UniProtKB - Q8VHJ7 (PRGC2_MOUSE)
Protein
Peroxisome proliferator-activated receptor gamma coactivator 1-beta
Gene
Ppargc1b
Organism
Mus musculus (Mouse)
Status
Functioni
Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta-oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Induces also the expression of mitochondrial genes involved in oxidative metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.4 Publications
Miscellaneous
Transgenic mice overexpressing PPARGC1B exhibits increased expression of medium-chain acyl CoA dehydrogenase. They are hyperphagic but lean, with increased energy expenditure and resistance to obesity.
GO - Molecular functioni
- AF-2 domain binding Source: UniProtKB
- estrogen receptor binding Source: MGI
- nuclear receptor transcription coactivator activity Source: UniProtKB
- RNA binding Source: UniProtKB-KW
- transcription coregulator activity Source: MGI
- transcription factor binding Source: GO_Central
GO - Biological processi
- actin filament organization Source: DFLAT
- bone trabecula formation Source: DFLAT
- cellular response to reactive oxygen species Source: DFLAT
- intracellular estrogen receptor signaling pathway Source: UniProtKB
- mitochondrial transcription Source: DFLAT
- negative regulation of transcription, DNA-templated Source: DFLAT
- ossification Source: DFLAT
- positive regulation of alkaline phosphatase activity Source: DFLAT
- positive regulation of bone resorption Source: DFLAT
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of DNA-binding transcription factor activity Source: GO_Central
- positive regulation of osteoclast differentiation Source: DFLAT
- positive regulation of phosphorylation Source: DFLAT
- positive regulation of transcription, DNA-templated Source: DFLAT
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- response to cAMP Source: Ensembl
- response to glucocorticoid Source: Ensembl
Keywordsi
Molecular function | Activator, RNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Peroxisome proliferator-activated receptor gamma coactivator 1-betaShort name: PGC-1-beta Short name: PPAR-gamma coactivator 1-beta Short name: PPARGC-1-beta Alternative name(s): ERR ligand 1 |
Gene namesi | Name:Ppargc1b Synonyms:Errl1, Pgc1, Pgc1b, Ppargc1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2444934, Ppargc1b |
Subcellular locationi
Nucleus
- Nucleus By similarity
Mitochondrion
- mitochondrion Source: GOC
Nucleus
- mediator complex Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000240159 | 1 – 1014 | Peroxisome proliferator-activated receptor gamma coactivator 1-betaAdd BLAST | 1014 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 145 | PhosphoserineCombined sources | 1 | |
Modified residuei | 148 | PhosphoserineCombined sources | 1 | |
Modified residuei | 384 | PhosphoserineBy similarity | 1 | |
Modified residuei | 519 | PhosphoserineBy similarity | 1 | |
Modified residuei | 630 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q8VHJ7 |
PRIDEi | Q8VHJ7 |
PTM databases
iPTMneti | Q8VHJ7 |
PhosphoSitePlusi | Q8VHJ7 |
Expressioni
Tissue specificityi
Ubiquitous with higher expression in heart, brown adipose tissue, brain and skeletal muscle.2 Publications
Inductioni
Induced by fasting in the liver, but not by cold exposure in brown adipose tissue. Induced also by saturated fatty acids in primary hepatocytes.2 Publications
Gene expression databases
Bgeei | ENSMUSG00000033871, Expressed in brown adipose tissue and 260 other tissues |
Genevisiblei | Q8VHJ7, MM |
Interactioni
Subunit structurei
Interacts with estrogen receptor alpha/ESR1 (By similarity).
Interacts with hepatocyte nuclear factor 4-alpha/HNF4A, Sterol regulatory binding transcription factor 1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1.
Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA.
Interacts with PRDM16.
By similarity6 PublicationsGO - Molecular functioni
- AF-2 domain binding Source: UniProtKB
- estrogen receptor binding Source: MGI
- transcription factor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 228460, 6 interactors |
IntActi | Q8VHJ7, 1 interactor |
STRINGi | 10090.ENSMUSP00000074771 |
Miscellaneous databases
RNActi | Q8VHJ7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 893 – 967 | RRMPROSITE-ProRule annotationAdd BLAST | 75 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 91 | Abolishes DNA transcriptional activity when missingBy similarityAdd BLAST | 91 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 140 – 144 | LXXLL motif 1 | 5 | |
Motifi | 156 – 160 | LXXLL motif 2 | 5 | |
Motifi | 343 – 347 | LXXLL motif 3 | 5 | |
Motifi | 683 – 686 | HCFC1-binding-motif (HBM) | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 246 – 250 | Poly-Glu | 5 | |
Compositional biasi | 429 – 451 | Glu-richAdd BLAST | 23 | |
Compositional biasi | 786 – 856 | Ser-richAdd BLAST | 71 |
Domaini
Contains 3 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors.By similarity
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QTA7, Eukaryota |
GeneTreei | ENSGT00950000183137 |
HOGENOMi | CLU_014202_0_0_1 |
InParanoidi | Q8VHJ7 |
OMAi | KPYRLHS |
PhylomeDBi | Q8VHJ7 |
TreeFami | TF343068 |
Family and domain databases
CDDi | cd12356, RRM_PPARGC1B, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR034605, PGC-1 IPR034621, PGC-1beta IPR034177, PPARGC1B_RRM IPR035979, RBD_domain_sf IPR000504, RRM_dom |
PANTHERi | PTHR15528, PTHR15528, 1 hit PTHR15528:SF12, PTHR15528:SF12, 1 hit |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8VHJ7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGNDCGALL DEELSSFFLN YLSDTQGGDS GEEQLCADLP ELDLSQLDAS
60 70 80 90 100
DFDSATCFGE LQWCPETSET EPSQYSPDDS ELFQIDSENE ALLAALTKTL
110 120 130 140 150
DDIPEDDVGL AAFPELDEGD TPSCTPASPA PLSAPPSPTL ERLLSPASDV
160 170 180 190 200
DELSLLQKLL LATSSPTASS DALKDGATWS QTSLSSRSQR PCVKVDGTQD
210 220 230 240 250
KKTPTLRAQS RPCTELHKHL TSVLPCPRVK ACSPTPHPSP RLLSKEEEEE
260 270 280 290 300
VGEDCPSPWP TPASPQDSLA QDTASPDSAQ PPEEDVRAMV QLIRYMHTYC
310 320 330 340 350
LPQRKLPQRA PEPIPQACSS LSRQVQPRSR HPPKAFWTEF SILRELLAQD
360 370 380 390 400
ILCDVSKPYR LAIPVYASLT PQSRPRPPKD SQASPAHSAM AEEVRITASP
410 420 430 440 450
KSTGPRPSLR PLRLEVKRDV NKPTRQKREE DEEEEEEEEE EEEEKEEEEE
460 470 480 490 500
EWGRKRPGRG LPWTKLGRKM DSSVCPVRRS RRLNPELGPW LTFTDEPLGA
510 520 530 540 550
LPSMCLDTET HNLEEDLGSL TDSSQGRQLP QGSQIPALES PCESGCGDTD
560 570 580 590 600
EDPSCPQPTS RDSSRCLMLA LSQSDSLGKK SFEESLTVEL CGTAGLTPPT
610 620 630 640 650
TPPYKPMEED PFKPDTKLSP GQDTAPSLPS PEALPLTATP GASHKLPKRH
660 670 680 690 700
PERSELLSHL QHATTQPVSQ AGQKRPFSCS FGDHDYCQVL RPEAALQRKV
710 720 730 740 750
LRSWEPIGVH LEDLAQQGAP LPTETKAPRR EANQNCDPTH KDSMQLRDHE
760 770 780 790 800
IRASLTKHFG LLETALEGED LASCKSPEYD TVFEDSSSSS GESSFLLEEE
810 820 830 840 850
EEEEEGGEED DEGEDSGVSP PCSDHCPYQS PPSKASRQLC SRSRSSSGSS
860 870 880 890 900
SCSSWSPATR KNFRRESRGP CSDGTPSVRH ARKRREKAIG EGRVVYIRNL
910 920 930 940 950
