UniProtKB - Q8VHR0 (PCD18_MOUSE)
Protein
Protocadherin 18
Gene
Pcdh18
Organism
Mus musculus (Mouse)
Status
Functioni
Potential calcium-dependent cell-adhesion protein.
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
GO - Biological processi
- brain development Source: UniProtKB
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: MGI
- cell adhesion Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Protocadherin 18 |
Gene namesi | Name:Pcdh18 Synonyms:Kiaa1562 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1920423, Pcdh18 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 28 – 699 | ExtracellularSequence analysisAdd BLAST | 672 | |
Transmembranei | 700 – 720 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 721 – 1134 | CytoplasmicSequence analysisAdd BLAST | 414 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_5000061325 | 28 – 1134 | Protocadherin 18Add BLAST | 1107 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 103 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 269 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 559 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
CPTACi | non-CPTAC-4050 |
PaxDbi | Q8VHR0 |
PRIDEi | Q8VHR0 |
PTM databases
GlyGeni | Q8VHR0, 3 sites |
iPTMneti | Q8VHR0 |
PhosphoSitePlusi | Q8VHR0 |
Expressioni
Tissue specificityi
Predominantly expressed in kidney and lung.1 Publication
Developmental stagei
Expressed at high levels throughout the developing embryo, except in the heart and liver. In the developing brain, expressed at high levels in the ventricular zone (vz) in the forebrain and midbrain. Expression in the developing brain is maximal around birth and gradually decreases until it is completely absent from the adult brain.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000037892, Expressed in manus and 258 other tissues |
Genevisiblei | Q8VHR0, MM |
Interactioni
Subunit structurei
Interacts with DAB1.
1 PublicationBinary interactionsi
Q8VHR0
With | #Exp. | IntAct |
---|---|---|
Dab1 [P97318] | 2 | EBI-399910,EBI-81680 |
Protein-protein interaction databases
BioGRIDi | 215816, 2 interactors |
IntActi | Q8VHR0, 2 interactors |
STRINGi | 10090.ENSMUSP00000039245 |
Miscellaneous databases
RNActi | Q8VHR0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 137 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 110 | |
Domaini | 138 – 246 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 109 | |
Domaini | 247 – 354 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 361 – 465 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 105 | |
Domaini | 466 – 576 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 111 | |
Domaini | 582 – 688 | Cadherin 6PROSITE-ProRule annotationAdd BLAST | 107 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 892 – 1134 | Interaction with DAB11 PublicationAdd BLAST | 243 |
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000156295 |
InParanoidi | Q8VHR0 |
OrthoDBi | 64478at2759 |
PhylomeDBi | Q8VHR0 |
TreeFami | TF352008 |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR013164, Cadherin_N IPR030714, Protocadherin-18 |
PANTHERi | PTHR24028:SF9, PTHR24028:SF9, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF08266, Cadherin_2, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 6 hits |
SUPFAMi | SSF49313, SSF49313, 5 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 5 hits PS50268, CADHERIN_2, 6 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8VHR0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHQMNTKMHF RFALALLMAF FSHDVLAKNL KYRIYEEQRV GSVIARLSED
60 70 80 90 100
VADVLLKLPN PSAVRFRAMP RGNSPLLVVN ENTGEISIGA KIDREQLCQK
110 120 130 140 150
NLNCSIEFDV LTLPTEHLQL FHIEVDVLDI NDNSPQFSRP VIPIEISESA
160 170 180 190 200
AVGTRIPLDS AFDPDVGENS LHTYSLSAND YFNIEVRTRT DGAKYAELIV
210 220 230 240 250
VKELDRELKA SYELQLTASD MGVPQRSGSS ILKISISDSN DNSPAFEQPS
260 270 280 290 300
YTIQLLENSP VGTLLLDLNA TDPDEGANGR IVYSFSSHVS PKIIETFKID
310 320 330 340 350
SEKGHLTLFK PVDYEITKSY EIDVQAQDLG PNSIPAHCKI IIKVVDVNDN
360 370 380 390 400
KPEISINLMS PGKEEVSYVF EGDPIDTFVA IVRVQDKDSG LNGEIICKLH
410 420 430 440 450
GHGHFKLQKT YENNYLILTN ATLDREKRSE YSLTVIAEDK GTPSLSSVRH
460 470 480 490 500
