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Protein

Hepatoma-derived growth factor

Gene

Hdgf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei19HeparinBy similarity1
Binding sitei21HeparinBy similarity1
Binding sitei72HeparinBy similarity1
Binding sitei75HeparinBy similarity1
Binding sitei79HeparinBy similarity1
Binding sitei80HeparinBy similarity1

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: BHF-UCL
  • positive regulation of transcription by RNA polymerase II Source: BHF-UCL
  • protein localization to nucleus Source: BHF-UCL
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Growth factor, Heparin-binding, Repressor
Biological processTranscription, Transcription regulation
LigandNucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatoma-derived growth factor
Short name:
HDGF
Gene namesi
Name:Hdgf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70961 Hdgf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001917021 – 237Hepatoma-derived growth factorAdd BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44N6-acetyllysineBy similarity1
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei132PhosphoserineCombined sources1
Modified residuei133PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei199PhosphoserineCombined sources1
Modified residuei200PhosphothreonineCombined sources1
Modified residuei202PhosphoserineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Modified residuei236PhosphoserineBy similarity1

Post-translational modificationi

Sumoylated with SUMO1. Sumoylation prevents binding to chromatin (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8VHK7
PRIDEiQ8VHK7

PTM databases

iPTMnetiQ8VHK7
PhosphoSitePlusiQ8VHK7

Interactioni

Subunit structurei

Monomer, and domain-swapped homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017234

Structurei

Secondary structure

1237
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi15 – 20Combined sources6
Beta strandi23 – 32Combined sources10
Beta strandi45 – 49Combined sources5
Turni50 – 53Combined sources4
Beta strandi54 – 58Combined sources5
Helixi60 – 62Combined sources3
Beta strandi63 – 65Combined sources3
Helixi66 – 73Combined sources8
Beta strandi78 – 81Combined sources4
Helixi82 – 91Combined sources10

3D structure databases

ProteinModelPortaliQ8VHK7
SMRiQ8VHK7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8VHK7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 69PWWPPROSITE-ProRule annotationAdd BLAST58

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi75 – 80Nuclear localization signalBy similarity6
Motifi155 – 170Bipartite nuclear localization signalBy similarityAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi111 – 227Glu-richAdd BLAST117

Domaini

The PWWP domain harbors the heparin-binding sites and is responsible for DNA-binding, while the C-terminal region is essentially unstructured.By similarity

Sequence similaritiesi

Belongs to the HDGF family.Curated

Phylogenomic databases

eggNOGiKOG1904 Eukaryota
ENOG410Y5WD LUCA
HOGENOMiHOG000112874
HOVERGENiHBG010574
InParanoidiQ8VHK7
KOiK16641
PhylomeDBiQ8VHK7

Family and domain databases

CDDicd05834 HDGF_related, 1 hit
InterProiView protein in InterPro
IPR035496 HDGF-rel_PWWP
IPR000313 PWWP_dom
PfamiView protein in Pfam
PF00855 PWWP, 1 hit
SMARTiView protein in SMART
SM00293 PWWP, 1 hit
PROSITEiView protein in PROSITE
PS50812 PWWP, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VHK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSNRQKEY KCGDLVFAKM KGYPHWPARI DEMPEAAVKS TANKYQVFFF
60 70 80 90 100
GTHETAFLGP KDLFPYEESK EKFGKPNKRK GFSEGLWEIE NNPTVKASGY
110 120 130 140 150
QSSQKKSCAE EPEVEPEAHE GDGDKKGNAE GSSDEEGKLV IDEPAKEKNE
160 170 180 190 200
KGMLKRRAGD MLEDSPKRPK ESGDHEEEEK EIAALEGERP LPVEMEKNST
210 220 230
PSEPDSGQGP PPEEEEGEEE AAKEEAEAQG VRDHESL
Length:237
Mass (Da):26,488
Last modified:September 27, 2004 - v2
Checksum:iC120F798BD40D360
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti231V → I in AAL47132 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF448810 mRNA Translation: AAL47132.1
AF389348 mRNA Translation: AAK72966.1
BC070943 mRNA Translation: AAH70943.1
RefSeqiNP_446159.1, NM_053707.2
UniGeneiRn.860

Genome annotation databases

GeneIDi114499
KEGGirno:114499
UCSCiRGD:70961 rat

Similar proteinsi

Entry informationi

Entry nameiHDGF_RAT
AccessioniPrimary (citable) accession number: Q8VHK7
Secondary accession number(s): Q923W3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: September 27, 2004
Last modified: May 23, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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