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Entry version 139 (12 Aug 2020)
Sequence version 2 (27 Jul 2011)
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Protein

Dynein heavy chain 5, axonemal

Gene

Dnah5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1977 – 1984ATPSequence analysis8
Nucleotide bindingi2259 – 2266ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein heavy chain 5, axonemalCurated
Alternative name(s):
Axonemal beta dynein heavy chain 5
Short name:
mDNAH5
Ciliary dynein heavy chain 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dnah5Imported
Synonyms:Dnahc5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:107718, Dnah5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Dnah5 are the cause of primary ciliary dyskinesia (PCD). PCD is characterized by recurrent respiratory infections, situs inversus and ciliary immotility and hydrocephalus.1 Publication

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice display defects in motility of the ependymal cells lining the brain ventricles and aqueduct. This results in impaired flow of cerebrospinal fluid through the cerebral aqueduct and gives rise to closure of the aqueduct and subsequent formation of triventricular hydrocephalus during early postnatal brain development.1 Publication

Keywords - Diseasei

Ciliopathy, Primary ciliary dyskinesia

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001146311 – 4621Dynein heavy chain 5, axonemalAdd BLAST4621

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8VHE6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8VHE6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8VHE6

PeptideAtlas

More...
PeptideAtlasi
Q8VHE6

PRoteomics IDEntifications database

More...
PRIDEi
Q8VHE6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8VHE6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8VHE6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in lung and kidney and weaker expression seen in brain, heart and testis. In the brain, expressed in ependymal cells lining the brain ventricles and the aqueduct.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Embryos show a weak expression confined to the node from 7.0 to 8.25 dpc.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000022262, Expressed in female gonad and 49 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8VHE6, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DNAL1 (By similarity). Consists of at least two heavy chains and a number of intermediate and light chains.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
225282, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q8VHE6, 2 interactors

Molecular INTeraction database

More...
MINTi
Q8VHE6

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000069751

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8VHE6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8VHE6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1938StemBy similarityAdd BLAST1938
Regioni1939 – 2161AAA 1By similarityAdd BLAST223
Regioni2221 – 2440AAA 2By similarityAdd BLAST220
Regioni2547 – 2800AAA 3By similarityAdd BLAST254
Regioni2913 – 3167AAA 4By similarityAdd BLAST255
Regioni3182 – 3479StalkBy similarityAdd BLAST298
Regioni3564 – 3794AAA 5By similarityAdd BLAST231
Regioni4009 – 4223AAA 6By similarityAdd BLAST215

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili260 – 305Sequence analysisAdd BLAST46
Coiled coili803 – 825Sequence analysisAdd BLAST23
Coiled coili1065 – 1094Sequence analysisAdd BLAST30
Coiled coili1433 – 1462Sequence analysisAdd BLAST30
Coiled coili3186 – 3299Sequence analysisAdd BLAST114
Coiled coili3423 – 3490Sequence analysisAdd BLAST68
Coiled coili3729 – 3814Sequence analysisAdd BLAST86
Coiled coili4389 – 4417Sequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155533

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000038_9_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8VHE6

KEGG Orthology (KO)

More...
KOi
K10408

Identification of Orthologs from Complete Genome Data

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OMAi
FQKRDRY

Database of Orthologous Groups

More...
OrthoDBi
6295at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316836

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR041589, DNAH3_AAA_lid_1
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013594, Dynein_heavy_dom-1
IPR013602, Dynein_heavy_dom-2
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF17857, AAA_lid_1, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08385, DHC_N1, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8VHE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRIGRRQLW KQSVTRVLTQ RLKEEKEAKR ARLDGRHDYL FAIVASCLDL
60 70 80 90 100
NKPEVEDALL EGNQIERMDQ LFAVGGLRHL MFYYQDVEGA EAGHCGSSGG
110 120 130 140 150
VNPASGKMKK PKVFVTEGKD VALMGACVFF IRSDPSKAIT PENIHREVSF
160 170 180 190 200
NTLDTADGGL LNSVRRLLSD IFIPALRASS HGWGELEGLQ DASSIRQEFL
210 220 230 240 250
SSLEGFVGIL SGAQNSLKEK VNLQKCDIIE LKSLKEPTDY LALASNPETV
260 270 280 290 300
EKVECCMRVW IKQMEQILAE NSQLRKEADD VGPRAELEHW KQRLSRFNYL
310 320 330 340 350
LDQLKSPDVK AALALLAAAK SKLLKVWRDT DIRITDAANE AKDNVKYLYT
360 370 380 390 400
LEKCCDPLYS SDPVTMIDAI PTLINAIKMV YSISHYYNTS EKITSLFVKV
410 420 430 440 450
TNQMISACKA HITNNGTATI WSQPQEIVMQ KIAAVIKLKQ GYQSCFQETK
460 470 480 490 500
QKLKQNPSEK QFDFSEMYIF GKFETFHRRL AKIMDIFTTF KTYSVLQDSK
510 520 530 540 550
IEGLEDMATK YQDIVAAIKK KEYNFLDQRE MDFDQDYEEF CKRINELHND
560 570 580 590 600
LQRFMDITFE KIPSTRQALS TLKKFERLNI PNLGIEEKYQ IIFQNFATDI
610 620 630 640 650
DTISKLYTKQ KYDPPLARNQ PPIAGKILWA RQLFHRLEQP MQLFQQHPFV
660 670 680 690 700
LRTAEAKPVI RSYNRIAKVL LEFEVLYHRA WLQQIEEIHA GLEASLLVKA
710 720 730 740 750
PGTGELFVNF DPQILVLFRE TQCMSQLGLP VSPFAAALFQ KRDMFKKNFS
760 770 780 790 800
DMKMMLSEYE RVKLKMPPAI EQLMFPHLAR VDEALQPGLA VLTWTSLNIG
810 820 830 840 850
GYLENAFAKI KDLELLLDRV NDLIEFRIHA ILEEMSSMAL CQLPQDDPLT
860 870 880 890 900
CEEFLQMTKD LCVSGAQLLH FKSSLVEEAV NELINMLLDV DVPPEEAAEN
910 920 930 940 950
VCHENASPSG NTSGRREGHS EALASSFNAG ASSLPLTATA RKKKETEVLE
960 970 980 990 1000
EARELLSHFN HQNTDALLKV TRNTLEAIRR RIHFSHMINF RDSNDASKAK
1010 1020 1030 1040 1050
QNHLPIFRAS VTLAIPNIAM TPALEDIQQT LNKAVECIIS VPKGVRQWSS
1060 1070 1080 1090 1100
ELLSKRKMHE RKMAAVKNNE DSDSDAEVEE NELQETLEIA SINLPIPVQT
1110 1120 1130 1140 1150
QNYYKNISDN KEIVKLVSVL STVISSTKKE VITSMDRFKR YNHIWQKEKE
1160 1170 1180 1190 1200
DTIMTFIAQN PLLPEFESRI LYFQSLEQEI NAEPEYIRVG SIALYTADLK
1210 1220 1230 1240 1250
LSLTAETKAW MAVIGRHCNR KYRAEMENIL TVVEESQKKL SRPIKDLDDI
1260 1270 1280 1290 1300
RIAMAALKEI REQQISTDFQ VGPIEESYAL LNKYGLLVAK EEMDKVDTLR
1310 1320 1330 1340 1350
YAWEKLLARA SDVQNELGAL QPSFRKELIS TVEVFLQDCQ QFYLDYDLNG
1360 1370 1380 1390 1400
PMASGLKPQE ASGRLIIFQN QFDNIYRKYI TYTGGEELFG LPVTPYPQLL
1410 1420 1430 1440 1450
EIKRQLNLLQ KIYSLYNNVI ETVNSYQDTL WSDVNIEKIN NELLEFQNRC
1460 1470 1480 1490 1500
RKLPRALKDW QAFLDLKKTI DDFSECCPLL EYMASNAMVE RHWQRITALT
1510 1520 1530 1540 1550
GHSLDVGNET FKLRNIMEAP LLKYKEEIED ICISAVKERD IEQKLRQVIN
1560 1570 1580 1590 1600
EWDNKTLTFS GFKTRGELLL RGDSTSEVIA SMEDSLMLLG SLLSNRYNMP
1610 1620 1630 1640 1650
FKAQIQKWVQ CLSNSTDIIE NWMTVQNLWI YLEAVFVGGD IAKQLPKEAK
1660 1670 1680 1690 1700
RFSNIDKSWV KIMTRAHEIP NVVQCCVGDE TMGQLLPHLL DQLEICQKSL
1710 1720 1730 1740 1750
TGYLEKKRLC FPRFFFVSDP ALLEILGQAS DSHTIQAHLL NVFDNIKTVK
1760 1770 1780 1790 1800
FHDKIYDRIL SISSREGETI ELDKPVMAEG NVEVWLNSLL EESQSSLHLV
1810 1820 1830 1840 1850
IRQAAANIQE PGFQLIEFLS SFPAQVGLLG IQMLWTRDSE EALRNAKFDK
1860 1870 1880 1890 1900
KIMQKTNQAF LELLNMLIEI TTKDLSSMER VKYETLITIH VHQRDIFDDL
1910 1920 1930 1940 1950
CHMHVKSPTD FEWLKQCRFY FKEDSDKTMI HITDVAFIYQ NEFLGCTDRL
1960 1970 1980 1990 2000
VITPLTDRCY ITLAQALGMS MGGAPAGPAG TGKTETTKDM GRCLGKYVVV
2010 2020 2030 2040 2050
FNCSDQMDFR GLGRIFKGLA QSGSWGCFDE FNRIDLPVLS VAAQQISIIL
2060 2070 2080 2090 2100
TCKKEHKKSF IFTDGDNVTM NPEFGLFLTM NPGYAGRQEL PENLKINFRS
2110 2120 2130 2140 2150
VAMMVPDRQI IIRVKLASCG FIDNVVLARK FFTLYQLCEE QLSKQVHYDF
2160 2170 2180 2190 2200
GLRNILSVLR TLGAAKRASP TDTESTIVMR VLRDMNLSKL IDEDEPLFLS
2210 2220 2230 2240 2250
LIEDLFPNIL LDKAGYPELE TAISKQVEEA GLINHPPWKL KVIQLFETQR
2260 2270 2280 2290 2300
VRHGMMTLGP SGSGKTTCIH TLMKAMTDCG KPHREMRMNP KAITAPQMFG
2310 2320 2330 2340 2350
RLDVATNDWT DGIFSTLWRK TLKAKKGEHI WIVLDGPVDA IWIENLNSVL
2360 2370 2380 2390 2400
DDNKTLTLAN GDRIPMAPNC KIVFEPHNID NASPATVSRN GMVFMSSSVL
2410 2420 2430 2440 2450
DWSPILEGFL KRRSPQEAEI LRQLYAETFP DLYRFSIQNL EFKMEVLEAF
2460 2470 2480 2490 2500
VITQSTHMLQ GLIPPKEQAG EVDPEHLGRL FVFAMMWSVG AVLELEGRRR
2510 2520 2530 2540 2550
MELWLRSREG PTLHLPQLTD AGDTMFDYYV APNGTWRHWS LCTPEYVYPP
2560 2570 2580 2590 2600
DTTPEYGSIL VPNVDNVRTD FLIKTIAKQG KAVLLIGEQG TAKTVIIKGF
2610 2620 2630 2640 2650
MSKFDPESHM VKNLNFSSAT TPVMFQRTIE SYVDKRMGTT YGPPAGKKMA
2660 2670 2680 2690 2700
VFIDDLNMPV INEWGDQVTN EIVRQLMEQS GFYNLEKPGE FTSIVDIQFL
2710 2720 2730 2740 2750
AAMIHPGGGR NDIPQRLKRQ FSIFNCTLPS DASMDKIFGV IGAGYYCAQR
2760 2770 2780 2790 2800
GFSEEVQDAL IKLVPLTRRL WQMTKLKMLP TPAKFHYVFN LRDLSRIWQG
2810 2820 2830 2840 2850
MLNITSEVIK DTDELLRLWK HECKRVIADR FSMSSDVTWF DKAVVSLVEE
2860 2870 2880 2890 2900
EFGEEKAPVV DCGVDAYFVD FLRDAPEATG ETPEEADAEM PKLYEPIASL
2910 2920 2930 2940 2950
NHLRERLSVF LQLYNESIRG TGMDMVFFID AMVHLVKISR VIRTPRGNAL
2960 2970 2980 2990 3000
LVGVGGSGKQ SLTRLASFIA GYTSFQITLT RSYNTSNLME DLKVLYRTAG
3010 3020 3030 3040 3050
QQGKGITFIF TDNEIKEESF LEYMNNVLSS GEVSNLFARD EIDEINSDLT
3060 3070 3080 3090 3100
PIMKKEHPRR PPTNDNLYEY FMSRVRGNLH IVLCFSPVGE KFRNRALKFP
3110 3120 3130 3140 3150
ALISGCTIDW FSRWPKDALV AVSEHFLSSY TIDCTAEIKK ELVQCMGSFQ
3160 3170 3180 3190 3200
DGVAEKCADY FQRFRRSTHV TPKSYLSFIQ GYKFIYEEKH MEVQSLANRM
3210 3220 3230 3240 3250
NTGLEKLKEA SESVAALSKE LAGKEKELQV ANEKADTVLK EVTMKAQAAE
3260 3270 3280 3290 3300
KVKAEVQKVK DKAQAIVDSI SKDKAIAEEK LEAAKPALEE AEAALQTIKP
3310 3320 3330 3340 3350
SDIATVRTLG RPPHLIMRIM DCVLLLFQRR VNAVKIDVDK GCTMPSWQES
3360 3370 3380 3390 3400
LKLMTAGNFL QNLQQFPKDT INEEVIEFLN PYFEMSDYNI ETAKRVCGNV
3410 3420 3430 3440 3450
AGLCSWTKAM ASFFSINKEV LPLKANLIVQ ENRHILAMQD LQKAQAELDA
3460 3470 3480 3490 3500
KQAELDVVQA EYEQAMAEKQ TLLEDADRCR HKMQTASTLI SGLAGEKERW
3510 3520 3530 3540 3550
TEQSKEFAAQ TKRLVGDVLL ATAFLSYSGP FNQEFRDLLL HDWKKEMKAR
3560 3570 3580 3590 3600
KIPFGNGLNL NEMLIDAPTI SEWNLQGLPN DDLSIQNGII VTKASRYPLL
3610 3620 3630 3640 3650
IDPQTQGKIW IKNKESQNEL QITSLNHKYF RNHLEDSLSL GRPLLIEDVG
3660 3670 3680 3690 3700
EELDPALDNV LEKNFIKTGS TFKVKVGDKE VDVMDGFKLY ITTKLPNPAY
3710 3720 3730 3740 3750
TPEISARTSI IDFTVTVKGL EDQLLGRVIL TEKQELEKER THLLEDVTAN
3760 3770 3780 3790 3800
KRRMKELEDN LLYRLTSTQG SLVEDESLII VLSNTKKTAE EVTQKLEISG
3810 3820 3830 3840 3850
ETEIQINSAR EEYRPVATRG SILYFLITEM RLVNEMYQTS LRQFLGLFDL
3860 3870 3880 3890 3900
SLARSVKSPI TSKRIANIIE HMTYEVFKYA ARGLYEEHKF LFTLLLTLKI
3910 3920 3930 3940 3950
DIQRNLVKHE EFLTLIKGGA SLDLKACPPK PSKWILDMTW LNLVELSKLK
3960 3970 3980 3990 4000
QFSDILDQIS RNEKMWRVWF DKENPEEEPL PNAYDKSLDC FRRLLLIRSW
4010 4020 4030 4040 4050
CPDRTIAQAR KYIMDSMGEN YAEGVILDLE KTWEESDPRT PLICLLSMGS
4060 4070 4080 4090 4100
DPTDSIIALG KRLKIETRYV SMGQGQEVHA RKLLHQTMAN GGWVLLQNCH
4110 4120 4130 4140 4150
LGLDFLDELM DVVTETETVH DTFRLWITTE VHKQFPITLL QMSIKFANEP
4160 4170 4180 4190 4200
PQGLRAGLRR TYGGVSQDLL DVSVGAQWKP MLYAVAFLHS TVQERRKFGP
4210 4220 4230 4240 4250
LGWNIPYEFN QADFNATVQF IQNHLDDMDV KKGVSWTTVR YMIGEIQYGG
4260 4270 4280 4290 4300
RVTDDYDKRL LNTFAKVWFS ENMFGPDFTF YQGYNIPKCS TVDGYLQYIQ
4310 4320 4330 4340 4350
SLPAYDSPEV FGLHPNADIT YQSKLAKDVL DTILGIQPKD SSGGGDETRE
4360 4370 4380 4390 4400
AVVARLADDM LEKLPEDYSP FEVKERLQKM GPFQPMNIFL RQEIDRMQRV
4410 4420 4430 4440 4450
LSLVRSTLTE LKLAVDGTII MSENLRDALD CMFDARIPAR WKKASWVSST
4460 4470 4480 4490 4500
LGFWFTELLE RNCQFTSWVS NGRPHCFWMT GFFNPQGFLT AMRQEITRAN
4510 4520 4530 4540 4550
KGWALDNMVL CNEVTKFMKD DISAPPTEGV YVYGLYLEGA GWDKRNMKLI
4560 4570 4580 4590 4600
ESKPKVLFEL MPVIRIFAEN NTARDPRLYC CPIYKKPVRT DLNYIAAVDL
4610 4620
KTAQAPEHWV LRGVALLCDV K
Length:4,621
Mass (Da):527,558
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC6F243FF149B214
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti892V → A in AAL69993 (PubMed:11912187).Curated1
Sequence conflicti898A → S in AAL69993 (PubMed:11912187).Curated1
Sequence conflicti3854 – 3858RSVKS → SLSRA in AAL69993 (PubMed:11912187).Curated5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF466704 mRNA Translation: AAL69993.1
AC131997 Genomic DNA No translation available.
AC154880 Genomic DNA No translation available.
AK052643 mRNA Translation: BAC35077.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS27404.1

NCBI Reference Sequences

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RefSeqi
NP_579943.3, NM_133365.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000067048; ENSMUSP00000069751; ENSMUSG00000022262

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
110082

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:110082

UCSC genome browser

More...
UCSCi
uc007vjy.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF466704 mRNA Translation: AAL69993.1
AC131997 Genomic DNA No translation available.
AC154880 Genomic DNA No translation available.
AK052643 mRNA Translation: BAC35077.2
CCDSiCCDS27404.1
RefSeqiNP_579943.3, NM_133365.3

3D structure databases

SMRiQ8VHE6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi225282, 3 interactors
IntActiQ8VHE6, 2 interactors
MINTiQ8VHE6
STRINGi10090.ENSMUSP00000069751

PTM databases

iPTMnetiQ8VHE6
PhosphoSitePlusiQ8VHE6

Proteomic databases

EPDiQ8VHE6
MaxQBiQ8VHE6
PaxDbiQ8VHE6
PeptideAtlasiQ8VHE6
PRIDEiQ8VHE6

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
50446, 53 antibodies

Genome annotation databases

EnsembliENSMUST00000067048; ENSMUSP00000069751; ENSMUSG00000022262
GeneIDi110082
KEGGimmu:110082
UCSCiuc007vjy.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1767
MGIiMGI:107718, Dnah5

Phylogenomic databases

eggNOGiKOG3595, Eukaryota
GeneTreeiENSGT00940000155533
HOGENOMiCLU_000038_9_1_1
InParanoidiQ8VHE6
KOiK10408
OMAiFQKRDRY
OrthoDBi6295at2759
TreeFamiTF316836

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
110082, 1 hit in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Dnah5, mouse

Protein Ontology

More...
PROi
PR:Q8VHE6
RNActiQ8VHE6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000022262, Expressed in female gonad and 49 other tissues
GenevisibleiQ8VHE6, MM

Family and domain databases

Gene3Di1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR041589, DNAH3_AAA_lid_1
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013594, Dynein_heavy_dom-1
IPR013602, Dynein_heavy_dom-2
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF17857, AAA_lid_1, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08385, DHC_N1, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 3 hits
SUPFAMiSSF52540, SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYH5_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VHE6
Secondary accession number(s): E9QKD7, Q8BWG1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 27, 2011
Last modified: August 12, 2020
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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