Annotation score:
D3Z6X1D3Z6X1_MOUSE
Solute carrier family 12 member 8
Slc12a8
584Annotation score:
D3YTS8D3YTS8_MOUSE
Solute carrier family 12 (Potassium...
Slc12a8 mCG_130131
426Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183L → P in AAL37178 (Ref. 1) Curated1
Sequence conflicti236F → L in AAL37178 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0283331 – 246Missing in isoform 4. 1 PublicationAdd BLAST246
Alternative sequenceiVSP_0283341 – 31Missing in isoform 3. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_0283351 – 6MAQRSP → MSQV in isoform 2. 1 Publication6
Alternative sequenceiVSP_028336304 – 352Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319951 mRNA Translation: AAL37178.1
AK165080 mRNA Translation: BAE38029.1
AC121570 Genomic DNA No translation available.
AC127412 Genomic DNA No translation available.
BC030926 mRNA Translation: AAH30926.1
CCDSiCCDS37317.1 [Q8VI23-3]
CCDS49834.1 [Q8VI23-1]
RefSeqiNP_001077371.1, NM_001083902.1 [Q8VI23-3]
NP_599012.2, NM_134251.2 [Q8VI23-1]
XP_006521883.1, XM_006521820.2 [Q8VI23-1]
UniGeneiMm.35253

Genome annotation databases

EnsembliENSMUST00000059056; ENSMUSP00000062337; ENSMUSG00000035506 [Q8VI23-1]
ENSMUST00000119173; ENSMUSP00000113633; ENSMUSG00000035506 [Q8VI23-3]
ENSMUST00000121925; ENSMUSP00000112439; ENSMUSG00000035506 [Q8VI23-1]
GeneIDi171286
KEGGimmu:171286
UCSCiuc007zad.1 mouse [Q8VI23-1]
uc007zae.1 mouse [Q8VI23-3]
uc007zag.1 mouse [Q8VI23-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319951 mRNA Translation: AAL37178.1
AK165080 mRNA Translation: BAE38029.1
AC121570 Genomic DNA No translation available.
AC127412 Genomic DNA No translation available.
BC030926 mRNA Translation: AAH30926.1
CCDSiCCDS37317.1 [Q8VI23-3]
CCDS49834.1 [Q8VI23-1]
RefSeqiNP_001077371.1, NM_001083902.1 [Q8VI23-3]
NP_599012.2, NM_134251.2 [Q8VI23-1]
XP_006521883.1, XM_006521820.2 [Q8VI23-1]
UniGeneiMm.35253

3D structure databases

ProteinModelPortaliQ8VI23
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062337

PTM databases

iPTMnetiQ8VI23
PhosphoSitePlusiQ8VI23

Proteomic databases

PaxDbiQ8VI23
PRIDEiQ8VI23

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059056; ENSMUSP00000062337; ENSMUSG00000035506 [Q8VI23-1]
ENSMUST00000119173; ENSMUSP00000113633; ENSMUSG00000035506 [Q8VI23-3]
ENSMUST00000121925; ENSMUSP00000112439; ENSMUSG00000035506 [Q8VI23-1]
GeneIDi171286
KEGGimmu:171286
UCSCiuc007zad.1 mouse [Q8VI23-1]
uc007zae.1 mouse [Q8VI23-3]
uc007zag.1 mouse [Q8VI23-4]

Organism-specific databases

CTDi84561
MGIiMGI:2443672 Slc12a8

Phylogenomic databases

eggNOGiKOG2083 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00760000119053
HOGENOMiHOG000045198
HOVERGENiHBG108430
InParanoidiQ8VI23
KOiK14428
OMAiCNRWFSL
OrthoDBiEOG091G02VO
PhylomeDBiQ8VI23
TreeFamiTF313191

Miscellaneous databases

PROiPR:Q8VI23
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035506 Expressed in 90 organ(s), highest expression level in submandibular gland
ExpressionAtlasiQ8VI23 baseline and differential
GenevisibleiQ8VI23 MM

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS12A8_MOUSE
AccessioniPrimary (citable) accession number: Q8VI23
Secondary accession number(s): Q3TNQ9, Q8K0M9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 7, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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