UniProtKB - Q8VEC4 (CAHM2_MOUSE)
Protein
Calcium homeostasis modulator protein 2
Gene
Calhm2
Organism
Mus musculus (Mouse)
Status
Functioni
Pore-forming subunit of a voltage-gated ion channel.By similarity
GO - Molecular functioni
- cation channel activity Source: GO_Central
GO - Biological processi
- positive regulation of apoptotic process Source: UniProtKB
Keywordsi
Molecular function | Ion channel |
Biological process | Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium homeostasis modulator protein 2Alternative name(s): Protein FAM26B |
Gene namesi | Name:Calhm2 Synonyms:Fam26b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1919941, Calhm2 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 21 – 41 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 55 – 75 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 100 – 120 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 185 – 205 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186721 | 1 – 323 | Calcium homeostasis modulator protein 2Add BLAST | 323 |
Proteomic databases
MaxQBi | Q8VEC4 |
PaxDbi | Q8VEC4 |
PRIDEi | Q8VEC4 |
PTM databases
SwissPalmi | Q8VEC4 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000033033, Expressed in spleen and 130 other tissues |
ExpressionAtlasi | Q8VEC4, baseline and differential |
Genevisiblei | Q8VEC4, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000047278 |
Miscellaneous databases
RNActi | Q8VEC4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the CALHM family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QVU7, Eukaryota |
GeneTreei | ENSGT01000000214456 |
HOGENOMi | CLU_069286_1_0_1 |
InParanoidi | Q8VEC4 |
OrthoDBi | 833717at2759 |
PhylomeDBi | Q8VEC4 |
TreeFami | TF329085 |
Family and domain databases
InterProi | View protein in InterPro IPR029569, CALHM IPR029570, CALHM2 |
PANTHERi | PTHR32261, PTHR32261, 1 hit PTHR32261:SF3, PTHR32261:SF3, 1 hit |
Pfami | View protein in Pfam PF14798, Ca_hom_mod, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8VEC4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAALIAENFR FLSLFFKSKD VMIFNGLVAL GTVGSQELFS VVAFHCPCSP
60 70 80 90 100
ARNYLYGLTA IGVPALALFL IGVILNNHTW NLVAECQYRR AKNCSAAPNF
110 120 130 140 150
LLLSSILGRA AVAPVTWSVI SLLRGEAYVC ALSEFVDPSS LTAGDKGFPP
160 170 180 190 200
AHATEVLARF PCGEGPANLS SFREEVSRRL KYESQLFGWL LIGVVAILVF
210 220 230 240 250
LTKCLKHYCS PLSYRQEAYW AQYRTNEDQL FQRTAEVHSR VLAANNVRRF
260 270 280 290 300
FGFVALNKDD EELVAKFPVE GTQPRPQWNA ITGVYLYREN QGLPLYSRLH
310 320
KWAQGLTGNG TAPDNVEMAL LTA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3Z2E8 | D3Z2E8_MOUSE | Calcium homeostasis modulator prote... | Calhm2 | 322 | Annotation score: |
Sequence cautioni
The sequence BAC25382 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 97 | A → P in BAC25382 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 109 | R → S in BAC40825 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 145 – 148 | DKGF → IKLP in BAC25382 (PubMed:16141072).Curated | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK012923 mRNA Translation: BAC25382.1 Frameshift. AK089278 mRNA Translation: BAC40825.1 AK170068 mRNA Translation: BAE41544.1 BC019197 mRNA Translation: AAH19197.1 |
CCDSi | CCDS29889.1 |
RefSeqi | NP_598507.3, NM_133746.5 |
Genome annotation databases
Ensembli | ENSMUST00000035822; ENSMUSP00000047278; ENSMUSG00000033033 |
GeneIDi | 72691 |
KEGGi | mmu:72691 |
UCSCi | uc008hur.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK012923 mRNA Translation: BAC25382.1 Frameshift. AK089278 mRNA Translation: BAC40825.1 AK170068 mRNA Translation: BAE41544.1 BC019197 mRNA Translation: AAH19197.1 |
CCDSi | CCDS29889.1 |
RefSeqi | NP_598507.3, NM_133746.5 |
3D structure databases
SMRi | Q8VEC4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000047278 |
PTM databases
SwissPalmi | Q8VEC4 |
Proteomic databases
MaxQBi | Q8VEC4 |
PaxDbi | Q8VEC4 |
PRIDEi | Q8VEC4 |
Protocols and materials databases
Antibodypediai | 18174, 20 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000035822; ENSMUSP00000047278; ENSMUSG00000033033 |
GeneIDi | 72691 |
KEGGi | mmu:72691 |
UCSCi | uc008hur.2, mouse |
Organism-specific databases
CTDi | 51063 |
MGIi | MGI:1919941, Calhm2 |
Phylogenomic databases
eggNOGi | ENOG502QVU7, Eukaryota |
GeneTreei | ENSGT01000000214456 |
HOGENOMi | CLU_069286_1_0_1 |
InParanoidi | Q8VEC4 |
OrthoDBi | 833717at2759 |
PhylomeDBi | Q8VEC4 |
TreeFami | TF329085 |
Miscellaneous databases
BioGRID-ORCSi | 72691, 0 hits in 17 CRISPR screens |
ChiTaRSi | Calhm2, mouse |
PROi | PR:Q8VEC4 |
RNActi | Q8VEC4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000033033, Expressed in spleen and 130 other tissues |
ExpressionAtlasi | Q8VEC4, baseline and differential |
Genevisiblei | Q8VEC4, MM |
Family and domain databases
InterProi | View protein in InterPro IPR029569, CALHM IPR029570, CALHM2 |
PANTHERi | PTHR32261, PTHR32261, 1 hit PTHR32261:SF3, PTHR32261:SF3, 1 hit |
Pfami | View protein in Pfam PF14798, Ca_hom_mod, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAHM2_MOUSE | |
Accessioni | Q8VEC4Primary (citable) accession number: Q8VEC4 Secondary accession number(s): Q3TDQ7, Q8BT85, Q8C246 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | March 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families