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UniProtKB - Q8VHR5 (P66B_MOUSE)

Entry version 153 (25 May 2022)
Sequence version 1 (01 Mar 2002)
Previous versions | rss
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Protein

Transcriptional repressor p66-beta

Gene

Gatad2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor (By similarity).

Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A (By similarity).

Targets MBD3 to discrete loci in the nucleus (By similarity).

Plays a role in synapse development (By similarity).

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri415 – 468GATA-typePROSITE-ProRule annotationAdd BLAST54

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-3214815, HDACs deacetylate histones
R-MMU-6804758, Regulation of TP53 Activity through Acetylation
R-MMU-73762, RNA Polymerase I Transcription Initiation
R-MMU-8943724, Regulation of PTEN gene transcription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional repressor p66-beta
Alternative name(s):
GATA zinc finger domain-containing protein 2B
p66/p68
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gatad2b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2443225, Gatad2b

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000042390

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000835031 – 594Transcriptional repressor p66-betaAdd BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei17PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki66Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki98Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei121PhosphothreonineCombined sources1
Modified residuei123PhosphoserineCombined sources1
Modified residuei130PhosphoserineCombined sources1
Modified residuei135PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Cross-linki148Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki200Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei209PhosphoserineBy similarity1
Cross-linki282Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei334PhosphoserineBy similarity1
Modified residuei339PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1
Cross-linki354Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki455Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki468Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei487PhosphoserineBy similarity1
Cross-linki499Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8VHR5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8VHR5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8VHR5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8VHR5

PeptideAtlas

More...PeptideAtlasi		Q8VHR5

PRoteomics IDEntifications database

More...PRIDEi		Q8VHR5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		294313 [Q8VHR5-1]
294314 [Q8VHR5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8VHR5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8VHR5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000042390, Expressed in secondary oocyte and 279 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8VHR5, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MBD2 and MBD3 (By similarity). Interaction with MBD2 is required for the enhancement of MBD2-mediated repression and for targeting to the chromatin (By similarity).

Component of the MeCP1 histone deacetylase complex (By similarity).

Interacts with histone tails, including that of histones H2A, H2B, H3 and H4 (By similarity).

Interacts with ERCC6 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		230858, 18 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-953, MBD2/NuRD nucleosome remodeling and deacetylase complex
CPX-954, MBD3/NuRD nucleosome remodeling and deacetylase complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8VHR5

Database of interacting proteins

More...DIPi		DIP-62049N

Protein interaction database and analysis system

More...IntActi		Q8VHR5, 8 interactors

Molecular INTeraction database

More...MINTi		Q8VHR5

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000041370

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8VHR5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8VHR5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8VHR5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni62 – 143DisorderedSequence analysisAdd BLAST82
Regioni166 – 191CR1; interaction with MBD2 and MBD3By similarityAdd BLAST26
Regioni214 – 237DisorderedSequence analysisAdd BLAST24
Regioni341 – 481CR2; histone tail-bindingBy similarityAdd BLAST141

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili141 – 195Sequence analysisAdd BLAST55
Coiled coili450 – 483Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi91 – 119Basic and acidic residuesSequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Both CR1 and CR2 regions are required for speckled nuclear localization.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri415 – 468GATA-typePROSITE-ProRule annotationAdd BLAST54

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3740, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000004097

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8VHR5

Identification of Orthologs from Complete Genome Data

More...OMAi		PEERMHQ

Database of Orthologous Groups

More...OrthoDBi		885815at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8VHR5

TreeFam database of animal gene trees

More...TreeFami		TF321369

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.50.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040386, P66
IPR032346, P66_CC
IPR000679, Znf_GATA
IPR013088, Znf_NHR/GATA

The PANTHER Classification System

More...PANTHERi		PTHR13455, PTHR13455, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00320, GATA, 1 hit
PF16563, P66_CC, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50114, GATA_ZN_FINGER_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8VHR5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRMTEDALR LNLLKRSLDP ADERDDVLAK RLKMEGHEAM ERLKMLALLK 
        60         70         80         90        100
RKDLANLEVP HELPTKQDGS GVKGYEEKLN GNLRPHGDNN RTAGRPGKEN 
       110        120        130        140        150
INDEPVDMSA RRSEPDRGRL TPSPDIIVLS DNEASSPRSS SRMEERLKAA 
       160        170        180        190        200
NLEMFKGKGM EERQQLIKQL RDELRLEEAR LVLLKKLRQS QLQKENVVQK 
       210        220        230        240        250
TPVVQNAASI VQPSPAHVGQ QGLSKLPSRP GAQGIEPQNM RTLQGHSVIR 
       260        270        280        290        300
SATNTTLPHM LMSQRVIAPN PAQLQGQRGP PKPGIVRTTT PNMNPAISYQ 
       310        320        330        340        350
PQSSSSVPCQ RTTSSAIYMN LASHIQPGTV NRVSSPLPSP SAMSDAANSQ 
       360        370        380        390        400
AAAKLALRKQ LEKTLLEIPP PKPPAPLLHF LPSAANSEFI YMVGLEEVVQ 
       410        420        430        440        450
SVIDSQGKNC ASLLRVEPFV CAQCRTDFTP HWKQEKNGKI LCEQCMTSNQ 
       460        470        480        490        500
KKALKAEHTN RLKNAFVKAL QQEQEIEQRL QQQAALSPTT APAVSSVSKQ 
       510        520        530        540        550
ETIMRHHTLR QAPQPQSSLQ RGIPTSARSM LSNFAQAPQL SVPGGLLGMP 
       560        570        580        590 
GVNIAYLNTG IGGHKAPSLA DRQREYLLDM IPPRSISQSI SGQK
Length:594
Mass (Da):65,411
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC57330259EADAAE6
GO
Isoform 2 (identifier: Q8VHR5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     475-485: EIEQRLQQQAA → VRTLTPTCTVI
     486-594: Missing.

