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Protein

Wiskott-Aldrich syndrome protein family member 3

Gene

Wasf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs

Names & Taxonomyi

Protein namesi
Recommended name:
Wiskott-Aldrich syndrome protein family member 3
Short name:
WASP family protein member 3
Alternative name(s):
Protein WAVE-3
Gene namesi
Name:Wasf3
Synonyms:Wave3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2658986 Wasf3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001889971 – 501Wiskott-Aldrich syndrome protein family member 3Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei151Phosphotyrosine; by ABL1By similarity1
Modified residuei248Phosphotyrosine; by ABL1By similarity1
Modified residuei337Phosphotyrosine; by ABL1By similarity1
Modified residuei485Phosphotyrosine; by ABL1By similarity1

Post-translational modificationi

Phosphorylation by ABL1 promotes lamellipodia formation and cell migration.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VHI6
PaxDbiQ8VHI6
PRIDEiQ8VHI6

PTM databases

iPTMnetiQ8VHI6
PhosphoSitePlusiQ8VHI6

Expressioni

Gene expression databases

BgeeiENSMUSG00000029636 Expressed in 213 organ(s), highest expression level in ventral tegmental area
CleanExiMM_WASF3
GenevisibleiQ8VHI6 MM

Interactioni

Subunit structurei

Binds actin and the Arp2/3 complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi232846, 1 interactor
IntActiQ8VHI6, 1 interactor
MINTiQ8VHI6
STRINGi10090.ENSMUSP00000016143

Structurei

3D structure databases

ProteinModelPortaliQ8VHI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini439 – 456WH2PROSITE-ProRule annotationAdd BLAST18

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili57 – 93Sequence analysisAdd BLAST37
Coiled coili162 – 206Sequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi304 – 310Poly-Pro7
Compositional biasi343 – 350Poly-Pro8
Compositional biasi395 – 410Poly-ProAdd BLAST16

Domaini

Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.

Sequence similaritiesi

Belongs to the SCAR/WAVE family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1830 Eukaryota
ENOG410XRBQ LUCA
GeneTreeiENSGT00730000110593
HOGENOMiHOG000021456
HOVERGENiHBG058482
InParanoidiQ8VHI6
KOiK06083
OMAiQPHNTRE
OrthoDBiEOG091G08O1
PhylomeDBiQ8VHI6
TreeFamiTF315031

Family and domain databases

InterProiView protein in InterPro
IPR028288 SCAR/WAVE_fam
IPR003124 WH2_dom
PANTHERiPTHR12902 PTHR12902, 1 hit
PfamiView protein in Pfam
PF02205 WH2, 1 hit
SMARTiView protein in SMART
SM00246 WH2, 1 hit
PROSITEiView protein in PROSITE
PS51082 WH2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VHI6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLVKRNIEP RHLCRGALPE GVTSELECVT NSTLAAIIRQ LSSLSKHAED
60 70 80 90 100
IFGELFNEAN NFYIRANSLQ DRIDRLAVKV TQLDSTVEEV SLQDINMKKA
110 120 130 140 150
FKSSTIQDQQ VVSKNSIPNP VADIYNQSDK PPPLSILTPY RDDKKDGLKF
160 170 180 190 200
YTDPSYFFDL WKEKMLQDTE DKRKEKRRQK EQKRVDGTTR EVKKVRKARN
210 220 230 240 250
RRQEWNMMAY DKELRPDNRL SQSVHHGASS EGSLSPDTRS HTSDVTDYSY
260 270 280 290 300
PATPNHALQA QPATPSYTAG DAPLHGTTNQ GAEHEYRPSS ASARHMALNR
310 320 330 340 350
PQQPPPPPPP QAPEGSQAST SVAPADYGML PAQIIEYYSP SGPPPPPPPP
360 370 380 390 400
MIPSAQTAFV SPLQMPTQPP FPASAVSTYP TPPHQPSTGL LATAPPPPGP
410 420 430 440 450
PPPPPGPPGP SSLSSSPMHG PPVAEAKRPE PAQPPISDAR SDLLAAIRMG
460 470 480 490 500
IQLKKVQEQR EQEAKREPVG NDVATILSRR IAVEYSDSDD DSEFDENDWS

D
Length:501
Mass (Da):55,204
Last modified:March 1, 2002 - v1
Checksum:iFD30EEC6867D4AF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454703 mRNA Translation: AAL51033.1
BC027038 mRNA Translation: AAH27038.1
CCDSiCCDS19870.1
RefSeqiNP_660137.1, NM_145155.3
XP_006504896.1, XM_006504833.3
UniGeneiMm.472750

Genome annotation databases

EnsembliENSMUST00000016143; ENSMUSP00000016143; ENSMUSG00000029636
GeneIDi245880
KEGGimmu:245880
UCSCiuc009anf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454703 mRNA Translation: AAL51033.1
BC027038 mRNA Translation: AAH27038.1
CCDSiCCDS19870.1
RefSeqiNP_660137.1, NM_145155.3
XP_006504896.1, XM_006504833.3
UniGeneiMm.472750

3D structure databases

ProteinModelPortaliQ8VHI6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232846, 1 interactor
IntActiQ8VHI6, 1 interactor
MINTiQ8VHI6
STRINGi10090.ENSMUSP00000016143

PTM databases

iPTMnetiQ8VHI6
PhosphoSitePlusiQ8VHI6

Proteomic databases

MaxQBiQ8VHI6
PaxDbiQ8VHI6
PRIDEiQ8VHI6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000016143; ENSMUSP00000016143; ENSMUSG00000029636
GeneIDi245880
KEGGimmu:245880
UCSCiuc009anf.1 mouse

Organism-specific databases

CTDi10810
MGIiMGI:2658986 Wasf3

Phylogenomic databases

eggNOGiKOG1830 Eukaryota
ENOG410XRBQ LUCA
GeneTreeiENSGT00730000110593
HOGENOMiHOG000021456
HOVERGENiHBG058482
InParanoidiQ8VHI6
KOiK06083
OMAiQPHNTRE
OrthoDBiEOG091G08O1
PhylomeDBiQ8VHI6
TreeFamiTF315031

Enzyme and pathway databases

ReactomeiR-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs

Miscellaneous databases

ChiTaRSiWasf3 mouse
PROiPR:Q8VHI6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029636 Expressed in 213 organ(s), highest expression level in ventral tegmental area
CleanExiMM_WASF3
GenevisibleiQ8VHI6 MM

Family and domain databases

InterProiView protein in InterPro
IPR028288 SCAR/WAVE_fam
IPR003124 WH2_dom
PANTHERiPTHR12902 PTHR12902, 1 hit
PfamiView protein in Pfam
PF02205 WH2, 1 hit
SMARTiView protein in SMART
SM00246 WH2, 1 hit
PROSITEiView protein in PROSITE
PS51082 WH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWASF3_MOUSE
AccessioniPrimary (citable) accession number: Q8VHI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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