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Entry version 88 (07 Oct 2020)
Sequence version 1 (01 Mar 2002)
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Protein
Submitted name:

Nesprin-1

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nesprin-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 2787CytoplasmicPROSITE-ProRule annotationAdd BLAST2787
Topological domaini2809 – 2838Perinuclear spacePROSITE-ProRule annotationAdd BLAST30

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8VHJ9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8VHJ9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2779 – 2838KASHInterPro annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2255 – 2299DisorderedSequence analysisAdd BLAST45
Regioni2712 – 2773DisorderedSequence analysisAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili20 – 40Sequence analysisAdd BLAST21
Coiled coili75 – 110Sequence analysisAdd BLAST36
Coiled coili179 – 213Sequence analysisAdd BLAST35
Coiled coili436 – 456Sequence analysisAdd BLAST21
Coiled coili543 – 563Sequence analysisAdd BLAST21
Coiled coili1074 – 1108Sequence analysisAdd BLAST35
Coiled coili1180 – 1200Sequence analysisAdd BLAST21
Coiled coili1829 – 1856Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2263 – 2283PolarSequence analysisAdd BLAST21
Compositional biasi2712 – 2772PolarSequence analysisAdd BLAST61

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nesprin family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8VHJ9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012315, KASH
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
IPR030265, SYNE1

The PANTHER Classification System

More...
PANTHERi
PTHR14514:SF3, PTHR14514:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10541, KASH, 1 hit
PF00435, Spectrin, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01249, KASH, 1 hit
SM00150, SPEC, 16 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51049, KASH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8VHJ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLSESLQPG RSPESQMAEH QALMDEVQML QDEINGLQAS LAEELVAESH
60 70 80 90 100
ESDPAEQLAL QSTLTVLAER MSTIRMKAAG KRQLLEEKLN DQLEEQRQEQ
110 120 130 140 150
ALQRYRCEAE ELDHWLLNTK ATLDFAAGIP QEPMDTDAQL VDCQNMLVEI
160 170 180 190 200
EQKVVALSQL SVRSENLLLE GKAHTKDEAE QLASKLRMLK GSLMELQRAL
210 220 230 240 250
RDRQLNMQGV TQEKEENDVD FTATQSPGVQ EWLAQARNTR THQRQSSLQQ
260 270 280 290 300
QKEFEQELAE QKSLLRSVAS RGEEILIQHS TAEGSGGLGE KPDALSQELV
310 320 330 340 350
MEGAKSFAED QMRAKWESLH QEFSTKQKLL QNILEQEQEQ MLYSSPNRLL
360 370 380 390 400
SGVLPLRGEA QTQDKSSVTS LLDGLSQAFG EVSSQSGGTD RQNIHLEQKL
410 420 430 440 450
YDGVSATSTW LDDVEEHLFV ATALLPEETE TCLFNQEALA KDIKEMSEEM
460 470 480 490 500
DKNKNLFSQA FPEDSDNRDV IEDTLGCLLG RLSLLDSVVG QRCHQMKERL
510 520 530 540 550
QQVLSFQNDL KVLFTSLADN NYIILQKLAN MFKQPIVEQI QAIQQAEEGL
560 570 580 590 600
RELDGGISEL KQRGDKLQVD QSALQELSKL QDMYDELLVT ISSRRSNLNQ
610 620 630 640 650
NLALKSQYDK ALQDLVDLLD TGQEKMAGDQ KIIVSSKEEV QQLLSKHKEY
660 670 680 690 700
FQGLESHLIL TETLFRKIVD FAAMKETQLH SDRMAQASAV LKQAHKRGVE
710 720 730 740 750
LEYILEMWSH LDENLQELSR QLEVIENSIP SVGLVEESED RLVERTSLYQ
760 770 780 790 800
HLKSSLNEYQ PKLYQVLDDG KRLMMSISCS ELESQLNQLG ERWLGNTNKV
810 820 830 840 850
SKELHRLETI LKHWTRYQSE AADLIHWLES AKDKLAFWTQ QSVTVPQELE
860 870 880 890 900
MVRDHLNAFL EFSKEVDAKS SLKSSVTSTG NQLLRLKKVD TAALRAELSC
910 920 930 940 950
MDSQWTDLLA GIPAVQEKLH QLQMDKLPSR HAISEVMSWI SLMESVILKD
960 970 980 990 1000
EEDIRNAIGY KAIYEYLQKY KGFKIDLNCK QLTADFVNQS VLQISSQDVE
1010 1020 1030 1040 1050
SKRSDKTDFA EQLGAMNKSW QLLQGRVGEK IQMLEGLLES WSEYENSIQS
1060 1070 1080 1090 1100
LKAWFANQER KLEEHHQIGD QNSVQNALKD CQELEDLIKA KEKEVEKIEQ
1110 1120 1130 1140 1150
NGLALIQNKR EEVSCSVLNT LWELRQTWAS LERTVGQLKI QLTLVLGQWS
1160 1170 1180 1190 1200
IHKAAFEEIS NHLMEARYSL SRFRLLTGSS DAVQVQVDNL QNLHDDLEKQ
1210 1220 1230 1240 1250
EGDLQKFGSL TNHLLKECHP PVAEALSSTL QEVNMRWNNL LEEIAKQLHS
1260 1270 1280 1290 1300
SKALLQLWQR YKDYSKQCAS AVQRQEEQTN ALLKAATSKD IADDEVAKWI
1310 1320 1330 1340 1350
QDCNDLLKGL GTVKDSLFIL HELGEQLGQQ VDDSAATTIQ CEQLCFSQRL
1360 1370 1380 1390 1400
EALEQALCKQ QAVLQAGVVD YETFAKSLEA LEAWIVEAEG ILQAQDPTHS
1410 1420 1430 1440 1450
SDLSTIQERM EELKGQMLKF SSMAPDLDRL NELGYRLPLN DKEIKRMQNL
1460 1470 1480 1490 1500
NRHWSLISSQ TTERFSKLQS FLLQHQTFLE KCETWMEFLV QTEHKLAVEI
1510 1520 1530 1540 1550
SGNYQHLLEQ QRAHELFQAE MFSRQQILHS IIVDGQNLLE QGQVDDREEF
1560 1570 1580 1590 1600
SLKLTLLSNQ WQGVIRRAQQ RRGIIDSQIR QWQRYREMAE KLRKWLVEVS
1610 1620 1630 1640 1650
HLPLSGLGSI PVPLQQVRTL FDEVQFKEKV FLRQQGSYIL TVEAGKQLLL
1660 1670 1680 1690 1700
SADSGAEAAL QAELTDIQEK WKSASTHLEE QKKKLAFLLK DWEKCEKGIA
1710 1720 1730 1740 1750
DSLEKLRTFK KRLSQPLPDH HEELHAEQMR CKELENAVGR WTDDLAELVL
1760 1770 1780 1790 1800
LREALAAHLS AEDISILKER VELLQRQWEE LCHQVSLRRQ QVSERLNEWA
1810 1820 1830 1840 1850
VFSEKNKELC EWLTQMESKV SQNGDILIEE MIEKLKKDYQ EKIAVAQENK
1860 1870 1880 1890 1900
IQLQQMGERL AKASHESKAS EIQYKLSKVN DRWQHLLDLM AARVKKLKET
1910 1920 1930 1940 1950
LVAVQQLDKN MGSLRIWLAH MESELAKPIV YDSCNSEEIQ KKLSEQQELQ
1960 1970 1980 1990 2000
RDIEKHSTGV ASVLNLCEVL LHDCDACATD AECDSIQQAT RNLDRRWRNI
2010 2020 2030 2040 2050
CAMSMERRLK IEETWRLWQK FLDDYSRFED WLEISERTAA FPSSSGVLYT
2060 2070 2080 2090 2100
VAKEELKKFE AFQRQVHESL TQLELINKQY RRLARENRTD SACSLRQMAH
2110 2120 2130 2140 2150
GGNQRWDDLL KRVTSILRRL KHFISQREEF ETARDSILVW LTEMDLQLTN
2160 2170 2180 2190 2200
IEHFSECDVQ AKIKQLKAFQ QEISLNHSKI EQIIAQGEQL IEKSEPLDAA
2210 2220 2230 2240 2250
VIEEELDELR RYCQEVFGRV ERYHKKLIRL PLPDDHDLSD RELDLEDSMA
2260 2270 2280 2290 2300
LSDLHWQDPS EDGMPSPQPS SNPSLSLPQP LRSERSGRDT PASVDSIPLE
2310 2320 2330 2340 2350
WDHDYDHDYD LSRDLESASR TLPSEDEEGE EDKEFYLRGA VGLSDVVIPE
2360 2370 2380 2390 2400
NPEAYVKLTE NAIRNTSGDP TSLESQMRQL DKALDDSRFQ IQQTANILRG
2410 2420 2430 2440 2450
KTPTGPDLGT SYKGYMKLLG ECSGTIDSVR RLEHKLAEEE SFPGFTNPTS
2460 2470 2480 2490 2500
TETQPAGVID RWELLQAQAM SKELKMKQNL QKWQQFNSDL NNICAWLGET
2510 2520 2530 2540 2550
EEELDRLQHL ALSTVIHTIK SHIKKLKELQ KALDHRKAII LSINLCSSEF
2560 2570 2580 2590 2600
TQADSKESHD LQDRLSQMNR RWDRVCSLLE DWRGSLQDAL MQCQDFHEMT
2610 2620 2630 2640 2650
HALLLLLENT DRRKNEIVPI DSTLDPETLQ DHHTQLTQIK QELLKSQLRV
2660 2670 2680 2690 2700
ASLQNMSRQL LVNAEGSDCL EAKEKVHVIG NRLKLLLKEV SRHIKDLEKL
2710 2720 2730 2740 2750
LGMSSSQQDL SSWSSADEVD TSGSVSPTSG RSTPNRQKSP RGKCSLSQPG
2760 2770 2780 2790 2800
PSVSSPKSRS TKGGSDSSLS ETRPARAGRD FLFRVLRAAL PIQLLLLLLI
2810 2820 2830
GLTSRVPISE EDYSCALSNN FARSFHPMLR YTNGPPPL
Length:2,838
Mass (Da):325,098
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36B1BEB8A3F8B596
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF452647 mRNA Translation: AAL47053.1

Genome annotation databases

UCSC genome browser

More...
UCSCi
RGD:620546, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF452647 mRNA Translation: AAL47053.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

iPTMnetiQ8VHJ9
PhosphoSitePlusiQ8VHJ9

Genome annotation databases

UCSCiRGD:620546, rat

Phylogenomic databases

PhylomeDBiQ8VHJ9

Family and domain databases

InterProiView protein in InterPro
IPR012315, KASH
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
IPR030265, SYNE1
PANTHERiPTHR14514:SF3, PTHR14514:SF3, 1 hit
PfamiView protein in Pfam
PF10541, KASH, 1 hit
PF00435, Spectrin, 7 hits
SMARTiView protein in SMART
SM01249, KASH, 1 hit
SM00150, SPEC, 16 hits
PROSITEiView protein in PROSITE
PS51049, KASH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8VHJ9_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VHJ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: October 7, 2020
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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