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Entry version 140 (03 Jul 2019)
Sequence version 3 (03 Oct 2012)
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Protein

Chondroitin sulfate proteoglycan 4

Gene

Cspg4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.2 Publications

Miscellaneous

Valuable marker for several incompletely differentiated precursor cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Transducer
Biological processAngiogenesis, Differentiation, Tissue remodeling

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-MMU-2022870 Chondroitin sulfate biosynthesis
R-MMU-2022923 Dermatan sulfate biosynthesis
R-MMU-2024101 CS/DS degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chondroitin sulfate proteoglycan 4
Alternative name(s):
Chondroitin sulfate proteoglycan NG2
Proteoglycan AN2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cspg4
Synonyms:An2, Kiaa4232, Ng2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2153093 Cspg4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 2229ExtracellularBy similarityAdd BLAST2200
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2230 – 2250HelicalSequence analysisAdd BLAST21
Topological domaini2251 – 2327CytoplasmicBy similarityAdd BLAST77

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are unresponsive to PDGF-AA through PDGF-alpha receptor.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2324Q → G: No effect on interaction with GRIP1 and GRIP2. 1 Publication1
Mutagenesisi2325Y → F: No effect on interaction with GRIP1 and GRIP2. 1 Publication1
Mutagenesisi2325Y → G: Loss of interaction with GRIP1 and GRIP2. 1 Publication1
Mutagenesisi2326W → G: Loss of interaction with GRIP1 and GRIP2. 1 Publication1
Mutagenesisi2327V → G: Loss of interaction with GRIP1 and GRIP2. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004196330 – 2327Chondroitin sulfate proteoglycan 4Add BLAST2298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi130N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi170 ↔ 193PROSITE-ProRule annotation
Glycosylationi349N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi355 ↔ 381PROSITE-ProRule annotation
Glycosylationi428N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi686N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi773N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1000O-linked (Xyl...) (chondroitin sulfate) serineBy similarity1
Glycosylationi1136N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1207N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1369N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1454N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1650N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1914N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2021N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi2039N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2045N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2080N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2257Phosphothreonine; by PKC/PRKCABy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation. Involved in interaction with MMP16 and ITGA4 (By similarity).By similarity
Phosphorylation by PRKCA regulates its subcellular location and function in cell motility.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8VHY0

PeptideAtlas

More...
PeptideAtlasi
Q8VHY0

PRoteomics IDEntifications database

More...
PRIDEi
Q8VHY0

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2213

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8VHY0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8VHY0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in microcascular pericytes and not endothelial cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032911 Expressed in 224 organ(s), highest expression level in humerus cartilage element

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8VHY0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan.

Interacts with BCAR1, CDC42 and ACK1.

Interacts with MMP16.

Interacts with the first PDZ domain of MPDZ.

Interacts with PRKCA.

Interacts with LGALS3 and the integrin composed of ITGB1 and ITGA3. Binds TNC, laminin-1, COL5A1 and COL6A2.

Interacts with PLG and angiostatin. Binds FGF2 and PDGFA (By similarity).

Interacts with GRIP1, GRIP2 and GRIA2.

Forms a ternary complex with GRIP1 and GRIA2.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
228250, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q8VHY0

Protein interaction database and analysis system

More...
IntActi
Q8VHY0, 5 interactors

Molecular INTeraction database

More...
MINTi
Q8VHY0

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000038909

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8VHY0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 193Laminin G-like 1PROSITE-ProRule annotationAdd BLAST164
Domaini203 – 381Laminin G-like 2PROSITE-ProRule annotationAdd BLAST179
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati429 – 524CSPG 1PROSITE-ProRule annotationAdd BLAST96
Repeati554 – 646CSPG 2PROSITE-ProRule annotationAdd BLAST93
Repeati663 – 765CSPG 3PROSITE-ProRule annotationAdd BLAST103
Repeati784 – 883CSPG 4PROSITE-ProRule annotationAdd BLAST100
Repeati903 – 994CSPG 5PROSITE-ProRule annotationAdd BLAST92
Repeati1023 – 1115CSPG 6PROSITE-ProRule annotationAdd BLAST93
Repeati1131 – 1221CSPG 7PROSITE-ProRule annotationAdd BLAST91
Repeati1243 – 1342CSPG 8PROSITE-ProRule annotationAdd BLAST100
Repeati1361 – 1454CSPG 9PROSITE-ProRule annotationAdd BLAST94
Repeati1478 – 1568CSPG 10PROSITE-ProRule annotationAdd BLAST91
Repeati1586 – 1684CSPG 11PROSITE-ProRule annotationAdd BLAST99
Repeati1709 – 1808CSPG 12PROSITE-ProRule annotationAdd BLAST100
Repeati1837 – 1929CSPG 13PROSITE-ProRule annotationAdd BLAST93
Repeati1946 – 2034CSPG 14PROSITE-ProRule annotationAdd BLAST89
Repeati2043 – 2152CSPG 15PROSITE-ProRule annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni30 – 640Globular or compact configuration stabilized by disulfide bondsAdd BLAST611
Regioni30 – 640Neurite growth inhibitionBy similarityAdd BLAST611
Regioni575 – 1045Interaction with COL6A2By similarityAdd BLAST471
Regioni632 – 1451Interaction with COL5A1By similarityAdd BLAST820
Regioni1591 – 2226Neurite growth inhibitionBy similarityAdd BLAST636
Regioni1592 – 2226Cysteine-containingAdd BLAST635

