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Entry version 129 (18 Sep 2019)
Sequence version 3 (24 Jul 2007)
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Protein

Angiomotin

Gene

Amot

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions (By similarity).By similarity

Miscellaneous

'Motus' means 'motility' in Latin.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2028269 Signaling by Hippo

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Angiomotin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Amot
Synonyms:Kiaa1071
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:108440 Amot

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Tight junction

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001906691 – 1126AngiomotinAdd BLAST1126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki573Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki574Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei693PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyubiquitinated by NEDD4, NEDD4L and ITCH, leading to proteasomal degradation.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8VHG2

PeptideAtlas

More...
PeptideAtlasi
Q8VHG2

PRoteomics IDEntifications database

More...
PRIDEi
Q8VHG2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8VHG2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8VHG2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, skeletal muscle and placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000041688 Expressed in 288 organ(s), highest expression level in placenta labyrinth

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8VHG2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8VHG2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, PATJ and PARD3/PAR3.

Interacts with MAGI1 and angiostatin (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
205274, 17 interactors

Protein interaction database and analysis system

More...
IntActi
Q8VHG2, 9 interactors

Molecular INTeraction database

More...
MINTi
Q8VHG2

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000108455

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8VHG2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili408 – 668Sequence analysisAdd BLAST261
Coiled coili700 – 730Sequence analysisAdd BLAST31

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1123 – 1126PDZ-bindingBy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi855 – 988Ala-richAdd BLAST134

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The angiostatin binding domain (850-1047) allows the binding to angiostatin.
The coiled coil domain interacts directly with the BAR domain of ARHGAP17.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the angiomotin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJU5 Eukaryota
ENOG410XSY2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159055

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8VHG2

KEGG Orthology (KO)

More...
KOi
K16819

Identification of Orthologs from Complete Genome Data

More...
OMAi
TDGPVFH

Database of Orthologous Groups

More...
OrthoDBi
369983at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8VHG2

TreeFam database of animal gene trees

More...
TreeFami
TF333368

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009114 Angiomotin
IPR024646 Angiomotin_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12240 Angiomotin_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01807 ANGIOMOTIN

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8VHG2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSSDDQPSG GTTVLQRLLQ EQLRYGNPSE NRSLLAIHQQ ATGNSSPFST
60 70 80 90 100
GSGNQGPQND VLSSQDHHQQ QLVAHPARQE PQGQEIQSEN GVMEKQLSPR
110 120 130 140 150
MQNNEELPTY EEAKVQSQYF RGQQHASVGA AFYVTGVTNQ KMRTEGRPSV
160 170 180 190 200
QRLTPGKMHQ DEGLRDLKQG HVRSLSERLM QMSLATSGVK AHPPVTSAPL
210 220 230 240 250
SPPQPNDLYK NATSSSEFYK AQGPPPSQHS LKGMEHRGPP PEYPFKGVPS
260 270 280 290 300
QSVVCKSQEP GHFYSEHRLN QPGRTEGQLM RYQHPPEYGA ARATQDISSL
310 320 330 340 350
SLSARNSQPH SPTSSLTAGA SSLPLLQSPP STRLPPGQHL VSNQGDHSAH
360 370 380 390 400
LSRHQQHLLS SQSHQGDHYR HAQASLTSAQ QQPGEAYSAM PRAQQSASYQ
410 420 430 440 450
PMPADPFAMV SRAQQMVEIL SDENRNLRQE LDGCYEKVAR LQKVETEIQR
460 470 480 490 500
VSEAYENLVK SSSKREALEK AMRNKLEGEI RRMHDFNRDL RDRLETANKQ
510 520 530 540 550
LAEKEYEGSE DTRKTISQLF AKHKENQREK EKLEAELATA RSTNEDQRRH
560 570 580 590 600
IEIRDQALSN AQAKVVKLEE ELKKKQVYVD KVEKMQQALV QLQAACEKRE
610 620 630 640 650
QLEHRLRTRL ERELESLRIQ QRQGNSQPTN ASEYNAAALM ELLREKEERI
660 670 680 690 700
LALEADMTKW EQKYLEENVM RHFALDAAAT VAAQRDTTVI SHSPNTSYDT
710 720 730 740 750
ALEARIQKEE EEILMANKRC LDMEGRIKTL HAQIIEKDAM IKVLQQRSRK
760 770 780 790 800
EPSKTEQLSS MRPAKSLMSI SNAGSGLLAH SSTLTGAPIM EEKRDDKSWK
810 820 830 840 850
GSLGVLLGGD YRVEPVPSTP SPVPPSTPLL SAHSKTGSRD CSTQTERGPE
860 870 880 890 900
STKTAAVTPI SAPMAGPVAA AAPAAAINAT AATNTATAAT NTTIMVAAAP
910 920 930 940 950
VAVAAVAAPA AAAATPSPAN AAALAAAAAP ATSVSAATSV SAANSISPAA
960 970 980 990 1000
PVAPAAVVPP AAPVSPAAAV QIPAAASLTP ATVSPTAATA TAAVAAATTA
1010 1020 1030 1040 1050
AITAAAAAAT TAIQVAPATS APVPSPASIP APATAQASAP TPTQASTPAP
1060 1070 1080 1090 1100
TEPPSPVPTP TPALVQTEGP ANPGASSGPR RLSTPNLMCN PDKPDAPAFH
1110 1120
SSTLERKTPI QILGQEPDAE MVEYLI
Length:1,126
Mass (Da):120,915
Last modified:July 24, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i530D84854E943CD4
GO
Isoform 2 (identifier: Q8VHG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     805-853: VLLGGDYRVE...QTERGPESTK → KEKESNRSKG...ESPLSMELDL
     854-1126: Missing.

