Ppargc1b

Functionⁱ

Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta-oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Induces also the expression of mitochondrial genes involved in oxidative metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.4 Publications

Miscellaneous

Transgenic mice overexpressing PPARGC1B exhibits increased expression of medium-chain acyl CoA dehydrogenase. They are hyperphagic but lean, with increased energy expenditure and resistance to obesity.

GO - Molecular functionⁱ

AF-2 domain binding Source: UniProtKB
estrogen receptor binding Source: MGI
nuclear receptor transcription coactivator activity Source: UniProtKB
RNA binding Source: UniProtKB-KW
transcription coregulator activity Source: MGI
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin filament organization
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19252502
bone trabecula formation
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19252502
cellular response to reactive oxygen species
Source: DFLAT
Inferred from direct assayⁱ
- 19252502
intracellular estrogen receptor signaling pathway Source: UniProtKB
mitochondrial transcription
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19252502
negative regulation of transcription, DNA-templated
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19252502
ossification
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19252502
positive regulation of alkaline phosphatase activity
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19252502
positive regulation of bone resorption
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19252502
positive regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from mutant phenotypeⁱ
- 17090215
positive regulation of DNA-binding transcription factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of osteoclast differentiation
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19252502
positive regulation of phosphorylation
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19252502
positive regulation of transcription, DNA-templated
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19252502
positive regulation of transcription by RNA polymerase II Source: UniProtKB
regulation of transcription, DNA-templated Source: UniProtKB
response to cAMP Source: Ensembl
response to glucocorticoid Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, RNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Peroxisome proliferator-activated receptor gamma coactivator 1-beta Short name: PGC-1-beta Short name: PPAR-gamma coactivator 1-beta Short name: PPARGC-1-beta Alternative name(s): ERR ligand 1
Gene namesⁱ	Name:Ppargc1b Synonyms:Errl1, Pgc1, Pgc1b, Ppargc1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 18

Organism-specific databases

MGIⁱ	MGI:2444934 Ppargc1b

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000240159	1 – 1014	Peroxisome proliferator-activated receptor gamma coactivator 1-betaAdd BLAST		1014

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	145	PhosphoserineCombined sources	1
Modified residueⁱ	148	PhosphoserineCombined sources	1
Modified residueⁱ	384	PhosphoserineBy similarity	1
Modified residueⁱ	519	PhosphoserineBy similarity	1
Modified residueⁱ	630	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q8VHJ7
PRIDEⁱ	Q8VHJ7

PTM databases

iPTMnetⁱ	Q8VHJ7
PhosphoSitePlusⁱ	Q8VHJ7

Expressionⁱ

Tissue specificityⁱ

Ubiquitous with higher expression in heart, brown adipose tissue, brain and skeletal muscle.2 Publications

Inductionⁱ

Induced by fasting in the liver, but not by cold exposure in brown adipose tissue. Induced also by saturated fatty acids in primary hepatocytes.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000033871 Expressed in 246 organ(s), highest expression level in brown adipose tissue
Genevisibleⁱ	Q8VHJ7 MM

Interactionⁱ

Subunit structureⁱ

Interacts with estrogen receptor alpha/ESR1 (By similarity). Interacts with hepatocyte nuclear factor 4-alpha/HNF4A, Sterol regulatory binding transcription factor 1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16.By similarity6 Publications

GO - Molecular functionⁱ

AF-2 domain binding Source: UniProtKB
estrogen receptor binding Source: MGI
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	228460, 4 interactors
IntActⁱ	Q8VHJ7, 1 interactor
STRINGⁱ	10090.ENSMUSP00000074771

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8VHJ7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	893 – 967	RRMPROSITE-ProRule annotationAdd BLAST		75

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 91	Abolishes DNA transcriptional activity when missingBy similarityAdd BLAST		91

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	140 – 144	LXXLL motif 1	5
Motifⁱ	156 – 160	LXXLL motif 2	5
Motifⁱ	343 – 347	LXXLL motif 3	5
Motifⁱ	683 – 686	HCFC1-binding-motif (HBM)	4

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	246 – 250	Poly-Glu	5
Compositional biasⁱ	429 – 451	Glu-richAdd BLAST	23
Compositional biasⁱ	786 – 856	Ser-richAdd BLAST	71

Domainⁱ

Contains 3 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors.By similarity

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IIJJ Eukaryota ENOG4111PZ5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063196
HOGENOMⁱ	HOG000236356
HOVERGENⁱ	HBG080730
InParanoidⁱ	Q8VHJ7
KEGG Orthology (KO) More...KOⁱ	K17962
OMAⁱ	DYCQVLK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G029M
PhylomeDBⁱ	Q8VHJ7
TreeFamⁱ	TF343068

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12356 RRM_PPARGC1B, 1 hit
Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR034605 PGC-1 IPR034621 PGC-1beta IPR034177 PPARGC1B_RRM IPR035979 RBD_domain_sf IPR000504 RRM_dom
PANTHERⁱ	PTHR15528 PTHR15528, 1 hit PTHR15528:SF12 PTHR15528:SF12, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q8VHJ7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGNDCGALL DEELSSFFLN YLSDTQGGDS GEEQLCADLP ELDLSQLDAS 
        60         70         80         90        100
DFDSATCFGE LQWCPETSET EPSQYSPDDS ELFQIDSENE ALLAALTKTL 
       110        120        130        140        150
DDIPEDDVGL AAFPELDEGD TPSCTPASPA PLSAPPSPTL ERLLSPASDV 
       160        170        180        190        200
DELSLLQKLL LATSSPTASS DALKDGATWS QTSLSSRSQR PCVKVDGTQD 
       210        220        230        240        250
KKTPTLRAQS RPCTELHKHL TSVLPCPRVK ACSPTPHPSP RLLSKEEEEE 
       260        270        280        290        300
VGEDCPSPWP TPASPQDSLA QDTASPDSAQ PPEEDVRAMV QLIRYMHTYC 
       310        320        330        340        350
LPQRKLPQRA PEPIPQACSS LSRQVQPRSR HPPKAFWTEF SILRELLAQD 
       360        370        380        390        400
ILCDVSKPYR LAIPVYASLT PQSRPRPPKD SQASPAHSAM AEEVRITASP 
       410        420        430        440        450
KSTGPRPSLR PLRLEVKRDV NKPTRQKREE DEEEEEEEEE EEEEKEEEEE 
       460        470        480        490        500
EWGRKRPGRG LPWTKLGRKM DSSVCPVRRS RRLNPELGPW LTFTDEPLGA 
       510        520        530        540        550
LPSMCLDTET HNLEEDLGSL TDSSQGRQLP QGSQIPALES PCESGCGDTD 
       560        570        580        590        600
EDPSCPQPTS RDSSRCLMLA LSQSDSLGKK SFEESLTVEL CGTAGLTPPT 
       610        620        630        640        650
TPPYKPMEED PFKPDTKLSP GQDTAPSLPS PEALPLTATP GASHKLPKRH 
       660        670        680        690        700
PERSELLSHL QHATTQPVSQ AGQKRPFSCS FGDHDYCQVL RPEAALQRKV 
       710        720        730        740        750
LRSWEPIGVH LEDLAQQGAP LPTETKAPRR EANQNCDPTH KDSMQLRDHE 
       760        770        780        790        800
IRASLTKHFG LLETALEGED LASCKSPEYD TVFEDSSSSS GESSFLLEEE 
       810        820        830        840        850
EEEEEGGEED DEGEDSGVSP PCSDHCPYQS PPSKASRQLC SRSRSSSGSS 
       860        870        880        890        900
SCSSWSPATR KNFRRESRGP CSDGTPSVRH ARKRREKAIG EGRVVYIRNL 
       910        920        930        940        950
SSDMSSRELK KRFEVFGEIV ECQVLTRSKR GQKHGFITFR CSEHAALSVR 
       960        970        980        990       1000
NGATLRKRNE PSFHLSYGGL RHFRWPRYTD YDPTSEESLP SSGKSKYEAM 
      1010 
DFDSLLKEAQ QSLH

Length:1,014

Mass (Da):112,075

Last modified:March 1, 2002 - v1

Checksum:ⁱ004BCB7797EAFD1F

GO

Isoform 2 (identifier: Q8VHJ7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-26: MAGNDCGALLDEELSSFFLNYLSDTQ → MKSSRPSSSTISLTRRSAEGLEEVDHEALDRDGCGRRRLADM

« Hide

        10         20         30         40         50
MKSSRPSSST ISLTRRSAEG LEEVDHEALD RDGCGRRRLA DMGGDSGEEQ 
        60         70         80         90        100
LCADLPELDL SQLDASDFDS ATCFGELQWC PETSETEPSQ YSPDDSELFQ 
       110        120        130        140        150
IDSENEALLA ALTKTLDDIP EDDVGLAAFP ELDEGDTPSC TPASPAPLSA 
       160        170        180        190        200
PPSPTLERLL SPASDVDELS LLQKLLLATS SPTASSDALK DGATWSQTSL 
       210        220        230        240        250
SSRSQRPCVK VDGTQDKKTP TLRAQSRPCT ELHKHLTSVL PCPRVKACSP 
       260        270        280        290        300
TPHPSPRLLS KEEEEEVGED CPSPWPTPAS PQDSLAQDTA SPDSAQPPEE 
       310        320        330        340        350
DVRAMVQLIR YMHTYCLPQR KLPQRAPEPI PQACSSLSRQ VQPRSRHPPK 
       360        370        380        390        400
AFWTEFSILR ELLAQDILCD VSKPYRLAIP VYASLTPQSR PRPPKDSQAS 
       410        420        430        440        450
PAHSAMAEEV RITASPKSTG PRPSLRPLRL EVKRDVNKPT RQKREEDEEE 
       460        470        480        490        500
EEEEEEEEEE KEEEEEEWGR KRPGRGLPWT KLGRKMDSSV CPVRRSRRLN 
       510        520        530        540        550
PELGPWLTFT DEPLGALPSM CLDTETHNLE EDLGSLTDSS QGRQLPQGSQ 
       560        570        580        590        600
IPALESPCES GCGDTDEDPS CPQPTSRDSS RCLMLALSQS DSLGKKSFEE 
       610        620        630        640        650
SLTVELCGTA GLTPPTTPPY KPMEEDPFKP DTKLSPGQDT APSLPSPEAL 
       660        670        680        690        700
PLTATPGASH KLPKRHPERS ELLSHLQHAT TQPVSQAGQK RPFSCSFGDH 
       710        720        730        740        750
DYCQVLRPEA ALQRKVLRSW EPIGVHLEDL AQQGAPLPTE TKAPRREANQ 
       760        770        780        790        800
NCDPTHKDSM QLRDHEIRAS LTKHFGLLET ALEGEDLASC KSPEYDTVFE 
       810        820        830        840        850
DSSSSSGESS FLLEEEEEEE EGGEEDDEGE DSGVSPPCSD HCPYQSPPSK 
       860        870        880        890        900
ASRQLCSRSR SSSGSSSCSS WSPATRKNFR RESRGPCSDG TPSVRHARKR 
       910        920        930        940        950
REKAIGEGRV VYIRNLSSDM SSRELKKRFE VFGEIVECQV LTRSKRGQKH 
       960        970        980        990       1000
GFITFRCSEH AALSVRNGAT LRKRNEPSFH LSYGGLRHFR WPRYTDYDPT 
      1010       1020       1030
SEESLPSSGK SKYEAMDFDS LLKEAQQSLH

Show »

Length:1,030

Mass (Da):113,898

Checksum:ⁱ4F2B27E32E91C84C

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	55	A → P in BAC25964 (PubMed:16141072).Curated		1
Sequence conflictⁱ	579	K → R in BAC25964 (PubMed:16141072).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_019302	1 – 26	MAGND…LSDTQ → MKSSRPSSSTISLTRRSAEG LEEVDHEALDRDGCGRRRLA DM in isoform 2. 1 PublicationAdd BLAST		26

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF453324 mRNA Translation: AAL47054.1 AK028464 mRNA Translation: BAC25964.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29284.1 [Q8VHJ7-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_573512.1, NM_133249.2 [Q8VHJ7-1]
UniGeneⁱ	Mm.415302

Genome annotation databases

Ensemblⁱ	ENSMUST00000063307; ENSMUSP00000069431; ENSMUSG00000033871 [Q8VHJ7-2] ENSMUST00000075299; ENSMUSP00000074771; ENSMUSG00000033871 [Q8VHJ7-1]
GeneIDⁱ	170826
KEGGⁱ	mmu:170826
UCSC genome browser More...UCSCⁱ	uc008fbx.1 mouse [Q8VHJ7-1] uc012bdq.1 mouse [Q8VHJ7-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8VHJ7	Peroxisome proliferator-activated receptor gamma coactivator 1-beta		RAT		1010	UniRef90_Q8VHJ7
Isoform 2 of Peroxisome proliferator-activated receptor gamma coactivator 1-beta		MOUSE		1030
Uncharacterized protein		NEOLE		983
UPI000A310363		MUSPA		1021
UPI000A3187D8		MUSCR		1000
+4

Protein	Similar proteins		Species	Score	Length	Source
Q8VHJ7	Peroxisome proliferator-activated receptor gamma coactivator 1-beta		RAT		1010	UniRef50_Q8VHJ7
Isoform 2 of Peroxisome proliferator-activated receptor gamma coactivator 1-beta		MOUSE		1030
Uncharacterized protein		NEOLE		983
peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform X2		DIPOR		980
Peroxisome proliferator-activated receptor gamma coactivator 1-beta		PTEAL		1026
+84

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF453324 mRNA Translation: AAL47054.1 AK028464 mRNA Translation: BAC25964.1
CCDSⁱ	CCDS29284.1 [Q8VHJ7-1]
RefSeqⁱ	NP_573512.1, NM_133249.2 [Q8VHJ7-1]
UniGeneⁱ	Mm.415302

3D structure databases

ProteinModelPortalⁱ	Q8VHJ7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	228460, 4 interactors
IntActⁱ	Q8VHJ7, 1 interactor
STRINGⁱ	10090.ENSMUSP00000074771

PTM databases

iPTMnetⁱ	Q8VHJ7
PhosphoSitePlusⁱ	Q8VHJ7

Proteomic databases

PaxDbⁱ	Q8VHJ7
PRIDEⁱ	Q8VHJ7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000063307; ENSMUSP00000069431; ENSMUSG00000033871 [Q8VHJ7-2] ENSMUST00000075299; ENSMUSP00000074771; ENSMUSG00000033871 [Q8VHJ7-1]
GeneIDⁱ	170826
KEGGⁱ	mmu:170826
UCSCⁱ	uc008fbx.1 mouse [Q8VHJ7-1] uc012bdq.1 mouse [Q8VHJ7-2]

Organism-specific databases

CTDⁱ	133522
MGIⁱ	MGI:2444934 Ppargc1b

Phylogenomic databases

eggNOGⁱ	ENOG410IIJJ Eukaryota ENOG4111PZ5 LUCA
GeneTreeⁱ	ENSGT00530000063196
HOGENOMⁱ	HOG000236356
HOVERGENⁱ	HBG080730
InParanoidⁱ	Q8VHJ7
KOⁱ	K17962
OMAⁱ	DYCQVLK
OrthoDBⁱ	EOG091G029M
PhylomeDBⁱ	Q8VHJ7
TreeFamⁱ	TF343068

Miscellaneous databases

ChiTaRSⁱ	Ppargc1b mouse
Protein Ontology More...PROⁱ	PR:Q8VHJ7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000033871 Expressed in 246 organ(s), highest expression level in brown adipose tissue
Genevisibleⁱ	Q8VHJ7 MM

Family and domain databases

CDDⁱ	cd12356 RRM_PPARGC1B, 1 hit
Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR034605 PGC-1 IPR034621 PGC-1beta IPR034177 PPARGC1B_RRM IPR035979 RBD_domain_sf IPR000504 RRM_dom
PANTHERⁱ	PTHR15528 PTHR15528, 1 hit PTHR15528:SF12 PTHR15528:SF12, 1 hit
Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PRGC2_MOUSE
Accessionⁱ	Q8VHJ7Primary (citable) accession number: Q8VHJ7 Secondary accession number(s): Q8C1C0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
	Last sequence update:	March 1, 2002
	Last modified:	November 7, 2018
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8VHJ7 (PRGC2_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Peroxisome proliferator-activated receptor gamma coactivator 1-beta

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Mitochondrion

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