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Entry version 143 (12 Aug 2020)
Sequence version 1 (01 Mar 2002)
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Protein

Suppressor of cytokine signaling 7

Gene

Socs7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionSignal transduction inhibitor
Biological processGrowth regulation, Ubl conjugation pathway

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Suppressor of cytokine signaling 7
Short name:
SOCS-7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Socs7
Synonyms:Cish7, Nap4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2651588, Socs7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are smaller and half of them develop fatal hydrocephalus between 3 to 15 weeks of age. They display subtle alterations in glucose homeostasis with an enhanced response to insulin which causes hypoglycemia. Pancreatic islets become progressively larger.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001812541 – 579Suppressor of cytokine signaling 7Add BLAST579

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8VHQ2

PeptideAtlas

More...
PeptideAtlasi
Q8VHQ2

PRoteomics IDEntifications database

More...
PRIDEi
Q8VHQ2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8VHQ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8VHQ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with higher expression in brain and testis where it is expressed by spermatocytes and early spermatids. Also significantly expressed in spleen, skeletal muscle and kidney.3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Ubiquitously expressed at low level in 12.5 dpc and 15.5 dpc embryos. More significantly expressed in the nervous system at 12.5 dpc and the cortical plate at 15.5 dpc. Expressed in the brain postnatally in particular in the hippocampal formation and the medial habenular nuclei at P7. Low-level expression in other brain areas was present at P7 and was reduced to very low levels at P14 and P21. The hippocampal granule cell layer and the cerebellar granular layer maintained moderate expression levels at P7, P14, and P21.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000038485, Expressed in primary oocyte and 261 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8VHQ2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with phosphorylated IRS4 and PIK3R1.

Interacts, via the third proline-rich region, with the second SH3 domain of the adapter protein NCK1.

Also interacts with GRB2, INSR, IRS1, PLCG1, SORBS3/vinexin and phosphorylated STAT3 and STAT5 (By similarity).

Interacts with SEPT6 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
228649, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q8VHQ2, 1 interactor

Molecular INTeraction database

More...
MINTi
Q8VHQ2

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000040896

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8VHQ2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8VHQ2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini398 – 507SH2PROSITE-ProRule annotationAdd BLAST110
Domaini502 – 552SOCS boxPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni124 – 492Mediates interaction with SORBS3By similarityAdd BLAST369

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi82 – 202Pro-richAdd BLAST121
Compositional biasi84 – 97Poly-ProAdd BLAST14
Compositional biasi141 – 149Poly-Gly9
Compositional biasi181 – 185Poly-Gln5
Compositional biasi186 – 195Poly-Pro10
Compositional biasi301 – 381Pro-richAdd BLAST81
Compositional biasi301 – 310Poly-Pro10
Compositional biasi341 – 348Poly-Pro8

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SOCS box domain is required for IRS1 ubiquitination and subsequent proteasomal degradation.By similarity
The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4566, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156314

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_022661_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8VHQ2

KEGG Orthology (KO)

More...
KOi
K04699

Identification of Orthologs from Complete Genome Data

More...
OMAi
KTAGGGC

Database of Orthologous Groups

More...
OrthoDBi
924518at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8VHQ2

