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Protein

Myotubularin-related protein 14

Gene

Mtmr14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei329Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-MMU-1632852 Macroautophagy
R-MMU-1660499 Synthesis of PIPs at the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 14 (EC:3.1.3.-)
Alternative name(s):
mJumpy
Gene namesi
Name:Mtmr14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1916075 Mtmr14

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002602151 – 648Myotubularin-related protein 14Add BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei193N6-acetyllysineBy similarity1
Glycosylationi225N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi240N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei516PhosphoserineBy similarity1
Glycosylationi517N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei528PhosphoserineCombined sources1
Modified residuei578PhosphoserineBy similarity1
Modified residuei622PhosphoserineBy similarity1
Modified residuei636Omega-N-methylarginineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

EPDiQ8VEL2
MaxQBiQ8VEL2
PaxDbiQ8VEL2
PeptideAtlasiQ8VEL2
PRIDEiQ8VEL2

PTM databases

iPTMnetiQ8VEL2
PhosphoSitePlusiQ8VEL2

Expressioni

Developmental stagei

In C2C12 cell line, increased expression during myotube formation and differentiation in culture.1 Publication

Gene expression databases

BgeeiENSMUSG00000030269 Expressed in 270 organ(s), highest expression level in primary oocyte
CleanExiMM_MTMR14
ExpressionAtlasiQ8VEL2 baseline and differential
GenevisibleiQ8VEL2 MM

Interactioni

Protein-protein interaction databases

IntActiQ8VEL2, 1 interactor
STRINGi10090.ENSMUSP00000108771

Structurei

3D structure databases

ProteinModelPortaliQ8VEL2
SMRiQ8VEL2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi479 – 562Ser-richAdd BLAST84

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IHSK Eukaryota
ENOG410XSF4 LUCA
GeneTreeiENSGT00390000018852
HOGENOMiHOG000294065
HOVERGENiHBG062969
InParanoidiQ8VEL2
KOiK18086
OMAiYKDRDYT
OrthoDBiEOG091G03F3
PhylomeDBiQ8VEL2
TreeFamiTF324044

Family and domain databases

CDDicd13213 PH-GRAM_MTMR14, 1 hit
InterProiView protein in InterPro
IPR039802 MTMR14
IPR039803 MTMR14_PH-GRAM
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
PANTHERiPTHR13524 PTHR13524, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

Q8VEL2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGARAAAAA SAGSTASSGS PPPQEPGLWE LLEEFSRTQY RAKDSGGKSG
60 70 80 90 100
SKVERIEKRC LELFGRDYCF SVIPNVNGDI CGHYPRHIVF LEYESSEKEK
110 120 130 140 150
DTFQSTVQVN KLQDLIHRSK MARCRGRFVC PVILFKGKHI CRSATLAGWG
160 170 180 190 200
ELYGRSGYNY LFSGGADDTW ASTEDVTEED FVLRSGDTHL FDKVRGYDIK
210 220 230 240 250
LLQYLSVKYI CDLMVENKKV KFGMNVTSSE KVDKAQRYAN FTLLSIPYPG
260 270 280 290 300
CEFFKEYKDR DYMAEGLIFN WKQDYVDAPL NIPNFLTQSL NIDWSQYQSW
310 320 330 340 350
DLVQQTQNYL KLLLFIMNRD DDSGLLVHCI SGWDRTPLFI SLLRLSLWAD
360 370 380 390 400
GLIHTSLKPA EILYLTVAYD WFLFGHMLVD RLSKGEEIFF FCFNFLKHIT
410 420 430 440 450
SEEFCLKTQR RKSLPTRDAG FTVEDICMLR HKDRGSTTSL GSDFSLVLEH
460 470 480 490 500
SPGAVGSFSY ETVELAPAGA PTQAAWRKSH SSSPQSMLWS RPQPSEERLP
510 520 530 540 550
SHHGLTEAKS SSSSSSNHSD NFFRMGSSPL EVPKPRSVDH PLPGSSLSTD
560 570 580 590 600
FGSWQLVSGC GSIQDRPVLH TDSSLPFSFQ DELPNSCLLT ALSDRETRLQ
610 620 630 640
EVRSAFLAAY SSTVGLRAAT PSPSGAIGGL LEQFARGVGL RGTSTSTL
Length:648
Mass (Da):72,443
Last modified:November 28, 2006 - v2
Checksum:iE1927FE8F32BB38D
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6W741F6W741_MOUSE
Myotubularin-related protein 14
Mtmr14
264Annotation score:
F6SBM1F6SBM1_MOUSE
Myotubularin-related protein 14
Mtmr14
119Annotation score:
F6RV41F6RV41_MOUSE
Myotubularin-related protein 14
Mtmr14
298Annotation score:
D6RDS6D6RDS6_MOUSE
Myotubularin-related protein 14
Mtmr14
331Annotation score:
D3Z1C1D3Z1C1_MOUSE
Myotubularin-related protein 14
Mtmr14
189Annotation score:
D6RFN8D6RFN8_MOUSE
Myotubularin-related protein 14
Mtmr14
140Annotation score:
F7BA73F7BA73_MOUSE
Myotubularin-related protein 14
Mtmr14
142Annotation score:
F6YA17F6YA17_MOUSE
Myotubularin-related protein 14
Mtmr14
57Annotation score:
A0A0N4SV39A0A0N4SV39_MOUSE
Myotubularin-related protein 14
Mtmr14
73Annotation score:

Sequence cautioni

The sequence AAH18294 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018294 mRNA Translation: AAH18294.1 Different initiation.
CCDSiCCDS20412.2
RefSeqiNP_081125.2, NM_026849.2
XP_006506888.1, XM_006506825.1
UniGeneiMm.197816

Genome annotation databases

EnsembliENSMUST00000113146; ENSMUSP00000108771; ENSMUSG00000030269
GeneIDi97287
KEGGimmu:97287
UCSCiuc009dex.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018294 mRNA Translation: AAH18294.1 Different initiation.
CCDSiCCDS20412.2
RefSeqiNP_081125.2, NM_026849.2
XP_006506888.1, XM_006506825.1
UniGeneiMm.197816

3D structure databases

ProteinModelPortaliQ8VEL2
SMRiQ8VEL2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VEL2, 1 interactor
STRINGi10090.ENSMUSP00000108771

PTM databases

iPTMnetiQ8VEL2
PhosphoSitePlusiQ8VEL2

Proteomic databases

EPDiQ8VEL2
MaxQBiQ8VEL2
PaxDbiQ8VEL2
PeptideAtlasiQ8VEL2
PRIDEiQ8VEL2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113146; ENSMUSP00000108771; ENSMUSG00000030269
GeneIDi97287
KEGGimmu:97287
UCSCiuc009dex.2 mouse

Organism-specific databases

CTDi64419
MGIiMGI:1916075 Mtmr14

Phylogenomic databases

eggNOGiENOG410IHSK Eukaryota
ENOG410XSF4 LUCA
GeneTreeiENSGT00390000018852
HOGENOMiHOG000294065
HOVERGENiHBG062969
InParanoidiQ8VEL2
KOiK18086
OMAiYKDRDYT
OrthoDBiEOG091G03F3
PhylomeDBiQ8VEL2
TreeFamiTF324044

Enzyme and pathway databases

ReactomeiR-MMU-1632852 Macroautophagy
R-MMU-1660499 Synthesis of PIPs at the plasma membrane

Miscellaneous databases

PROiPR:Q8VEL2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030269 Expressed in 270 organ(s), highest expression level in primary oocyte
CleanExiMM_MTMR14
ExpressionAtlasiQ8VEL2 baseline and differential
GenevisibleiQ8VEL2 MM

Family and domain databases

CDDicd13213 PH-GRAM_MTMR14, 1 hit
InterProiView protein in InterPro
IPR039802 MTMR14
IPR039803 MTMR14_PH-GRAM
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
PANTHERiPTHR13524 PTHR13524, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMTMRE_MOUSE
AccessioniPrimary (citable) accession number: Q8VEL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: November 7, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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