UniProtKB - Q8VHW1 (CCGL_RAT)
Protein
Voltage-dependent calcium channel gamma-like subunit
Gene
Tmem37
Organism
Rattus norvegicus (Rat)
Status
Functioni
Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity).By similarity
GO - Molecular functioni
- calcium channel activity Source: UniProtKB-KW
- voltage-gated ion channel activity Source: UniProtKB-KW
GO - Biological processi
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Calcium channel, Ion channel, Voltage-gated channel |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-dependent calcium channel gamma-like subunitAlternative name(s): Neuronal voltage-gated calcium channel gamma-like subunit Transmembrane protein 37 |
Gene namesi | |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 628689, Tmem37 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 25 – 45 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 96 – 116 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 131 – 151 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 155 – 175 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000225602 | 1 – 209 | Voltage-dependent calcium channel gamma-like subunitCuratedAdd BLAST | 209 |
Proteomic databases
PaxDbi | Q8VHW1 |
PRIDEi | Q8VHW1 |
Interactioni
Subunit structurei
The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000067466 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S0PU, Eukaryota |
InParanoidi | Q8VHW1 |
OrthoDBi | 1302934at2759 |
PhylomeDBi | Q8VHW1 |
Family and domain databases
InterProi | View protein in InterPro IPR029372, Tmem37 |
PANTHERi | PTHR31767, PTHR31767, 1 hit |
Pfami | View protein in Pfam PF15108, TMEM37, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8VHW1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTAIGAQAYK LLGPKRPHRS FFESFIRTLI IVCTALAVVL SSVSICDGHW
60 70 80 90 100
LLVEDRLFGL WYFCTISNHS EPHCLRDLSQ AQVPGVAVGM GLARSVAAMA
110 120 130 140 150
VVAAIFGLEL LIVSQVCEDV RSRSKWAIGS YLLLVAFILS SGGLLTFIIL
160 170 180 190 200
LKNQITLMGF TLMFWCEFTA SFLFFLNATS GLHINSLTRS PPAGTLAYRK
QGYDGTSLI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0RCX9 | M0RCX9_RAT | Voltage-dependent calcium channel g... | Tmem37 | 209 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF361355 mRNA Translation: AAL50050.1 |
RefSeqi | NP_620795.1, NM_139095.1 |
Genome annotation databases
GeneIDi | 245953 |
KEGGi | rno:245953 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF361355 mRNA Translation: AAL50050.1 |
RefSeqi | NP_620795.1, NM_139095.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000067466 |
Proteomic databases
PaxDbi | Q8VHW1 |
PRIDEi | Q8VHW1 |
Genome annotation databases
GeneIDi | 245953 |
KEGGi | rno:245953 |
Organism-specific databases
CTDi | 140738 |
RGDi | 628689, Tmem37 |
Phylogenomic databases
eggNOGi | ENOG502S0PU, Eukaryota |
InParanoidi | Q8VHW1 |
OrthoDBi | 1302934at2759 |
PhylomeDBi | Q8VHW1 |
Miscellaneous databases
PROi | PR:Q8VHW1 |
Family and domain databases
InterProi | View protein in InterPro IPR029372, Tmem37 |
PANTHERi | PTHR31767, PTHR31767, 1 hit |
Pfami | View protein in Pfam PF15108, TMEM37, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCGL_RAT | |
Accessioni | Q8VHW1Primary (citable) accession number: Q8VHW1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 7, 2006 |
Last sequence update: | March 1, 2002 | |
Last modified: | August 12, 2020 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families