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Protein

Kelch domain-containing protein 3

Gene

Klhdc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in meiotic recombination process.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch domain-containing protein 3
Alternative name(s):
Protein Peas
Testis intracellular mediator protein
Gene namesi
Name:Klhdc3
Synonyms:Peas
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2651568 Klhdc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002289961 – 382Kelch domain-containing protein 3Add BLAST382

Proteomic databases

MaxQBiQ8VEM9
PaxDbiQ8VEM9
PeptideAtlasiQ8VEM9
PRIDEiQ8VEM9

PTM databases

PhosphoSitePlusiQ8VEM9

Expressioni

Tissue specificityi

Expressed specifically in testis, particularly in pachytene spermatocytes.1 Publication

Gene expression databases

CleanExiMM_KLHDC3

Interactioni

Protein-protein interaction databases

BioGridi214909, 1 interactor
STRINGi10090.ENSMUSP00000071743

Structurei

3D structure databases

ProteinModelPortaliQ8VEM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati25 – 77Kelch 1Add BLAST53
Repeati88 – 138Kelch 2Add BLAST51
Repeati139 – 189Kelch 3Add BLAST51
Repeati191 – 249Kelch 4Add BLAST59
Repeati251 – 301Kelch 5Add BLAST51

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG0379 Eukaryota
ENOG410Y5WM LUCA
HOGENOMiHOG000276538
HOVERGENiHBG071311
InParanoidiQ8VEM9
PhylomeDBiQ8VEM9
TreeFamiTF354289

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR015915 Kelch-typ_b-propeller
IPR011498 Kelch_2
PfamiView protein in Pfam
PF07646 Kelch_2, 2 hits
SUPFAMiSSF117281 SSF117281, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8VEM9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRWTVHLEG GPRRVNHAAV AVGHRVYSFG GYCSGEDYET LRQIDVHIFN
60 70 80 90 100
AVSLRWTKLP PVRPAVRGQA PVVPYMRYGH STVLIDDTVF LWGGRNDTEG
110 120 130 140 150
ACNVLYAFDV NTHKWSTPRV SGTVPGARDG HSACVLGKIM YIFGGYEQLA
160 170 180 190 200
DCFSNDIHKL DTSTMTWTLV CTKGNPARWR DFHSATMLGN HMYVFGGRAD
210 220 230 240 250
RFGPFHSNNE IYCNRIRVFD TRTEAWLDCP HTPVLPEGRR SHSAFGYNGE
260 270 280 290 300
LYIFGGYNAR LNRHFHDLWK FNPGSFTWKK IEPKGKGPCP RRRQCCCIVG
310 320 330 340 350
DKIVLFGGTS PSPEEGLGDE FDLIDHSDLH ILDFSPSLKT LCKLAVIQYS
360 370 380
LDQSCLPHDI RWELNAMTTN SNISRPIVSS HG
Length:382
Mass (Da):43,082
Last modified:March 1, 2002 - v1
Checksum:i275296C5F7919B03
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0W0A0A0R4J0W0_MOUSE
Kelch domain containing 3, isoform ...
Klhdc3 mCG_2693
382Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2L → I in BAE41917 (PubMed:16141072).Curated1
Sequence conflicti19A → T in BAB62016 (PubMed:12606021).Curated1
Sequence conflicti168T → A in BAB23704 (PubMed:16141072).Curated1
Sequence conflicti201R → H in BAE24793 (PubMed:16141072).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti123T → A3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074009 Genomic DNA Translation: BAB91441.1
AB053465 mRNA Translation: BAB62016.1
AJ278127 mRNA Translation: CAC34582.1
AK004964 mRNA Translation: BAB23704.1
AK141673 mRNA Translation: BAE24793.1
AK170623 mRNA Translation: BAE41917.1
BC018154 mRNA Translation: AAH18154.1
CCDSiCCDS28834.1
RefSeqiNP_001157201.2, NM_001163729.2
NP_082186.2, NM_027910.3
XP_006525006.1, XM_006524943.3
UniGeneiMm.254784

Genome annotation databases

GeneIDi71765
KEGGimmu:71765
UCSCiuc008ctw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074009 Genomic DNA Translation: BAB91441.1
AB053465 mRNA Translation: BAB62016.1
AJ278127 mRNA Translation: CAC34582.1
AK004964 mRNA Translation: BAB23704.1
AK141673 mRNA Translation: BAE24793.1
AK170623 mRNA Translation: BAE41917.1
BC018154 mRNA Translation: AAH18154.1
CCDSiCCDS28834.1
RefSeqiNP_001157201.2, NM_001163729.2
NP_082186.2, NM_027910.3
XP_006525006.1, XM_006524943.3
UniGeneiMm.254784

3D structure databases

ProteinModelPortaliQ8VEM9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214909, 1 interactor
STRINGi10090.ENSMUSP00000071743

PTM databases

PhosphoSitePlusiQ8VEM9

Proteomic databases

MaxQBiQ8VEM9
PaxDbiQ8VEM9
PeptideAtlasiQ8VEM9
PRIDEiQ8VEM9

Protocols and materials databases

DNASUi71765
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi71765
KEGGimmu:71765
UCSCiuc008ctw.2 mouse

Organism-specific databases

CTDi116138
MGIiMGI:2651568 Klhdc3

Phylogenomic databases

eggNOGiKOG0379 Eukaryota
ENOG410Y5WM LUCA
HOGENOMiHOG000276538
HOVERGENiHBG071311
InParanoidiQ8VEM9
PhylomeDBiQ8VEM9
TreeFamiTF354289

Miscellaneous databases

ChiTaRSiKlhdc3 mouse
PROiPR:Q8VEM9
SOURCEiSearch...

Gene expression databases

CleanExiMM_KLHDC3

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR015915 Kelch-typ_b-propeller
IPR011498 Kelch_2
PfamiView protein in Pfam
PF07646 Kelch_2, 2 hits
SUPFAMiSSF117281 SSF117281, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKLDC3_MOUSE
AccessioniPrimary (citable) accession number: Q8VEM9
Secondary accession number(s): Q3TCN9
, Q3UR95, Q91XU6, Q99JH9, Q9DBG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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