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Protein

Cadherin-related family member 5

Gene

Cdhr5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDifferentiation
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-related family member 5Curated
Alternative name(s):
Mu-protocadherinImported
Gene namesi
Name:Cdhr5Imported
Synonyms:MucdhlImported, MupcdhImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1919290 Cdhr5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 641ExtracellularSequence analysisAdd BLAST613
Transmembranei642 – 662HelicalSequence analysisAdd BLAST21
Topological domaini663 – 831CytoplasmicSequence analysisAdd BLAST169

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000401329 – 831Cadherin-related family member 5Add BLAST803

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...) asparagineCurated1
Glycosylationi45N-linked (GlcNAc...) asparagineCurated1
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineCurated1
Glycosylationi143N-linked (GlcNAc...) asparagineCurated1
Glycosylationi173N-linked (GlcNAc...) asparagineCurated1
Glycosylationi201N-linked (GlcNAc...) asparagineCurated1
Glycosylationi287N-linked (GlcNAc...) asparagineCurated1
Glycosylationi311N-linked (GlcNAc...) asparagineCurated1
Glycosylationi408N-linked (GlcNAc...) asparagineCurated1
Glycosylationi475N-linked (GlcNAc...) asparagineCurated1
Modified residuei699PhosphoserineBy similarity1
Modified residuei721PhosphoserineCombined sources1
Modified residuei725PhosphoserineCombined sources1
Modified residuei728PhosphothreonineCombined sources1
Modified residuei736PhosphoserineCombined sources1
Modified residuei753PhosphoserineCombined sources1
Modified residuei795PhosphothreonineBy similarity1
Modified residuei802PhosphoserineBy similarity1
Modified residuei804PhosphoserineBy similarity1
Modified residuei806PhosphoserineBy similarity1

Post-translational modificationi

N- and O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8VHF2
PRIDEiQ8VHF2

PTM databases

iPTMnetiQ8VHF2
PhosphoSitePlusiQ8VHF2

Expressioni

Developmental stagei

Detected at embryonic day 7. Expression decreases by day 11 and increases again between embryonic days 15 and 17.1 Publication

Gene expression databases

BgeeiENSMUSG00000025497 Expressed in 65 organ(s), highest expression level in jejunum
CleanExiMM_MUPCDH
ExpressionAtlasiQ8VHF2 baseline and differential
GenevisibleiQ8VHF2 MM

Interactioni

Subunit structurei

Part of the IMAC/intermicrovillar adhesion complex/intermicrovillar tip-link complex composed of ANKS4B, MYO7B, USH1C, CDHR2 and CDHR5. Interacts (via cytoplasmic domain) with USH1C and MYO7B; required for proper localization of CDHR5 to microvilli tips and its function in brush border differentiation.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127292

Structurei

3D structure databases

ProteinModelPortaliQ8VHF2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 125Cadherin 1PROSITE-ProRule annotationCuratedAdd BLAST73
Domaini128 – 240Cadherin 2PROSITE-ProRule annotationCuratedAdd BLAST113
Domaini252 – 357Cadherin 3PROSITE-ProRule annotationCuratedAdd BLAST106
Domaini358 – 459Cadherin 4PROSITE-ProRule annotationCuratedAdd BLAST102
Repeati541 – 5711CuratedAdd BLAST31
Repeati572 – 6022CuratedAdd BLAST31
Repeati605 – 6143; truncated10

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni541 – 6143 X 31 AA approximate tandem repeatsAdd BLAST74
Regioni663 – 831Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organizationBy similarityAdd BLAST169

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00390000001008
HOGENOMiHOG000113693
HOVERGENiHBG052536
InParanoidiQ8VHF2
KOiK16505
OMAiTYRITNN
PhylomeDBiQ8VHF2

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR030326 Mucdhl
PANTHERiPTHR45160 PTHR45160, 1 hit
SMARTiView protein in SMART
SM00112 CA, 2 hits
SUPFAMiSSF49313 SSF49313, 2 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 1 hit
PS50268 CADHERIN_2, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1Curated (identifier: Q8VHF2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGAPALLWPS LLLPWLTVLF GQPPGTLAQT QVCSVNQTIF RVEENTTVSE
60 70 80 90 100
PLVNIFVPDG LHVTLGPLST PYAFRIEGKD LFLNVTPDYE ENSLLQADVE
110 120 130 140 150
CKRGDAVVVR LEVFVAVLDI NDNAPKFSFE IKTFNVSEDT KVNTTVIPET
160 170 180 190 200
QLKATDADIN DILVYTLQEV TPNASKFFSL EGVNYPALKL DQTLDYFKNQ
210 220 230 240 250
NMTFMLLARD TWEENVEPSH TATATLVLNT LPADLRTPWF LPCSFTDGYV
260 270 280 290 300
CIHAQYSAVV PTGHKLPSPL IMSPGPIYAV DGDQAINQSI IYSIIAGNTD
310 320 330 340 350
GTFIINAHDG NLTMTKSIPS PMKFTLLIRA DQEDMAQYSV TQAIVEARSV
360 370 380 390 400
TGNPLQFSQS LYYGTVVLGS EAGTAVKDKT FPSEILRIQA QYPGFPDLNS
410 420 430 440 450
AVTYRVTNSS EFMMNKDIML TAVPMEEART IRVEVEASNT VTKDTATAVV
460 470 480 490 500
EIQVSERERT PTPPEAGGTT GPSSNTTMEA PLTSGTSQRP ATTSSGGSVG
510 520 530 540 550
PFPPGGTTLR PPTPASSIPG GSPTLGTSTS PQTTTPGGDS AQTPKPGTSH
560 570 580 590 600
PTAPTSRTST SLMTTSSRSD STQTPKPGTS QPMVPIPGAS TSSQPATPSG
610 620 630 640 650
SSPQTPKPGT SQSTATGPIS LPSTGAGEQG DGQRFSTVDM AVLGGVLGAL
660 670 680 690 700
LLLALICLVI LVHKHYRHRL ACCSGKASEP QPSGYDNLTF LPDHKAKWSP
710 720 730 740 750
TPNRKPEPSP KLAQPPLRPP SPMSSSPTPP SSTPPSPQPK ASGSPKTVQA
760 770 780 790 800
GDSPSAVRSI LTKERRPEGE GGYKAVWFGK DIGAEADVVV LNEPTADVDS
810 820 830
ASASGSEGSD DDDPDQKKTL RFGVDADNTY I
Length:831
Mass (Da):88,208
Last modified:March 1, 2002 - v1
Checksum:iF0ABF867A37F558B
GO
Isoform 2Curated (identifier: Q8VHF2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     459-620: Missing.

Show »
Length:669
Mass (Da):72,616
Checksum:i15723511BE0D5A22
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0PJK7A0PJK7_MOUSE
Cadherin-related family member 5
Cdhr5 Mucdhl, Mupcdh, mCG_23289
831Annotation score:
A0A1B0GSY5A0A1B0GSY5_MOUSE
Cadherin-related family member 5
Cdhr5
333Annotation score:
A0A1B0GRD3A0A1B0GRD3_MOUSE
Cadherin-related family member 5
Cdhr5
131Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti459 – 460RT → LPSTEF in BAC25662 (PubMed:16141072).Curated2
Sequence conflicti621 – 624Missing in BAC25662 (PubMed:16141072).Curated4

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_050689459 – 620Missing in isoform 2. 2 PublicationsAdd BLAST162

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462391 mRNA Translation: AAL67856.1
AK007988 mRNA Translation: BAB25392.1
AK027913 mRNA Translation: BAC25662.1
BC054469 mRNA Translation: AAH54469.1
CCDSiCCDS22006.1 [Q8VHF2-2]
RefSeqiNP_001107794.1, NM_001114322.1
NP_082345.1, NM_028069.3 [Q8VHF2-2]
UniGeneiMm.29080

Genome annotation databases

EnsembliENSMUST00000080654; ENSMUSP00000079484; ENSMUSG00000025497 [Q8VHF2-2]
GeneIDi72040
KEGGimmu:72040
UCSCiuc009kkj.2 mouse [Q8VHF2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462391 mRNA Translation: AAL67856.1
AK007988 mRNA Translation: BAB25392.1
AK027913 mRNA Translation: BAC25662.1
BC054469 mRNA Translation: AAH54469.1
CCDSiCCDS22006.1 [Q8VHF2-2]
RefSeqiNP_001107794.1, NM_001114322.1
NP_082345.1, NM_028069.3 [Q8VHF2-2]
UniGeneiMm.29080

3D structure databases

ProteinModelPortaliQ8VHF2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127292

PTM databases

iPTMnetiQ8VHF2
PhosphoSitePlusiQ8VHF2

Proteomic databases

PaxDbiQ8VHF2
PRIDEiQ8VHF2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080654; ENSMUSP00000079484; ENSMUSG00000025497 [Q8VHF2-2]
GeneIDi72040
KEGGimmu:72040
UCSCiuc009kkj.2 mouse [Q8VHF2-2]

Organism-specific databases

CTDi53841
MGIiMGI:1919290 Cdhr5

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00390000001008
HOGENOMiHOG000113693
HOVERGENiHBG052536
InParanoidiQ8VHF2
KOiK16505
OMAiTYRITNN
PhylomeDBiQ8VHF2

Miscellaneous databases

PROiPR:Q8VHF2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025497 Expressed in 65 organ(s), highest expression level in jejunum
CleanExiMM_MUPCDH
ExpressionAtlasiQ8VHF2 baseline and differential
GenevisibleiQ8VHF2 MM

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR030326 Mucdhl
PANTHERiPTHR45160 PTHR45160, 1 hit
SMARTiView protein in SMART
SM00112 CA, 2 hits
SUPFAMiSSF49313 SSF49313, 2 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 1 hit
PS50268 CADHERIN_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCDHR5_MOUSE
AccessioniPrimary (citable) accession number: Q8VHF2
Secondary accession number(s): Q8CEJ3, Q9D8I9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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