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Protein

Ribulose-phosphate 3-epimerase

Gene

Rpe

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.By similarity

Catalytic activityi

D-ribulose 5-phosphate = D-xylulose 5-phosphate.

Cofactori

Fe2+By similarity, Mn2+By similarity, Zn2+By similarity, Co2+By similarityNote: Binds 1 divalent metal cation per subunit. Active with Fe2+, and probably also with Mn2+, Zn2+ and Co2+.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10SubstrateBy similarity1
Metal bindingi35Divalent metal cationBy similarity1
Active sitei37Proton acceptorBy similarity1
Metal bindingi37Divalent metal cationBy similarity1
Metal bindingi70Divalent metal cationBy similarity1
Binding sitei70SubstrateBy similarity1
Active sitei175Proton donorBy similarity1
Metal bindingi175Divalent metal cationBy similarity1
Binding sitei177Substrate; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism
LigandCobalt, Iron, Manganese, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-71336 Pentose phosphate pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose-phosphate 3-epimerase (EC:5.1.3.1)
Alternative name(s):
Ribulose-5-phosphate-epimerase
Gene namesi
Name:Rpe
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1913896 Rpe

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001715882 – 228Ribulose-phosphate 3-epimeraseAdd BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8VEE0
MaxQBiQ8VEE0
PaxDbiQ8VEE0
PRIDEiQ8VEE0

PTM databases

iPTMnetiQ8VEE0
PhosphoSitePlusiQ8VEE0

Expressioni

Gene expression databases

BgeeiENSMUSG00000026005 Expressed in 291 organ(s), highest expression level in secondary oocyte
CleanExiMM_RPE
ExpressionAtlasiQ8VEE0 baseline and differential
GenevisibleiQ8VEE0 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027157

Structurei

3D structure databases

ProteinModelPortaliQ8VEE0
SMRiQ8VEE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni146 – 149Substrate bindingBy similarity4
Regioni197 – 198Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3111 Eukaryota
COG0036 LUCA
GeneTreeiENSGT00390000001447
HOGENOMiHOG000259349
HOVERGENiHBG044821
InParanoidiQ8VEE0
KOiK01783
OMAiCHLMIED
PhylomeDBiQ8VEE0
TreeFamiTF300157

Family and domain databases

CDDicd00429 RPE, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR026019 Ribul_P_3_epim
IPR000056 Ribul_P_3_epim-like
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR11749 PTHR11749, 1 hit
PfamiView protein in Pfam
PF00834 Ribul_P_3_epim, 1 hit
PIRSFiPIRSF001461 RPE, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR01163 rpe, 1 hit
PROSITEiView protein in PROSITE
PS01085 RIBUL_P_3_EPIMER_1, 1 hit
PS01086 RIBUL_P_3_EPIMER_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8VEE0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGCKIGPS ILNSDLANLG AECLRMLDSG ADYLHLDVMD GHFVPNITFG
60 70 80 90 100
HPVVESLRKQ LGQDPFFDMH MMVSRPEQWV KPMAVAGANQ YTFHLEATEN
110 120 130 140 150
PGALIKDIRE NGMKVGLAIK PGTTVEYLAP WANQIDMALV MTVEPGFGGQ
160 170 180 190 200
KFMEDMMPKV HWLRTQFPTL DIEVDGGVGP DTVQKCAEAG ANMIVSGSAI
210 220
MRSDDPRAVI NLLRNVCSEA AQKRSLDR
Length:228
Mass (Da):24,945
Last modified:March 1, 2002 - v1
Checksum:i81BBAF45F7EF48A8
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2KGF0B2KGF0_MOUSE
Ribulose-phosphate 3-epimerase
Rpe mCG_121562
235Annotation score:
M0QWQ0M0QWQ0_MOUSE
Ribulose-phosphate 3-epimerase
Rpe
71Annotation score:
M0QWJ2M0QWJ2_MOUSE
Ribulose-phosphate 3-epimerase
Rpe
41Annotation score:
A0A087WQM3A0A087WQM3_MOUSE
Ribulose-phosphate 3-epimerase
Rpe
50Annotation score:

Sequence cautioni

The sequence BAC26287 differs from that shown.Curated
The sequence BAC26287 differs from that shown. Reason: Erroneous termination at position 229. Translated as stop.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007735 mRNA No translation available.
AK017774 mRNA Translation: BAB30922.2
AK088152 mRNA Translation: BAC40175.1
AK029088 mRNA Translation: BAC26287.1 Sequence problems.
BC019126 mRNA Translation: AAH19126.1
CCDSiCCDS15022.1
RefSeqiNP_001297571.1, NM_001310642.1
NP_001297572.1, NM_001310643.1
NP_001297573.1, NM_001310644.1
NP_079959.2, NM_025683.3
UniGeneiMm.240912

Genome annotation databases

EnsembliENSMUST00000027157; ENSMUSP00000027157; ENSMUSG00000026005
GeneIDi66646
KEGGimmu:66646
UCSCiuc007bik.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007735 mRNA No translation available.
AK017774 mRNA Translation: BAB30922.2
AK088152 mRNA Translation: BAC40175.1
AK029088 mRNA Translation: BAC26287.1 Sequence problems.
BC019126 mRNA Translation: AAH19126.1
CCDSiCCDS15022.1
RefSeqiNP_001297571.1, NM_001310642.1
NP_001297572.1, NM_001310643.1
NP_001297573.1, NM_001310644.1
NP_079959.2, NM_025683.3
UniGeneiMm.240912

3D structure databases

ProteinModelPortaliQ8VEE0
SMRiQ8VEE0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027157

PTM databases

iPTMnetiQ8VEE0
PhosphoSitePlusiQ8VEE0

Proteomic databases

EPDiQ8VEE0
MaxQBiQ8VEE0
PaxDbiQ8VEE0
PRIDEiQ8VEE0

Protocols and materials databases

DNASUi66646
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027157; ENSMUSP00000027157; ENSMUSG00000026005
GeneIDi66646
KEGGimmu:66646
UCSCiuc007bik.1 mouse

Organism-specific databases

CTDi6120
MGIiMGI:1913896 Rpe

Phylogenomic databases

eggNOGiKOG3111 Eukaryota
COG0036 LUCA
GeneTreeiENSGT00390000001447
HOGENOMiHOG000259349
HOVERGENiHBG044821
InParanoidiQ8VEE0
KOiK01783
OMAiCHLMIED
PhylomeDBiQ8VEE0
TreeFamiTF300157

Enzyme and pathway databases

ReactomeiR-MMU-71336 Pentose phosphate pathway

Miscellaneous databases

PROiPR:Q8VEE0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026005 Expressed in 291 organ(s), highest expression level in secondary oocyte
CleanExiMM_RPE
ExpressionAtlasiQ8VEE0 baseline and differential
GenevisibleiQ8VEE0 MM

Family and domain databases

CDDicd00429 RPE, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR026019 Ribul_P_3_epim
IPR000056 Ribul_P_3_epim-like
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR11749 PTHR11749, 1 hit
PfamiView protein in Pfam
PF00834 Ribul_P_3_epim, 1 hit
PIRSFiPIRSF001461 RPE, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR01163 rpe, 1 hit
PROSITEiView protein in PROSITE
PS01085 RIBUL_P_3_EPIMER_1, 1 hit
PS01086 RIBUL_P_3_EPIMER_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRPE_MOUSE
AccessioniPrimary (citable) accession number: Q8VEE0
Secondary accession number(s): Q8C130, Q9BSB5, Q9CQZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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