FTVQINDIND NPPRFQRSRY EFVISENNSP GAYITTVTAT DPDLGENGHV
510 520 530 540 550
TYTILESFVL GSSITTYVTI DPSNGAIYAL RIFDHEEVSQ ITFVVEARDG
560 570 580 590 600
GSQKQLSSNT TVVLTIIDEN DNVPVVIGPA MHNNTAEISI PKGAESGFHV
610 620 630 640 650
TRIRVVDRDS GANAEFSCSI VSGNEENIFI MDPRSCDIHT NVSMESIPSA
660 670 680 690 700
EWALSVIIQD KGSPPLHTKV LLRCMVFDYA ESVTSTAMTS VSRASLDVSM
710 720 730 740 750
IIIISLGAIC AVLLVIMVLF ATRCNREKKD TRSYNCRVAE STYQHHPKRP
760 770 780 790 800
SRQIHKGDIT LVPTINGTLP IRSHHRSSPS SSPTLERGQM GSRQSHNSHQ
810 820 830 840 850
SLNSLVTISS NHVPENFSLE LTHATPAVEV SQLLSMLHQG QYQPRPSFRG
860 870 880 890 900
NKYSRSYRYA LQDMDKFSLK DSGRGDSEAG DSDYDLGRDS PIDRLLGEGF
910 920 930 940 950
SDLFLTDGRI PAAMRLCTEE CRVLGHSDQC WMPPLPSPSS DYRSNMFIPG
960 970 980 990 1000
EEFPAQPQQQ HSHQGLDDDS QPAENGEKKK SFSTFGKDSP SDEDSGDSST
1010 1020 1030 1040 1050
SSLLSEMSSV FQRLLPASLD TFSECNEGDR SNSLERRKGP AQGKTGGYPQ
1060 1070 1080 1090 1100
GVAAWAASTH FQNPTSSSGT PLGTHSSVQP SSKWLPAMEE IPENYEEDDF
1110 1120 1130
DNVLNHLSDG KHELMDASEL VAEINKLLQD VRQS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A6YXH7 | A0A0A6YXH7_MOUSE | Protocadherin 18 | Pcdh18 | 917 | Annotation score: | ||
A0A0A6YXT8 | A0A0A6YXT8_MOUSE | Protocadherin 18 | Pcdh18 | 455 | Annotation score: |
Sequence cautioni
The sequence BAD32482 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 650 | A → T in AAL47095 (PubMed:11716507).Curated | 1 | |
Sequence conflicti | 650 | A → T in BAD32482 (PubMed:15368895).Curated | 1 | |
Sequence conflicti | 650 | A → T in AAH52198 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1066 | S → N in BAD32482 (PubMed:15368895).Curated | 1 | |
Sequence conflicti | 1066 | S → N in AAH52198 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF416735 mRNA Translation: AAL47095.1 AK173204 mRNA Translation: BAD32482.1 Different initiation. AK036560 mRNA Translation: BAC29477.1 BC052198 mRNA Translation: AAH52198.1 |
CCDSi | CCDS17334.1 |
RefSeqi | NP_569715.3, NM_130448.3 |
Genome annotation databases
Ensembli | ENSMUST00000035931; ENSMUSP00000039245; ENSMUSG00000037892 |
GeneIDi | 73173 |
KEGGi | mmu:73173 |
UCSCi | uc008pdg.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF416735 mRNA Translation: AAL47095.1 AK173204 mRNA Translation: BAD32482.1 Different initiation. AK036560 mRNA Translation: BAC29477.1 BC052198 mRNA Translation: AAH52198.1 |
CCDSi | CCDS17334.1 |
RefSeqi | NP_569715.3, NM_130448.3 |
3D structure databases
SMRi | Q8VHR0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 215816, 2 interactors |
IntActi | Q8VHR0, 2 interactors |
STRINGi | 10090.ENSMUSP00000039245 |
PTM databases
GlyGeni | Q8VHR0, 3 sites |
iPTMneti | Q8VHR0 |
PhosphoSitePlusi | Q8VHR0 |
Proteomic databases
CPTACi | non-CPTAC-4050 |
PaxDbi | Q8VHR0 |
PRIDEi | Q8VHR0 |
Protocols and materials databases
Antibodypediai | 2719, 103 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000035931; ENSMUSP00000039245; ENSMUSG00000037892 |
GeneIDi | 73173 |
KEGGi | mmu:73173 |
UCSCi | uc008pdg.2, mouse |
Organism-specific databases
CTDi | 54510 |
MGIi | MGI:1920423, Pcdh18 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000156295 |
InParanoidi | Q8VHR0 |
OrthoDBi | 64478at2759 |
PhylomeDBi | Q8VHR0 |
TreeFami | TF352008 |
Miscellaneous databases
BioGRID-ORCSi | 73173, 1 hit in 18 CRISPR screens |
PROi | PR:Q8VHR0 |
RNActi | Q8VHR0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037892, Expressed in manus and 258 other tissues |
Genevisiblei | Q8VHR0, MM |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR013164, Cadherin_N IPR030714, Protocadherin-18 |
PANTHERi | PTHR24028:SF9, PTHR24028:SF9, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF08266, Cadherin_2, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 6 hits |
SUPFAMi | SSF49313, SSF49313, 5 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 5 hits PS50268, CADHERIN_2, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PCD18_MOUSE | |
Accessioni | Q8VHR0Primary (citable) accession number: Q8VHR0 Secondary accession number(s): Q69ZG2, Q80VY4, Q8CB88 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 14, 2008 |
Last sequence update: | October 14, 2008 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot