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Protein

Endoplasmic reticulum lectin 1

Gene

Erlec1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-382556 ABC-family proteins mediated transport
R-MMU-5358346 Hedgehog ligand biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum lectin 1
Alternative name(s):
ER lectin
Short name:
Erlectin
Gene namesi
Name:Erlec1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1914003 Erlec1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000004218334 – 483Endoplasmic reticulum lectin 1Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8VEH8
MaxQBiQ8VEH8
PaxDbiQ8VEH8
PeptideAtlasiQ8VEH8
PRIDEiQ8VEH8

PTM databases

PhosphoSitePlusiQ8VEH8

Expressioni

Gene expression databases

BgeeiENSMUSG00000020311 Expressed in 272 organ(s), highest expression level in prostate gland
CleanExiMM_4933407N01RIK
ExpressionAtlasiQ8VEH8 baseline and differential
GenevisibleiQ8VEH8 MM

Interactioni

Subunit structurei

May form a complex with OS9, HSPA5, SYVN1, and SEL1L with which it interacts directly. Interacts (via PRKCSH 2 domain) with KREMEN2 (when glycosylated). Interacts with HSPA5 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8VEH8, 2 interactors
MINTiQ8VEH8
STRINGi10090.ENSMUSP00000072929

Structurei

3D structure databases

ProteinModelPortaliQ8VEH8
SMRiQ8VEH8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 180PRKCSH 1Add BLAST70
Domaini342 – 418PRKCSH 2Add BLAST77

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3394 Eukaryota
ENOG410XR8A LUCA
GeneTreeiENSGT00530000063603
InParanoidiQ8VEH8
KOiK14008
OMAiQYHEERE
OrthoDBiEOG091G07NJ
PhylomeDBiQ8VEH8
TreeFamiTF314309

Family and domain databases

Gene3Di2.70.130.10, 2 hits
InterProiView protein in InterPro
IPR009011 Man6P_isomerase_rcpt-bd_dom_sf
IPR012913 OS9-like
PfamiView protein in Pfam
PF07915 PRKCSH, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8VEH8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEGDGGLRS LVPGGPLLLV LYGLLEASGG GRALPQLSDD IPFRVNWPGT
60 70 80 90 100
EFSLPTTGVL YKEDNYIIMT TAHKEKYKCI LPLVTSGDEE EEKDYKGPNP
110 120 130 140 150
RELLEPLFKQ SSCSYRIESY WTYEVCHGKH IRQYHEEKET GQKVNIHEYY
160 170 180 190 200
LGNMLAKNLL YEKEREAKEN EKSNEIPTKN IEGQMTPYYP VGMGNGTPCS
210 220 230 240 250
LKQNRPRSST VMYICHPESK HEILSVAEVT TCEYEVVILT PLLCSHPKYK
260 270 280 290 300
FRASPVNDIF CQSLPGSPFK PLTLRQLEQQ EEILRVPFRR NKEEDLPSAK
310 320 330 340 350
EERFPAIHKP IAVGSQPVLT VGTTHISKLT DDQLIKEFLS GSYCFHGGVG
360 370 380 390 400
WWKYEFCYGK HVHQYHEDKD NGKTSVVVGT WNQEEHVEWA KKNTARAYHL
410 420 430 440 450
QDDGTQTVRM VSHFYGNGDI CDITDKPRQV TVKLKCKESD SPHAVTVYML
460 470 480
EPHSCQYILG VESPVICKIL DTADENGLLS LPN
Length:483
Mass (Da):54,906
Last modified:March 1, 2002 - v1
Checksum:iBB521BB85C3595D2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Z458F6Z458_MOUSE
Endoplasmic reticulum lectin 1
Erlec1
238Annotation score:
F7AQQ2F7AQQ2_MOUSE
Endoplasmic reticulum lectin 1
Erlec1
80Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10S → T in BAC36623 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077120 mRNA Translation: BAC36623.1
AK133874 mRNA Translation: BAE21904.1
AL662891 Genomic DNA No translation available.
BC018468 mRNA Translation: AAH18468.1
CCDSiCCDS24509.1
RefSeqiNP_080021.3, NM_025745.3
UniGeneiMm.294641

Genome annotation databases

EnsembliENSMUST00000073192; ENSMUSP00000072929; ENSMUSG00000020311
GeneIDi66753
KEGGimmu:66753
UCSCiuc007iic.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077120 mRNA Translation: BAC36623.1
AK133874 mRNA Translation: BAE21904.1
AL662891 Genomic DNA No translation available.
BC018468 mRNA Translation: AAH18468.1
CCDSiCCDS24509.1
RefSeqiNP_080021.3, NM_025745.3
UniGeneiMm.294641

3D structure databases

ProteinModelPortaliQ8VEH8
SMRiQ8VEH8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VEH8, 2 interactors
MINTiQ8VEH8
STRINGi10090.ENSMUSP00000072929

PTM databases

PhosphoSitePlusiQ8VEH8

Proteomic databases

EPDiQ8VEH8
MaxQBiQ8VEH8
PaxDbiQ8VEH8
PeptideAtlasiQ8VEH8
PRIDEiQ8VEH8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073192; ENSMUSP00000072929; ENSMUSG00000020311
GeneIDi66753
KEGGimmu:66753
UCSCiuc007iic.1 mouse

Organism-specific databases

CTDi27248
MGIiMGI:1914003 Erlec1

Phylogenomic databases

eggNOGiKOG3394 Eukaryota
ENOG410XR8A LUCA
GeneTreeiENSGT00530000063603
InParanoidiQ8VEH8
KOiK14008
OMAiQYHEERE
OrthoDBiEOG091G07NJ
PhylomeDBiQ8VEH8
TreeFamiTF314309

Enzyme and pathway databases

ReactomeiR-MMU-382556 ABC-family proteins mediated transport
R-MMU-5358346 Hedgehog ligand biogenesis

Miscellaneous databases

PROiPR:Q8VEH8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020311 Expressed in 272 organ(s), highest expression level in prostate gland
CleanExiMM_4933407N01RIK
ExpressionAtlasiQ8VEH8 baseline and differential
GenevisibleiQ8VEH8 MM

Family and domain databases

Gene3Di2.70.130.10, 2 hits
InterProiView protein in InterPro
IPR009011 Man6P_isomerase_rcpt-bd_dom_sf
IPR012913 OS9-like
PfamiView protein in Pfam
PF07915 PRKCSH, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiERLEC_MOUSE
AccessioniPrimary (citable) accession number: Q8VEH8
Secondary accession number(s): Q3UZF3, Q8BVN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2002
Last modified: September 12, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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