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Protein

U3 small nucleolar ribonucleoprotein protein IMP4

Gene

Imp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity).By similarity

GO - Molecular functioni

  • rRNA primary transcript binding Source: GO_Central
  • snoRNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein
Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar ribonucleoprotein protein IMP4
Short name:
U3 snoRNP protein IMP4
Gene namesi
Name:Imp4
Synonyms:D1Wsu40e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:106572 Imp4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202371 – 291U3 small nucleolar ribonucleoprotein protein IMP4Add BLAST291

Proteomic databases

EPDiQ8VHZ7
MaxQBiQ8VHZ7
PaxDbiQ8VHZ7
PeptideAtlasiQ8VHZ7
PRIDEiQ8VHZ7

PTM databases

PhosphoSitePlusiQ8VHZ7

Expressioni

Gene expression databases

BgeeiENSMUSG00000026127 Expressed in 293 organ(s), highest expression level in primary oocyte
ExpressionAtlasiQ8VHZ7 baseline and differential
GenevisibleiQ8VHZ7 MM

Interactioni

Subunit structurei

Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10 (By similarity).By similarity

Protein-protein interaction databases

BioGridi205703, 2 interactors
IntActiQ8VHZ7, 1 interactor
STRINGi10090.ENSMUSP00000027303

Structurei

3D structure databases

ProteinModelPortaliQ8VHZ7
SMRiQ8VHZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 264BrixPROSITE-ProRule annotationAdd BLAST182

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 48Arg/Glu/Lys-richAdd BLAST46

Phylogenomic databases

eggNOGiKOG2781 Eukaryota
COG2136 LUCA
GeneTreeiENSGT00550000074987
HOGENOMiHOG000172063
HOVERGENiHBG056795
InParanoidiQ8VHZ7
KOiK14561
OMAiFFNISDV
OrthoDBiEOG091G0GP1
PhylomeDBiQ8VHZ7
TreeFamiTF300016

Family and domain databases

InterProiView protein in InterPro
IPR007109 Brix
PfamiView protein in Pfam
PF04427 Brix, 1 hit
SMARTiView protein in SMART
SM00879 Brix, 1 hit
PROSITEiView protein in PROSITE
PS50833 BRIX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8VHZ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRREARLRR EYLYRKAREE AQRSVQEKKE RVKRALEENQ LIPTELRREA
60 70 80 90 100
LALQGSLEFD DAGGEGVTSH VDDEYRWAGV EDPKVMITTS RDPSSRLKMF
110 120 130 140 150
AKELKLVFPG AQRMNRGRHE VGALVRACKA NGVTDLLVVH EHRGTPVGLI
160 170 180 190 200
VSHLPFGPTA YFTLCNVVMR HDIPDLGTMS EAKPHLITHG FSSRLGKRVS
210 220 230 240 250
DILRYLFPVP KDDSHRVITF ANQDDYISFR HHVYKKTDHR NVELTEVGPR
260 270 280 290
FELKLYMIRL GTLEQEATAD VEWRWHPYTN TARKRVFLSA E
Length:291
Mass (Da):33,656
Last modified:March 1, 2002 - v1
Checksum:i5AFF74AA16E0C7BC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6VY64F6VY64_MOUSE
U3 small nucleolar ribonucleoprotei...
Imp4
171Annotation score:
D6RCI8D6RCI8_MOUSE
U3 small nucleolar ribonucleoprotei...
Imp4
97Annotation score:

Sequence cautioni

The sequence BAB26989 differs from that shown. Reason: Frameshift at position 249.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22 – 23QR → HG in BAB28797 (PubMed:16141072).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334609 mRNA Translation: AAL73190.1
AK010504 mRNA Translation: BAB26989.1 Frameshift.
AK013334 mRNA Translation: BAB28797.1
AK084933 mRNA Translation: BAC39313.1
AK151176 mRNA Translation: BAE30178.1
AK152214 mRNA Translation: BAE31042.1
AK166903 mRNA Translation: BAE39105.1
BC037602 mRNA Translation: AAH37602.1
BC069930 mRNA Translation: AAH69930.1
CCDSiCCDS35536.1
RefSeqiNP_848716.2, NM_178601.3
UniGeneiMm.289667

Genome annotation databases

EnsembliENSMUST00000027303; ENSMUSP00000027303; ENSMUSG00000026127
GeneIDi27993
KEGGimmu:27993
UCSCiuc007aor.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334609 mRNA Translation: AAL73190.1
AK010504 mRNA Translation: BAB26989.1 Frameshift.
AK013334 mRNA Translation: BAB28797.1
AK084933 mRNA Translation: BAC39313.1
AK151176 mRNA Translation: BAE30178.1
AK152214 mRNA Translation: BAE31042.1
AK166903 mRNA Translation: BAE39105.1
BC037602 mRNA Translation: AAH37602.1
BC069930 mRNA Translation: AAH69930.1
CCDSiCCDS35536.1
RefSeqiNP_848716.2, NM_178601.3
UniGeneiMm.289667

3D structure databases

ProteinModelPortaliQ8VHZ7
SMRiQ8VHZ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205703, 2 interactors
IntActiQ8VHZ7, 1 interactor
STRINGi10090.ENSMUSP00000027303

PTM databases

PhosphoSitePlusiQ8VHZ7

Proteomic databases

EPDiQ8VHZ7
MaxQBiQ8VHZ7
PaxDbiQ8VHZ7
PeptideAtlasiQ8VHZ7
PRIDEiQ8VHZ7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027303; ENSMUSP00000027303; ENSMUSG00000026127
GeneIDi27993
KEGGimmu:27993
UCSCiuc007aor.2 mouse

Organism-specific databases

CTDi92856
MGIiMGI:106572 Imp4

Phylogenomic databases

eggNOGiKOG2781 Eukaryota
COG2136 LUCA
GeneTreeiENSGT00550000074987
HOGENOMiHOG000172063
HOVERGENiHBG056795
InParanoidiQ8VHZ7
KOiK14561
OMAiFFNISDV
OrthoDBiEOG091G0GP1
PhylomeDBiQ8VHZ7
TreeFamiTF300016

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

PROiPR:Q8VHZ7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026127 Expressed in 293 organ(s), highest expression level in primary oocyte
ExpressionAtlasiQ8VHZ7 baseline and differential
GenevisibleiQ8VHZ7 MM

Family and domain databases

InterProiView protein in InterPro
IPR007109 Brix
PfamiView protein in Pfam
PF04427 Brix, 1 hit
SMARTiView protein in SMART
SM00879 Brix, 1 hit
PROSITEiView protein in PROSITE
PS50833 BRIX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIMP4_MOUSE
AccessioniPrimary (citable) accession number: Q8VHZ7
Secondary accession number(s): Q3U8H6
, Q8CI42, Q9CWN6, Q9CYT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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