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Protein

Chondroitin sulfate proteoglycan 4

Gene

Cspg4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.2 Publications

Miscellaneous

Valuable marker for several incompletely differentiated precursor cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Transducer
Biological processAngiogenesis, Differentiation, Tissue remodeling

Enzyme and pathway databases

ReactomeiR-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-MMU-2022870 Chondroitin sulfate biosynthesis
R-MMU-2022923 Dermatan sulfate biosynthesis
R-MMU-2024101 CS/DS degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Chondroitin sulfate proteoglycan 4
Alternative name(s):
Chondroitin sulfate proteoglycan NG2
Proteoglycan AN2
Gene namesi
Name:Cspg4
Synonyms:An2, Kiaa4232, Ng2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2153093 Cspg4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 2229ExtracellularBy similarityAdd BLAST2200
Transmembranei2230 – 2250HelicalSequence analysisAdd BLAST21
Topological domaini2251 – 2327CytoplasmicBy similarityAdd BLAST77

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are unresponsive to PDGF-AA through PDGF-alpha receptor.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2324Q → G: No effect on interaction with GRIP1 and GRIP2. 1 Publication1
Mutagenesisi2325Y → F: No effect on interaction with GRIP1 and GRIP2. 1 Publication1
Mutagenesisi2325Y → G: Loss of interaction with GRIP1 and GRIP2. 1 Publication1
Mutagenesisi2326W → G: Loss of interaction with GRIP1 and GRIP2. 1 Publication1
Mutagenesisi2327V → G: Loss of interaction with GRIP1 and GRIP2. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000004196330 – 2327Chondroitin sulfate proteoglycan 4Add BLAST2298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi130N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi170 ↔ 193PROSITE-ProRule annotation
Glycosylationi349N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi355 ↔ 381PROSITE-ProRule annotation
Glycosylationi428N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi686N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi773N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1000O-linked (Xyl...) (chondroitin sulfate) serineBy similarity1
Glycosylationi1136N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1207N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1369N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1454N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1650N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1914N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2021N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi2039N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2045N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2080N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei2257Phosphothreonine; by PKC/PRKCABy similarity1

Post-translational modificationi

O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation. Involved in interaction with MMP16 and ITGA4 (By similarity).By similarity
Phosphorylation by PRKCA regulates its subcellular location and function in cell motility.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiQ8VHY0
PeptideAtlasiQ8VHY0
PRIDEiQ8VHY0

PTM databases

iPTMnetiQ8VHY0
PhosphoSitePlusiQ8VHY0

Expressioni

Tissue specificityi

Expressed in microcascular pericytes and not endothelial cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000032911 Expressed in 224 organ(s), highest expression level in humerus cartilage element
CleanExiMM_CSPG4
GenevisibleiQ8VHY0 MM

Interactioni

Subunit structurei

Interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan. Interacts with BCAR1, CDC42 and ACK1. Interacts with MMP16. Interacts with the first PDZ domain of MPDZ. Interacts with PRKCA. Interacts with LGALS3 and the integrin composed of ITGB1 and ITGA3. Binds TNC, laminin-1, COL5A1 and COL6A2. Interacts with PLG and angiostatin. Binds FGF2 and PDGFA (By similarity). Interacts with GRIP1, GRIP2 and GRIA2. Forms a ternary complex with GRIP1 and GRIA2.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi228250, 1 interactor
CORUMiQ8VHY0
IntActiQ8VHY0, 5 interactors
MINTiQ8VHY0
STRINGi10090.ENSMUSP00000038909

Structurei

3D structure databases

ProteinModelPortaliQ8VHY0
SMRiQ8VHY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 193Laminin G-like 1PROSITE-ProRule annotationAdd BLAST164
Domaini203 – 381Laminin G-like 2PROSITE-ProRule annotationAdd BLAST179
Repeati429 – 524CSPG 1PROSITE-ProRule annotationAdd BLAST96
Repeati554 – 646CSPG 2PROSITE-ProRule annotationAdd BLAST93
Repeati663 – 765CSPG 3PROSITE-ProRule annotationAdd BLAST103
Repeati784 – 883CSPG 4PROSITE-ProRule annotationAdd BLAST100
Repeati903 – 994CSPG 5PROSITE-ProRule annotationAdd BLAST92
Repeati1023 – 1115CSPG 6PROSITE-ProRule annotationAdd BLAST93
Repeati1131 – 1221CSPG 7PROSITE-ProRule annotationAdd BLAST91
Repeati1243 – 1342CSPG 8PROSITE-ProRule annotationAdd BLAST100
Repeati1361 – 1454CSPG 9PROSITE-ProRule annotationAdd BLAST94
Repeati1478 – 1568CSPG 10PROSITE-ProRule annotationAdd BLAST91
Repeati1586 – 1684CSPG 11PROSITE-ProRule annotationAdd BLAST99
Repeati1709 – 1808CSPG 12PROSITE-ProRule annotationAdd BLAST100
Repeati1837 – 1929CSPG 13PROSITE-ProRule annotationAdd BLAST93
Repeati1946 – 2034CSPG 14PROSITE-ProRule annotationAdd BLAST89
Repeati2043 – 2152CSPG 15PROSITE-ProRule annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 640Globular or compact configuration stabilized by disulfide bondsAdd BLAST611
Regioni30 – 640Neurite growth inhibitionBy similarityAdd BLAST611
Regioni575 – 1045Interaction with COL6A2By similarityAdd BLAST471
Regioni632 – 1451Interaction with COL5A1By similarityAdd BLAST820
Regioni1591 – 2226Neurite growth inhibitionBy similarityAdd BLAST636
Regioni1592 – 2226Cysteine-containingAdd BLAST635

