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Protein

Peroxisome proliferator-activated receptor gamma coactivator 1-beta

Gene

Ppargc1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta-oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Induces also the expression of mitochondrial genes involved in oxidative metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.4 Publications

Miscellaneous

Transgenic mice overexpressing PPARGC1B exhibits increased expression of medium-chain acyl CoA dehydrogenase. They are hyperphagic but lean, with increased energy expenditure and resistance to obesity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, RNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor gamma coactivator 1-beta
Short name:
PGC-1-beta
Short name:
PPAR-gamma coactivator 1-beta
Short name:
PPARGC-1-beta
Alternative name(s):
ERR ligand 1
Gene namesi
Name:Ppargc1b
Synonyms:Errl1, Pgc1, Pgc1b, Ppargc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2444934 Ppargc1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002401591 – 1014Peroxisome proliferator-activated receptor gamma coactivator 1-betaAdd BLAST1014

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei145PhosphoserineCombined sources1
Modified residuei148PhosphoserineCombined sources1
Modified residuei384PhosphoserineBy similarity1
Modified residuei519PhosphoserineBy similarity1
Modified residuei630PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8VHJ7
PRIDEiQ8VHJ7

PTM databases

iPTMnetiQ8VHJ7
PhosphoSitePlusiQ8VHJ7

Expressioni

Tissue specificityi

Ubiquitous with higher expression in heart, brown adipose tissue, brain and skeletal muscle.2 Publications

Inductioni

Induced by fasting in the liver, but not by cold exposure in brown adipose tissue. Induced also by saturated fatty acids in primary hepatocytes.2 Publications

Gene expression databases

BgeeiENSMUSG00000033871 Expressed in 246 organ(s), highest expression level in brown adipose tissue
GenevisibleiQ8VHJ7 MM

Interactioni

Subunit structurei

Interacts with estrogen receptor alpha/ESR1 (By similarity). Interacts with hepatocyte nuclear factor 4-alpha/HNF4A, Sterol regulatory binding transcription factor 1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16.By similarity6 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi228460, 4 interactors
IntActiQ8VHJ7, 1 interactor
STRINGi10090.ENSMUSP00000074771

Structurei

3D structure databases

ProteinModelPortaliQ8VHJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini893 – 967RRMPROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 91Abolishes DNA transcriptional activity when missingBy similarityAdd BLAST91

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi140 – 144LXXLL motif 15
Motifi156 – 160LXXLL motif 25
Motifi343 – 347LXXLL motif 35
Motifi683 – 686HCFC1-binding-motif (HBM)4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi246 – 250Poly-Glu5
Compositional biasi429 – 451Glu-richAdd BLAST23
Compositional biasi786 – 856Ser-richAdd BLAST71

Domaini

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IIJJ Eukaryota
ENOG4111PZ5 LUCA
GeneTreeiENSGT00530000063196
HOGENOMiHOG000236356
HOVERGENiHBG080730
InParanoidiQ8VHJ7
KOiK17962
OMAiDYCQVLK
OrthoDBiEOG091G029M
PhylomeDBiQ8VHJ7
TreeFamiTF343068

Family and domain databases

CDDicd12356 RRM_PPARGC1B, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034605 PGC-1
IPR034621 PGC-1beta
IPR034177 PPARGC1B_RRM
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR15528 PTHR15528, 1 hit
PTHR15528:SF12 PTHR15528:SF12, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8VHJ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGNDCGALL DEELSSFFLN YLSDTQGGDS GEEQLCADLP ELDLSQLDAS
60 70 80 90 100
DFDSATCFGE LQWCPETSET EPSQYSPDDS ELFQIDSENE ALLAALTKTL
110 120 130 140 150
DDIPEDDVGL AAFPELDEGD TPSCTPASPA PLSAPPSPTL ERLLSPASDV
160 170 180 190 200
DELSLLQKLL LATSSPTASS DALKDGATWS QTSLSSRSQR PCVKVDGTQD
210 220 230 240 250
KKTPTLRAQS RPCTELHKHL TSVLPCPRVK ACSPTPHPSP RLLSKEEEEE
260 270 280 290 300
VGEDCPSPWP TPASPQDSLA QDTASPDSAQ PPEEDVRAMV QLIRYMHTYC
310 320 330 340 350
LPQRKLPQRA PEPIPQACSS LSRQVQPRSR HPPKAFWTEF SILRELLAQD
360 370 380 390 400
ILCDVSKPYR LAIPVYASLT PQSRPRPPKD SQASPAHSAM AEEVRITASP
410 420 430 440 450
KSTGPRPSLR PLRLEVKRDV NKPTRQKREE DEEEEEEEEE EEEEKEEEEE
460 470 480 490 500
EWGRKRPGRG LPWTKLGRKM DSSVCPVRRS RRLNPELGPW LTFTDEPLGA
510 520 530 540 550
LPSMCLDTET HNLEEDLGSL TDSSQGRQLP QGSQIPALES PCESGCGDTD
560 570 580 590 600
EDPSCPQPTS RDSSRCLMLA LSQSDSLGKK SFEESLTVEL CGTAGLTPPT
610 620 630 640 650
TPPYKPMEED PFKPDTKLSP GQDTAPSLPS PEALPLTATP GASHKLPKRH
660 670 680 690 700
PERSELLSHL QHATTQPVSQ AGQKRPFSCS FGDHDYCQVL RPEAALQRKV
710 720 730 740 750
LRSWEPIGVH LEDLAQQGAP LPTETKAPRR EANQNCDPTH KDSMQLRDHE
760 770 780 790 800
IRASLTKHFG LLETALEGED LASCKSPEYD TVFEDSSSSS GESSFLLEEE
810 820 830 840 850
EEEEEGGEED DEGEDSGVSP PCSDHCPYQS PPSKASRQLC SRSRSSSGSS
860 870 880 890 900
SCSSWSPATR KNFRRESRGP CSDGTPSVRH ARKRREKAIG EGRVVYIRNL
910 920 930 940 950
SSDMSSRELK KRFEVFGEIV ECQVLTRSKR GQKHGFITFR CSEHAALSVR
960 970 980 990 1000
NGATLRKRNE PSFHLSYGGL RHFRWPRYTD YDPTSEESLP SSGKSKYEAM
1010
DFDSLLKEAQ QSLH
Length:1,014
Mass (Da):112,075
Last modified:March 1, 2002 - v1
Checksum:i004BCB7797EAFD1F
GO
Isoform 2 (identifier: Q8VHJ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MAGNDCGALLDEELSSFFLNYLSDTQ → MKSSRPSSSTISLTRRSAEGLEEVDHEALDRDGCGRRRLADM

