UniProtKB - Q8VEB4 (PAG15_MOUSE)
Protein
Phospholipase A2 group XV
Gene
Pla2g15
Organism
Mus musculus (Mouse)
Status
Functioni
Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments (PubMed:16837646, PubMed:17626977, PubMed:11790796, PubMed:16106046, PubMed:16880524, PubMed:19017977, PubMed:20410020). Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity). Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines (PubMed:20410020). Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines and phosphatidylethanolamines (PubMed:16837646, PubMed:17626977). Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide (PubMed:16837646, PubMed:17626977). Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress (PubMed:27993948). Required for normal phospholipid degradation in alveolar macrophages with potential implications in pulmonary surfactant clearance (PubMed:16880524, PubMed:19017977). At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines (By similarity).By similarity8 Publications
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+1 PublicationEC:3.1.1.321 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H+ + hexadecanoate1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 2-nonadioyl-sn-glycero-3-phosphocholine + H+ + hexadecanoate1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = 2-glutaroyl-sn-glycero-3-phosphocholine + H+ + hexadecanoate1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H+ + hexadecanoate1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H+ + hexadecanoate1 PublicationThis reaction proceeds in the forward1 Publication direction.
- a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+1 PublicationEC:3.1.1.41 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholineBy similarityEC:3.1.1.5By similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H+ + hexadecanoate + sn-glycerol 3-phosphocholineBy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine7 PublicationsThis reaction proceeds in the forward1 Publication direction.
Activity regulationi
Phospholipase sn-2 versus sn-1 positional specificity is affected by the phospholipid composition of membranes. Phospholipase A2 activity toward 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine (PAPE) is enhanced in the presence of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), which promotes lipid bilayer formation (PubMed:16837646). O-acyltransferase activity is inhibited by antiarrhythmic drug amiodarone (PubMed:27993948).2 Publications
Kineticsi
- KM=171 µM for 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine (O-acyltransferase activity)1 Publication
- Vmax=5.55 µmol/min/mg enzyme toward 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine (O-acyltransferase activity)1 Publication
pH dependencei
Optimum pH is 4.5.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 46 | Substrate; via amide nitrogenBy similarity | 1 | |
Active sitei | 198 | Acyl-ester intermediateSequence analysis2 Publications | 1 | |
Binding sitei | 199 | Substrate; via amide nitrogenBy similarity | 1 | |
Active sitei | 360 | Charge relay systemBy similarity1 Publication | 1 | |
Active sitei | 392 | Charge relay systemBy similarity1 Publication | 1 |
GO - Molecular functioni
- 1-acyl-2-lysophosphatidylserine acylhydrolase activity Source: UniProtKB-EC
- acylglycerol O-acyltransferase activity Source: UniProtKB
- calcium-independent phospholipase A2 activity Source: UniProtKB
- O-acyltransferase activity Source: UniProtKB
- phosphatidyl phospholipase B activity Source: UniProtKB-EC
- phosphatidylserine 1-acylhydrolase activity Source: UniProtKB-EC
- phospholipase A1 activity Source: UniProtKB
- phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) Source: UniProtKB-EC
- phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) Source: UniProtKB-EC
