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Entry version 136 (12 Aug 2020)
Sequence version 1 (01 Mar 2002)
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Protein

Adhesion G-protein coupled receptor V1

Gene

Adgrv1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled receptor which has an essential role in the development of hearing and vision (PubMed:16775142, PubMed:17567809, PubMed:20502675, PubMed:24191038). Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production (PubMed:24191038, PubMed:24962568). Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear (PubMed:16775142, PubMed:17567809). In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing the stability of this protein in myelin-forming cells of the auditory pathway (PubMed:24191038). In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport (PubMed:20502675). Involved in the regulation of bone metabolism (PubMed:22419726).6 Publications
Cleaved ADGRV1 beta-subunit couples with G-alpha(i)-proteins, GNAI1/2/3, and constitutively inhibits adenylate cyclase (AC) activity with a stronger effect than full ADGRV1.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Hydrolase, Receptor, Transducer
Biological processSensory transduction
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G-protein coupled receptor V1Curated (EC:3.4.-.-1 Publication)
Short name:
ADGRV1Curated
Alternative name(s):
G-protein coupled receptor 98
Monogenic audiogenic seizure susceptibility protein 11 Publication
Short name:
MASS11 Publication
Neurepin
Very large G-protein coupled receptor 11 Publication
Short name:
VLGR11 Publication
Cleaved into the following 2 chains:
Alternative name(s):
VLGR1 subunit beta1 Publication
Short name:
Vbeta1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Adgrv1Imported
Synonyms:Gpr98, Kiaa0686, Mass11 Publication, Vlgr13 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1274784, Adgrv1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 5901ExtracellularSequence analysisAdd BLAST5873
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5902 – 5922Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini5923 – 5932CytoplasmicSequence analysis10
Transmembranei5933 – 5953Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini5954 – 5973ExtracellularSequence analysisAdd BLAST20
Transmembranei5974 – 5994Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini5995 – 6003CytoplasmicSequence analysis9
Transmembranei6004 – 6024Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini6025 – 6052ExtracellularSequence analysisAdd BLAST28
Transmembranei6053 – 6073Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini6074 – 6097CytoplasmicSequence analysisAdd BLAST24
Transmembranei6098 – 6118Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini6119 – 6126ExtracellularSequence analysis8
Transmembranei6127 – 6147Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini6148 – 6298CytoplasmicSequence analysisAdd BLAST151

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice display audiogenic epilepsy. Audiogenic epilepsy syndrome is an autosomal recessive mutation, characterized by generalized self-sustained convulsive seizures in which acoustics stimulations evoke wild running, tonic flexion and extension. They are induced by exposing animals to a loud noise during the early stages of their development. Mutants show a decreased bone mineral density (PubMed:22419726).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi5882H → A: Reduces autoproteolysis. No effect on inhibition of adenylate cyclase activity. 1 Publication1
Mutagenesisi5884S → A: Abolishes autoproteolysis. No effect on inhibition of adenylate cyclase activity. 1 Publication1
Mutagenesisi6002R → A: Abolishes coupling to G(i)-proteins. Abolishes inhibition of adenylate cyclase activity. No effect on interaction with PDZD7. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000023273629 – 6298Adhesion G-protein coupled receptor V1Add BLAST6270
ChainiPRO_000044573329 – 5883ADGRV1 subunit alpha1 PublicationAdd BLAST5855
ChainiPRO_00004457345884 – 6298ADGRV1 subunit beta1 PublicationAdd BLAST415

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei5883 – 5884Cleavage; by autolysis1 Publication2

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8VHN7

PRoteomics IDEntifications database

More...
PRIDEi
Q8VHN7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8VHN7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8VHN7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by oligodendrocytes. In midbrain, enriched in the myelinated regions of the superior and inferior colliculi (PubMed:24191038). In the cochlea, expressed in develpong hair cells (PubMed:16775142, PubMed:20502675, PubMed:17567809). Expressed by photorecereptors in the retina (PubMed:20502675).4 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

High level expression restricted to the developing central nervous system and eye. At mid-gestation expression is prominent in the ventricular zone and in the eye. At late gestation expression declines (PubMed:11606593). In the inner ear, highly expressed at 17 dpc at the base of emerging hair bundle and on peripheral subpopulation of microvilli located at the neural edge of the hair cell apical surface. At P0-P1, the expression extends from the very base of the stereocilia. From P4 to P9, expression becomes restricted, forming a basal band-like pattern at the ankle link level above the stereocilia. From P12 onward, no longer detectable in the cochlear hair cells (PubMed:16775142, PubMed:20502675). In the utricle of the vestibular system, the expression persists for longer, being present at both P4 and P11, but no longer detectable by P18 (PubMed:16775142).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000069170, Expressed in liver and 185 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit) (PubMed:24962568).

Interacts (via the cytoplasmic region) with PDZD7 (PubMed:24962568, PubMed:23055499).

Component of USH2 complex, composed of ADGRV1, PDZD7, USH2A and WHRN (PubMed:20502675, PubMed:25406310).

Interacts with USH2A and WHRN (PubMed:20502675, PubMed:23055499).

Interacts (via the cytoplasmic region) with MYO7A (via MyTH4-FERM domains) (PubMed:17567809).

5 Publications

GO - Molecular functioni

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8VHN7

Protein interaction database and analysis system

More...
IntActi
Q8VHN7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000093245

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8VHN7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8VHN7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 116Calx-beta 1Sequence analysisAdd BLAST88
Domaini132 – 236Calx-beta 2Sequence analysisAdd BLAST105
Domaini251 – 362Calx-beta 3Sequence analysisAdd BLAST112
Domaini389 – 489Calx-beta 4CuratedAdd BLAST101
Domaini646 – 746Calx-beta 5CuratedAdd BLAST101
Domaini764 – 862Calx-beta 6Sequence analysisAdd BLAST99
Domaini877 – 980Calx-beta 7Sequence analysisAdd BLAST104
Domaini994 – 1094Calx-beta 8Sequence analysisAdd BLAST101
Domaini1108 – 1208Calx-beta 9CuratedAdd BLAST101
Domaini1440 – 1540Calx-beta 10CuratedAdd BLAST101
Domaini1562 – 1662Calx-beta 11CuratedAdd BLAST101
Domaini1706 – 1805Calx-beta 12Sequence analysisAdd BLAST100
Domaini1846 – 1948Calx-beta 13Sequence analysisAdd BLAST103
Domaini1962 – 2075Calx-beta 14Sequence analysisAdd BLAST114
Domaini2103 – 2202Calx-beta 15Sequence analysisAdd BLAST100
Domaini2218 – 2320Calx-beta 16Sequence analysisAdd BLAST103
Domaini2437 – 2537Calx-beta 17CuratedAdd BLAST101
Domaini2576 – 2672Calx-beta 18Sequence analysisAdd BLAST97
Domaini2687 – 2786Calx-beta 19Sequence analysisAdd BLAST100
Domaini2810 – 2921Calx-beta 20Sequence analysisAdd BLAST112
Domaini2945 – 3044Calx-beta 21Sequence analysisAdd BLAST100
Domaini3067 – 3167Calx-beta 22CuratedAdd BLAST101
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati3251 – 3292EAR 1PROSITE-ProRule annotationAdd BLAST42
Repeati3293 – 3341EAR 2PROSITE-ProRule annotationAdd BLAST49
Repeati3344 – 3389EAR 3PROSITE-ProRule annotationAdd BLAST46
Repeati3391 – 3435EAR 4PROSITE-ProRule annotationAdd BLAST45
Repeati3437 – 3484EAR 5PROSITE-ProRule annotationAdd BLAST48
Repeati3488 – 3530EAR 6PROSITE-ProRule annotationAdd BLAST43
Domaini3581 – 3622Calx-beta 23Sequence analysisAdd BLAST42
Domaini3636 – 3736Calx-beta 24CuratedAdd BLAST101
Domaini3772 – 3872Calx-beta 25CuratedAdd BLAST101
Domaini3919 – 4003Calx-beta 26Sequence analysisAdd BLAST85
Domaini4017 – 4120Calx-beta 27Sequence analysisAdd BLAST104
Domaini4135 – 4235Calx-beta 28CuratedAdd BLAST101
Domaini4251 – 4351Calx-beta 29Sequence analysisAdd BLAST101
Domaini4384 – 4484Calx-beta 30Sequence analysisAdd BLAST101
Domaini4507 – 4607Calx-beta 31CuratedAdd BLAST101
Domaini4628 – 4728Calx-beta 32CuratedAdd BLAST101
Domaini4989 – 5089Calx-beta 33Sequence analysisAdd BLAST101
Domaini5281 – 5325Calx-beta 34Sequence analysisAdd BLAST45
Domaini5361 – 5461Calx-beta 35CuratedAdd BLAST101
Domaini5846 – 5895GPSPROSITE-ProRule annotationAdd BLAST50

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The 7 transmembrane domain is required in hair cells for the hair bundle ankle formation.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1306, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000154880

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8VHN7

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8VHN7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.2030, 34 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026919, ADGRV1
IPR038081, CalX-like_sf
IPR003644, Calx_beta
IPR013320, ConA-like_dom_sf
IPR009039, EAR
IPR005492, EPTP
IPR017981, GPCR_2-like
IPR000832, GPCR_2_secretin-like
IPR000203, GPS
IPR006558, LamG-like