Show »
Length:853
Mass (Da):95,963
Checksum:i75463F4AC487A03D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AXE9B1AXE9_MOUSE
Angiomotin
Amot
522Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6QYS7F6QYS7_MOUSE
Angiomotin
Amot
929Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YMV1F6YMV1_MOUSE
Angiomotin
Amot
672Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A067XG49A0A067XG49_MOUSE
Angiomotin
Amot
737Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH57638 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL73436 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAM22158 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAM22159 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti298S → Y in AAL73436 (PubMed:12406577).Curated1
Sequence conflicti342S → P in AAL73436 (PubMed:12406577).Curated1
Sequence conflicti342S → P in AAH57638 (PubMed:15489334).Curated1
Sequence conflicti409M → I in AAL73436 (PubMed:12406577).Curated1
Sequence conflicti409M → I in AAH57638 (PubMed:15489334).Curated1
Sequence conflicti525 – 556ENQRE…EIRDQ → FCQPYNPAERKAEVRGGRFT IEAQRGHIKIRAR in AAL73436 (PubMed:12406577).CuratedAdd BLAST32
Sequence conflicti565 – 566VV → W in AAL73436 (PubMed:12406577).Curated2
Sequence conflicti735I → M in AAL73436 (PubMed:12406577).Curated1
Sequence conflicti752 – 754PSK → RE in AAL73436 (PubMed:12406577).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027108805 – 853VLLGG…PESTK → KEKESNRSKGTVTDLESVLT LLHTARKRDNGPGSREENLE SPLSMELDL in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_027109854 – 1126Missing in isoform 2. 1 PublicationAdd BLAST273

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL807753 Genomic DNA Translation: CAM22158.1 Different initiation.
AL807753 Genomic DNA Translation: CAM22159.1 Different initiation.
BC057638 mRNA Translation: AAH57638.1 Different initiation.
AF461135 mRNA Translation: AAL73436.1 Different initiation.
AK129277 mRNA Translation: BAC98087.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS72443.1 [Q8VHG2-1]

NCBI Reference Sequences

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RefSeqi
NP_001277203.1, NM_001290274.1 [Q8VHG2-2]
NP_695231.3, NM_153319.3 [Q8VHG2-1]
XP_006528927.1, XM_006528864.3 [Q8VHG2-1]
XP_011246130.1, XM_011247828.2 [Q8VHG2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000112836; ENSMUSP00000108455; ENSMUSG00000041688 [Q8VHG2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
27494

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:27494

UCSC genome browser

More...
UCSCi
uc009una.2 mouse [Q8VHG2-1]
uc009unb.2 mouse [Q8VHG2-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807753 Genomic DNA Translation: CAM22158.1 Different initiation.
AL807753 Genomic DNA Translation: CAM22159.1 Different initiation.
BC057638 mRNA Translation: AAH57638.1 Different initiation.
AF461135 mRNA Translation: AAL73436.1 Different initiation.
AK129277 mRNA Translation: BAC98087.1
CCDSiCCDS72443.1 [Q8VHG2-1]
RefSeqiNP_001277203.1, NM_001290274.1 [Q8VHG2-2]
NP_695231.3, NM_153319.3 [Q8VHG2-1]
XP_006528927.1, XM_006528864.3 [Q8VHG2-1]
XP_011246130.1, XM_011247828.2 [Q8VHG2-1]

3D structure databases

SMRiQ8VHG2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi205274, 17 interactors
IntActiQ8VHG2, 9 interactors
MINTiQ8VHG2
STRINGi10090.ENSMUSP00000108455

PTM databases

iPTMnetiQ8VHG2
PhosphoSitePlusiQ8VHG2

Proteomic databases

PaxDbiQ8VHG2
PeptideAtlasiQ8VHG2
PRIDEiQ8VHG2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112836; ENSMUSP00000108455; ENSMUSG00000041688 [Q8VHG2-1]
GeneIDi27494
KEGGimmu:27494
UCSCiuc009una.2 mouse [Q8VHG2-1]
uc009unb.2 mouse [Q8VHG2-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
154796
MGIiMGI:108440 Amot

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiENOG410IJU5 Eukaryota
ENOG410XSY2 LUCA
GeneTreeiENSGT00940000159055
InParanoidiQ8VHG2
KOiK16819
OMAiTDGPVFH
OrthoDBi369983at2759
PhylomeDBiQ8VHG2
TreeFamiTF333368

Enzyme and pathway databases

ReactomeiR-MMU-2028269 Signaling by Hippo

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Amot mouse

Protein Ontology

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PROi
PR:Q8VHG2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000041688 Expressed in 288 organ(s), highest expression level in placenta labyrinth
ExpressionAtlasiQ8VHG2 baseline and differential
GenevisibleiQ8VHG2 MM

Family and domain databases

InterProiView protein in InterPro
IPR009114 Angiomotin
IPR024646 Angiomotin_C
PfamiView protein in Pfam
PF12240 Angiomotin_C, 1 hit
PRINTSiPR01807 ANGIOMOTIN

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMOT_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VHG2
Secondary accession number(s): A2AMJ9
, A2AMK0, Q6PFB8, Q6ZPZ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 24, 2007
Last modified: September 18, 2019
This is version 129 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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