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Protein

Calcium-responsive transcription factor

Gene

Carf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-responsive transcription factor
Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein
Calcium-response factor
Short name:
CaRF
Gene namesi
Name:Carf
Synonyms:Als2cr8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2182269 Carf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000761731 – 689Calcium-responsive transcription factorAdd BLAST689

Proteomic databases

PaxDbiQ8VHI4
PRIDEiQ8VHI4

PTM databases

iPTMnetiQ8VHI4
PhosphoSitePlusiQ8VHI4

Expressioni

Tissue specificityi

Highly expressed in brain and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000026017 Expressed in 229 organ(s), highest expression level in pineal body
CleanExiMM_CARF
ExpressionAtlasiQ8VHI4 baseline and differential
GenevisibleiQ8VHI4 MM

Interactioni

Protein-protein interaction databases

BioGridi232270, 1 interactor
STRINGi10090.ENSMUSP00000027171

Structurei

3D structure databases

ProteinModelPortaliQ8VHI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminus is necessary for DNA-binding. The C-terminus is necessary for transcriptional activation.

Phylogenomic databases

eggNOGiENOG410II1S Eukaryota
ENOG410XRIT LUCA
GeneTreeiENSGT00390000013916
HOGENOMiHOG000033888
HOVERGENiHBG080829
InParanoidiQ8VHI4
KOiK21595
OMAiTCMDSRD
OrthoDBiEOG091G0M3G
PhylomeDBiQ8VHI4
TreeFamiTF333279

Family and domain databases

InterProiView protein in InterPro
IPR029309 CaRF
PfamiView protein in Pfam
PF15299 ALS2CR8, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8VHI4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQRHSLAGN CDDGEKSERE AQGFEHRTCM DSGDPSFGQN DPPTILPITA
60 70 80 90 100
PKTYDSLTSQ DMPETLTDTQ ALHEEQFHLL DQNGQPIQYD LQSLGNSTAQ
110 120 130 140 150
MTGMEQVAIP QEPFADEHSP QDISEEKPTG VRADVLEDST SNYGLRSPAS
160 170 180 190 200
LVLPKKAGAR LVEEPLLAPL QPLSCNTPMW ACRLRSCEKI GDSYRGYCVS
210 220 230 240 250
ETELESVLTF HKQQTQTVWG TRQSPSPAKP ATRLMWKSQY VPYDGIPFVN
260 270 280 290 300
AGSRAVVMEC QYGPRRKGFQ LKKISEQESR SCHLYKATCP ARIYIKKVQK
310 320 330 340 350
FPEYRVPTDP QIDRKIIRLE QEKAFTMLKK NLMDAGGVLR WYVQLPTQQA
360 370 380 390 400
HQYHESETPG VPLSPSPFPM SPLEEEEAIV RDENCALPSR LHPQVAHKIQ
410 420 430 440 450
ELVSQGVGQV YAVRKQLRKF VERELFKPDE IPERHNLSYF PTVNDIKNHI
460 470 480 490 500
HEVQKSLRTG DVVYNSEIIP ATLQWTTDSG NILRETVTVT FAEGNLLGEP
510 520 530 540 550
IPSKMGTSQT QTAVSPEPLS SFPPKIFTHF QALKLQPRLS SPDGSQALVS
560 570 580 590 600
VDSHASSSPP GLVDTVGNAE VDNHSVLLGQ SQNPGTDTCL TQDNSTSSST
610 620 630 640 650
GHLPESVPNP VAEDQLLEGE DVEDAGNPEG SVNRTLLGDV QTVPIQIIDS
660 670 680
RPVLVEESLS KNQVKQETNE PTLSTEAKTF LDCKKISAT
Length:689
Mass (Da):76,397
Last modified:March 1, 2002 - v1
Checksum:i34CFCD3B37D0B342
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8VI08A8VI08_MOUSE
Calcium-responsive transcription fa...
Carf
654Annotation score:
D3Z2W4D3Z2W4_MOUSE
Calcium-responsive transcription fa...
Carf
79Annotation score:
A8VI09A8VI09_MOUSE
Calcium-responsive transcription fa...
Carf
255Annotation score:
A0A087WPQ8A0A087WPQ8_MOUSE
Calcium-responsive transcription fa...
Carf
55Annotation score:
M0QWJ8M0QWJ8_MOUSE
Calcium-responsive transcription fa...
Carf
87Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454947 mRNA Translation: AAL62331.1
BC138644 mRNA Translation: AAI38645.1
BC138645 mRNA Translation: AAI38646.1
CCDSiCCDS14989.1
RefSeqiNP_001272402.1, NM_001285473.1
NP_631889.1, NM_139150.5
XP_011236812.1, XM_011238510.1
XP_017176083.1, XM_017320594.1
UniGeneiMm.276441
Mm.370325

Genome annotation databases

EnsembliENSMUST00000180952; ENSMUSP00000137825; ENSMUSG00000026017
ENSMUST00000187978; ENSMUSP00000141169; ENSMUSG00000026017
GeneIDi241066
KEGGimmu:241066
UCSCiuc007beh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454947 mRNA Translation: AAL62331.1
BC138644 mRNA Translation: AAI38645.1
BC138645 mRNA Translation: AAI38646.1
CCDSiCCDS14989.1
RefSeqiNP_001272402.1, NM_001285473.1
NP_631889.1, NM_139150.5
XP_011236812.1, XM_011238510.1
XP_017176083.1, XM_017320594.1
UniGeneiMm.276441
Mm.370325

3D structure databases

ProteinModelPortaliQ8VHI4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232270, 1 interactor
STRINGi10090.ENSMUSP00000027171

PTM databases

iPTMnetiQ8VHI4
PhosphoSitePlusiQ8VHI4

Proteomic databases

PaxDbiQ8VHI4
PRIDEiQ8VHI4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000180952; ENSMUSP00000137825; ENSMUSG00000026017
ENSMUST00000187978; ENSMUSP00000141169; ENSMUSG00000026017
GeneIDi241066
KEGGimmu:241066
UCSCiuc007beh.2 mouse

Organism-specific databases

CTDi79800
MGIiMGI:2182269 Carf

Phylogenomic databases

eggNOGiENOG410II1S Eukaryota
ENOG410XRIT LUCA
GeneTreeiENSGT00390000013916
HOGENOMiHOG000033888
HOVERGENiHBG080829
InParanoidiQ8VHI4
KOiK21595
OMAiTCMDSRD
OrthoDBiEOG091G0M3G
PhylomeDBiQ8VHI4
TreeFamiTF333279

Miscellaneous databases

PROiPR:Q8VHI4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026017 Expressed in 229 organ(s), highest expression level in pineal body
CleanExiMM_CARF
ExpressionAtlasiQ8VHI4 baseline and differential
GenevisibleiQ8VHI4 MM

Family and domain databases

InterProiView protein in InterPro
IPR029309 CaRF
PfamiView protein in Pfam
PF15299 ALS2CR8, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCARTF_MOUSE
AccessioniPrimary (citable) accession number: Q8VHI4
Secondary accession number(s): B2RRZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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