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Protein

Membrane protein MLC1

Gene

Mlc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein MLC1
Gene namesi
Name:Mlc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2157910 Mlc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Transmembranei88 – 107HelicalSequence analysisAdd BLAST20
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000964981 – 382Membrane protein MLC1Add BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei183PhosphoserineCombined sources1
Modified residuei185PhosphoserineCombined sources1
Modified residuei188PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VHK5
PaxDbiQ8VHK5
PRIDEiQ8VHK5

PTM databases

iPTMnetiQ8VHK5
PhosphoSitePlusiQ8VHK5
SwissPalmiQ8VHK5

Expressioni

Gene expression databases

BgeeiENSMUSG00000035805 Expressed in 112 organ(s), highest expression level in cranial nerve II
ExpressionAtlasiQ8VHK5 baseline and differential
GenevisibleiQ8VHK5 MM

Interactioni

Subunit structurei

Interacts with ATP1B1. Part of a complex containing ATP1B1, TRPV4, AQP4 and HEPACAM.By similarity

Protein-protein interaction databases

BioGridi228441, 1 interactor
STRINGi10090.ENSMUSP00000047667

Structurei

3D structure databases

ProteinModelPortaliQ8VHK5
SMRiQ8VHK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi178 – 181Poly-Lys4

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGRJ Eukaryota
ENOG410YAP9 LUCA
GeneTreeiENSGT00390000015442
HOGENOMiHOG000065767
HOVERGENiHBG049239
InParanoidiQ8VHK5
KOiK20070
PhylomeDBiQ8VHK5
TreeFamiTF333109

Family and domain databases

InterProiView protein in InterPro
IPR033280 Membrane_MLC1
PANTHERiPTHR17597 PTHR17597, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD492528 PD492528, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8VHK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTREGQFREE LGYDRMPTLE RGRQDAGRQD PGSYTPDSKP KDLQLSKRLP
60 70 80 90 100
PCFSYKTWVF SVLMGSCLLV TSGFSLYLGN VFPSEMDYLR CAAGSCIPSA
110 120 130 140 150
IVSFAVGRRN VSAIPNFQIL FVSTFAVTTT CLIWFGCKLI LNPSAININF
160 170 180 190 200
NLILLLLLEL LMAATVIISA RSSEEPCKKK KGSISDGSNI LDEVTFPARV
210 220 230 240 250
LKSYSVVEVI AGVSAVLGGV IALNVEEAVS GPHLSVTFFW ILVACFPSAI
260 270 280 290 300
ASHVTAECPS KCLVEVLIAI SSLTSPLLFT ASGYLSFSVM RVVEIFKDYP
310 320 330 340 350
PAIKSYDVLL LLLLLLLLLQ GGLNTGTAIQ CVSFKVSARL QAASWDPQSC
360 370 380
PQERPAGEVV RGPLKEFDKE KAWRAVVVQM AQ
Length:382
Mass (Da):41,596
Last modified:March 1, 2002 - v1
Checksum:i0F5573B1F89327E0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QP87E9QP87_MOUSE
Membrane protein MLC1
Mlc1
388Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449425 mRNA Translation: AAL66020.1
AK030396 mRNA Translation: BAC26941.1
BC024719 mRNA Translation: AAH24719.1
CCDSiCCDS37173.1
RefSeqiNP_573504.1, NM_133241.2
UniGeneiMm.32780

Genome annotation databases

EnsembliENSMUST00000042594; ENSMUSP00000047667; ENSMUSG00000035805
GeneIDi170790
KEGGimmu:170790
UCSCiuc007xev.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449425 mRNA Translation: AAL66020.1
AK030396 mRNA Translation: BAC26941.1
BC024719 mRNA Translation: AAH24719.1
CCDSiCCDS37173.1
RefSeqiNP_573504.1, NM_133241.2
UniGeneiMm.32780

3D structure databases

ProteinModelPortaliQ8VHK5
SMRiQ8VHK5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228441, 1 interactor
STRINGi10090.ENSMUSP00000047667

PTM databases

iPTMnetiQ8VHK5
PhosphoSitePlusiQ8VHK5
SwissPalmiQ8VHK5

Proteomic databases

MaxQBiQ8VHK5
PaxDbiQ8VHK5
PRIDEiQ8VHK5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042594; ENSMUSP00000047667; ENSMUSG00000035805
GeneIDi170790
KEGGimmu:170790
UCSCiuc007xev.1 mouse

Organism-specific databases

CTDi23209
MGIiMGI:2157910 Mlc1

Phylogenomic databases

eggNOGiENOG410IGRJ Eukaryota
ENOG410YAP9 LUCA
GeneTreeiENSGT00390000015442
HOGENOMiHOG000065767
HOVERGENiHBG049239
InParanoidiQ8VHK5
KOiK20070
PhylomeDBiQ8VHK5
TreeFamiTF333109

Miscellaneous databases

PROiPR:Q8VHK5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035805 Expressed in 112 organ(s), highest expression level in cranial nerve II
ExpressionAtlasiQ8VHK5 baseline and differential
GenevisibleiQ8VHK5 MM

Family and domain databases

InterProiView protein in InterPro
IPR033280 Membrane_MLC1
PANTHERiPTHR17597 PTHR17597, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD492528 PD492528, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMLC1_MOUSE
AccessioniPrimary (citable) accession number: Q8VHK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2002
Last modified: September 12, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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