The PANTHER Classification System

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PANTHERi
PTHR46682, PTHR46682, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002, 7tm_2, 1 hit
PF03160, Calx-beta, 37 hits
PF03736, EPTP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00237, Calx_beta, 20 hits
SM00560, LamGL, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF141072, SSF141072, 38 hits
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50912, EAR, 6 hits
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8VHN7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVTSEPGMI SSFLLVYLST LFISFVFGEA EIRFTGQTEF FVNETSTTVI
60 70 80 90 100
RLVIERIGEP ANVTAIVSLS GEDTGDFFDT YAAAFIPARG TNRTVYIAVC
110 120 130 140 150
DDDLPEPDET FTFHLTLQKP SANVKLGWPR AASVTILSND NAFGIISFST
160 170 180 190 200
PSSISVIEPR SRNASVPLTL IREKGTYGMV TVTFDVSGGP NPPEEDLNPV
210 220 230 240 250
RGNITFPPGR ATVIYNVTVL DDEVPENDEL FLIQLRSVEG GAEINASRSS
260 270 280 290 300
VEIIVKKNDS PVNFMQSVYV VPEDDHVLTI PVLRGKDSDG NLIGSDETQV
310 320 330 340 350
SIRYKVMTWD STAHAQQNVD FIDLQPDTTL VFPPFVHESH LKFQIIDDLI
360 370 380 390 400
PEIAESFHIM LLKNTLQGDA VLMGPSTVQV TIKPNDKPYG VLSFNSILFE
410 420 430 440 450
RPVIIDEDTA SSSRFEEIAV VRNGGTHGNV SVSWVLTRNS SDPSPVTADI
460 470 480 490 500
TPASGTLQFA QGQMLAPISL VVFDDDLPEE AEAYLLTILP HTIQGGAEVS
510 520 530 540 550
EPAQLLFYIQ DSDNVYGEIA FFPGESQKIE SSPSERSLSL SLARRGGSKG
560 570 580 590 600
DVRVIYSALY IPAGAMDPLR AKDGILNTSR RSSLLFPEQN QQVSIKLPIR
610 620 630 640 650
NDAFLQNGAH FLVQLEAVVL VNIFPPIPPV SPRFGEIRNI SLLVTPAIAN
660 670 680 690 700
GEIGFLSNLP IILHEPKDSS AEVVSIPLHR DGTDGQATVY WSLRPSGFNS
710 720 730 740 750
KAVTLDDAGP FNGSVVFLSG QNETSINITV KGDDIPELNE TVTLSLDRVS
760 770 780 790 800
VDSDVLKSGY TSRDLIILEN DDPGGIFEFS YDSRGPYVIK EGDAVELRIT
810 820 830 840 850
RSRGSLVKQF LRFHVEPRES NEFYGNMGVL EFTPGEREVV ITLLTRLDGT
860 870 880 890 900
PELDEHFWVI LSSHGERESK LGRATLVNIT ILKNDYPHGI IEFVSDGLSA
910 920 930 940 950
SIKESKGEDI YHAVYGVIRT RGNFGAVNVS WMVSPDFTQD VFPVQGTVCF
960 970 980 990 1000
GDQEFFKNIT VYSLVDEIPE EMEEFTIILL NATGGAQTGI RTTASLRILR
1010 1020 1030 1040 1050
NDDPVYFAEP CVLRVQEGET ANFTVLRNGS VDGACTVQYA TVDGKASGEE
1060 1070 1080 1090 1100
GDFAPVEKGE TLVFEVGSRE QSISVHVKDD GIPETDEPFY IVLFNSTGDT
1110 1120 1130 1140 1150
VVYEYGVATV IIEANDDPNG VFSLEPIDKA VEEGKTNAFW ILRHRGHFGN
1160 1170 1180 1190 1200
VSVAWQLFQN ASLQPGQEFY ETSGTVNFTD GEETKPVILR AFPDRIPEFN
1210 1220 1230 1240 1250
EFYILRLVNI SGPGGQLAET NFQVTVMIPF NDDPFGIFIL DPECLEREVA
1260 1270 1280 1290 1300
EDVLSEDDMS YITSFTILRQ QGVFGDVRVG WEVLSREFTA GLPPMIDFIL
1310 1320 1330 1340 1350
LGSFPSTVPL QPHMRRHHSG TDVLYFSGLE GAFGTVDPKY QPFRNNTIAN
1360 1370 1380 1390 1400
FTFSAWVMPN ANTNGFLIAK DDSHGSIYYG VKIQTNETHV TLSLHYKTFG