Show »
Length:1,030
Mass (Da):113,898
Checksum:i4F2B27E32E91C84C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55A → P in BAC25964 (PubMed:16141072).Curated1
Sequence conflicti579K → R in BAC25964 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0193021 – 26MAGND…LSDTQ → MKSSRPSSSTISLTRRSAEG LEEVDHEALDRDGCGRRRLA DM in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453324 mRNA Translation: AAL47054.1
AK028464 mRNA Translation: BAC25964.1
CCDSiCCDS29284.1 [Q8VHJ7-1]
RefSeqiNP_573512.1, NM_133249.2 [Q8VHJ7-1]
UniGeneiMm.415302

Genome annotation databases

EnsembliENSMUST00000063307; ENSMUSP00000069431; ENSMUSG00000033871 [Q8VHJ7-2]
ENSMUST00000075299; ENSMUSP00000074771; ENSMUSG00000033871 [Q8VHJ7-1]
GeneIDi170826
KEGGimmu:170826
UCSCiuc008fbx.1 mouse [Q8VHJ7-1]
uc012bdq.1 mouse [Q8VHJ7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453324 mRNA Translation: AAL47054.1
AK028464 mRNA Translation: BAC25964.1
CCDSiCCDS29284.1 [Q8VHJ7-1]
RefSeqiNP_573512.1, NM_133249.2 [Q8VHJ7-1]
UniGeneiMm.415302

3D structure databases

ProteinModelPortaliQ8VHJ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228460, 4 interactors
IntActiQ8VHJ7, 1 interactor
STRINGi10090.ENSMUSP00000074771

PTM databases

iPTMnetiQ8VHJ7
PhosphoSitePlusiQ8VHJ7

Proteomic databases

PaxDbiQ8VHJ7
PRIDEiQ8VHJ7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063307; ENSMUSP00000069431; ENSMUSG00000033871 [Q8VHJ7-2]
ENSMUST00000075299; ENSMUSP00000074771; ENSMUSG00000033871 [Q8VHJ7-1]
GeneIDi170826
KEGGimmu:170826
UCSCiuc008fbx.1 mouse [Q8VHJ7-1]
uc012bdq.1 mouse [Q8VHJ7-2]

Organism-specific databases

CTDi133522
MGIiMGI:2444934 Ppargc1b

Phylogenomic databases

eggNOGiENOG410IIJJ Eukaryota
ENOG4111PZ5 LUCA
GeneTreeiENSGT00530000063196
HOGENOMiHOG000236356
HOVERGENiHBG080730
InParanoidiQ8VHJ7
KOiK17962
OMAiDYCQVLK
OrthoDBiEOG091G029M
PhylomeDBiQ8VHJ7
TreeFamiTF343068

Miscellaneous databases

ChiTaRSiPpargc1b mouse
PROiPR:Q8VHJ7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033871 Expressed in 246 organ(s), highest expression level in brown adipose tissue
GenevisibleiQ8VHJ7 MM

Family and domain databases

CDDicd12356 RRM_PPARGC1B, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034605 PGC-1
IPR034621 PGC-1beta
IPR034177 PPARGC1B_RRM
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR15528 PTHR15528, 1 hit
PTHR15528:SF12 PTHR15528:SF12, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRGC2_MOUSE
AccessioniPrimary (citable) accession number: Q8VHJ7
Secondary accession number(s): Q8C1C0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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