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Protein

Inhibitor of growth protein 3

Gene

Ing3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei365Histone H3K4me3By similarity1
Metal bindingi366Zinc 1By similarity1
Metal bindingi368Zinc 1By similarity1
Binding sitei376Histone H3K4me3By similarity1
Metal bindingi379Zinc 2By similarity1
Binding sitei380Histone H3K4me3By similarity1
Metal bindingi384Zinc 2By similarity1
Binding sitei388Histone H3K4me3By similarity1
Metal bindingi390Zinc 1; via pros nitrogenBy similarity1
Metal bindingi393Zinc 1By similarity1
Metal bindingi406Zinc 2By similarity1
Metal bindingi409Zinc 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri363 – 412PHD-typePROSITE-ProRule annotationAdd BLAST50

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processGrowth regulation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of growth protein 3
Alternative name(s):
p47ING3
Gene namesi
Name:Ing3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1919027 Ing3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126661 – 421Inhibitor of growth protein 3Add BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki148Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki165Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei181N6-acetyllysineCombined sources1
Cross-linki256Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei264N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8VEK6
MaxQBiQ8VEK6
PaxDbiQ8VEK6
PRIDEiQ8VEK6

PTM databases

iPTMnetiQ8VEK6
PhosphoSitePlusiQ8VEK6

Expressioni

Gene expression databases

BgeeiENSMUSG00000029670
CleanExiMM_ING3
ExpressionAtlasiQ8VEK6 baseline and differential
GenevisibleiQ8VEK6 MM

Interactioni

Subunit structurei

Interacts with H3K4me3 and to a lesser extent with H3K4me2 (By similarity). Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC. HTATTIP/TIP60, EPC1, and ING3 together constitute a minimal HAT complex termed Piccolo NuA4. Component of a SWR1-like complex (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi214920, 3 interactors
ComplexPortaliCPX-747 Piccolo NuA4 histone acetyltransferase complex
CPX-990 NuA4 histone acetyltransferase complex
IntActiQ8VEK6, 3 interactors
STRINGi10090.ENSMUSP00000031680

Structurei

3D structure databases

ProteinModelPortaliQ8VEK6
SMRiQ8VEK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi313 – 324Poly-SerAdd BLAST12

Domaini

The PHD-type zinc finger mediates the binding to H3K4me3.By similarity

Sequence similaritiesi

Belongs to the ING family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri363 – 412PHD-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1973 Eukaryota
COG5034 LUCA
GeneTreeiENSGT00550000074538
HOGENOMiHOG000239725
HOVERGENiHBG006607
InParanoidiQ8VEK6
KOiK11319
OMAiPDWTYDP
OrthoDBiEOG091G0J8Y
PhylomeDBiQ8VEK6
TreeFamiTF106497

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR038004 ING3
IPR024610 ING_N_histone_binding
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10333:SF91 PTHR10333:SF91, 1 hit
PfamiView protein in Pfam
PF12998 ING, 1 hit
SMARTiView protein in SMART
SM01408 ING, 1 hit
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VEK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYLEDYLEM IEQLPMDLRD RFTEMREMDL QVQNAMDQLE QRVSEFFMNA
60 70 80 90 100
KKNKPEWREE QMASIKKDYY KALEDADEKV QLANQIYDLV DRHLRKLDQE
110 120 130 140 150
LAKFKMELEA DNAGITEILE RRSLELDAPS QPVNNHHAHS HTPVEKRKYN
160 170 180 190 200
PTSHHAAADH IPEKKFKSEA LLSTLTSDAS KENTLGCRNN NSTASCNNAY
210 220 230 240 250
NVNSSQPLAS YNIGSLSSGA GAGAITMAAA QAVQATAQMK EGRRTSSLKA
260 270 280 290 300
SYEAFKNNDF QLGKEFSIPR ETAGYSSSSA LMTTLTQNAS SSATDSRSGR
310 320 330 340 350
KSKNNTKSSS QQSSSSSSSS SSSSLSLCSS SSTVVQEVSQ QATVVPESDS
360 370 380 390 400
NSQVDWTYDP NEPRYCICNQ VSYGEMVGCD NQDCPIEWFH YGCVGLTEAP
410 420
KGKWFCPQCT AAMKRRGSRH K
Length:421
Mass (Da):46,847
Last modified:February 15, 2005 - v2
Checksum:iE786062A26E3BF96
GO

Sequence cautioni

The sequence AAG23286 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH18342 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC38021 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti257N → T in AAG23286 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007791 mRNA Translation: AAG23286.1 Different initiation.
AK080787 mRNA Translation: BAC38021.1 Different initiation.
BC005721 mRNA Translation: AAH05721.1
BC018342 mRNA Translation: AAH18342.1 Different initiation.
CCDSiCCDS39434.1
RefSeqiNP_001297990.1, NM_001311061.1
NP_076115.3, NM_023626.4
UniGeneiMm.39999

Genome annotation databases

EnsembliENSMUST00000031680; ENSMUSP00000031680; ENSMUSG00000029670
GeneIDi71777
KEGGimmu:71777
UCSCiuc009bat.1 mouse

Similar proteinsi

Entry informationi

Entry nameiING3_MOUSE
AccessioniPrimary (citable) accession number: Q8VEK6
Secondary accession number(s): Q99JS6, Q9ERB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: July 18, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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