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Entry version 165 (02 Dec 2020)
Sequence version 3 (12 Dec 2006)
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Protein

Filamin-C

Gene

Flnc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-446353, Cell-extracellular matrix interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Filamin-C
Short name:
FLN-C
Alternative name(s):
ABP-280-like protein
ABP-L
Actin-binding-like protein
Filamin-2
Gamma-filamin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Flnc
Synonyms:Abpl, Fln2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:95557, Flnc

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000873021 – 2726Filamin-CAdd BLAST2726

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei5PhosphoserineBy similarity1
Modified residuei1003Omega-N-methylarginineCombined sources1
Modified residuei1162PhosphoserineBy similarity1
Modified residuei1339PhosphoserineBy similarity1
Modified residuei2043PhosphoserineBy similarity1
Modified residuei2234PhosphoserineCombined sources1
Modified residuei2237PhosphoserineBy similarity1
Modified residuei2239PhosphothreonineBy similarity1
Modified residuei2587PhosphoserineBy similarity1
Modified residuei2618PhosphoserineBy similarity1
Modified residuei2621PhosphoserineBy similarity1
Modified residuei2633PhosphoserineBy similarity1
Modified residuei2715PhosphoserineBy similarity1
Modified residuei2719PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by FBXL22, leading to proteasomal degradation.By similarity

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8VHX6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8VHX6

PeptideAtlas

More...
PeptideAtlasi
Q8VHX6

PRoteomics IDEntifications database

More...
PRIDEi
Q8VHX6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8VHX6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8VHX6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

During myogenesis, isoform 1 is expressed the first day, then is replaced by isoform 2.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000068699, Expressed in hindlimb stylopod muscle and 221 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8VHX6, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; the filamin repeat 24 and the second hinge domain are important for dimer formation (By similarity).

Interacts with FLNB, INPPL1, ITGB1A, KCND2, MYOT, MYOZ1 and MYOZ3.

Interacts with sarcoglycans SGCD and SGCG.

Interacts (via filament repeats 17-18, 20-21 and 24) with USP25 (isoform USP25m only).

Interacts with FBLIM1 (By similarity).

Interacts with XIRP1; this interaction is mediated by filamin 20 repeat (By similarity).

Interacts with KY.

Interacts with IGFN1.

Interacts with MICALL2.

Interacts with ANK3.

Interacts with MICALL2 (By similarity).

Interacts with ANK3.

Interacts with SYNPO2 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
213053, 13 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8VHX6

Protein interaction database and analysis system

More...
IntActi
Q8VHX6, 13 interactors

Molecular INTeraction database

More...
MINTi
Q8VHX6

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000064163

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8VHX6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8VHX6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 143Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST107
Domaini160 – 263Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST104
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati271 – 369Filamin 1Add BLAST99
Repeati371 – 469Filamin 2Add BLAST99
Repeati470 – 566Filamin 3Add BLAST97
Repeati567 – 659Filamin 4Add BLAST93
Repeati663 – 759Filamin 5Add BLAST97
Repeati760 – 862Filamin 6Add BLAST103
Repeati863 – 961Filamin 7Add BLAST99
Repeati962 – 1057Filamin 8Add BLAST96
Repeati1058 – 1150Filamin 9Add BLAST93
Repeati1151 – 1245Filamin 10Add BLAST95
Repeati1246 – 1345Filamin 11Add BLAST100
Repeati1346 – 1438Filamin 12Add BLAST93
Repeati1439 – 1534Filamin 13Add BLAST96
Repeati1535 – 1631Filamin 14Add BLAST97
Repeati1636 – 1735Filamin 15Add BLAST100
Repeati1760 – 1855Filamin 16Add BLAST96
Repeati1856 – 1947Filamin 17Add BLAST92
Repeati1948 – 2034Filamin 18Add BLAST87
Repeati2037 – 2129Filamin 19Add BLAST93
Repeati2212 – 2307Filamin 20; mediates interaction with XIRP1PROSITE-ProRule annotationAdd BLAST96
Repeati2310 – 2402Filamin 21Add BLAST93
Repeati2404 – 2497Filamin 22Add BLAST94
Repeati2501 – 2593Filamin 23Add BLAST93
Repeati2631 – 2725Filamin 24Add BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 260Actin-bindingAdd BLAST260
Regioni1736 – 1759Hinge 1Add BLAST24
Regioni2163 – 2244Intradomain insert; mediate targeting to Z linesBy similarityAdd BLAST82
Regioni2404 – 2725Interaction with INPPL1By similarityAdd BLAST322
Regioni2594 – 2726Self-association site, tailBy similarityAdd BLAST133
Regioni2594 – 2630Hinge 2Add BLAST37

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the filamin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0518, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153588