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2325 – 2327PDZ-binding3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi640 – 1591Gly/Ser-rich (glycosaminoglycan attachment domain)Add BLAST952

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3597 Eukaryota
ENOG410XQ29 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154091

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000170195

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8VHY0

KEGG Orthology (KO)

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KOi
K08115

Identification of Orthologs from Complete Genome Data

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OMAi
TYILPIQ

Database of Orthologous Groups

More...
OrthoDBi
219190at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316876

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR039005 CSPG_rpt
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00054 Laminin_G_1, 1 hit
PF02210 Laminin_G_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00282 LamG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51854 CSPG, 15 hits
PS50025 LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8VHY0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLGPGHPLS APALALALTL ALLVRSTAPA SFFGENHLEV PVPSALTRVD
60 70 80 90 100
LLLQFSTSQP EALLLLAAGQ DDHLLLQLHS GCLQVRLALG QKELKLQTPA
110 120 130 140 150
DTVLSDSAPH TVVLTVSDSW AVLSVDGVLN TSAPIPRASH LKATYGLFVG
160 170 180 190 200
SSGSLDLPYL KGISRPLRGC LHSAILNGRN LLRPLTSDVH EGCAEEFSAG
210 220 230 240 250
DEVGLGFSGP HSLAAFPAWS TREEGTLEFT LTTRSQQAPL AFQAGDKRGN
260 270 280 290 300
FIYVDIFEGH LRAVVEKGQG TMLLRNSVPV ADGQPHEVSV HIDVHRLEIS
310 320 330 340 350
VDQYPTRTFN RGVLSYLEPR GSLLLGGLDT EASRHLQEHR LGLAPGAANI
360 370 380 390 400
SLVGCIEDFS VNGRRQGLRD AWLTRDMSAG CRPEEDEYEE EVYGPYETFS
410 420 430 440 450
TLAPEAWPAM ELPEPCIPEP GLPAVFANFT QLLTISPLVV AEGGTAWLEW
460 470 480 490 500
RHVQPTLDLT EAELRKSQVL FSVSQSARHG DLELDILGAQ TRKMFTLLDV
510 520 530 540 550
VNRKARFVHD GSEDTSDQLM LEVSVTARAP VPSCLRRGQI YILPIQVNPV
560 570 580 590 600
NDPPRIIFPH GSLMVILEHT QKPLGPEIFQ AYDPDSACEG LTFQLLGVSS
610 620 630 640 650
GVPVEHRDQP GEPATEFSCR ELEVGDIVYV HRGGPAQDLT FRVSDGMQAS
660 670 680 690 700
APATLKVVAV RPAIQILHNT GLHLAQGSAA AILPANLSVE TNAVGQDVSV
710 720 730 740 750
LFRVTGTLQF GELQKQGAGG VEGTEWWDTL AFHQRDVEQG RVRYLSTDPQ
760 770 780 790 800
HHTQDTVEDL ILEVQVGQET LSNLSFPVTI QRATVWMLRL EPLHTQNPHQ
810 820 830 840 850
ETLTPAHLEA SLEEEEEEGS PQPHTFHYEL VQAPRRGNLL LQGTRLSDGE
860 870 880 890 900
SFSQSDLQAG RVTYRATMRT SEAADDSFRF RVTSPPHFSP LYTFPIHIGG
