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Protein

Ankyrin repeat and SOCS box protein 16

Gene

Asb16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 16
Short name:
ASB-16
Gene namesi
Name:Asb16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2654437 Asb16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669571 – 453Ankyrin repeat and SOCS box protein 16Add BLAST453

Proteomic databases

PaxDbiQ8VHS5
PRIDEiQ8VHS5

PTM databases

PhosphoSitePlusiQ8VHS5

Expressioni

Gene expression databases

BgeeiENSMUSG00000034768
CleanExiMM_ASB16
GenevisibleiQ8VHS5 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038450

Structurei

3D structure databases

ProteinModelPortaliQ8VHS5
SMRiQ8VHS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati56 – 85ANK 1Add BLAST30
Repeati110 – 139ANK 2Add BLAST30
Repeati142 – 171ANK 3Add BLAST30
Repeati175 – 204ANK 4Add BLAST30
Repeati209 – 238ANK 5Add BLAST30
Repeati242 – 279ANK 6Add BLAST38
Repeati283 – 312ANK 7Add BLAST30
Domaini397 – 453SOCS boxPROSITE-ProRule annotationAdd BLAST57

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00390000011960
HOGENOMiHOG000232066
HOVERGENiHBG073573
InParanoidiQ8VHS5
KOiK10338
OMAiLHNACAN
OrthoDBiEOG091G08N2
PhylomeDBiQ8VHS5
TreeFamiTF333494

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VHS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGESFPFTS STLRALRLQR EWLDWEDRRR AAAQQCRRHR DLPCPQAQLL
60 70 80 90 100
RPRRSCRDPA VHNALFSGDL QQLQILFQDE DAANMIVETV SNQLAWSAEQ
110 120 130 140 150
GFWVLTPKTK QTAPLTIAVA RGYTDCARHL ILQGAELDAR IGGRAALHEA
160 170 180 190 200
CAQAHPDCVR LLLTFGAKAN VSSEEGMTPL HLCTSPESLQ CAKLLLEAGA
210 220 230 240 250
SVNVASQESE VTPLHVAAAR GLEQHVALYL QNGADVALRT SQGETALNAA
260 270 280 290 300
CAGAEGPGSS RQHEAAARQL LEAGADPQAA GRKRHTPLHN ACANGCGGLA
310 320 330 340 350
ELLLRHGASP GVTNGAGHTP MDCALQAVQD APNWEPEVLF AALLDYGAQP
360 370 380 390 400
VHPEMLKHCA NFPRALEVLL NAYPCVPSCD PWVEAVLPEL WQEHEAFYSS
410 420 430 440 450
ALSMENQPRQ LQHLARLAVR AQLGSHCRQA AAQLPLPPLL RDYLLLGVEG

RIQ
Length:453
Mass (Da):49,097
Last modified:March 1, 2002 - v1
Checksum:i6B8F4FB0165981F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403044 mRNA Translation: AAL57363.1
AK038411 mRNA Translation: BAC29990.1
CCDSiCCDS25493.1
RefSeqiNP_683755.1, NM_148953.2
UniGeneiMm.216432

Genome annotation databases

EnsembliENSMUST00000036467; ENSMUSP00000038450; ENSMUSG00000034768
GeneIDi217217
KEGGimmu:217217
UCSCiuc007lra.1 mouse

Similar proteinsi

Entry informationi

Entry nameiASB16_MOUSE
AccessioniPrimary (citable) accession number: Q8VHS5
Secondary accession number(s): Q8BYT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2002
Last modified: February 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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