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8VHX6

Identification of Orthologs from Complete Genome Data

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OMAi
VRYTAVQ

Database of Orthologous Groups

More...
OrthoDBi
657777at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8VHX6

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
2.60.40.10, 24 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR017868, Filamin/ABP280_repeat-like
IPR001298, Filamin/ABP280_rpt
IPR013783, Ig-like_fold
IPR014756, Ig_E-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF00630, Filamin, 23 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM00557, IG_FLMN, 24 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit
SSF81296, SSF81296, 24 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS50194, FILAMIN_REPEAT, 24 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8VHX6-1) [UniParc]FASTAAdd to basket
Also known as: H1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMNNSNYSDA SGLGLVDEAD EMPSTEKDLA EDAPWKKIQQ NTFTRWCNEH
60 70 80 90 100
LKCVGKRLTD LQRDLSDGLR LIALLEVLSQ KRMYRKFHPR PNFRQMKLEN
110 120 130 140 150
VSVALEFLER EHIKLVSIDS KAIVDGNLKL ILGLIWTLIL HYSISMPMWE
160 170 180 190 200
DEDDEDARKQ TPKQRLLGWI QNKVPQLPIT NFNRDWQDGK ALGALVDNCA
210 220 230 240 250
PGLCPDWEAW DPNQPVQNAR EAMQQADDWL GVPQVIAPEE IVDPNVDEHS
260 270 280 290 300
VMTYLSQFPK AKLKPGAPVR SKQLNPKKAI AYGPGIEPQG NTVLQPAHFT
310 320 330 340 350
VQTVDAGVGE VLVYIEDPEG HTEEAKVVPN NDKDRTYAVS YVPKVAGLHK
360 370 380 390 400
VTVLFAGQNI ERSPFEVNVG MALGDANKVS ARGPGLEPVG NVANKPTYFD
410 420 430 440 450
IYTAGAGTGD VAVVIVDPQG RRDTVEVALE DKGDNTFRCT YRPVMEGPHT
460 470 480 490 500
VHVAFAGAPI TRSPFPVHVA EACNPNACRA SGRGLQPKGV RVKEVADFKV
510 520 530 540 550
FTKGAGSGEL KVTVKGPKGT EEPVKVREAG DGVFECEYYP VVPGKYVVTI
560 570 580 590 600
TWGGYAIPRS PFEVQVSPEA GAQKVRAWGP GLETGQVGKS ADFVVEAIGT
610 620 630 640 650
EVGTLGFSIE GPSQAKIECD DKGDGSCDVR YWPTEPGEYA VHVICDDEDI
660 670 680 690 700
RDSPFIAHIQ PAPPDCFPDK VKAFGPGLEP TGCIVDRPAE FTIDARAAGK
710 720 730 740 750
GDLKLYAQDA DGCPIDIKVI PNGDGTFRCS YVPTKPIKHT IIVSWGGVNV
760 770 780 790 800
PKSPFRVNVG EGSHPERVKV YGPGVEKTGL KANEPTYFTV DCSEAGQGDV
810 820 830 840 850
SIGIKCAPGV VGPVEADIDF DIIKNDNDTF TVKYTPPGAG HYTIMVLFAN
860 870 880 890 900
QEIPASPFHI KVDPSHDASK VKAEGPGLSR TGVEVGKPTH FTVLTKGAGK
910 920 930 940 950
AKLDVHFAGA AKGEAVRDFE IIDNHDYSYT VKYTAVQQGN MAVTVTYGGD
960 970 980 990 1000
PVPKSPFVVN VAPPLDLSKV KVQGLNSKVA VGQEQAFSVN TRGAGGQGQL
1010 1020 1030 1040 1050
DVRMTSPSRR PIPCKLEPGG GAEAQAVRYM PPEEGPYKVD ITYDGHPVPG
1060 1070 1080 1090 1100
SPFAVEGVLP PDPSKVCAYG PGLKGGLVGT PAPFSIDTKG AGTGGLGLTV
1110 1120 1130 1140 1150
EGPCEAKIEC QDNGDGSCAV SYLPTEPGEY TINILFAEAH IPGSPFKATI
1160 1170 1180 1190 1200
QPVFDPSKVR ASGPGLERGK AGEAATFTVD CSEAGEAELT IEILSDAGVK
1210 1220 1230 1240 1250
AEVLIQNNAD GTYHITYSPA FPGTYTITIK YGGHPIPKFP TRVHVQPAVD
1260 1270 1280 1290 1300
TSGIKVSGPG VEPHGVLREV TTEFTVDARS LTATGGNHVT ARVLNPSGAK
1310 1320 1330 1340 1350
TDTYVTDNGD GTYRVQYTAY EEGVHLVEVL YDEVAVPKSP FRVGVTEGCD
1360 1370 1380 1390 1400
PTRVRAFGPG LEGGLVNKAN RFTVETRGAG TGGLGLAIEG PSEAKMSCKD
1410 1420 1430 1440 1450
NKDGSCTVEY IPFTPGDYDV NITFGGQPIP GSPFRVPVKD VVDPGKVKCS
1460 1470 1480 1490 1500
GPGLGTGVRA RVPQTFTVDC SQAGRAPLQV AVLGPTGVAE PVEVRDNGDG
1510 1520 1530 1540 1550
THTVHYTPAT DGPYTVAVKY ADQEVPRSPF KIKVLPSHDA SKVRASGPGL
1560 1570 1580 1590 1600
NASGIPASLP VEFTIDARDA GQGLLTVQIL DPEGKPKKAN IRDNGDGTYT
1610 1620 1630 1640 1650
VSYLPDMSGR YTITIKYGGD EIPYSPFRIH ALPTGDASKC LVTVSIGGHG
1660 1670 1680 1690 1700
LGACLGPRIQ IGEETVITVD AKAAGKGKVT CTVSTPDGAE LDVDVVENHD
1710 1720 1730 1740 1750
GTFDIYYTAP EPGKYVITIR FGGEHIPNSP FHVLACDPLP HVEEPAEMLQ
1760 1770 1780 1790 1800
MRQPYAPLRP GTCPTHWATE EPVVPVEPLE SMLRPFNLVI PFTVQKGELT
1810 1820 1830 1840 1850
GEVRMPSGKT ARPNITDNKD GTITVRYAPT EKGLHQMGIK YDGNHIPGSP
1860 1870 1880 1890 1900
LQFYVDAINS RHVSAYGPGL SHGMVNKPAT FTIVTKDAGE GGLSLAVEGP
1910 1920 1930 1940 1950
SKAEITCKDN KDGTCTVSYL PTAPGDYSII VRFDDKHIPG SPFTAKITGD
1960 1970 1980 1990 2000
DSMRTSQLNV GTSTDVSLKI TEGDLSQLTA SIRAPSGNEE PCLLKRLPNR
2010 2020 2030 2040 2050
HIGISFTPKE VGEHVVSVRK SGKHVTNSPF KILVGPSEIG DASKVRVWGK
2060 2070 2080 2090 2100
GLSEGQTFQV AEFIVDTRNA GYGGLGLSIE GPSKVDINCE DMEDGTCKVT
2110 2120 2130 2140 2150
YCPTEPGTYI INIKFADKHV PGSPFTVKVT GEGRMKESIT RRRQAPSIAT
2160 2170 2180 2190 2200
IGSTCDLNLK IPGNWFQMVS AQERLTRTFT RSSHTYTRTE RTEISKTRGG
2210 2220 2230 2240 2250
ETKREVRVEE STQVGGDPFP AVFGDFLGRE RLGSFGSITR QQEGEASSQD
2260 2270 2280 2290 2300
MTAQVTSPSG KTEAAEIVEG EDSAYSVRFV PQEMGPHTVT VKYRGQHVPG
2310 2320 2330 2340 2350
SPFQFTVGPL GEGGAHKVRA GGTGLERGVA GVPAEFSIWT REAGAGGLSI
2360 2370 2380 2390 2400
AVEGPSKAEI AFEDRKDGSC GVSYVVQEPG DYEVSIKFND EHIPDSPFVV
2410 2420 2430 2440 2450
PVASLSDDAR RLTVTSLQET GLKVNQPASF AVQLNGARGV IDARVHTPSG
2460 2470 2480 2490 2500
AVEECYVSEL DSDKHTIRFI PHENGVHSID VKFNGAHIPG SPFKIRVGEQ
2510 2520 2530 2540 2550
SQAGDPGLVS AYGPGLEGGT TGVSSEFIVN TQNAGSGALS VTIDGPSKVQ
2560 2570 2580 2590 2600
LDCRECPEGH VVTYTPMAPG NYLIAIKYGG PQHIVGSPFK AKVTGPRLSG
2610 2620 2630 2640 2650
GHSLHETSTV LVETVTKSSS SRGASYSSIP KFSSDASKVV TRGPGLSQAF
2660 2670 2680 2690 2700
VGQKNSFTVD CSKAGTNMMM VGVHGPKTPC EEVYVKHMGN RVYNVTYTVK
2710 2720
EKGDYILIVK WGDESVPGSP FKVNVP
Length:2,726
Mass (Da):291,119
Last modified:December 12, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFBE03CBFFEE3863
GO
Isoform 2 (identifier: Q8VHX6-2) [UniParc]FASTAAdd to basket
Also known as: Delta-H1

The sequence of this isoform differs from the canonical sequence as follows:
     1735-1767: Missing.

Show »
Length:2,693
Mass (Da):287,365
Checksum:i3CB7C227D50195F4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1406C → R in AAI51098 (PubMed:15489334).Curated1
Sequence conflicti2606E → Q in AAF97411 (PubMed:10679933).Curated1
Sequence conflicti2609T → S in AAF97411 (PubMed:10679933).Curated1
Sequence conflicti2617K → H in AAF97411 (PubMed:10679933).Curated1
Sequence conflicti2631K → N in AAF97411 (PubMed:10679933).Curated1
Sequence conflicti2663 – 2665KAG → QAR in AAF97411 (PubMed:10679933).Curated3
Sequence conflicti2669M → I in AAF97411 (PubMed:10679933).Curated1
Sequence conflicti2695V → F in AAF97411 (PubMed:10679933).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0075801735 – 1767Missing in isoform 2. 2 PublicationsAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC044807 Genomic DNA No translation available.
BC052186 mRNA Translation: AAH52186.1
BC060276 mRNA Translation: AAH60276.1
BC151097 mRNA Translation: AAI51098.1
BC158128 mRNA Translation: AAI58129.1
AF353670 mRNA Translation: AAL68446.1
AF119148 mRNA Translation: AAF97411.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS39452.1 [Q8VHX6-1]
CCDS80503.1 [Q8VHX6-2]

NCBI Reference Sequences

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RefSeqi
NP_001074654.1, NM_001081185.1 [Q8VHX6-1]
NP_001298003.1, NM_001311074.1 [Q8VHX6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000065090; ENSMUSP00000064163; ENSMUSG00000068699 [Q8VHX6-1]
ENSMUST00000101617; ENSMUSP00000099139; ENSMUSG00000068699 [Q8VHX6-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
68794

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:68794

UCSC genome browser

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UCSCi
uc009bdn.1, mouse [Q8VHX6-1]
uc009bdo.2, mouse [Q8VHX6-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC044807 Genomic DNA No translation available.
BC052186 mRNA Translation: AAH52186.1
BC060276 mRNA Translation: AAH60276.1
BC151097 mRNA Translation: AAI51098.1
BC158128 mRNA Translation: AAI58129.1
AF353670 mRNA Translation: AAL68446.1
AF119148 mRNA Translation: AAF97411.1
CCDSiCCDS39452.1 [Q8VHX6-1]
CCDS80503.1 [Q8VHX6-2]
RefSeqiNP_001074654.1, NM_001081185.1 [Q8VHX6-1]
NP_001298003.1, NM_001311074.1 [Q8VHX6-2]

3D structure databases

SMRiQ8VHX6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi213053, 13 interactors
CORUMiQ8VHX6
IntActiQ8VHX6, 13 interactors
MINTiQ8VHX6
STRINGi10090.ENSMUSP00000064163

PTM databases

iPTMnetiQ8VHX6
PhosphoSitePlusiQ8VHX6

Proteomic databases

jPOSTiQ8VHX6
PaxDbiQ8VHX6
PeptideAtlasiQ8VHX6
PRIDEiQ8VHX6

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1492, 144 antibodies

Genome annotation databases

EnsembliENSMUST00000065090; ENSMUSP00000064163; ENSMUSG00000068699 [Q8VHX6-1]
ENSMUST00000101617; ENSMUSP00000099139; ENSMUSG00000068699 [Q8VHX6-2]
GeneIDi68794
KEGGimmu:68794
UCSCiuc009bdn.1, mouse [Q8VHX6-1]
uc009bdo.2, mouse [Q8VHX6-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2318
MGIiMGI:95557, Flnc

Phylogenomic databases

eggNOGiKOG0518, Eukaryota
GeneTreeiENSGT00940000153588
InParanoidiQ8VHX6
OMAiVRYTAVQ
OrthoDBi657777at2759
PhylomeDBiQ8VHX6

Enzyme and pathway databases

ReactomeiR-MMU-446353, Cell-extracellular matrix interactions

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
68794, 0 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Flnc, mouse

Protein Ontology

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PROi
PR:Q8VHX6
RNActiQ8VHX6, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000068699, Expressed in hindlimb stylopod muscle and 221 other tissues
GenevisibleiQ8VHX6, MM

Family and domain databases

CDDicd00014, CH, 2 hits
Gene3Di1.10.418.10, 2 hits
2.60.40.10, 24 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR017868, Filamin/ABP280_repeat-like
IPR001298, Filamin/ABP280_rpt
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF00630, Filamin, 23 hits
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00557, IG_FLMN, 24 hits
SUPFAMiSSF47576, SSF47576, 1 hit
SSF81296, SSF81296, 24 hits
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS50194, FILAMIN_REPEAT, 24 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFLNC_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VHX6
Secondary accession number(s): B2RY80
, B9EKT2, Q6PAI6, Q9JJ38
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: December 12, 2006
Last modified: December 2, 2020
This is version 165 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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