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Protein

Suppressor of cytokine signaling 7

Gene

Socs7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).By similarity2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • 1-phosphatidylinositol-3-kinase regulator activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processGrowth regulation, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of cytokine signaling 7
Short name:
SOCS-7
Gene namesi
Name:Socs7
Synonyms:Cish7, Nap4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2651588 Socs7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are smaller and half of them develop fatal hydrocephalus between 3 to 15 weeks of age. They display subtle alterations in glucose homeostasis with an enhanced response to insulin which causes hypoglycemia. Pancreatic islets become progressively larger.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001812541 – 579Suppressor of cytokine signaling 7Add BLAST579

Proteomic databases

PaxDbiQ8VHQ2
PeptideAtlasiQ8VHQ2
PRIDEiQ8VHQ2

PTM databases

iPTMnetiQ8VHQ2
PhosphoSitePlusiQ8VHQ2

Expressioni

Tissue specificityi

Widely expressed with higher expression in brain and testis where it is expressed by spermatocytes and early spermatids. Also significantly expressed in spleen, skeletal muscle and kidney.3 Publications

Developmental stagei

Ubiquitously expressed at low level in 12.5 dpc and 15.5 dpc embryos. More significantly expressed in the nervous system at 12.5 dpc and the cortical plate at 15.5 dpc. Expressed in the brain postnatally in particular in the hippocampal formation and the medial habenular nuclei at P7. Low-level expression in other brain areas was present at P7 and was reduced to very low levels at P14 and P21. The hippocampal granule cell layer and the cerebellar granular layer maintained moderate expression levels at P7, P14, and P21.1 Publication

Gene expression databases

BgeeiENSMUSG00000038485 Expressed in 248 organ(s), highest expression level in primary oocyte
CleanExiMM_SOCS7
GenevisibleiQ8VHQ2 MM

Interactioni

Subunit structurei

Interacts with phosphorylated IRS4 and PIK3R1. Interacts, via the third proline-rich region, with the second SH3 domain of the adapter protein NCK1. Also interacts with GRB2, INSR, IRS1, PLCG1, SORBS3/vinexin and phosphorylated STAT3 and STAT5 (By similarity). Interacts with SEPT6 (By similarity).By similarity

Protein-protein interaction databases

BioGridi228649, 4 interactors
IntActiQ8VHQ2, 1 interactor
MINTiQ8VHQ2
STRINGi10090.ENSMUSP00000040896

Structurei

3D structure databases

ProteinModelPortaliQ8VHQ2
SMRiQ8VHQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini398 – 507SH2PROSITE-ProRule annotationAdd BLAST110
Domaini502 – 552SOCS boxPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni124 – 492Mediates interaction with SORBS3By similarityAdd BLAST369

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi82 – 202Pro-richAdd BLAST121
Compositional biasi84 – 97Poly-ProAdd BLAST14
Compositional biasi141 – 149Poly-Gly9
Compositional biasi181 – 185Poly-Gln5
Compositional biasi186 – 195Poly-Pro10
Compositional biasi301 – 381Pro-richAdd BLAST81
Compositional biasi301 – 310Poly-Pro10
Compositional biasi341 – 348Poly-Pro8

Domaini

The SOCS box domain is required for IRS1 ubiquitination and subsequent proteasomal degradation.By similarity
The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000035093
HOVERGENiHBG079201
InParanoidiQ8VHQ2
KOiK04699
OMAiFPMQDLV
OrthoDBiEOG091G0EP6
PhylomeDBiQ8VHQ2
TreeFamiTF321368

Family and domain databases

CDDicd10388 SH2_SOCS7, 1 hit
cd03741 SOCS_SOCS7, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR028423 SOCS7
IPR035866 SOCS7_SH2
IPR037346 SOCS7_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR45052 PTHR45052, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VHQ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVFRNVGRPP EEEDAEAARE PGPSELLCPR HRCALDPKAL PPGLALERTW
60 70 80 90 100
GPVAGLEAQL AALGLGQPAG PGIKTAGGGC CPCPCPPQPP PPQPPPPAAA
110 120 130 140 150
PQAGEDPTET SDALLVLEGL ESEAESLETN SCSEEELSSP GRGGGGVGGR
160 170 180 190 200
LLLQPPGPEL PPVPFPLQDL VPPGRLSRGE QQQQQPPPPP PPPGPLRPLA
210 220 230 240 250
GPSRKGSFKI RLSRLFRTKS CNGGSGGGDG TGKRPSGDLA ASAASLTDMG
260 270 280 290 300
GSAVRELDTG RKPRLTRTQS AFSPVSFSPL FTGETVSLVD VDISQRGLTS
310 320 330 340 350
PHPPTPPPPP RRSLSLLDDI SGTLPTSVLV APMGSSLQSF PLPPPPPPHA
360 370 380 390 400
PDAFPRIAPI RASESLHSQP PQHLQCPLYR PDSSSFAASL RELEKCGWYW
410 420 430 440 450
GPMNWEDAEM KLKGKPDGSF LVRDSSDPRY ILSLSFRSQG ITHHTRMEHY
460 470 480 490 500
RGTFSLWCHP KFEDRCQSVV EFIKRAIMHS KNGKFLYFLR SRVPGLPPTP
510 520 530 540 550
VQLLYPVSRF SNVKSLQHLC RFRIRQLVRI DHIPDLPLPK PLISYIRKFY
560 570
YYDPQEEVYL SLKEAQLISK QKQEVEPST
Length:579
Mass (Da):62,784
Last modified:March 1, 2002 - v1
Checksum:iFAB66BF2A0BE685A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF424814 mRNA Translation: AAL60516.1
AK147580 mRNA Translation: BAE28006.1
AK147650 mRNA Translation: BAE28049.1
AL596088 Genomic DNA No translation available.
CCDSiCCDS25319.1
RefSeqiNP_619598.1, NM_138657.3
UniGeneiMm.34339

Genome annotation databases

EnsembliENSMUST00000045540; ENSMUSP00000040896; ENSMUSG00000038485
GeneIDi192157
KEGGimmu:192157
UCSCiuc007lea.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF424814 mRNA Translation: AAL60516.1
AK147580 mRNA Translation: BAE28006.1
AK147650 mRNA Translation: BAE28049.1
AL596088 Genomic DNA No translation available.
CCDSiCCDS25319.1
RefSeqiNP_619598.1, NM_138657.3
UniGeneiMm.34339

3D structure databases

ProteinModelPortaliQ8VHQ2
SMRiQ8VHQ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228649, 4 interactors
IntActiQ8VHQ2, 1 interactor
MINTiQ8VHQ2
STRINGi10090.ENSMUSP00000040896

PTM databases

iPTMnetiQ8VHQ2
PhosphoSitePlusiQ8VHQ2

Proteomic databases

PaxDbiQ8VHQ2
PeptideAtlasiQ8VHQ2
PRIDEiQ8VHQ2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045540; ENSMUSP00000040896; ENSMUSG00000038485
GeneIDi192157
KEGGimmu:192157
UCSCiuc007lea.1 mouse

Organism-specific databases

CTDi30837
MGIiMGI:2651588 Socs7

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000035093
HOVERGENiHBG079201
InParanoidiQ8VHQ2
KOiK04699
OMAiFPMQDLV
OrthoDBiEOG091G0EP6
PhylomeDBiQ8VHQ2
TreeFamiTF321368

Enzyme and pathway databases

UniPathwayi
UPA00143

Miscellaneous databases

ChiTaRSiSocs7 mouse
PROiPR:Q8VHQ2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038485 Expressed in 248 organ(s), highest expression level in primary oocyte
CleanExiMM_SOCS7
GenevisibleiQ8VHQ2 MM

Family and domain databases

CDDicd10388 SH2_SOCS7, 1 hit
cd03741 SOCS_SOCS7, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR028423 SOCS7
IPR035866 SOCS7_SH2
IPR037346 SOCS7_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR45052 PTHR45052, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOCS7_MOUSE
AccessioniPrimary (citable) accession number: Q8VHQ2
Secondary accession number(s): B1AQY1, Q3UH08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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