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Protein

Protein crumbs homolog 1

Gene

Crb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion. Isoform 3 could play a role in epidermal tissue morphogenesis. May function in cell attachment for stratified epithelial organization.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • eye photoreceptor cell development Source: MGI
  • membrane organization Source: MGI
  • plasma membrane organization Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein crumbs homolog 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Crb1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2136343 Crb1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 1339ExtracellularSequence analysisAdd BLAST1312
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1340 – 1360HelicalSequence analysisAdd BLAST21
Topological domaini1361 – 1405CytoplasmicSequence analysisAdd BLAST45

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Crb1 are a cause of focal retinal dysplasia and degeneration associated with a shortening of inner and outer segments. Affected mice produce a secreted truncated protein that lacks the single transmembrane and the intracellular domain, and develop irregularities at the outer limiting membrane and loss of photoreceptor cells.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000750128 – 1405Protein crumbs homolog 1Add BLAST1378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi34 ↔ 45By similarity
Disulfide bondi39 ↔ 54By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi55 ↔ 66By similarity
Disulfide bondi73 ↔ 84By similarity
Disulfide bondi78 ↔ 95By similarity
Disulfide bondi97 ↔ 106By similarity
Disulfide bondi113 ↔ 124By similarity
Disulfide bondi118 ↔ 133By similarity
Disulfide bondi135 ↔ 144By similarity
Disulfide bondi151 ↔ 162By similarity
Disulfide bondi156 ↔ 171By similarity
Disulfide bondi173 ↔ 182By similarity
Disulfide bondi189 ↔ 200By similarity
Disulfide bondi194 ↔ 209By similarity
Disulfide bondi211 ↔ 220By similarity
Disulfide bondi227 ↔ 238By similarity
Disulfide bondi232 ↔ 247By similarity
Disulfide bondi249 ↔ 258By similarity
Disulfide bondi265 ↔ 276By similarity
Disulfide bondi270 ↔ 285By similarity
Disulfide bondi287 ↔ 297By similarity
Disulfide bondi304 ↔ 315By similarity
Disulfide bondi309 ↔ 324By similarity
Disulfide bondi326 ↔ 335By similarity
Disulfide bondi342 ↔ 353By similarity
Disulfide bondi347 ↔ 382By similarity
Disulfide bondi384 ↔ 393By similarity
Disulfide bondi400 ↔ 411By similarity
Disulfide bondi405 ↔ 420By similarity
Disulfide bondi422 ↔ 437By similarity
Disulfide bondi444 ↔ 455By similarity
Disulfide bondi449 ↔ 468By similarity
Disulfide bondi470 ↔ 479By similarity
Glycosylationi560N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi641 ↔ 669By similarity
Glycosylationi656N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi675 ↔ 686By similarity
Disulfide bondi680 ↔ 695By similarity
Disulfide bondi697 ↔ 706By similarity
Glycosylationi756N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi850 ↔ 884By similarity
Glycosylationi879N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi890 ↔ 901By similarity
Disulfide bondi895 ↔ 910By similarity
Disulfide bondi912 ↔ 921By similarity
Disulfide bondi927 ↔ 938By similarity
Disulfide bondi932 ↔ 947By similarity
Glycosylationi967N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi974N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi999N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1095 ↔ 1136By similarity
Disulfide bondi1142 ↔ 1153By similarity
Disulfide bondi1147 ↔ 1162By similarity
Disulfide bondi1164 ↔ 1173By similarity
Disulfide bondi1180 ↔ 1190By similarity
Disulfide bondi1185 ↔ 1199By similarity
Glycosylationi1189N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1201 ↔ 1210By similarity
Disulfide bondi1217 ↔ 1228By similarity
Disulfide bondi1222 ↔ 1237By similarity
Disulfide bondi1239 ↔ 1248By similarity
Glycosylationi1242N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1258 ↔ 1273By similarity
Glycosylationi1264N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1267 ↔ 1282By similarity
Disulfide bondi1284 ↔ 1293By similarity
Disulfide bondi1300 ↔ 1311By similarity
Disulfide bondi1305 ↔ 1320By similarity
Disulfide bondi1322 ↔ 1331By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8VHS2