910 920 930 940 950
DPNAPVLTNV LLMVPEGGEG VLSADHLFVK SLNSASYLYE VMEQPHHGKL
960 970 980 990 1000
AWRDPKGKST PVTSFTNEDL LHGRLVYQHD DSETIEDDIP FVATRQGEGS
1010 1020 1030 1040 1050
GDMAWEEVRG VFRVAIQPVN DHAPVQTISR VFHVARGGQR LLTTDDVAFS
1060 1070 1080 1090 1100
DADSGFSDAQ LVLTRKDLLF GSIVAMEEPT RPIYRFTQED LRKKQVLFVH
1110 1120 1130 1140 1150
SGADHGWLQL QVSDGQHQAT AMLEVQASEP YLHVANSSSL VVPQGGQGTI
1160 1170 1180 1190 1200
DTAVLQLDTN LDIRSGNEVH YHVTAGPQWG QLLRDGQSVT SFSQRDLLDG
1210 1220 1230 1240 1250
AILYSHNGSL SPQDTLAFSV AAGPVHTNTF LQVTIALEGP LAPLQLVQHK
1260 1270 1280 1290 1300
KIYVFQGEAA EIRRDQLEVV QEAVLPADIM FSLRSPPNAG YLVMVSHGAS
1310 1320 1330 1340 1350
AEEPPSLDPV QSFSQEAVNS GRVLYLHSRP GAWSDSFSLD VASGLGDPLE
1360 1370 1380 1390 1400
GISVELEVLP TVIPLDVQNF SVPEGGTRTL APPLVQITGP YFPTLPGLVL
1410 1420 1430 1440 1450
QVLEPPQHGA LQKEDHSQDG SLSTFSWREV EEQLIRYVHD GSETQTDAFV
1460 1470 1480 1490 1500
LLANASEMDR QSQPVAFTIT ILPVNDQPPV LTTNTGLQIW EGAIVPIPPE
1510 1520 1530 1540 1550
ALRGTDNDSG PEDLVYTIEQ PSNGRIALRV APDTEVHRFT QAQLDSGLVL
1560 1570 1580 1590 1600
FSHRGALEGG FHFDLSDGAH TSPGHFFRVV AQKQALLSLE GTRKLTVCPE
1610 1620 1630 1640 1650
SVQPLSSQSL SASSSTGADP RHLLYRVVRG PQLGRLLHAQ QGSAEEVLVN
1660 1670 1680 1690 1700
FTQAEVNAGN ILYEHEMSSE PFWEAHDTIG LLLSSPPARD LAATLAVMVS
1710 1720 1730 1740 1750
FDAACPQRPS RLWKNKGLWV PEGQRAKITV AALDAANLLA SVPASQRSRH
1760 1770 1780 1790 1800
DVLFQVTQFP TRGQLLVSEE PLHARRPYFL QSELAAGQLV YAHGGGGTQQ
1810 1820 1830 1840 1850
DGFRFRAHLQ GPTGTSVAGP QTSEAFVITV RDVNERPPQP QASIPLRVTR
1860 1870 1880 1890 1900
GSRAPVSRAQ LSVVDPDSAP GEIEYEVQRA PHNGFLSLAG DNTGPVTHFT
1910 1920 1930 1940 1950
QADVDAGRLA FVANGSSVAG VFQLSMSDGA SPPIPMSLAV DVLPSTIEVQ
1960 1970 1980 1990 2000
LRAPLEVPQA LGRTSLSRQQ LQVISDREEP DVAYRLTQGP LYGQLLVGGQ
2010 2020 2030 2040 2050
PASAFSQLQV DQGDVVFVFT NFSSSQDHFK VVALARGVNA SATVNVTVQA
2060 2070 2080 2090 2100
LLHVWAGGPW PQGTTLRLDP TVLDASELAN RTGSMPHFRL LAGPRYGRVV
2110 2120 2130 2140 2150
RVSQGRTESR SNQLVEHFTQ RDLEEGQLGL EVGKPEGRST GPAGDRLTLE
2160 2170 2180 2190 2200
LWAKGVPPAV ALLDFATEPY HAAKSYSVAL LSVPEAVRTE TEKPGRSVPT
2210 2220 2230 2240 2250
GQPGQAASSP VPTAAKGGFL GFLEANMFSI IIPVCLILLL LALILPLLFY
2260 2270 2280 2290 2300
LRKRNKTGKH DVQVLTAKPR NGLAGDTETF RKVEPGQAIP LITVPGQGPP
2310 2320
PGGQPDPELL QFCRTPNPAL RNGQYWV
Length:2,327
Mass (Da):252,309
Last modified:October 3, 2012 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC101DF60FCE3A7BC
GO
Isoform 2 (identifier: Q8VHY0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1666: Missing.

Note: No experimental confirmation available.
Show »
Length:661
Mass (Da):70,843
Checksum:iDA679F6CCF894532
GO
Isoform 3 (identifier: Q8VHY0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1657-1694: NAGNILYEHE...SPPARDLAAT → RASLLSHHTD...ASLDPVPAQG
     1695-2327: Missing.

Note: No experimental confirmation available.
Show »
Length:1,694
Mass (Da):184,393
Checksum:i52625A76C5070FBB
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC26150 differs from that shown. Reason: Frameshift at position 1889.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1058D → V in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti1113S → P in BAD90326 (Ref. 5) Curated1
Sequence conflicti1427W → R in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti1520Q → E in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti1546S → G in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti1929G → E in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti2000Q → R in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti2011D → H in BAC26150 (PubMed:16141072).Curated1
Sequence conflicti2093G → E in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti2248L → H in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti2300P → S in AAL37505 (PubMed:12458226).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0156561 – 1666Missing in isoform 2. 1 PublicationAdd BLAST1666
Alternative sequenceiVSP_0156571657 – 1694NAGNI…DLAAT → RASLLSHHTDPNLTSGGCQL EHPPHWQLASLDPVPAQG in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_0156581695 – 2327Missing in isoform 3. 1 PublicationAdd BLAST633

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF352400 mRNA Translation: AAL37505.1
AK028844 mRNA Translation: BAC26150.1 Sequence problems.
AK075625 mRNA Translation: BAC35866.1
AC126257 Genomic DNA No translation available.
CH466522 Genomic DNA Translation: EDL25876.1
AK220559 mRNA Translation: BAD90326.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS23211.1 [Q8VHY0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_620570.2, NM_139001.2 [Q8VHY0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000035661; ENSMUSP00000038909; ENSMUSG00000032911 [Q8VHY0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
121021

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:121021

UCSC genome browser

More...
UCSCi
uc009ptl.1 mouse [Q8VHY0-1]
uc009ptn.1 mouse [Q8VHY0-3]
uc009pto.1 mouse [Q8VHY0-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352400 mRNA Translation: AAL37505.1
AK028844 mRNA Translation: BAC26150.1 Sequence problems.
AK075625 mRNA Translation: BAC35866.1
AC126257 Genomic DNA No translation available.
CH466522 Genomic DNA Translation: EDL25876.1
AK220559 mRNA Translation: BAD90326.1
CCDSiCCDS23211.1 [Q8VHY0-1]
RefSeqiNP_620570.2, NM_139001.2 [Q8VHY0-1]

3D structure databases

SMRiQ8VHY0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi228250, 1 interactor
CORUMiQ8VHY0
IntActiQ8VHY0, 5 interactors
MINTiQ8VHY0
STRINGi10090.ENSMUSP00000038909

PTM databases

GlyConnecti2213
iPTMnetiQ8VHY0
PhosphoSitePlusiQ8VHY0

Proteomic databases

PaxDbiQ8VHY0
PeptideAtlasiQ8VHY0
PRIDEiQ8VHY0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035661; ENSMUSP00000038909; ENSMUSG00000032911 [Q8VHY0-1]
GeneIDi121021
KEGGimmu:121021
UCSCiuc009ptl.1 mouse [Q8VHY0-1]
uc009ptn.1 mouse [Q8VHY0-3]
uc009pto.1 mouse [Q8VHY0-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1464
MGIiMGI:2153093 Cspg4

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG3597 Eukaryota
ENOG410XQ29 LUCA
GeneTreeiENSGT00940000154091
HOGENOMiHOG000170195
InParanoidiQ8VHY0
KOiK08115
OMAiTYILPIQ
OrthoDBi219190at2759
TreeFamiTF316876

Enzyme and pathway databases

ReactomeiR-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-MMU-2022870 Chondroitin sulfate biosynthesis
R-MMU-2022923 Dermatan sulfate biosynthesis
R-MMU-2024101 CS/DS degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Cspg4 mouse

Protein Ontology

More...
PROi
PR:Q8VHY0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032911 Expressed in 224 organ(s), highest expression level in humerus cartilage element
GenevisibleiQ8VHY0 MM

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR039005 CSPG_rpt
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00054 Laminin_G_1, 1 hit
PF02210 Laminin_G_2, 1 hit
SMARTiView protein in SMART
SM00282 LamG, 2 hits
SUPFAMiSSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS51854 CSPG, 15 hits
PS50025 LAM_G_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSPG4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VHY0
Secondary accession number(s): G5E892
, Q5DTG1, Q8BPI8, Q8CE79
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 3, 2012
Last modified: July 3, 2019
This is version 140 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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