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Protein

ADP-ribosylation factor-like protein 8A

Gene

Arl8a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 35GTPBy similarity7
Nucleotide bindingi71 – 75GTPBy similarity5
Nucleotide bindingi130 – 133GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Mitosis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 8A
Alternative name(s):
ADP-ribosylation factor-like protein 10B
Novel small G protein indispensable for equal chromosome segregation 2
Gene namesi
Name:Arl8a
Synonyms:Arl10b, Gie2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1915974 Arl8a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Intramembranei1 – 19Note=Mediates targeting to membranesBy similarityAdd BLAST19

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002329171 – 186ADP-ribosylation factor-like protein 8AAdd BLAST186

Proteomic databases

EPDiQ8VEH3
MaxQBiQ8VEH3
PaxDbiQ8VEH3
PeptideAtlasiQ8VEH3
PRIDEiQ8VEH3
TopDownProteomicsiQ8VEH3

PTM databases

iPTMnetiQ8VEH3
PhosphoSitePlusiQ8VEH3

Expressioni

Gene expression databases

BgeeiENSMUSG00000026426 Expressed in 272 organ(s), highest expression level in brain
CleanExiMM_ARL8A
ExpressionAtlasiQ8VEH3 baseline and differential
GenevisibleiQ8VEH3 MM

Interactioni

Protein-protein interaction databases

BioGridi213014, 1 interactor
IntActiQ8VEH3, 6 interactors
MINTiQ8VEH3
STRINGi10090.ENSMUSP00000027684

Structurei

3D structure databases

ProteinModelPortaliQ8VEH3
SMRiQ8VEH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0075 Eukaryota
ENOG410XNUK LUCA
GeneTreeiENSGT00780000121855
HOGENOMiHOG000163692
HOVERGENiHBG105214
InParanoidiQ8VEH3
KOiK07955
OMAiFVNVIAX
OrthoDBiEOG091G0USZ
PhylomeDBiQ8VEH3
TreeFamiTF105470

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8VEH3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIALFNKLLD WFKALFWKEE MELTLVGLQY SGKTTFVNVI ASGQFNEDMI
60 70 80 90 100
PTVGFNMRKI TKGNVTIKLW DIGGQPRFRS MWERYCRGVS AIVYMVDAAD
110 120 130 140 150
QEKIEASKNE LHNLLDKPQL QGIPVLVLGN KRDLAGALDE KELIEKMNLS
160 170 180
AIQDREICCY SISCKEKDNI DITLQWLIQH SKSRRS
Length:186
Mass (Da):21,390
Last modified:March 1, 2002 - v1
Checksum:iEE51413EF78D5F64
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6QKK2F6QKK2_MOUSE
ADP-ribosylation factor-like protei...
Arl8a
165Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB185207 mRNA Translation: BAD30091.1
BC004035 mRNA Translation: AAH04035.1
BC018479 mRNA Translation: AAH18479.1
AK004080 mRNA Translation: BAB23160.1
CCDSiCCDS15316.1
RefSeqiNP_081099.1, NM_026823.2
UniGeneiMm.174998

Genome annotation databases

EnsembliENSMUST00000027684; ENSMUSP00000027684; ENSMUSG00000026426
GeneIDi68724
KEGGimmu:68724
UCSCiuc007csu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB185207 mRNA Translation: BAD30091.1
BC004035 mRNA Translation: AAH04035.1
BC018479 mRNA Translation: AAH18479.1
AK004080 mRNA Translation: BAB23160.1
CCDSiCCDS15316.1
RefSeqiNP_081099.1, NM_026823.2
UniGeneiMm.174998

3D structure databases

ProteinModelPortaliQ8VEH3
SMRiQ8VEH3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213014, 1 interactor
IntActiQ8VEH3, 6 interactors
MINTiQ8VEH3
STRINGi10090.ENSMUSP00000027684

PTM databases

iPTMnetiQ8VEH3
PhosphoSitePlusiQ8VEH3

Proteomic databases

EPDiQ8VEH3
MaxQBiQ8VEH3
PaxDbiQ8VEH3
PeptideAtlasiQ8VEH3
PRIDEiQ8VEH3
TopDownProteomicsiQ8VEH3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027684; ENSMUSP00000027684; ENSMUSG00000026426
GeneIDi68724
KEGGimmu:68724
UCSCiuc007csu.1 mouse

Organism-specific databases

CTDi127829
MGIiMGI:1915974 Arl8a

Phylogenomic databases

eggNOGiKOG0075 Eukaryota
ENOG410XNUK LUCA
GeneTreeiENSGT00780000121855
HOGENOMiHOG000163692
HOVERGENiHBG105214
InParanoidiQ8VEH3
KOiK07955
OMAiFVNVIAX
OrthoDBiEOG091G0USZ
PhylomeDBiQ8VEH3
TreeFamiTF105470

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiArl8a mouse
PROiPR:Q8VEH3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026426 Expressed in 272 organ(s), highest expression level in brain
CleanExiMM_ARL8A
ExpressionAtlasiQ8VEH3 baseline and differential
GenevisibleiQ8VEH3 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARL8A_MOUSE
AccessioniPrimary (citable) accession number: Q8VEH3
Secondary accession number(s): Q99KS1, Q9CTB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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