1410 1420 1430 1440 1450
SNVTYIAKST VMKYLEEGVW LHVLIILDDG IIEFYLDGKA MPRGIKSLKG
1460 1470 1480 1490 1500
EAITDGPGIL RIGAGMDGGA RFTGWMQDVR TYERKLTPEE IYELHAVPAR
1510 1520 1530 1540 1550
TDLHPISGYL EFRQGESNKS FIVAARDDSE EEGEELFLLK LVSVDGGAQI
1560 1570 1580 1590 1600
SKENTTARLR IQKSDNANGL FGFTGACIPE MTEEGSTVSC VVERTRGALG
1610 1620 1630 1640 1650
YVHVFYTISQ IESEGINYLV DDFANASGTI TFLPWQRSEV LNLYVLDEDM
1660 1670 1680 1690 1700
PELNEYFRVT LVSAVPGDGK LGSTPISGAS IDPEKETTGI TVKASDHPYG
1710 1720 1730 1740 1750
LMQFSTGLPP QPEDSMSLPA SSVPHITVQE EDGEIRLLVI RAQGLLGRVT
1760 1770 1780 1790 1800
VGFRTVSLTA FSPEDYQSTA GTLEFQSGER YKYIFVNITD NSIPELEKSF
1810 1820 1830 1840 1850
KVELLNLDGG VSDLFRVDGS GSGEADTDFF LPPVLPHASL GVASQILVTI
1860 1870 1880 1890 1900
AASDHAHGVF EFSPESLFVS GTEPEDGYST VVLNVTRTRG ALSAVTLQWK
1910 1920 1930 1940 1950
VDSDLDGDLA ITSGNITFET GQRIASITVE ILSDEEPELD KALTVSILNV
1960 1970 1980 1990 2000
SSGSLGVLTN ATLTILASDD PYGVFIFPNK TRPLSVEEAT QNVALSIIRL
2010 2020 2030 2040 2050
KGLMGEVAVS YATIDDMEKP PYFPPNLARA TQGGDYISAS GLALFRVNQT
2060 2070 2080 2090 2100
EATITISILD DAEPERSESV FIELFNSSLV DKVQNRPIPH SPRLGPKVET
2110 2120 2130 2140 2150
VAHLVIVAND DAFGTVQLSA TSVHVAENHV GPIINVTRTG GTFADVSVKF
2160 2170 2180 2190 2200
KAVPITAAAG EDYSIASSDV VLLEGETTKA VPIYIINDIY PELEETFLVQ
2210 2220 2230 2240 2250
LLNETTGGAT LGPLREAVIT IEASDDPYGL FGFQNTKFIV EEPEFNSVRV
2260 2270 2280 2290 2300
NVPIIRNSGT LGNVTVQWVA IINGQFATGD LRVVSGNVTF APGETIQTLL
2310 2320 2330 2340 2350
LEVLADDVPE IEEVVQVQLA AASGGGTIGL DRVANIVIPA NDNPYGSVAF
2360 2370 2380 2390 2400
VQSVFRVQEP LERSSYANIT VRRSGGHFGR LLLCYGTSDI DVVARAVEEG
2410 2420 2430 2440 2450
EDVLSYYESP TQGVPDPLWR TWVNVSAVEE TQYTCATLCL KERACSAFSV
2460 2470 2480 2490 2500
VSGAEGPRCF WMTSWVSGTV NSSDFQTYKK NMTRVASLFS GQAVAGSDYE
2510 2520 2530 2540 2550
PVTRQWAVIL EGDEFANLTV SVLPDDAPEM DESFLISLLE VHLMNISDSF
2560 2570 2580 2590 2600
KNQPTIGHPN TSAVVIGLNG DAFGVFIIYS VSPNTSEDGL CVEVQEQPQT
2610 2620 2630 2640 2650
SVELVIYRTG GSLGQVMVEW RVVGGTATEG LDFMGAGDIL TFAEGETKKM
2660 2670 2680 2690 2700
AILTILDDSE PEDNESILVR LGATEGGSRI LPSSDTVTVN ILANDNVAGI
2710 2720 2730 2740 2750
VSFQTASRSV IGHEGEMLQF HVVRTPPGRG NVTVNWKVVG QNLEVNFANF
2760 2770 2780 2790 2800
TGQLFFSEGT LNKTIFVHLL DDNIPEEKEV YQVVLYDVKT QGVSPAGVAL
2810 2820 2830 2840 2850
LDAQGYAAVL TVEASDEPHG VLNFALSSRF VVLQEANVTI QLFVNREFGS
2860 2870 2880 2890 2900
LGAINVTYAT VPGIVSLKNN TEGNLAEPES DFIPVVGSLV LEEGETTAAI
2910 2920 2930 2940 2950
SITVLEDDIP ELKEYFLVNL THVDLIMAPL TSSPPRLDSE GLTAQIVIDA
2960 2970 2980 2990 3000
NDGAQGMIEW QRNRFEVNET DGVVTLVAQR SRAALGQVSL FMYAQNLEAQ
3010 3020 3030 3040 3050
AGLDYMRTPQ ILHFTDGERF KHVDVMILDD DMPEGDERFQ LLLTNPSPGL
3060 3070 3080 3090 3100