TreeFam database of animal gene trees

More...
TreeFami
TF321368

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10388, SH2_SOCS7, 1 hit
cd03741, SOCS_SOCS7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR028423, SOCS7
IPR035866, SOCS7_SH2
IPR037346, SOCS7_SOCS
IPR001496, SOCS_box
IPR036036, SOCS_box-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10155:SF5, PTHR10155:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00017, SH2, 1 hit
PF07525, SOCS_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00252, SH2, 1 hit
SM00253, SOCS, 1 hit
SM00969, SOCS_box, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF158235, SSF158235, 1 hit
SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50001, SH2, 1 hit
PS50225, SOCS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8VHQ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVFRNVGRPP EEEDAEAARE PGPSELLCPR HRCALDPKAL PPGLALERTW
60 70 80 90 100
GPVAGLEAQL AALGLGQPAG PGIKTAGGGC CPCPCPPQPP PPQPPPPAAA
110 120 130 140 150
PQAGEDPTET SDALLVLEGL ESEAESLETN SCSEEELSSP GRGGGGVGGR
160 170 180 190 200
LLLQPPGPEL PPVPFPLQDL VPPGRLSRGE QQQQQPPPPP PPPGPLRPLA
210 220 230 240 250
GPSRKGSFKI RLSRLFRTKS CNGGSGGGDG TGKRPSGDLA ASAASLTDMG
260 270 280 290 300
GSAVRELDTG RKPRLTRTQS AFSPVSFSPL FTGETVSLVD VDISQRGLTS
310 320 330 340 350
PHPPTPPPPP RRSLSLLDDI SGTLPTSVLV APMGSSLQSF PLPPPPPPHA
360 370 380 390 400
PDAFPRIAPI RASESLHSQP PQHLQCPLYR PDSSSFAASL RELEKCGWYW
410 420 430 440 450
GPMNWEDAEM KLKGKPDGSF LVRDSSDPRY ILSLSFRSQG ITHHTRMEHY
460 470 480 490 500
RGTFSLWCHP KFEDRCQSVV EFIKRAIMHS KNGKFLYFLR SRVPGLPPTP
510 520 530 540 550
VQLLYPVSRF SNVKSLQHLC RFRIRQLVRI DHIPDLPLPK PLISYIRKFY
560 570
YYDPQEEVYL SLKEAQLISK QKQEVEPST
Length:579
Mass (Da):62,784
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFAB66BF2A0BE685A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A571BEJ5A0A571BEJ5_MOUSE
Suppressor of cytokine-signaling 7
Socs7
648Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF424814 mRNA Translation: AAL60516.1
AK147580 mRNA Translation: BAE28006.1
AK147650 mRNA Translation: BAE28049.1
AL596088 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_619598.1, NM_138657.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000045540; ENSMUSP00000040896; ENSMUSG00000038485

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
192157

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:192157

UCSC genome browser

More...
UCSCi
uc007lea.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF424814 mRNA Translation: AAL60516.1
AK147580 mRNA Translation: BAE28006.1
AK147650 mRNA Translation: BAE28049.1
AL596088 Genomic DNA No translation available.
RefSeqiNP_619598.1, NM_138657.3

3D structure databases

SMRiQ8VHQ2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi228649, 4 interactors
IntActiQ8VHQ2, 1 interactor
MINTiQ8VHQ2
STRINGi10090.ENSMUSP00000040896

PTM databases

iPTMnetiQ8VHQ2
PhosphoSitePlusiQ8VHQ2

Proteomic databases

PaxDbiQ8VHQ2
PeptideAtlasiQ8VHQ2
PRIDEiQ8VHQ2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
72315, 213 antibodies

Genome annotation databases

EnsembliENSMUST00000045540; ENSMUSP00000040896; ENSMUSG00000038485
GeneIDi192157
KEGGimmu:192157
UCSCiuc007lea.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
30837
MGIiMGI:2651588, Socs7

Phylogenomic databases

eggNOGiKOG4566, Eukaryota
GeneTreeiENSGT00940000156314
HOGENOMiCLU_022661_0_0_1
InParanoidiQ8VHQ2
KOiK04699
OMAiKTAGGGC
OrthoDBi924518at2759
PhylomeDBiQ8VHQ2
TreeFamiTF321368

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
192157, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Socs7, mouse

Protein Ontology

More...
PROi
PR:Q8VHQ2
RNActiQ8VHQ2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000038485, Expressed in primary oocyte and 261 other tissues
GenevisibleiQ8VHQ2, MM

Family and domain databases

CDDicd10388, SH2_SOCS7, 1 hit
cd03741, SOCS_SOCS7, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR028423, SOCS7
IPR035866, SOCS7_SH2
IPR037346, SOCS7_SOCS
IPR001496, SOCS_box
IPR036036, SOCS_box-like_dom_sf
PANTHERiPTHR10155:SF5, PTHR10155:SF5, 1 hit
PfamiView protein in Pfam
PF00017, SH2, 1 hit
PF07525, SOCS_box, 1 hit
SMARTiView protein in SMART
SM00252, SH2, 1 hit
SM00253, SOCS, 1 hit
SM00969, SOCS_box, 1 hit
SUPFAMiSSF158235, SSF158235, 1 hit
SSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001, SH2, 1 hit
PS50225, SOCS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSOCS7_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VHQ2
Secondary accession number(s): B1AQY1, Q3UH08
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2002
Last modified: August 12, 2020
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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