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Entry version 139 (16 Oct 2019)
Sequence version 1 (01 Mar 2002)
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Protein

Galectin-related protein

Gene

Lgalsl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Does not bind lactose, and may not bind carbohydrates.By similarity

Caution

Most of the residues in the galectin domain that have been shown to be critical for carbohydrate-binding in other galectins are not conserved.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLectin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Galectin-related protein
Alternative name(s):
Galectin-related protein A
Lectin galactoside-binding-like protein A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lgalsl
Synonyms:Grpa, Lgalsla
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1916114 Lgalsl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003157672 – 172Galectin-related proteinAdd BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei22PhosphoserineBy similarity1
Modified residuei25PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8VED9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8VED9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8VED9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8VED9

PeptideAtlas

More...
PeptideAtlasi
Q8VED9

PRoteomics IDEntifications database

More...
PRIDEi
Q8VED9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8VED9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8VED9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8VED9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000042363 Expressed in 291 organ(s), highest expression level in camera-type eye

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8VED9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8VED9, 1 interactor

Molecular INTeraction database

More...
MINTi
Q8VED9

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000044342

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8VED9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 168GalectinPROSITE-ProRule annotationAdd BLAST130

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3587 Eukaryota
ENOG4111EA0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155337

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293279

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8VED9

Identification of Orthologs from Complete Genome Data

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OMAi
CVSGEWG

Database of Orthologous Groups

More...
OrthoDBi
829777at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8VED9

TreeFam database of animal gene trees

More...
TreeFami
TF315551

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00070 GLECT, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030651 Galectin-rel
IPR001079 Galectin_CRD

The PANTHER Classification System

More...
PANTHERi
PTHR11346:SF98 PTHR11346:SF98, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00337 Gal-bind_lectin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51304 GALECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VED9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGSVADSDA VVKLDDGHLN NSLGSPVQAD VYFPRLIVPF CGHIKGGMRP
60 70 80 90 100
GKKVLVMGIV DLNPESFAIS LTCGDSEDPP ADVAIELKAV FTDRQLLRNS
110 120 130 140 150
CISGERGEEQ SAIPYFPFIP DQPFRVEILC EHPRFRVFVD GHQLFDFYHR
160 170
IQTLSAIDTI KINGDLQITK LG
Length:172
Mass (Da):18,956
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i56D40BE7D56FC336
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK041053 mRNA Translation: BAC30800.1
AK081513 mRNA Translation: BAC38245.1
AK156350 mRNA Translation: BAE33684.1
AK167557 mRNA Translation: BAE39621.1
AL662817 Genomic DNA No translation available.
BC019131 mRNA Translation: AAH19131.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24461.1

NCBI Reference Sequences

More...
RefSeqi
NP_776113.1, NM_173752.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000047028; ENSMUSP00000044342; ENSMUSG00000042363

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
216551

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:216551

UCSC genome browser

More...
UCSCi
uc007idj.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041053 mRNA Translation: BAC30800.1
AK081513 mRNA Translation: BAC38245.1
AK156350 mRNA Translation: BAE33684.1
AK167557 mRNA Translation: BAE39621.1
AL662817 Genomic DNA No translation available.
BC019131 mRNA Translation: AAH19131.1
CCDSiCCDS24461.1
RefSeqiNP_776113.1, NM_173752.4

3D structure databases

SMRiQ8VED9
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8VED9, 1 interactor
MINTiQ8VED9
STRINGi10090.ENSMUSP00000044342

PTM databases

iPTMnetiQ8VED9
PhosphoSitePlusiQ8VED9
SwissPalmiQ8VED9

Proteomic databases

EPDiQ8VED9
jPOSTiQ8VED9
MaxQBiQ8VED9
PaxDbiQ8VED9
PeptideAtlasiQ8VED9
PRIDEiQ8VED9

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
216551

Genome annotation databases

EnsembliENSMUST00000047028; ENSMUSP00000044342; ENSMUSG00000042363
GeneIDi216551
KEGGimmu:216551
UCSCiuc007idj.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29094
MGIiMGI:1916114 Lgalsl

Phylogenomic databases

eggNOGiKOG3587 Eukaryota
ENOG4111EA0 LUCA
GeneTreeiENSGT00940000155337
HOGENOMiHOG000293279
InParanoidiQ8VED9
OMAiCVSGEWG
OrthoDBi829777at2759
PhylomeDBiQ8VED9
TreeFamiTF315551

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8VED9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000042363 Expressed in 291 organ(s), highest expression level in camera-type eye
GenevisibleiQ8VED9 MM

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030651 Galectin-rel
IPR001079 Galectin_CRD
PANTHERiPTHR11346:SF98 PTHR11346:SF98, 1 hit
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLEGL_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VED9
Secondary accession number(s): Q8C4P8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2002
Last modified: October 16, 2019
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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