ELGKNTIALI TVLANDDGPG VLSFNNSGHI FLREPTSLYV QESVAVLVIV
3110 3120 3130 3140 3150
REPAQGLFGT VAVQFVVTEV NSSTESKDLS PSKGFIVLEE GVRSKTLRIS
3160 3170 3180 3190 3200
AILDTEPEMD EHFVCTLFNP TGGARLGAHV QTLITIFQNQ APLGLFSISA
3210 3220 3230 3240 3250
VENSATSIDV EESNRSVYLN VSRTNGLDLT ASVQWETVSE TAFGMRGMDV
3260 3270 3280 3290 3300
VFSIFQSFFD KTALDWCFFT VEGSVYGVML RKSSLVVYRW QGTFVPVEDL
3310 3320 3330 3340 3350
KVESPKTCEA FNIGVSPYLV ITHGERSGEK PSINSVYMLT AGFRLVLIQT
3360 3370 3380 3390 3400
IIISGSCQVR HFTSDSQDYF IIASRRNDSE LTQVFRWNGN NFAWHQTLPV
3410 3420 3430 3440 3450
RGVLGMALFS RGGSVFLAIS QANIRQTSLL FTWSGTQFIN FQELPISGIT
3460 3470 3480 3490 3500
QVEALSSGDD VYLCFAKNTF LGNQNAIDIF VWEMGHSSLR YFQSLDFAAV
3510 3520 3530 3540 3550
KRIRSFTPAS GIVHILLTAQ DGSALYCWNS ELNAFSFVLE APAAHDAAFV
3560 3570 3580 3590 3600
TVKSLNSSKT LIALVGATDS HLYELTYVSS QSDFIPSLGE LIFEPGDKEA
3610 3620 3630 3640 3650
IIAVNVLDDT VPEKEESFRV QLKSPRGGAE IGINSSVRVT VLANDGAYGV
3660 3670 3680 3690 3700
VAFAQNSLHK QLEELERDSL VTLNVERLRG THGRITVAWE AAGSVSDVFP
3710 3720 3730 3740 3750
TSGVISFTED QAMSMITLTV LADDLPELSE AVVVTLTQIV TEGVEDPLKG
3760 3770 3780 3790 3800
ATIDQSRSRS VLTILPSDSP YGAVRWHTES LFNRVPEPTE NITVVQLHIV
3810 3820 3830 3840 3850
RDKGLFGDIS IHLIAKPNFL LHINNQATED EDFVLQDSVI IMKENIKETH
3860 3870 3880 3890 3900
AEVAILPDEV PELDEGLIVT IAAVNLVNPN FPAEQPRVQR PRMESAEILI
3910 3920 3930 3940 3950
EENDDPRGIF NFHVVRDVGG VIIAHEGPPP LNVLQVPVVR MAGTFETVNV
3960 3970 3980 3990 4000
YWKATPDSAG LEDFQPSHGM LQFADGQVIA PILVTIIDDS EFELLETFTI
4010 4020 4030 4040 4050
SLVSVTGGGR LGDDVSVNVV IAPNDSPFGI FGFEKKTVMV DGPLLSDDPD
4060 4070 4080 4090 4100
SYVTLTVVRS PGGKGAVRLH WAIEEKAKDD LSPLNGTLYF DETESQKSVI
4110 4120 4130 4140 4150
LHTLKDGMVG EDRRFIIELT AADEVEISPV KGSASVIIRG DKSISEVGIA
4160 4170 4180 4190 4200
SSSRHIIIGE PSATYNGTAI IDLVRGPGVS GEITVNWKIL PPSRGEFVET
4210 4220 4230 4240 4250
SGQLTMLDGQ TAATVVIQVL NDDIPEEKCH YEFQLTEISE GRMLHEASVS
4260 4270 4280 4290 4300
ARITMVASDA PYGRFSFSHE QLHVSKAAQR VNVTVVRSGG SFGRARVLYE
4310 4320 4330 4340 4350
TGSRTAEAGW DFVPASGELL FEAREKMKSL YIDILDDDLP EGPEEFVLAI
4360 4370 4380 4390 4400
TRVDLQGRGY DFTIQENGLQ IDQPPEIGNI SIVRIIIMKN DNAEGIIEFD
4410 4420 4430 4440 4450
PKYTDISVEE DAGVITLPVL RLHGTYGHVS ADFSSRGFSA VPGGYVLRGS
4460 4470 4480 4490 4500
SVTFQHGQNL SFINVSIIDD NGSEFEKQFE ILLIGATGGA ILGRHLVSKI
4510 4520 4530 4540 4550
TIAKSDSPFG IIRFLNQSKI SLPNPSSTMA LHLVLERTGG LLGEIQVSWE
4560 4570 4580 4590 4600
VVGPDAEEPL PPHNGDFADP VSGTVSFGDG EGGVRSIILR VCPHEETEAE
4610 4620 4630 4640 4650
ETFIVQLKPL REAKLDPRAK AVTLTIQKFG DPNGVIHFAP ESLSKRRFSE
4660 4670 4680 4690 4700
PPPSDGPLLV SFLVTRSKGT SGDIKVHWEL SSEFDITRDF LSTRGFFTIA
4710 4720 4730 4740 4750
DGESDANFDV HLLPDDVPEI EEEYAVQLVS VEGGAELDLG KCTARFSVSA
4760 4770 4780 4790 4800
NDDPHGVFAL YSDRQSVLIG QNLDRSIQIN ITRLAGAFGA VAVRVQILSD
4810 4820 4830 4840 4850
NKEDPVATEN EERQLVITDG ARYKVGLVPL KNQVFLSLGS NFTLQLVSVR
4860 4870 4880 4890 4900
LLSGPFYGIP TILQEAKNAI LSVPEEAANS QVGFESAAFQ LMDIKAGTSQ
4910 4920 4930 4940 4950
VMVSRKGTYG RLSVAWTTGY APGSEIPEPI VIGNMTPTLG SLSFVHGEER
4960 4970 4980 4990 5000
KGVLLWTFPS PGRPEAFVLH LSGLRSSAAG GAQLRSGFTT AEIEPMGVFQ
5010 5020 5030 5040 5050
FSPSSRNITV SEDAQTIRIC VQRLFGFHGD LIKVSYETTA GSAKPPEDFE
5060 5070 5080 5090 5100
AVQKGEVFFQ RFQPEIDFEI TIINDQLPEI EETYYINLTS VETRGLGKGG
5110 5120 5130 5140 5150
VNWRPRLNPD LSVAVVTIVD NDDLTGAAVS VPVTAGTVAV DSTLLAMETG
5160 5170 5180 5190 5200
STTHPNKSKI TTIPYTTEVF APVTETVTVS AIPEKLATAH SVISVKPDVV
5210 5220 5230 5240 5250
PGTVVASVYG TLSIGPPIVY VSEEMKNGTL STADILIQRM GGFAGNVTIT
5260 5270 5280 5290 5300
VKTFGGRCAQ KEPSVWPFQD VYGVGNLTTW AVEEEDFEEQ LLTLTFLYGE
5310 5320 5330 5340 5350
RERKIAVQIL DDDDAEGQEF FYVFLTDPQG GAEIVRGKDS TGFSAFAVII
5360 5370 5380 5390 5400
ISGSDLHNGI IGFSEESQRG LELREGADKN SQRLVVTRQP NRAFEEVQIF
5410 5420 5430 5440 5450
WRVTLNQTVT ILQEKGANLT DELRFVAGVT TCTGGQTRCF IHLELNPKKV
5460 5470 5480 5490 5500
HQVEMPFFVE LYDVTAGAAI NNSARFAPIK LSKSGAPQSL VSFSVGSRLA
5510 5520 5530 5540 5550
VAHKKSTLIS LQVARDSGTG IMMSVNFITQ ELRSAETVGR VLISPAVSGK
5560 5570 5580 5590 5600
DFVRTEGTLV FEPGQKSAVL DVVLTPEAGS LNKFPKRFQI VLFDPKGGAR
5610 5620 5630 5640 5650
IDKVYGTANI TLISDADSQA VWGLEDLLHR PLHEDILNRV LHNLNLRVAT
5660 5670 5680 5690 5700
ESTDEQLSAV MLIMEKITME GRNQAFSIKS RTLLYELLCV LINPKRKDTR
5710 5720 5730 5740 5750
GFSHFVEVAE HFAFSLLTDV TCGSPGEKSK TILDSCPYLS ILALHWNPQQ
5760 5770 5780 5790 5800
INGHKFEGKE GDYIQIPERL LDVPEAEMLD GKNACTLVQF VEYSSQQWFI
5810 5820 5830 5840 5850
AGDNLPALKD KVLSLNVKGQ SAQPLPNNNE VLYRIHAAEP RVVPHTSRCL
5860 5870 5880 5890 5900
LWNQAAASWL SDSQFCKVVE DASDYVECAC SHMSVYAVYA QTDNSSSYNE
5910 5920 5930 5940 5950
AFFSAGLICI SGLCLAVVSH MFCARHSMFA AKLLTHMMVA SLGTQILFLA
5960 5970 5980 5990 6000
SAYASPHLSE ESCSAVAAVA HYLYLCQFSW MLIQSVNFWY VLVVSDEHTE
6010 6020 6030 6040 6050
RRCLLFCLLS WGLPSFVVIL LILILRGIYH RSMPQIYGLI HGDLCFIPNI
6060 6070 6080 6090 6100
YAALFTAALV PLMCLVVVFV VFIHAYQLKP QWKGYDDVFR GRTNAAEIPL
6110 6120 6130 6140 6150
ILYLFALISM TWLWGGLHMA YGHFWMLVLF VIFNSLQGLY VFVVYFILHN
6160 6170 6180 6190 6200
QTCCPMKASY TVEMNGHPGP STAFFTPGSG IPPAGEINKS TQNLINAMEE
6210 6220 6230 6240 6250
VPSDWERSSF QQTSQASPDL KTSPQNGASF PSSGGYGPGS LIADEESQEF
6260 6270 6280 6290
DDLIFALKTG AGLSVSDNES GQGSQEGGTL TDSQIVELRR IPIADTHL
Length:6,298
Mass (Da):687,458
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF99E731B0ADBD66D
GO
Isoform 2 (identifier: Q8VHN7-2) [UniParc]FASTAAdd to basket
Also known as: Mass1.2

