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Protein

Vesicle transport protein SEC20

Gene

Bnip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Required for maintenance of ER network. Implicated in the suppression of cell death. May be involved in mitochondrial autophagy (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, Autophagy, ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport protein SEC20
Gene namesi
Name:Bnip1Imported
Synonyms:Sec20l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620799 Bnip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 199CytoplasmicSequence analysisAdd BLAST199
Transmembranei200 – 220Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini221 – 228LumenalSequence analysis8

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002324181 – 228Vesicle transport protein SEC20Add BLAST228

Post-translational modificationi

'Lys-63'-linked polyubiquitination by RNF185 allows recruiting of autophagy receptor SQSTM1, which simultaneously binds both ubiquitin and LC3 to link ubiquitination and autophagy.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ8VHI8
PRIDEiQ8VHI8

PTM databases

PhosphoSitePlusiQ8VHI8

Expressioni

Gene expression databases

BgeeiENSRNOG00000020753
GenevisibleiQ8VHI8 RN

Interactioni

Subunit structurei

Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18, RINT1/TIP20L and NAPA. Interacts with ZW10 through RINT1. Interacts with BCL2 and adenovirus E1B protein (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8VHI8, 1 interactor
STRINGi10116.ENSRNOP00000028173

Structurei

3D structure databases

SMRiQ8VHI8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili37 – 90Sequence analysisAdd BLAST54

Sequence similaritiesi

Belongs to the SEC20 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE4Q Eukaryota
ENOG4111Q80 LUCA
GeneTreeiENSGT00390000014412
HOGENOMiHOG000007218
HOVERGENiHBG050708
InParanoidiQ8VHI8
KOiK08497
OMAiCVFYIVQ
OrthoDBiEOG091G0T5O
PhylomeDBiQ8VHI8
TreeFamiTF324339

Family and domain databases

InterProiView protein in InterPro
IPR005606 Sec20
PfamiView protein in Pfam
PF03908 Sec20, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VHI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPQDVHVR ICNQEIVKFD LEVKALIQDI RDCSGPLSEL TELNTKVKEK
60 70 80 90 100
FQQLKHRIQE LEQSAKEQDK ESEKQLLLQE VENHKKQMLS NQTSWRKANL
110 120 130 140 150
TCKLAIDNLE KAELLQGGDS LRQRKTTKES LAQTSSTITE SLMGISRMMS
160 170 180 190 200
QQVQQSEEAM QTLVSSSRTL LDANEEFKSM SGTIQLGRKL ITKYNRRELT
210 220
DKLLIFLALA LFLATVLYIV KKRLFPFL
Length:228
Mass (Da):26,170
Last modified:March 1, 2002 - v1
Checksum:i5F2CFED85E18824E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454391 mRNA Translation: AAL50991.1
RefSeqiNP_543173.1, NM_080897.1
UniGeneiRn.16757

Genome annotation databases

EnsembliENSRNOT00000028173; ENSRNOP00000028173; ENSRNOG00000020753
GeneIDi140932
KEGGirno:140932
UCSCiRGD:620799 rat

Similar proteinsi

Entry informationi

Entry nameiSEC20_RAT
AccessioniPrimary (citable) accession number: Q8VHI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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