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Protein

Ankyrin repeat and SOCS box protein 18

Gene

Asb18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 18
Short name:
ASB-18
Gene namesi
Name:Asb18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2655109 Asb18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003118761 – 467Ankyrin repeat and SOCS box protein 18Add BLAST467

Proteomic databases

PaxDbiQ8VHA6
PRIDEiQ8VHA6

PTM databases

PhosphoSitePlusiQ8VHA6

Expressioni

Gene expression databases

BgeeiENSMUSG00000067081
CleanExiMM_ASB18
ExpressionAtlasiQ8VHA6 baseline and differential
GenevisibleiQ8VHA6 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084095

Structurei

3D structure databases

ProteinModelPortaliQ8VHA6
SMRiQ8VHA6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati15 – 45ANK 1Add BLAST31
Repeati57 – 87ANK 2Add BLAST31
Repeati119 – 148ANK 3Add BLAST30
Repeati151 – 180ANK 4Add BLAST30
Repeati184 – 213ANK 5Add BLAST30
Repeati218 – 247ANK 6Add BLAST30
Repeati251 – 292ANK 7Add BLAST42
Repeati293 – 322ANK 8Add BLAST30
Repeati326 – 362ANK 9Add BLAST37
Domaini406 – 464SOCS boxPROSITE-ProRule annotationAdd BLAST59

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00390000011960
HOGENOMiHOG000232066
HOVERGENiHBG073573
InParanoidiQ8VHA6
KOiK10340
OMAiGKRCFDL
OrthoDBiEOG091G0543
PhylomeDBiQ8VHA6
TreeFamiTF323921

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037341 ASB18
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44561 PTHR44561, 1 hit
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS50225 SOCS, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VHA6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSWDSPPDY PLSSDIVRRL KSALATGDED TVQKLICTEV EPVDAVIELA
60 70 80 90 100
NDDWMKEPSA ELPTGVLLGD LDHIRLLMDQ CFWDANAVFE ISNGEMEWQV
110 120 130 140 150
TSLATFGLSG LWTLEYQREL TTPLCIAAAH GHESCVRHLL SRKADPNASP
160 170 180 190 200
GGRGALHEAC LGNHTACARL LLQHGADPDL LNSEGLAPLH LCRTPASLGC
210 220 230 240 250
ARELLEHGAT VQLEGGPGRD TPLHVAAQRG LDEHAQLYLG FGARVDARNG
260 270 280 290 300
RGETALSAAC GAAARSPDEH ARCLRLCALL LRGGAAADAR DEDERSPLHK
310 320 330 340 350
ACGHARPGLC TLLLRHGADA GALDYGGASP LARALQTATC APPTAPQRTV
360 370 380 390 400
QVLLNHGSRS VWPDAFPKVL RTCAQVPEVI EVLFNSYTQL PVSESWREAI
410 420 430 440 450
PEEVYQMHKP FYRSLFALAH TPRCLQHLCR CTIRKLFGKE SVHLVPQLPL
460
PETLQNYLLL EPEGVLC
Length:467
Mass (Da):50,700
Last modified:March 1, 2002 - v1
Checksum:iB451A333B4A9D39B
GO
Isoform 2 (identifier: Q8VHA6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-109: Missing.
     200-200: C → F
     201-467: Missing.

Show »
Length:159
Mass (Da):17,112
Checksum:i12BBDE7C2A49A7F6
GO
Isoform 3 (identifier: Q8VHA6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-109: Missing.
     123-345: Missing.

Show »
Length:203
Mass (Da):23,155
Checksum:i000E3F09D8603583
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02962469 – 109Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_029625123 – 345Missing in isoform 3. 1 PublicationAdd BLAST223
Alternative sequenceiVSP_029626200C → F in isoform 2. 1 Publication1
Alternative sequenceiVSP_029627201 – 467Missing in isoform 2. 1 PublicationAdd BLAST267

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY057054 mRNA Translation: AAL18249.1
BC107370 mRNA Translation: AAI07371.1
BC107371 mRNA Translation: AAI07372.1
BC127152 mRNA Translation: AAI27153.1
CCDSiCCDS15151.1 [Q8VHA6-1]
RefSeqiNP_631891.1, NM_139152.1 [Q8VHA6-1]
UniGeneiMm.215164

Genome annotation databases

EnsembliENSMUST00000086882; ENSMUSP00000084095; ENSMUSG00000067081 [Q8VHA6-1]
ENSMUST00000154228; ENSMUSP00000117767; ENSMUSG00000067081 [Q8VHA6-2]
GeneIDi208372
KEGGimmu:208372
UCSCiuc007bzd.1 mouse [Q8VHA6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiASB18_MOUSE
AccessioniPrimary (citable) accession number: Q8VHA6
Secondary accession number(s): Q3B7Y5, Q3KNB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2002
Last modified: February 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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