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi2325 – 2327PDZ-binding3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi640 – 1591Gly/Ser-rich (glycosaminoglycan attachment domain)Add BLAST952

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3597 Eukaryota
ENOG410XQ29 LUCA
GeneTreeiENSGT00550000074429
HOGENOMiHOG000170195
HOVERGENiHBG081360
InParanoidiQ8VHY0
KOiK08115
OMAiHSFTQAQ
OrthoDBiEOG091G00BN
TreeFamiTF316876

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR039005 CSPG_rpt
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00054 Laminin_G_1, 1 hit
PF02210 Laminin_G_2, 1 hit
SMARTiView protein in SMART
SM00282 LamG, 2 hits
SUPFAMiSSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS51854 CSPG, 15 hits
PS50025 LAM_G_DOMAIN, 2 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8VHY0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLGPGHPLS APALALALTL ALLVRSTAPA SFFGENHLEV PVPSALTRVD
60 70 80 90 100
LLLQFSTSQP EALLLLAAGQ DDHLLLQLHS GCLQVRLALG QKELKLQTPA
110 120 130 140 150
DTVLSDSAPH TVVLTVSDSW AVLSVDGVLN TSAPIPRASH LKATYGLFVG
160 170 180 190 200
SSGSLDLPYL KGISRPLRGC LHSAILNGRN LLRPLTSDVH EGCAEEFSAG
210 220 230 240 250
DEVGLGFSGP HSLAAFPAWS TREEGTLEFT LTTRSQQAPL AFQAGDKRGN
260 270 280 290 300
FIYVDIFEGH LRAVVEKGQG TMLLRNSVPV ADGQPHEVSV HIDVHRLEIS
310 320 330 340 350
VDQYPTRTFN RGVLSYLEPR GSLLLGGLDT EASRHLQEHR LGLAPGAANI
360 370 380 390 400
SLVGCIEDFS VNGRRQGLRD AWLTRDMSAG CRPEEDEYEE EVYGPYETFS
410 420 430 440 450
TLAPEAWPAM ELPEPCIPEP GLPAVFANFT QLLTISPLVV AEGGTAWLEW
460 470 480 490 500
RHVQPTLDLT EAELRKSQVL FSVSQSARHG DLELDILGAQ TRKMFTLLDV
510 520 530 540 550
VNRKARFVHD GSEDTSDQLM LEVSVTARAP VPSCLRRGQI YILPIQVNPV
560 570 580 590 600
NDPPRIIFPH GSLMVILEHT QKPLGPEIFQ AYDPDSACEG LTFQLLGVSS
610 620 630 640 650
GVPVEHRDQP GEPATEFSCR ELEVGDIVYV HRGGPAQDLT FRVSDGMQAS
660 670 680 690 700
APATLKVVAV RPAIQILHNT GLHLAQGSAA AILPANLSVE TNAVGQDVSV
710 720 730 740 750
LFRVTGTLQF GELQKQGAGG VEGTEWWDTL AFHQRDVEQG RVRYLSTDPQ
760 770 780 790 800
HHTQDTVEDL ILEVQVGQET LSNLSFPVTI QRATVWMLRL EPLHTQNPHQ
810 820 830 840 850
ETLTPAHLEA SLEEEEEEGS PQPHTFHYEL VQAPRRGNLL LQGTRLSDGE
860 870 880 890 900
SFSQSDLQAG RVTYRATMRT SEAADDSFRF RVTSPPHFSP LYTFPIHIGG
910 920 930 940 950
DPNAPVLTNV LLMVPEGGEG VLSADHLFVK SLNSASYLYE VMEQPHHGKL
960 970 980 990 1000
AWRDPKGKST PVTSFTNEDL LHGRLVYQHD DSETIEDDIP FVATRQGEGS
1010 1020 1030 1040 1050
GDMAWEEVRG VFRVAIQPVN DHAPVQTISR VFHVARGGQR LLTTDDVAFS
1060 1070 1080 1090 1100
DADSGFSDAQ LVLTRKDLLF GSIVAMEEPT RPIYRFTQED LRKKQVLFVH
1110 1120 1130 1140 1150
SGADHGWLQL QVSDGQHQAT AMLEVQASEP YLHVANSSSL VVPQGGQGTI
1160 1170 1180 1190 1200
DTAVLQLDTN LDIRSGNEVH YHVTAGPQWG QLLRDGQSVT SFSQRDLLDG
1210 1220 1230 1240 1250
AILYSHNGSL SPQDTLAFSV AAGPVHTNTF LQVTIALEGP LAPLQLVQHK
1260 1270 1280 1290 1300
KIYVFQGEAA EIRRDQLEVV QEAVLPADIM FSLRSPPNAG YLVMVSHGAS
1310 1320 1330 1340 1350
AEEPPSLDPV QSFSQEAVNS GRVLYLHSRP GAWSDSFSLD VASGLGDPLE
1360 1370 1380 1390 1400
GISVELEVLP TVIPLDVQNF SVPEGGTRTL APPLVQITGP YFPTLPGLVL
1410 1420 1430 1440 1450
QVLEPPQHGA LQKEDHSQDG SLSTFSWREV EEQLIRYVHD GSETQTDAFV
1460 1470 1480 1490 1500
LLANASEMDR QSQPVAFTIT ILPVNDQPPV LTTNTGLQIW EGAIVPIPPE
1510 1520 1530 1540 1550
ALRGTDNDSG PEDLVYTIEQ PSNGRIALRV APDTEVHRFT QAQLDSGLVL
1560 1570 1580 1590 1600
FSHRGALEGG FHFDLSDGAH TSPGHFFRVV AQKQALLSLE GTRKLTVCPE
1610 1620 1630 1640 1650
SVQPLSSQSL SASSSTGADP RHLLYRVVRG PQLGRLLHAQ QGSAEEVLVN
1660 1670 1680 1690 1700
FTQAEVNAGN ILYEHEMSSE PFWEAHDTIG LLLSSPPARD LAATLAVMVS
1710 1720 1730 1740 1750
FDAACPQRPS RLWKNKGLWV PEGQRAKITV AALDAANLLA SVPASQRSRH
1760 1770 1780 1790 1800
DVLFQVTQFP TRGQLLVSEE PLHARRPYFL QSELAAGQLV YAHGGGGTQQ
1810 1820 1830 1840 1850
DGFRFRAHLQ GPTGTSVAGP QTSEAFVITV RDVNERPPQP QASIPLRVTR
1860 1870 1880 1890 1900
GSRAPVSRAQ LSVVDPDSAP GEIEYEVQRA PHNGFLSLAG DNTGPVTHFT
1910 1920 1930 1940 1950
QADVDAGRLA FVANGSSVAG VFQLSMSDGA SPPIPMSLAV DVLPSTIEVQ
1960 1970 1980 1990 2000
LRAPLEVPQA LGRTSLSRQQ LQVISDREEP DVAYRLTQGP LYGQLLVGGQ
2010 2020 2030 2040 2050
PASAFSQLQV DQGDVVFVFT NFSSSQDHFK VVALARGVNA SATVNVTVQA
2060 2070 2080 2090 2100
LLHVWAGGPW PQGTTLRLDP TVLDASELAN RTGSMPHFRL LAGPRYGRVV
2110 2120 2130 2140 2150
RVSQGRTESR SNQLVEHFTQ RDLEEGQLGL EVGKPEGRST GPAGDRLTLE
2160 2170 2180 2190 2200
LWAKGVPPAV ALLDFATEPY HAAKSYSVAL LSVPEAVRTE TEKPGRSVPT
2210 2220 2230 2240 2250
GQPGQAASSP VPTAAKGGFL GFLEANMFSI IIPVCLILLL LALILPLLFY
2260 2270 2280 2290 2300
LRKRNKTGKH DVQVLTAKPR NGLAGDTETF RKVEPGQAIP LITVPGQGPP
2310 2320
PGGQPDPELL QFCRTPNPAL RNGQYWV
Length:2,327
Mass (Da):252,309
Last modified:October 3, 2012 - v3
Checksum:iC101DF60FCE3A7BC
GO
Isoform 2 (identifier: Q8VHY0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1666: Missing.

Note: No experimental confirmation available.
Show »
Length:661
Mass (Da):70,843
Checksum:iDA679F6CCF894532
GO
Isoform 3 (identifier: Q8VHY0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1657-1694: NAGNILYEHE...SPPARDLAAT → RASLLSHHTD...ASLDPVPAQG
     1695-2327: Missing.

Note: No experimental confirmation available.
Show »
Length:1,694
Mass (Da):184,393
Checksum:i52625A76C5070FBB
GO

Sequence cautioni

The sequence BAC26150 differs from that shown. Reason: Frameshift at position 1889.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1058D → V in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti1113S → P in BAD90326 (Ref. 5) Curated1
Sequence conflicti1427W → R in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti1520Q → E in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti1546S → G in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti1929G → E in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti2000Q → R in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti2011D → H in BAC26150 (PubMed:16141072).Curated1
Sequence conflicti2093G → E in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti2248L → H in AAL37505 (PubMed:12458226).Curated1
Sequence conflicti2300P → S in AAL37505 (PubMed:12458226).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0156561 – 1666Missing in isoform 2. 1 PublicationAdd BLAST1666
Alternative sequenceiVSP_0156571657 – 1694NAGNI…DLAAT → RASLLSHHTDPNLTSGGCQL EHPPHWQLASLDPVPAQG in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_0156581695 – 2327Missing in isoform 3. 1 PublicationAdd BLAST633

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352400 mRNA Translation: AAL37505.1
AK028844 mRNA Translation: BAC26150.1 Sequence problems.
AK075625 mRNA Translation: BAC35866.1
AC126257 Genomic DNA No translation available.
CH466522 Genomic DNA Translation: EDL25876.1
AK220559 mRNA Translation: BAD90326.1
CCDSiCCDS23211.1 [Q8VHY0-1]
RefSeqiNP_620570.2, NM_139001.2 [Q8VHY0-1]
UniGeneiMm.41329

Genome annotation databases

EnsembliENSMUST00000035661; ENSMUSP00000038909; ENSMUSG00000032911 [Q8VHY0-1]
GeneIDi121021
KEGGimmu:121021
UCSCiuc009ptl.1 mouse [Q8VHY0-1]
uc009ptn.1 mouse [Q8VHY0-3]
uc009pto.1 mouse [Q8VHY0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352400 mRNA Translation: AAL37505.1
AK028844 mRNA Translation: BAC26150.1 Sequence problems.
AK075625 mRNA Translation: BAC35866.1
AC126257 Genomic DNA No translation available.
CH466522 Genomic DNA Translation: EDL25876.1
AK220559 mRNA Translation: BAD90326.1
CCDSiCCDS23211.1 [Q8VHY0-1]
RefSeqiNP_620570.2, NM_139001.2 [Q8VHY0-1]
UniGeneiMm.41329

3D structure databases

ProteinModelPortaliQ8VHY0
SMRiQ8VHY0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228250, 1 interactor
CORUMiQ8VHY0
IntActiQ8VHY0, 5 interactors
MINTiQ8VHY0
STRINGi10090.ENSMUSP00000038909

PTM databases

iPTMnetiQ8VHY0
PhosphoSitePlusiQ8VHY0

Proteomic databases

PaxDbiQ8VHY0
PeptideAtlasiQ8VHY0
PRIDEiQ8VHY0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035661; ENSMUSP00000038909; ENSMUSG00000032911 [Q8VHY0-1]
GeneIDi121021
KEGGimmu:121021
UCSCiuc009ptl.1 mouse [Q8VHY0-1]
uc009ptn.1 mouse [Q8VHY0-3]
uc009pto.1 mouse [Q8VHY0-2]

Organism-specific databases

CTDi1464
MGIiMGI:2153093 Cspg4
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3597 Eukaryota
ENOG410XQ29 LUCA
GeneTreeiENSGT00550000074429
HOGENOMiHOG000170195
HOVERGENiHBG081360
InParanoidiQ8VHY0
KOiK08115
OMAiHSFTQAQ
OrthoDBiEOG091G00BN
TreeFamiTF316876

Enzyme and pathway databases

ReactomeiR-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-MMU-2022870 Chondroitin sulfate biosynthesis
R-MMU-2022923 Dermatan sulfate biosynthesis
R-MMU-2024101 CS/DS degradation

Miscellaneous databases

ChiTaRSiCspg4 mouse
PROiPR:Q8VHY0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032911 Expressed in 224 organ(s), highest expression level in humerus cartilage element
CleanExiMM_CSPG4
GenevisibleiQ8VHY0 MM

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR039005 CSPG_rpt
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00054 Laminin_G_1, 1 hit
PF02210 Laminin_G_2, 1 hit
SMARTiView protein in SMART
SM00282 LamG, 2 hits
SUPFAMiSSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS51854 CSPG, 15 hits
PS50025 LAM_G_DOMAIN, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCSPG4_MOUSE
AccessioniPrimary (citable) accession number: Q8VHY0
Secondary accession number(s): G5E892
, Q5DTG1, Q8BPI8, Q8CE79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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