- triglyceride lipase activity Source: GO_Central
GO - Biological processi
- ceramide metabolic process Source: UniProtKB
- diacylglycerol biosynthetic process Source: UniProtKB
- fatty acid metabolic process Source: UniProtKB-KW
- glycerophospholipid metabolic process Source: UniProtKB
- lipid metabolic process Source: GO_Central
- phosphatidylcholine catabolic process Source: UniProtKB
- phosphatidylcholine metabolic process Source: MGI
- phosphatidylethanolamine catabolic process Source: UniProtKB
Keywordsi
Molecular function | Acyltransferase, Hydrolase, Transferase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Enzyme and pathway databases
Reactomei | R-MMU-1483115, Hydrolysis of LPC |
Protein family/group databases
ESTHERi | mouse-C87498, PC-sterol_acyltransferase |
Chemistry databases
SwissLipidsi | SLP:000000352 |
Names & Taxonomyi
Protein namesi | Recommended name: Phospholipase A2 group XVAlternative name(s): |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2178076, Pla2g15 |
Subcellular locationi
Lysosome
- Lysosome 1 Publication
Extracellular region or secreted
- Secreted 2 Publications
Other locations
- Membrane By similarity; Peripheral membrane protein By similarity
Extracellular region or secreted
- extracellular space Source: UniProtKB
Lysosome
- lysosome Source: MGI
Mitochondrion
- mitochondrion Source: MGI
Nucleus
- nucleoplasm Source: MGI
Other locations
- intracellular membrane-bounded organelle Source: MGI
- membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Lysosome, Membrane, SecretedPathology & Biotechi
Disruption phenotypei
Mice are born at the expected Mendelian rate, are viable and fertile. They display strongly reduced transacylase activity in lung alveolar macrophages and in peritoneal macrophages, leading to the accumulation of pulmonary surfactant phospholipids with phosphatidylethanolamine and phosphatidylcholine headgroups. Mice display higher numers of alveolar macrophages in the lung, together with a mononuclear cell infiltrate in airways and blood vessels. Alveolar nmacrophages are larger than normal and present lamellar inclusion bodies, indicative of cellular phospholipidosis. Besides, mutant mice display splenomegaly.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 65 | C → A: Abolishes enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 89 | C → A: Abolishes enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 198 | S → A: Abolishes enzyme activity. 2 Publications | 1 | |
Mutagenesisi | 360 | D → A: Abolishes enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 392 | H → A: Abolishes enzyme activity. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL3259497 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | By similarityAdd BLAST | 33 | |
ChainiPRO_0000017809 | 34 – 412 | Phospholipase A2 group XVAdd BLAST | 379 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 65 ↔ 89 | By similarity1 Publication | ||
Glycosylationi | 99 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 273 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 289 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 398 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated (PubMed:11790796). N-glycosylation is important for maturation of the enzyme and normal subcellular location (By similarity).By similarity1 Publication
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q8VEB4 |
MaxQBi | Q8VEB4 |
PaxDbi | Q8VEB4 |
PeptideAtlasi | Q8VEB4 |
PRIDEi | Q8VEB4 |
PTM databases
GlyConnecti | 2363, 7 N-Linked glycans (4 sites) |
GlyGeni | Q8VEB4, 4 sites |
PhosphoSitePlusi | Q8VEB4 |
Expressioni
Tissue specificityi
Detected in blood plasma (PubMed:20410020). Detected in alveolar macrophages (at protein level) (PubMed:16106046, PubMed:16880524, PubMed:19017977). Detected in heart, liver, spleen, kidney, thymus, brain and lung (PubMed:16880524).4 Publications