SSDMSSRELK KRFEVFGEIV ECQVLTRSKR GQKHGFITFR CSEHAALSVR
960 970 980 990 1000
NGATLRKRNE PSFHLSYGGL RHFRWPRYTD YDPTSEESLP SSGKSKYEAM
1010
DFDSLLKEAQ QSLH
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 55 | A → P in BAC25964 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 579 | K → R in BAC25964 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_019302 | 1 – 26 | MAGND…LSDTQ → MKSSRPSSSTISLTRRSAEG LEEVDHEALDRDGCGRRRLA DM in isoform 2. 1 PublicationAdd BLAST | 26 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF453324 mRNA Translation: AAL47054.1 AK028464 mRNA Translation: BAC25964.1 |
CCDSi | CCDS29284.1 [Q8VHJ7-1] CCDS89250.1 [Q8VHJ7-2] |
RefSeqi | NP_573512.1, NM_133249.2 [Q8VHJ7-1] |
Genome annotation databases
Ensembli | ENSMUST00000063307; ENSMUSP00000069431; ENSMUSG00000033871 [Q8VHJ7-2] ENSMUST00000075299; ENSMUSP00000074771; ENSMUSG00000033871 [Q8VHJ7-1] |
GeneIDi | 170826 |
KEGGi | mmu:170826 |
UCSCi | uc008fbx.1, mouse [Q8VHJ7-1] uc012bdq.1, mouse [Q8VHJ7-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF453324 mRNA Translation: AAL47054.1 AK028464 mRNA Translation: BAC25964.1 |
CCDSi | CCDS29284.1 [Q8VHJ7-1] CCDS89250.1 [Q8VHJ7-2] |
RefSeqi | NP_573512.1, NM_133249.2 [Q8VHJ7-1] |
3D structure databases
SMRi | Q8VHJ7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 228460, 6 interactors |
IntActi | Q8VHJ7, 1 interactor |
STRINGi | 10090.ENSMUSP00000074771 |
PTM databases
iPTMneti | Q8VHJ7 |
PhosphoSitePlusi | Q8VHJ7 |
Proteomic databases
PaxDbi | Q8VHJ7 |
PRIDEi | Q8VHJ7 |
Protocols and materials databases
Antibodypediai | 27863, 96 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000063307; ENSMUSP00000069431; ENSMUSG00000033871 [Q8VHJ7-2] ENSMUST00000075299; ENSMUSP00000074771; ENSMUSG00000033871 [Q8VHJ7-1] |
GeneIDi | 170826 |
KEGGi | mmu:170826 |
UCSCi | uc008fbx.1, mouse [Q8VHJ7-1] uc012bdq.1, mouse [Q8VHJ7-2] |
Organism-specific databases
CTDi | 133522 |
MGIi | MGI:2444934, Ppargc1b |
Phylogenomic databases
eggNOGi | ENOG502QTA7, Eukaryota |
GeneTreei | ENSGT00950000183137 |
HOGENOMi | CLU_014202_0_0_1 |
InParanoidi | Q8VHJ7 |
OMAi | KPYRLHS |
PhylomeDBi | Q8VHJ7 |
TreeFami | TF343068 |
Miscellaneous databases
BioGRID-ORCSi | 170826, 1 hit in 18 CRISPR screens |
ChiTaRSi | Ppargc1b, mouse |
PROi | PR:Q8VHJ7 |
RNActi | Q8VHJ7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000033871, Expressed in brown adipose tissue and 260 other tissues |
Genevisiblei | Q8VHJ7, MM |
Family and domain databases
CDDi | cd12356, RRM_PPARGC1B, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR034605, PGC-1 IPR034621, PGC-1beta IPR034177, PPARGC1B_RRM IPR035979, RBD_domain_sf IPR000504, RRM_dom |
PANTHERi | PTHR15528, PTHR15528, 1 hit PTHR15528:SF12, PTHR15528:SF12, 1 hit |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRGC2_MOUSE | |
Accessioni | Q8VHJ7Primary (citable) accession number: Q8VHJ7 Secondary accession number(s): Q8C1C0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 13, 2006 |
Last sequence update: | March 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot