UniProtKB - Q8VFD0 (OL486_MOUSE)
Protein
Olfactory receptor 486
Gene
Olfr486
Organism
Mus musculus (Mouse)
Status
Functioni
Potential odorant receptor.
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- odorant binding Source: GO_Central
- olfactory receptor activity Source: MGI
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: MGI
- sensory perception of smell Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 486Alternative name(s): Olfactory receptor 204-19 |
Gene namesi | Name:Olfr486 Synonyms:Mor204-19 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3030320 Olfr486 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 28 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 29 – 49 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 50 – 57 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 58 – 78 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 79 – 102 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 103 – 123 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 124 – 136 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 137 – 157 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 158 – 199 | ExtracellularSequence analysisAdd BLAST | 42 | |
Transmembranei | 200 – 220 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 221 – 240 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 241 – 261 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 262 – 274 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 275 – 295 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 296 – 314 | CytoplasmicSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150843 | 1 – 314 | Olfactory receptor 486Add BLAST | 314 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 6 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 100 ↔ 192 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8VFD0 |
PRIDEi | Q8VFD0 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
GeneTreei | ENSGT00950000182918 |
HOGENOMi | HOG000041364 |
InParanoidi | Q8VFD0 |
KOi | K04257 |
OMAi | MAREWIG |
OrthoDBi | 999769at2759 |
PhylomeDBi | Q8VFD0 |
TreeFami | TF338848 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8VFD0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAFIYNGSQT TVTEFILLGL TDDPVLKVIL FCIILCIYLV TVFGNLSTIL
60 70 80 90 100
LIGVSSKLHH PMYFFLSHLA SVDMGLSSSV TPNMLVNFLT EKNTISYLGC
110 120 130 140 150
GIQLSSAAFF GAVEFFLLAA MAYDRLVAIC NPLLYSTKMS SQVCIQLVAG
160 170 180 190 200
SYVGGFLNAS FVTHFFFSFL FCGPNRVNHF FCDLSPMMEL SCSDVSISEI
210 220 230 240 250
VISFSAGSFT MTTLFVIVIP YFYIFITILK IRSTEGRQKA FSTCTSHLTA
260 270 280 290 300
VTLYYGTIIF IYVMPKSTYS RDQNKVVSLF YMLVIPVLNP LIYSLRNNEI
310
KDALKRQFYR KTLL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY073601 Genomic DNA Translation: AAL61264.1 AY317594 Genomic DNA Translation: AAP70990.1 |
CCDSi | CCDS21707.1 |
RefSeqi | NP_666707.1, NM_146496.1 |
Genome annotation databases
Ensembli | ENSMUST00000072035; ENSMUSP00000071918; ENSMUSG00000096068 |
GeneIDi | 258489 |
KEGGi | mmu:258489 |
UCSCi | uc009jcb.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY073601 Genomic DNA Translation: AAL61264.1 AY317594 Genomic DNA Translation: AAP70990.1 |
CCDSi | CCDS21707.1 |
RefSeqi | NP_666707.1, NM_146496.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000071918 |
Protein family/group databases
GPCRDBi | Search... |
Proteomic databases
PaxDbi | Q8VFD0 |
PRIDEi | Q8VFD0 |
Genome annotation databases
Ensembli | ENSMUST00000072035; ENSMUSP00000071918; ENSMUSG00000096068 |
GeneIDi | 258489 |
KEGGi | mmu:258489 |
UCSCi | uc009jcb.1 mouse |
Organism-specific databases
CTDi | 258489 |
MGIi | MGI:3030320 Olfr486 |
Phylogenomic databases
GeneTreei | ENSGT00950000182918 |
HOGENOMi | HOG000041364 |
InParanoidi | Q8VFD0 |
KOi | K04257 |
OMAi | MAREWIG |
OrthoDBi | 999769at2759 |
PhylomeDBi | Q8VFD0 |
TreeFami | TF338848 |
Miscellaneous databases
PROi | PR:Q8VFD0 |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OL486_MOUSE | |
Accessioni | Q8VFD0Primary (citable) accession number: Q8VFD0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | March 1, 2002 | |
Last modified: | May 8, 2019 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot