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Protein

LIM and cysteine-rich domains protein 1

Gene

Lmcd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.2 Publications

GO - Molecular functioni

  • transcription corepressor activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of calcineurin-NFAT signaling cascade Source: UniProtKB
  • regulation of cardiac muscle hypertrophy Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-5683826 Surfactant metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
LIM and cysteine-rich domains protein 1
Gene namesi
Name:Lmcd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1353635 Lmcd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice display a marked increase in cardiac hypertrophy.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758161 – 365LIM and cysteine-rich domains protein 1Add BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VEE1
PaxDbiQ8VEE1
PRIDEiQ8VEE1

PTM databases

iPTMnetiQ8VEE1
PhosphoSitePlusiQ8VEE1

Expressioni

Tissue specificityi

Expressed in distal airway epithelium of the lung, vascular smooth muscle, and myocardium.1 Publication

Developmental stagei

At embryonic day 9.5 (E9.5) expressed in the myocardium and forming anterior foregut epithelium. By E12.5, expression is observed in the airways of the developing lung as well as in the myocardium. At E14.5, when proximal-distal differentiation in the lung is proceeding rapidly, expression is observed at high levels in the distal but not proximal airways of the developing lung. By E16.5, expression decreases in airway epithelium in the lung and expression is also observed in the vascular smooth muscle of pulmonary arteries (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000057604
CleanExiMM_LMCD1
ExpressionAtlasiQ8VEE1 baseline and differential
GenevisibleiQ8VEE1 MM

Interactioni

Subunit structurei

Interacts with beta-dystroglycan (By similarity). Interacts with GATA1, GATA4 and GATA6.By similarity1 Publication

Protein-protein interaction databases

BioGridi206014, 1 interactor
IntActiQ8VEE1, 1 interactor
STRINGi10090.ENSMUSP00000032376

Structurei

3D structure databases

ProteinModelPortaliQ8VEE1
SMRiQ8VEE1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 206PETPROSITE-ProRule annotationAdd BLAST108
Domaini241 – 306LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST66
Domaini307 – 365LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 58Cys-richAdd BLAST31

Domaini

The LIM zinc-binding domains and the Cys-rich region mediate interaction with GATA6.1 Publication

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410INGI Eukaryota
ENOG410ZPX3 LUCA
GeneTreeiENSGT00550000074438
HOGENOMiHOG000231628
HOVERGENiHBG001038
InParanoidiQ8VEE1
OMAiAGYSKQW
OrthoDBiEOG091G07C5
PhylomeDBiQ8VEE1
TreeFamiTF313265

Family and domain databases

CDDicd09829 PET_testin, 1 hit
InterProiView protein in InterPro
IPR010442 PET_domain
IPR033724 PET_testin
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
PF06297 PET, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits
PS51303 PET, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VEE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVAKDLNP GVQKMSLGQQ QSARGVACLR CKGMCSGFEP HSWRKICKSC
60 70 80 90 100
KCSQEEHCLS SDLDDDRKIG RLLMDSKYAT LTARVKGGDG IRIYKRNRMI
110 120 130 140 150
MTNPIATGKD PTFDTITYEW APPGVTQKLG LQYMELIPKE RQPVTGTEGA
160 170 180 190 200
LYRRRQLMHQ LPIYDQDPSR CRGLVENELK AMEEFVKHYK SEALGVGEVA
210 220 230 240 250
LPGQGGLPKE ENKTQEKPEG TETTAPTTNG SLGDPSKEVE YVCELCKGAA
260 270 280 290 300
PVDSPVVYAD RAGYSKQWHP TCFQCIKCSE PLVDLIYFWK DGAPWCGRHY
310 320 330 340 350
CESVRPRCSG CDEIIFSEDY QRVEDLAWHR KHFICEGCEQ LLSGRAYIVT
360
KGQLLCPTCS KSKRS
Length:365
Mass (Da):40,996
Last modified:March 1, 2002 - v1
Checksum:iDB8AA836364E47D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019124 mRNA Translation: AAH19124.1
CCDSiCCDS20403.1
RefSeqiNP_659048.1, NM_144799.2
UniGeneiMm.234441

Genome annotation databases

EnsembliENSMUST00000032376; ENSMUSP00000032376; ENSMUSG00000057604
GeneIDi30937
KEGGimmu:30937
UCSCiuc009ddv.2 mouse

Similar proteinsi

Entry informationi

Entry nameiLMCD1_MOUSE
AccessioniPrimary (citable) accession number: Q8VEE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: March 1, 2002
Last modified: June 20, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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