The sequence of this isoform differs from the canonical sequence as follows:
     1-720: Missing.
     721-748: QNETSINITVKGDDIPELNETVTLSLDR → MCLPSLCPSHCSFCVDRVETERFVVYFG
     2938-2958: DSEGLTAQIVIDANDGAQGMI → GMGLSFMNLLTNCESQRTSLF
     2959-6298: Missing.

Show »
Length:2,238
Mass (Da):244,000
Checksum:i63490CC1D4459E60
GO
Isoform 3 (identifier: Q8VHN7-3) [UniParc]FASTAAdd to basket
Also known as: Mass1.3

The sequence of this isoform differs from the canonical sequence as follows:
     1-1804: Missing.
     1805-1810: LNLDGG → MCVACE
     2938-2958: DSEGLTAQIVIDANDGAQGMI → GMGLSFMNLLTNCESQRTSLF
     2959-6298: Missing.

Show »
Length:1,154
Mass (Da):123,797
Checksum:iF590FB279848E001
GO
Isoform 4 (identifier: Q8VHN7-4) [UniParc]FASTAAdd to basket
Also known as: Neurepin-2, Vlgr1e

The sequence of this isoform differs from the canonical sequence as follows:
     1213-1218: PGGQLA → TNLSHL
     1219-6298: Missing.

Note: Secreted.Curated
Show »
Length:1,218
Mass (Da):133,698
Checksum:i4624468023BE9CA7
GO
Isoform 5 (identifier: Q8VHN7-5) [UniParc]FASTAAdd to basket
Also known as: Neurepin-1, Vlgr1d

The sequence of this isoform differs from the canonical sequence as follows:
     615-616: LE → VL
     617-6298: Missing.

Note: Secreted.Curated
Show »
Length:616
Mass (Da):67,330
Checksum:iAB4CF545CE1A5923
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8JJE0B8JJE0_MOUSE
Adhesion G-protein-coupled receptor...
Adgrv1 Gpr98
6,298Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8C1E5Q8C1E5_MOUSE
Adhesion G-protein-coupled receptor...
Adgrv1 Gpr98, Mass1
318Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8BPQ5Q8BPQ5_MOUSE
Adhesion G-protein-coupled receptor...
Adgrv1 Gpr98, Mass1
416Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6X844F6X844_MOUSE
Adhesion G-protein-coupled receptor...
Adgrv1
533Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YYF1D3YYF1_MOUSE
Adhesion G-protein-coupled receptor...
Adgrv1
1,218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E8P3G5E8P3_MOUSE
Adhesion G-protein-coupled receptor...
Adgrv1
2,238Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti412 – 416SSRFE → RYNLL (PubMed:15606908).Curated5
Sequence conflicti520A → S in BAC66506 (PubMed:15606908).Curated1
Sequence conflicti859V → A (PubMed:11545713).Curated1
Sequence conflicti873R → C in BAC66506 (PubMed:15606908).Curated1
Sequence conflicti963S → T in BAC66506 (PubMed:15606908).Curated1
Sequence conflicti1282E → K (PubMed:11545713).Curated1
Sequence conflicti1508G → E (PubMed:11545713).Curated1
Sequence conflicti1933S → P (PubMed:11545713).Curated1
Sequence conflicti1955L → M (PubMed:11545713).Curated1
Sequence conflicti1994A → T (PubMed:11545713).Curated1
Sequence conflicti2047V → A (PubMed:11545713).Curated1
Sequence conflicti2251 – 2252NV → SA (PubMed:11545713).Curated2
Sequence conflicti2672G → V (PubMed:11545713).Curated1
Sequence conflicti4816 – 4832VITDG…VPLKN → PLIGCPCSSGWCSTMHI (PubMed:14621295).CuratedAdd BLAST17
Sequence conflicti5084Y → F (PubMed:14621295).Curated1
Sequence conflicti5127A → V (PubMed:14621295).Curated1
Sequence conflicti5205V → L (PubMed:14621295).Curated1
Sequence conflicti5282V → F (PubMed:14621295).Curated1
Sequence conflicti5314 – 5315DA → EP (PubMed:14621295).Curated2
Sequence conflicti5417A → L (PubMed:14621295).Curated1
Sequence conflicti5578A → T (PubMed:14621295).Curated1
Sequence conflicti5630R → Q (PubMed:14621295).Curated1
Sequence conflicti6122G → R (PubMed:14621295).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0179511 – 1804Missing in isoform 3. 1 PublicationAdd BLAST1804
Alternative sequenceiVSP_0179521 – 720Missing in isoform 2. 1 PublicationAdd BLAST720
Alternative sequenceiVSP_017953615 – 616LE → VL in isoform 5. 1 Publication2
Alternative sequenceiVSP_017954617 – 6298Missing in isoform 5. 1 PublicationAdd BLAST5682
Alternative sequenceiVSP_017955721 – 748QNETS…LSLDR → MCLPSLCPSHCSFCVDRVET ERFVVYFG in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_0179561213 – 1218PGGQLA → TNLSHL in isoform 4. 1 Publication6
Alternative sequenceiVSP_0179571219 – 6298Missing in isoform 4. 1 PublicationAdd BLAST5080
Alternative sequenceiVSP_0179581805 – 1810LNLDGG → MCVACE in isoform 3. 1 Publication6
Alternative sequenceiVSP_0179592938 – 2958DSEGL…AQGMI → GMGLSFMNLLTNCESQRTSL F in isoform 2 and isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_0179602959 – 6298Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST3340

