UniProtKB - Q8VHN2 (NMD3B_RAT)
Glutamate receptor ionotropic, NMDA 3B
Grin3b
Functioni
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.
GO - Molecular functioni
- cation channel activity Source: RGD
- glycine binding Source: RGD
- ionotropic glutamate receptor activity Source: InterPro
- ligand-gated ion channel activity Source: GO_Central
- neurotransmitter binding Source: RGD
- neurotransmitter receptor activity Source: RGD
- signaling receptor activity Source: GO_Central
GO - Biological processi
- calcium ion transmembrane transport Source: GOC
- ionotropic glutamate receptor signaling pathway Source: RGD
- protein insertion into membrane Source: RGD
- regulation of calcium ion transport Source: RGD
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Transport |
Ligand | Calcium, Magnesium |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamate receptor ionotropic, NMDA 3BShort name: GluN3B Alternative name(s): N-methyl-D-aspartate receptor subtype 3B Short name: NMDAR3B Short name: NR3B |
Gene namesi | Name:Grin3b |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621705, Grin3b |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
- postsynaptic cell membrane By similarity
Note: Requires the presence of GRIN1 to be targeted at the plasma membrane.By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
Plasma Membrane
- integral component of postsynaptic density membrane Source: SynGO
- NMDA selective glutamate receptor complex Source: RGD
- plasma membrane Source: GO_Central
Other locations
- hippocampal mossy fiber to CA3 synapse Source: SynGO
- neuronal cell body Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 564 | ExtracellularSequence analysisAdd BLAST | 540 | |
Transmembranei | 565 – 585 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 586 – 648 | CytoplasmicSequence analysisAdd BLAST | 63 | |
Transmembranei | 649 – 669 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 670 – 826 | ExtracellularSequence analysisAdd BLAST | 157 | |
Transmembranei | 827 – 847 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 848 – 1002 | CytoplasmicSequence analysisAdd BLAST | 155 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL1907608 CHEMBL2096669 CHEMBL4524129 |
DrugCentrali | Q8VHN2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000011572 | 25 – 1002 | Glutamate receptor ionotropic, NMDA 3BAdd BLAST | 978 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 69 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 212 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 344 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 451 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 465 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 786 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q8VHN2 |
PRIDEi | Q8VHN2 |
PTM databases
GlyGeni | Q8VHN2, 6 sites |
Expressioni
Tissue specificityi
Interactioni
Subunit structurei
Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels.
Found in a complex containing GRIN1 and GRIN2A (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000017064 |
Chemistry databases
BindingDBi | Q8VHN2 |
Structurei
Secondary structure
3D structure databases
SMRi | Q8VHN2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8VHN2 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 882 – 910 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 951 – 984 | Involved in the trafficking and surface expression of NMDARsBy similarityAdd BLAST | 34 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 944 – 985 | Sequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 892 – 910 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1053, Eukaryota |
InParanoidi | Q8VHN2 |
OrthoDBi | 188544at2759 |
PhylomeDBi | Q8VHN2 |
Family and domain databases
