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UniProtKB - Q8VEI3 (HYAL3_MOUSE)

Entry version 139 (02 Jun 2021)
Sequence version 2 (27 Jul 2011)
Previous versions | rss
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Protein

Hyaluronidase-3

Gene

Hyal3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm (PubMed:20586096).

Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage (PubMed:18653706).

Has no hyaluronidase activity in embryonic fibroblasts in vitro (PubMed:18234732).

Has no hyaluronidase activity in granulosa cells in vitro (PubMed:18653706).

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 7. Higher activity at pH 4 than at pH 7 in sperm.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei129Proton donorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCell adhesion, Fertilization

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.2.1.35, 3474

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-2024101, CS/DS degradation
R-MMU-2160916, Hyaluronan uptake and degradation

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GH56, Glycoside Hydrolase Family 56

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hyaluronidase-3 (EC:3.2.1.35)
Short name:
Hyal-3
Alternative name(s):
Hyaluronoglucosaminidase-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hyal3
Synonyms:Hyl3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1330288, Hyal3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype. Both male and female mice are viable. Skeletal features, joints, whole-body weights, organ weights, organ morphologies and the serum hyaluronic acid (HA) levels are normal. No evidence of glycosaminoglycan accumulation, including vacuolization, in tissues analyzed including liver, lung, kidney, spleen, skin, fat, testes and seminal vesicles at 12-14 months of age. No difference in tissue organization or connective tissue thickness. Only a subtle change in the alveolar structure and extracellular matrix thickness in lung tissue sections at 12-14 months of age. Lungs have larger alveoli and more areas of thickened interstitium. Lung tissues from 6 months old mice show more immature alveoli compared to wild-type (PubMed:18762256). Mice are fully fertile (PubMed:18762256, PubMed:20586096). Sperm show delayed cumulus penetration and reduced acrosomal exocytosis (PubMed:20586096).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024820123 – 412Hyaluronidase-3Add BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi42 ↔ 332By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi206 ↔ 221By similarity
Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi357 ↔ 368By similarity
Disulfide bondi362 ↔ 396By similarity
Disulfide bondi398 ↔ 407By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8VEI3

PRoteomics IDEntifications database

More...PRIDEi		Q8VEI3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		273289

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8VEI3, 2 sites

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis, epididymal tissue, epididymal luminal fluid (ELF), acrosome-intact (AI) sperm and caput (CAP), corpus (COR) and caudal (CAU) sperm. Higher expression in sperm than testis (at protein level) (PubMed:20586096). Liver, kidney, skin, brain, stomach and testis (PubMed:11929860). Expressed mainly in granulosa cells of the ovaries. Expressed in small and large antral follicles. Not present in theca or stroma cells (PubMed:18653706). Expressed in testis and liver (PubMed:18762256). Expressed in testis and CAP, COR, and CAU epididymis tissue (PubMed:20586096).4 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated expression in apoptotic granulosa cells and in atretic follicles of the ovaries (PubMed:18653706).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000036091, Expressed in respiratory system and 87 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8VEI3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8VEI3, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000042667

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8VEI3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8VEI3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini353 – 408EGF-likeAdd BLAST56

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 56 family.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTXP, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01020000230364

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_036366_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8VEI3

Identification of Orthologs from Complete Genome Data

More...OMAi		FYRFPAC

Database of Orthologous Groups

More...OrthoDBi		1096692at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8VEI3

TreeFam database of animal gene trees

More...TreeFami		TF321598

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.20.20.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013785, Aldolase_TIM
IPR000742, EGF-like_dom
IPR013111, EGF_extracell
IPR017853, Glycoside_hydrolase_SF
IPR018155, Hyaluronidase
IPR027260, Hyaluronidase-3

The PANTHER Classification System

More...PANTHERi		PTHR11769, PTHR11769, 1 hit
PTHR11769:SF19, PTHR11769:SF19, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07974, EGF_2, 1 hit
PF01630, Glyco_hydro_56, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF038193, Hyaluronidase, 1 hit
PIRSF500776, Hyaluronidase_3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00846, GLHYDRLASE56

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51445, SSF51445, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8VEI3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIMHLGLMMV VGLTLCLMHG QALLQVPEHP FSVVWNVPSA RCKAHFGVHL 
        60         70         80         90        100
PLDALGIVAN HGQHFHGQNI SIFYKNQFGL YPYFGPRGTA HNGGIPQAVS 
       110        120        130        140        150
LDHHLARAAH QILHSLGSSF AGLAVLDWEE WYPLWAGNWG PHRQVYLAAS 
       160        170        180        190        200
WVWTQQMFPG LDPQEQLHKA HTSFEQAARA LMEYTLQLGR TLRPSGLWGF 
       210        220        230        240        250
YRYPACGNGW HKMASNYTGH CHAAITTRNT QLRWLWAASS ALFPSIYLPP 
       260        270        280        290        300
RLPLAYRQAF VRHRLEEAFR VALLEHSHPL PVLAYSRLTH RSSGRFLSLD 
       310        320        330        340        350
DLMQTIGVSA ALGTAGVVLW GDLSFSSSEE KCWRLHDYLV GTLGPYVINV 
       360        370        380        390        400
TKAAMACSHQ RCHGHGRCAR KDPGQMEAFL HLQPDDSLGA WNSFRCHCYS 
       410 
GWAGPTCLEP KP
Length:412
Mass (Da):46,132
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB4EB888C556BE920
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YVY7D3YVY7_MOUSE
Hyaluronidase
Hyal3
328Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti228R → Q in AAL06145 (PubMed:11929860).Curated1
Sequence conflicti228R → Q in AAH18457 (PubMed:15489334).Curated1
Sequence conflicti296F → S in AAL54883 (Ref. 3) Curated1
Sequence conflicti296F → S in AAL57175 (Ref. 3) Curated1
Sequence conflicti354A → D in AAL06145 (PubMed:11929860).Curated1
Sequence conflicti354A → D in AAH18457 (PubMed:15489334).Curated1
Sequence conflicti397H → R in AAL54882 (Ref. 2) Curated1
Sequence conflicti397H → R in AAL54883 (Ref. 3) Curated1
Sequence conflicti397H → R in AAL57175 (Ref. 3) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY048681 mRNA Translation: AAL06145.1
AF074489 mRNA Translation: AAL54882.1
AF075576 Genomic DNA Translation: AAL54883.1
AF338323 Genomic DNA Translation: AAL57175.1
AL672219 Genomic DNA No translation available.
BC018457 mRNA Translation: AAH18457.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS23499.1

NCBI Reference Sequences

More...RefSeqi		NP_821139.2, NM_178020.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000040059; ENSMUSP00000042667; ENSMUSG00000036091
ENSMUST00000148440; ENSMUSP00000119499; ENSMUSG00000036091

Database of genes from NCBI RefSeq genomes

More...GeneIDi		109685

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:109685

UCSC genome browser

More...UCSCi		uc009rmc.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY048681 mRNA Translation: AAL06145.1
AF074489 mRNA Translation: AAL54882.1
AF075576 Genomic DNA Translation: AAL54883.1
AF338323 Genomic DNA Translation: AAL57175.1
AL672219 Genomic DNA No translation available.
BC018457 mRNA Translation: AAH18457.1
CCDSiCCDS23499.1
RefSeqiNP_821139.2, NM_178020.3

3D structure databases

SMRiQ8VEI3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042667

Protein family/group databases

CAZyiGH56, Glycoside Hydrolase Family 56

PTM databases

GlyGeniQ8VEI3, 2 sites

Proteomic databases

PaxDbiQ8VEI3
PRIDEiQ8VEI3
ProteomicsDBi273289

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34877, 188 antibodies

The DNASU plasmid repository

More...DNASUi		109685

Genome annotation databases

EnsembliENSMUST00000040059; ENSMUSP00000042667; ENSMUSG00000036091
ENSMUST00000148440; ENSMUSP00000119499; ENSMUSG00000036091
GeneIDi109685
KEGGimmu:109685
UCSCiuc009rmc.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8372
MGIiMGI:1330288, Hyal3

Phylogenomic databases

eggNOGiENOG502QTXP, Eukaryota
GeneTreeiENSGT01020000230364
HOGENOMiCLU_036366_0_0_1
InParanoidiQ8VEI3
OMAiFYRFPAC
OrthoDBi1096692at2759
PhylomeDBiQ8VEI3
TreeFamiTF321598

Enzyme and pathway databases

BRENDAi3.2.1.35, 3474
ReactomeiR-MMU-2024101, CS/DS degradation
R-MMU-2160916, Hyaluronan uptake and degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		109685, 1 hit in 52 CRISPR screens

Protein Ontology

More...PROi		PR:Q8VEI3
RNActiQ8VEI3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000036091, Expressed in respiratory system and 87 other tissues
ExpressionAtlasiQ8VEI3, baseline and differential
GenevisibleiQ8VEI3, MM

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785, Aldolase_TIM
IPR000742, EGF-like_dom
IPR013111, EGF_extracell
IPR017853, Glycoside_hydrolase_SF
IPR018155, Hyaluronidase
IPR027260, Hyaluronidase-3
PANTHERiPTHR11769, PTHR11769, 1 hit
PTHR11769:SF19, PTHR11769:SF19, 1 hit
PfamiView protein in Pfam
PF07974, EGF_2, 1 hit
PF01630, Glyco_hydro_56, 1 hit
PIRSFiPIRSF038193, Hyaluronidase, 1 hit
PIRSF500776, Hyaluronidase_3, 1 hit
PRINTSiPR00846, GLHYDRLASE56
SUPFAMiSSF51445, SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHYAL3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VEI3
Secondary accession number(s): B1AV95, Q8VBX7, Q8VI77
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 27, 2011
Last modified: June 2, 2021
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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