PRoteomics IDEntifications database

More...
PRIDEi
Q8VHS2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8VHS2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8VHS2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed exclusively in brain and proliferative retinoblasts of the eye. In the brain, expressed in the granular layer of the cerebellum, the hippocampal dentate gyrus, the olfactory bulbs, the subventricular region lining the telencephalic ventricles and the rostral migratory stream. Isoform 3 is ubiquitously expressed.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Primarily detected in the central nervous system at E10.5, in the ventral part of the neural tube including the ventral spinal cord, the ventral part of the mesencephalon, the mammillary and the hypothalamic regions, the optic area and the zona limitans intrathalamica. Expressed by the V3 interneurons placed between the floor plate and the motorneurons all along the spinal cord axis. In late embryogenesis, expressed mainly in ventral neural structures of the developing brain, including the mammillary, tuberalis regions of the hypothalamus and the preoptic area. Starting from E12.5, also strongly expressed in the neural area that gives rise to the dorsal thalamus. In the retina, expression starts at E11.5 and is enhanced at E12.5, E14.5 and E16.5. In postnatal stages and in the adult eye, it is strongly expressed in photoreceptors and also found in inner nuclear layer and iris. Isoform 3 expression starts at E14, is enhanced at E15 and E16 during active proliferation of epidermal cells, decreases after birth but is maintained in adult skin. Detected in the skin basal cells at E16, it was observed in upper layers after birth (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000063681 Expressed in 136 organ(s), highest expression level in retina

CleanEx database of gene expression profiles

More...
CleanExi
MM_CRB1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8VHS2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8VHS2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

In photoreceptor cells, forms a complex with MPDZ, MPP4 and MPP5.

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8VHS2

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000060769

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8VHS2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8VHS2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 67EGF-like 1; atypicalPROSITE-ProRule annotationAdd BLAST38
Domaini69 – 107EGF-like 2PROSITE-ProRule annotationAdd BLAST39
Domaini109 – 145EGF-like 3PROSITE-ProRule annotationAdd BLAST37
Domaini147 – 183EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini185 – 221EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini223 – 259EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini261 – 298EGF-like 7PROSITE-ProRule annotationAdd BLAST38
Domaini300 – 336EGF-like 8PROSITE-ProRule annotationAdd BLAST37
Domaini338 – 394EGF-like 9PROSITE-ProRule annotationAdd BLAST57
Domaini396 – 438EGF-like 10PROSITE-ProRule annotationAdd BLAST43
Domaini440 – 480EGF-like 11PROSITE-ProRule annotationAdd BLAST41
Domaini482 – 669Laminin G-like 1PROSITE-ProRule annotationAdd BLAST188
Domaini671 – 707EGF-like 12PROSITE-ProRule annotationAdd BLAST37
Domaini713 – 884Laminin G-like 2PROSITE-ProRule annotationAdd BLAST172
Domaini886 – 922EGF-like 13PROSITE-ProRule annotationAdd BLAST37
Domaini923 – 959EGF-like 14PROSITE-ProRule annotationAdd BLAST37
Domaini950 – 1136Laminin G-like 3PROSITE-ProRule annotationAdd BLAST187
Domaini1138 – 1174EGF-like 15PROSITE-ProRule annotationAdd BLAST37
Domaini1176 – 1211EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini1213 – 1249EGF-like 17PROSITE-ProRule annotationAdd BLAST37
Domaini1254 – 1294EGF-like 18PROSITE-ProRule annotationAdd BLAST41
Domaini1296 – 1332EGF-like 19; calcium-bindingPROSITE-ProRule annotationAdd BLAST37

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Crumbs protein family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR70 Eukaryota
ENOG411193Y LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155152

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230899

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080001

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8VHS2

KEGG Orthology (KO)

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KOi
K16681

Identification of Orthologs from Complete Genome Data

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OMAi
SRVEMWS

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00H8

TreeFam database of animal gene trees

More...
TreeFami
TF316224

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 12 hits
PF02210 Laminin_G_2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 17 hits
SM00179 EGF_CA, 16 hits
SM00282 LamG, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 3 hits
SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 10 hits
PS00022 EGF_1, 15 hits
PS01186 EGF_2, 11 hits
PS50026 EGF_3, 17 hits
PS01187 EGF_CA, 6 hits
PS50025 LAM_G_DOMAIN, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8VHS2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLKRTAYLL FLYLSSSLLI CIKNSFCNKN NTRCLSGPCQ NNSTCKHFPQ
60 70 80 90 100
DNNCCLDTAN NLDKDCEDLK DPCFSSPCQG IATCVKIPGE GNFLCQCPPG
110 120 130 140 150
YSGLNCETAT NSCGGNLCQH GGTCRKDPEH PVCICPPGYA GRFCETDHNE
160 170 180 190 200
CASSPCHNGA MCQDGINGYS CFCVPGYQGR HCDLEVDECV SDPCKNEAVC
210 220 230 240 250
LNEIGRYTCV CPQEFSGVNC ELEIDECRSQ PCLHGATCQD APGGYSCDCA
260 270 280 290 300
PGFLGEHCEL SVNECESQPC LHGGLCVDGR NSYHCDCTGS GFTGMHCESL
310 320 330 340 350
IPLCWSKPCH NDATCEDTVD SYICHCRPGY TGALCETDIN ECSSNPCQFW
360 370 380 390 400
GECVELSSEG LYGNTAGLPS SFSYVGASGY VCICQPGFTG IHCEEDVDEC
410 420 430 440 450
LLHPCLNGGT CENLPGNYAC HCPFDDTSRT FYGGENCSEI LLGCTHHQCL
460 470 480 490 500
NNGKCIPHFQ NGQHGFTCQC LSGYAGPLCE TVTTLSFGSN GFLWVTSGSH
510 520 530 540 550
TGIGPECNIS LRFHTVQPNA LLLIRGNKDV SMKLELLNGC VHLSIEVWNQ
560 570 580 590 600
LKVLLSISHN TSDGEWHFVE VTIAETLTLA LVGGSCKEKC TTKSSVPVEN
610 620 630 640 650
HQSICALQDS FLGGLPMGTA NNSVSVLNIY NVPSTPSFVG CLQDIRFDLN
660 670 680 690 700
HITLENVSSG LSSNVKAGCL GKDWCESQPC QNRGRCINLW QGYQCECDRP
710 720 730 740 750
YTGSNCLKEY VAGRFGQDDS TGYAAFSVND NYGQNFSLSM FVRTRQPLGL
760 770 780 790 800
LLALENSTYQ YVSVWLEHGS LALQTPGSPK FMVNFFLSDG NVHLISLRIK
810 820 830 840 850
PNEIELYQSS QNLGFISVPT WTIRRGDVIF IGGLPDREKT EVYGGFFKGC
860 870 880 890 900
VQDVRLNSQT LEFFPNSTNN AYDDPILVNV TQGCPGDNTC KSNPCHNGGV
910 920 930 940 950
CHSLWDDFSC SCPTNTAGRA CEQVQWCQLS PCPPTAECQL LPQGFECIAN
960 970 980 990 1000
AVFSGLSREI LFRSNGNITR ELTNITFAFR THDTNVMILH AEKEPEFLNI
1010 1020 1030 1040 1050
SIQDARLFFQ LRSGNSFYTL HLMGSQLVND GTWHQVTFSM IDPVAQTSRW
1060 1070 1080 1090 1100
QMEVNDQTPF VISEVATGSL NFLKDNTDIY VGDQSVDNPK GLQGCLSTIE
1110 1120 1130 1140 1150
IGGIYLSYFE NLHGFPGKPQ EEQFLKVSTN MVLTGCLPSN ACHSSPCLHG
1160 1170 1180 1190 1200
GNCEDSYSSY RCACLSGWSG THCEINIDEC FSSPCIHGNC SDGVAAYHCR
1210 1220 1230 1240 1250
CEPGYTGVNC EVDVDNCKSH QCANGATCVP EAHGYSCLCF GNFTGRFCRH
1260 1270 1280 1290 1300
SRLPSTVCGN EKRNFTCYNG GSCSMFQEDW QCMCWPGFTG EWCEEDINEC
1310 1320 1330 1340 1350
ASDPCINGGL CRDLVNRFLC ICDVAFAGER CELDLADDRL LGIFTAVGSG
1360 1370 1380 1390 1400
TLALFFILLL AGVASLIASN KRATQGTYSP SGQEKAGPRV EMWIRMPPPA

LERLI
Length:1,405
Mass (Da):153,350
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE1ECCB17529797B
GO
Isoform 2 (identifier: Q8VHS2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     329-389: Missing.
     1298-1376: NECASDPCIN...IASNKRATQG → EASVPPIPAS...VVEWGAQENY
     1377-1405: Missing.

Show »
Length:1,315
Mass (Da):144,240
Checksum:iA7BFB777507D5D50
GO
Isoform 3 (identifier: Q8VHS2-3) [UniParc]FASTAAdd to basket
Also known as: Crb1s

The sequence of this isoform differs from the canonical sequence as follows:
     709-761: EYVAGRFGQD...LALENSTYQY → GERSGVPQSA...EIKWHSHDMY
     762-1405: Missing.

Show »
Length:761
Mass (Da):82,539
Checksum:i237635C3735E06A8
GO
Isoform 4 (identifier: Q8VHS2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-372: Missing.
     373-389: SYVGASGYVCICQPGFT → MFGHKTQGFHILMAVLI
     709-761: EYVAGRFGQD...LALENSTYQY → GERSGVPQSA...EIKWHSHDMY
     762-1405: Missing.

Note: No experimental confirmation available.
Show »
Length:389
Mass (Da):42,611
Checksum:i79E07040792E01A8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JDY0A0A0G2JDY0_MOUSE
Protein crumbs homolog 1
Crb1
1,314Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JG15A0A0G2JG15_MOUSE
Protein crumbs homolog 1
Crb1
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JEU4A0A0G2JEU4_MOUSE
Protein crumbs homolog 1
Crb1
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46K → E in AAL65131 (PubMed:11744384).Curated1
Sequence conflicti46K → E in AAR20495 (PubMed:14684155).Curated1
Sequence conflicti157H → L in AAL65131 (PubMed:11744384).Curated1
Sequence conflicti214E → K in AAR20495 (PubMed:14684155).Curated1
Sequence conflicti261S → T in AAR20495 (PubMed:14684155).Curated1
Sequence conflicti344S → N in AAR20495 (PubMed:14684155).Curated1
Sequence conflicti371S → T in AAR20495 (PubMed:14684155).Curated1
Sequence conflicti413N → S in AAL65131 (PubMed:11744384).Curated1
Sequence conflicti521Missing in AAR20495 (PubMed:14684155).Curated1
Sequence conflicti536L → W in AAQ06606 (Ref. 3) Curated1
Sequence conflicti540C → G in AAQ06606 (Ref. 3) Curated1
Sequence conflicti545I → M in AAQ06606 (Ref. 3) Curated1
Sequence conflicti572T → P in AAQ06606 (Ref. 3) Curated1
Sequence conflicti591T → A in AAQ06606 (Ref. 3) Curated1
Sequence conflicti673D → DD in AAR20495 (PubMed:14684155).Curated1
Sequence conflicti741F → L in AAQ06606 (Ref. 3) Curated1
Sequence conflicti745R → H in AAQ06606 (Ref. 3) Curated1
Sequence conflicti835P → L in AAQ06606 (Ref. 3) Curated1
Sequence conflicti886G → R in AAQ06606 (Ref. 3) Curated1
Sequence conflicti900 – 902VCH → ACR in AAQ06606 (Ref. 3) Curated3
Sequence conflicti942P → S in AAQ06606 (Ref. 3) Curated1
Sequence conflicti982H → Q in AAQ06606 (Ref. 3) Curated1
Sequence conflicti1062I → V in AAQ06606 (Ref. 3) Curated1
Sequence conflicti1275M → V in AAQ06606 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0147301 – 372Missing in isoform 4. 1 PublicationAdd BLAST372
Alternative sequenceiVSP_014731329 – 389Missing in isoform 2. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_014732373 – 389SYVGA…QPGFT → MFGHKTQGFHILMAVLI in isoform 4. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_014733709 – 761EYVAG…STYQY → GERSGVPQSAVPLSRAISNH PGCRPLLGNIRTPQDLCWYL FTNEIKWHSHDMY in isoform 3 and isoform 4. 2 PublicationsAdd BLAST53
Alternative sequenceiVSP_014734762 – 1405Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST644
Alternative sequenceiVSP_0147351298 – 1376NECAS…RATQG → EASVPPIPASMEDCAGTWST GSYASVMWPSLGERCELDVS GLSFYVSLLLWQNLFQLLSY LVLHMNDEPVVEWGAQENY in isoform 2. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_0147361377 – 1405Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF406641 mRNA Translation: AAL65131.1
AY450552 mRNA Translation: AAR20495.1
AF492496 mRNA Translation: AAQ06606.1
AK044345 mRNA Translation: BAC31879.1
AK044704 mRNA Translation: BAC32041.1
AL606536, AC116810, AC138741 Genomic DNA Translation: CAX16031.1
CH466520 Genomic DNA Translation: EDL39531.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS15336.1 [Q8VHS2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_573502.2, NM_133239.2 [Q8VHS2-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.95700