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF405693 mRNA Translation: AAL06013.1
AF405694 mRNA Translation: AAL06014.1
AF435926 mRNA Translation: AAL30812.1
AB086166 mRNA Translation: BAC66505.2
AB086167 mRNA Translation: BAC66506.1
AK129190 mRNA Translation: BAC98000.3

The Consensus CDS (CCDS) project

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CCDSi
CCDS36737.1 [Q8VHN7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000128585; ENSMUSP00000121899; ENSMUSG00000069170 [Q8VHN7-5]

UCSC genome browser

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UCSCi
uc007rht.1, mouse [Q8VHN7-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF405693 mRNA Translation: AAL06013.1
AF405694 mRNA Translation: AAL06014.1
AF435926 mRNA Translation: AAL30812.1
AB086166 mRNA Translation: BAC66505.2
AB086167 mRNA Translation: BAC66506.1
AK129190 mRNA Translation: BAC98000.3
CCDSiCCDS36737.1 [Q8VHN7-1]

3D structure databases

SMRiQ8VHN7
ModBaseiSearch...

Protein-protein interaction databases

CORUMiQ8VHN7
IntActiQ8VHN7, 1 interactor
STRINGi10090.ENSMUSP00000093245

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

iPTMnetiQ8VHN7
PhosphoSitePlusiQ8VHN7

Proteomic databases

PaxDbiQ8VHN7
PRIDEiQ8VHN7

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
6556, 121 antibodies

Genome annotation databases

EnsembliENSMUST00000128585; ENSMUSP00000121899; ENSMUSG00000069170 [Q8VHN7-5]
UCSCiuc007rht.1, mouse [Q8VHN7-5]

Organism-specific databases

MGIiMGI:1274784, Adgrv1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG1306, Eukaryota
GeneTreeiENSGT00940000154880
InParanoidiQ8VHN7
PhylomeDBiQ8VHN7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Adgrv1, mouse

Protein Ontology

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PROi
PR:Q8VHN7
RNActiQ8VHN7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000069170, Expressed in liver and 185 other tissues

Family and domain databases

Gene3Di2.60.40.2030, 34 hits
InterProiView protein in InterPro
IPR026919, ADGRV1
IPR038081, CalX-like_sf
IPR003644, Calx_beta
IPR013320, ConA-like_dom_sf
IPR009039, EAR
IPR005492, EPTP
IPR017981, GPCR_2-like
IPR000832, GPCR_2_secretin-like
IPR000203, GPS
IPR006558, LamG-like
PANTHERiPTHR46682, PTHR46682, 1 hit
PfamiView protein in Pfam
PF00002, 7tm_2, 1 hit
PF03160, Calx-beta, 37 hits
PF03736, EPTP, 1 hit
SMARTiView protein in SMART
SM00237, Calx_beta, 20 hits
SM00560, LamGL, 1 hit
SUPFAMiSSF141072, SSF141072, 38 hits
SSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50912, EAR, 6 hits
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRV1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VHN7
Secondary accession number(s): Q6ZQ69
, Q810D2, Q810D3, Q91ZS0, Q91ZS1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: March 1, 2002
Last modified: August 12, 2020
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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