InterProi | View protein in InterPro IPR019594, Glu/Gly-bd IPR001508, Iono_rcpt_met IPR001320, Iontro_rcpt IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF00060, Lig_chan, 1 hit PF10613, Lig_chan-Glu_bd, 1 hit |
PRINTSi | PR00177, NMDARECEPTOR |
SMARTi | View protein in SMART SM00918, Lig_chan-Glu_bd, 1 hit SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MESVRTLWLS VALALAVGSR VVRGHPQPCR VPTRAGASVR LAALLPRAPA
60 70 80 90 100
ARARVLAALA TPAPRLPHNL SLELVAVASP TRDPASLARG LCQVLAPPGV
110 120 130 140 150
VASIAFPEAR PELRLLQFLA AATETPVVSV LRREVRTALG APTPFHLQLD
160 170 180 190 200
WASPLETILD VLVSLVRAHA WEDIALVLCR VRDPGSLVTL WTNHASQAPK
210 220 230 240 250
FVLDLSRLDS RNDSLRAGLA LLGALEGGGT PVPAAVLLGC STARAHEVLE
260 270 280 290 300
AAPPGPQWLL GTPLPAEALP TTGLPPGVLA LGETEQHSLE AVVHDMVELV
310 320 330 340 350
AQALSSMALV HPERALLPAV VNCDDLKTGG SEATGRTLAR FLGNTSFQGR
360 370 380 390 400
TGAVWVTGSS QVHVSRHFKV WSLRRDPLGA PAWATVGSWQ DGQLDFQPGA
410 420 430 440 450
AALRVPSPSG TQARPKLRVV TLVEHPFVFT RESDEDGQCP AGQLCLDPGT
460 470 480 490 500
NDSARLDALF AALVNGSVPR TLRRCCYGYC IDLLERLAED LAFDFELYIV
510 520 530 540 550
GDGKYGALRD GRWTGLVGDL LAGRAHMAVT SFSINSARSQ VVDFTSPFFS
560 570 580 590 600
TSLGIMVRTR DTASPIGAFM WPLHWSMWVG VFAALHLTAL FLTLYEWRSP
610 620 630 640 650
YGLTPRGRNR GTVFSYSSAL NLCYAILFGR TVSSKTPKCP TGRFLMNLWA
660 670 680 690 700
IFCLLVLSSY TANLAAVMVG DKTFEELSGI HDPKLHHPSQ GFRFGTVWES
710 720 730 740 750
SAEAYIKASF PEMHAHMRRH SAPTTPHGVA MLTSDPPKLN AFIMDKSLLD
760 770 780 790 800
YEVSIDADCK LLTVGKPFAI EGYGIGLPQN SPLTSNLSEF ISRYKSSGFI
810 820 830 840 850
DLLHDKWYKM VPCGKRVFAV TETLQMGVYH FSGLFVLLCL GLGSALLTSL
860 870 880 890 900
GEHVFYRLVL PRIRRGNKLQ YWLHTSQKIH RALNTGPPEG QQERAEQERS
910 920 930 940 950
GPKDELPATD GAGRWRRVRR AVERERRVRF LLEPGEAGGD RPWLCSNGPG
960 970 980 990 1000
LQAELRELEL RIEAARERLR SALLRRGELR ALLGDGTRLR PLRLLHAAPA
ES
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF1LPZ6 | F1LPZ6_RAT | Glutamate receptor | Grin3b | 1,002 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF440691 mRNA Translation: AAL69893.2 |
RefSeqi | NP_579842.2, NM_133308.2 |
Genome annotation databases
GeneIDi | 170796 |
KEGGi | rno:170796 |
UCSCi | RGD:621705, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF440691 mRNA Translation: AAL69893.2 |
RefSeqi | NP_579842.2, NM_133308.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2RCA | X-ray | 1.58 | A/B | 413-560 | [»] | |
A/B | 676-815 | [»] | ||||
2RCB | X-ray | 1.62 | A/B | 413-560 | [»] | |
A/B | 676-815 | [»] | ||||
SMRi | Q8VHN2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000017064 |
Chemistry databases
BindingDBi | Q8VHN2 |
ChEMBLi | CHEMBL1907608 CHEMBL2096669 CHEMBL4524129 |
DrugCentrali | Q8VHN2 |
PTM databases
GlyGeni | Q8VHN2, 6 sites |
Proteomic databases
PaxDbi | Q8VHN2 |
PRIDEi | Q8VHN2 |
Genome annotation databases
GeneIDi | 170796 |
KEGGi | rno:170796 |
UCSCi | RGD:621705, rat |
Organism-specific databases
CTDi | 116444 |
RGDi | 621705, Grin3b |
Phylogenomic databases
eggNOGi | KOG1053, Eukaryota |
InParanoidi | Q8VHN2 |
OrthoDBi | 188544at2759 |
PhylomeDBi | Q8VHN2 |
Miscellaneous databases
EvolutionaryTracei | Q8VHN2 |
PROi | PR:Q8VHN2 |
Family and domain databases
InterProi | View protein in InterPro IPR019594, Glu/Gly-bd IPR001508, Iono_rcpt_met IPR001320, Iontro_rcpt IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF00060, Lig_chan, 1 hit PF10613, Lig_chan-Glu_bd, 1 hit |
PRINTSi | PR00177, NMDARECEPTOR |
SMARTi | View protein in SMART SM00918, Lig_chan-Glu_bd, 1 hit SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NMD3B_RAT | |
Accessioni | Q8VHN2Primary (citable) accession number: Q8VHN2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | June 1, 2002 | |
Last modified: | June 2, 2021 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families