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000059825; ENSMUSP00000060769; ENSMUSG00000063681 [Q8VHS2-1]
ENSMUST00000196402; ENSMUSP00000142702; ENSMUSG00000063681 [Q8VHS2-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
170788

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:170788

UCSC genome browser

More...
UCSCi
uc007cwc.1 mouse [Q8VHS2-1]
uc007cwe.1 mouse [Q8VHS2-4]
uc007cwf.1 mouse [Q8VHS2-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF406641 mRNA Translation: AAL65131.1
AY450552 mRNA Translation: AAR20495.1
AF492496 mRNA Translation: AAQ06606.1
AK044345 mRNA Translation: BAC31879.1
AK044704 mRNA Translation: BAC32041.1
AL606536, AC116810, AC138741 Genomic DNA Translation: CAX16031.1
CH466520 Genomic DNA Translation: EDL39531.1
CCDSiCCDS15336.1 [Q8VHS2-1]
RefSeqiNP_573502.2, NM_133239.2 [Q8VHS2-1]
UniGeneiMm.95700

3D structure databases

ProteinModelPortaliQ8VHS2
SMRiQ8VHS2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ8VHS2
STRINGi10090.ENSMUSP00000060769

PTM databases

iPTMnetiQ8VHS2
PhosphoSitePlusiQ8VHS2

Proteomic databases

PaxDbiQ8VHS2
PRIDEiQ8VHS2

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
170788
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059825; ENSMUSP00000060769; ENSMUSG00000063681 [Q8VHS2-1]
ENSMUST00000196402; ENSMUSP00000142702; ENSMUSG00000063681 [Q8VHS2-3]
GeneIDi170788
KEGGimmu:170788
UCSCiuc007cwc.1 mouse [Q8VHS2-1]
uc007cwe.1 mouse [Q8VHS2-4]
uc007cwf.1 mouse [Q8VHS2-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23418
MGIiMGI:2136343 Crb1

Phylogenomic databases

eggNOGiENOG410IR70 Eukaryota
ENOG411193Y LUCA
GeneTreeiENSGT00940000155152
HOGENOMiHOG000230899
HOVERGENiHBG080001
InParanoidiQ8VHS2
KOiK16681
OMAiSRVEMWS
OrthoDBiEOG091G00H8
TreeFamiTF316224

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8VHS2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000063681 Expressed in 136 organ(s), highest expression level in retina
CleanExiMM_CRB1
ExpressionAtlasiQ8VHS2 baseline and differential
GenevisibleiQ8VHS2 MM

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00008 EGF, 12 hits
PF02210 Laminin_G_2, 3 hits
SMARTiView protein in SMART
SM00181 EGF, 17 hits
SM00179 EGF_CA, 16 hits
SM00282 LamG, 3 hits
SUPFAMiSSF49899 SSF49899, 3 hits
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 10 hits
PS00022 EGF_1, 15 hits
PS01186 EGF_2, 11 hits
PS50026 EGF_3, 17 hits
PS01187 EGF_CA, 6 hits
PS50025 LAM_G_DOMAIN, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRUM1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VHS2
Secondary accession number(s): B7ZC63
, Q6ST50, Q71JF2, Q8BGR4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 27, 2011
Last modified: December 5, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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