Note: May be due to intron retention.Curated
Show »
Length:485
Mass (Da):53,734
Checksum:i319D9E907558D734
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A1L3S7A1L3S7_MOUSE
Gatad2b protein
Gatad2b
578Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RNM2A0A0U1RNM2_MOUSE
Transcriptional repressor p66-beta
Gatad2b
263Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010930475 – 485EIEQRLQQQAA → VRTLTPTCTVI in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_010931486 – 594Missing in isoform 2. 1 PublicationAdd BLAST109

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF411837 mRNA Translation: AAL39081.1
AK041594 mRNA Translation: BAC30997.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS17526.1 [Q8VHR5-1]

NCBI Reference Sequences

More...RefSeqi		NP_647465.1, NM_139304.1 [Q8VHR5-1]
XP_006501422.2, XM_006501359.3
XP_006501424.1, XM_006501361.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000049382; ENSMUSP00000041370; ENSMUSG00000042390 [Q8VHR5-1]
ENSMUST00000199607; ENSMUSP00000142617; ENSMUSG00000042390 [Q8VHR5-1]
ENSMUST00000199754; ENSMUSP00000142514; ENSMUSG00000042390 [Q8VHR5-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		229542

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:229542

UCSC genome browser

More...UCSCi		uc008qca.1, mouse [Q8VHR5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411837 mRNA Translation: AAL39081.1
AK041594 mRNA Translation: BAC30997.1
CCDSiCCDS17526.1 [Q8VHR5-1]
RefSeqiNP_647465.1, NM_139304.1 [Q8VHR5-1]
XP_006501422.2, XM_006501359.3
XP_006501424.1, XM_006501361.2

3D structure databases

AlphaFoldDBiQ8VHR5
SMRiQ8VHR5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi230858, 18 interactors
ComplexPortaliCPX-953, MBD2/NuRD nucleosome remodeling and deacetylase complex
CPX-954, MBD3/NuRD nucleosome remodeling and deacetylase complex
CORUMiQ8VHR5
DIPiDIP-62049N
IntActiQ8VHR5, 8 interactors
MINTiQ8VHR5
STRINGi10090.ENSMUSP00000041370

PTM databases

iPTMnetiQ8VHR5
PhosphoSitePlusiQ8VHR5

Proteomic databases

EPDiQ8VHR5
jPOSTiQ8VHR5
MaxQBiQ8VHR5
PaxDbiQ8VHR5
PeptideAtlasiQ8VHR5
PRIDEiQ8VHR5
ProteomicsDBi294313 [Q8VHR5-1]
294314 [Q8VHR5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1795, 272 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		229542

Genome annotation databases

EnsembliENSMUST00000049382; ENSMUSP00000041370; ENSMUSG00000042390 [Q8VHR5-1]
ENSMUST00000199607; ENSMUSP00000142617; ENSMUSG00000042390 [Q8VHR5-1]
ENSMUST00000199754; ENSMUSP00000142514; ENSMUSG00000042390 [Q8VHR5-1]
GeneIDi229542
KEGGimmu:229542
UCSCiuc008qca.1, mouse [Q8VHR5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57459
MGIiMGI:2443225, Gatad2b
VEuPathDBiHostDB:ENSMUSG00000042390

Phylogenomic databases

eggNOGiKOG3740, Eukaryota
GeneTreeiENSGT00390000004097
InParanoidiQ8VHR5
OMAiPEERMHQ
OrthoDBi885815at2759
PhylomeDBiQ8VHR5
TreeFamiTF321369

Enzyme and pathway databases

ReactomeiR-MMU-3214815, HDACs deacetylate histones
R-MMU-6804758, Regulation of TP53 Activity through Acetylation
R-MMU-73762, RNA Polymerase I Transcription Initiation
R-MMU-8943724, Regulation of PTEN gene transcription

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		229542, 4 hits in 63 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Gatad2b, mouse

Protein Ontology

More...PROi		PR:Q8VHR5
RNActiQ8VHR5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000042390, Expressed in secondary oocyte and 279 other tissues
GenevisibleiQ8VHR5, MM

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR040386, P66
IPR032346, P66_CC
IPR000679, Znf_GATA
IPR013088, Znf_NHR/GATA
PANTHERiPTHR13455, PTHR13455, 1 hit
PfamiView protein in Pfam
PF00320, GATA, 1 hit
PF16563, P66_CC, 1 hit
PROSITEiView protein in PROSITE
PS50114, GATA_ZN_FINGER_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP66B_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VHR5
Secondary accession number(s): Q8C9Q3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2002
Last modified: May 25, 2022
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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