Gene expression databases
Bgeei | ENSMUSG00000031903, Expressed in stroma of bone marrow and 261 other tissues |
ExpressionAtlasi | Q8VEB4, baseline and differential |
Genevisiblei | Q8VEB4, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 228695, 19 interactors |
IntActi | Q8VEB4, 2 interactors |
MINTi | Q8VEB4 |
STRINGi | 10090.ENSMUSP00000034377 |
Miscellaneous databases
RNActi | Q8VEB4, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG2369, Eukaryota |
GeneTreei | ENSGT00940000157499 |
HOGENOMi | CLU_037070_1_1_1 |
InParanoidi | Q8VEB4 |
OMAi | IPGWGDP |
OrthoDBi | 828056at2759 |
PhylomeDBi | Q8VEB4 |
TreeFami | TF313258 |
Family and domain databases
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR003386, LACT/PDAT_acylTrfase |
Pfami | View protein in Pfam PF02450, LCAT, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8VEB4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDRHLCTCRE TQLRSGLLLP LFLLMMLADL TLPAQRHPPV VLVPGDLGNQ
60 70 80 90 100
LEAKLDKPKV VHYLCSKKTD SYFTLWLNLE LLLPVIIDCW IDNIRLVYNR
110 120 130 140 150
TSRATQFPDG VDVRVPGFGE TFSMEFLDPS KRNVGSYFYT MVESLVGWGY
160 170 180 190 200
TRGEDVRGAP YDWRRAPNEN GPYFLALREM IEEMYQMYGG PVVLVAHSMG
210 220 230 240 250
NVYMLYFLQR QPQVWKDKYI HAFVSLGAPW GGVAKTLRVL ASGDNNRIPV
260 270 280 290 300
IGPLKIREQQ RSAVSTSWLL PYNHTWSHEK VFVYTPTTNY TLRDYHRFFR
310 320 330 340 350
DIGFEDGWFM RQDTEGLVEA MTPPGVELHC LYGTGVPTPN SFYYESFPDR
360 370 380 390 400
DPKICFGDGD GTVNLESVLQ CQAWQSRQEH RVSLQELPGS EHIEMLANAT
410
TLAYLKRVLL EP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1D5RLZ5 | A0A1D5RLZ5_MOUSE | Phospholipase A2 group XV | Pla2g15 | 236 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 342 | F → S in BAE32987 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF468958 mRNA Translation: AAL78651.1 AY179884 Genomic DNA Translation: AAO49009.1 AK085194 mRNA Translation: BAC39387.1 AK155004 mRNA Translation: BAE32987.1 AK163111 mRNA Translation: BAE37197.1 AK170814 mRNA Translation: BAE42046.1 BC019373 mRNA Translation: AAH19373.1 |
CCDSi | CCDS22630.1 |
RefSeqi | NP_598553.1, NM_133792.2 |
Genome annotation databases
Ensembli | ENSMUST00000034377; ENSMUSP00000034377; ENSMUSG00000031903 |
GeneIDi | 192654 |
KEGGi | mmu:192654 |
UCSCi | uc009nfj.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF468958 mRNA Translation: AAL78651.1 AY179884 Genomic DNA Translation: AAO49009.1 AK085194 mRNA Translation: BAC39387.1 AK155004 mRNA Translation: BAE32987.1 AK163111 mRNA Translation: BAE37197.1 AK170814 mRNA Translation: BAE42046.1 BC019373 mRNA Translation: AAH19373.1 |
CCDSi | CCDS22630.1 |
RefSeqi | NP_598553.1, NM_133792.2 |
3D structure databases
SMRi | Q8VEB4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 228695, 19 interactors |
IntActi | Q8VEB4, 2 interactors |
MINTi | Q8VEB4 |
STRINGi | 10090.ENSMUSP00000034377 |
Chemistry databases
ChEMBLi | CHEMBL3259497 |
SwissLipidsi | SLP:000000352 |
Protein family/group databases
ESTHERi | mouse-C87498, PC-sterol_acyltransferase |
PTM databases
GlyConnecti | 2363, 7 N-Linked glycans (4 sites) |
GlyGeni | Q8VEB4, 4 sites |
PhosphoSitePlusi | Q8VEB4 |
Proteomic databases
EPDi | Q8VEB4 |
MaxQBi | Q8VEB4 |
PaxDbi | Q8VEB4 |
PeptideAtlasi | Q8VEB4 |
PRIDEi | Q8VEB4 |
Protocols and materials databases
Antibodypediai | 29747, 104 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000034377; ENSMUSP00000034377; ENSMUSG00000031903 |
GeneIDi | 192654 |
KEGGi | mmu:192654 |
UCSCi | uc009nfj.1, mouse |
Organism-specific databases
CTDi | 23659 |
MGIi | MGI:2178076, Pla2g15 |
Phylogenomic databases
eggNOGi | KOG2369, Eukaryota |
GeneTreei | ENSGT00940000157499 |
HOGENOMi | CLU_037070_1_1_1 |
InParanoidi | Q8VEB4 |
OMAi | IPGWGDP |
OrthoDBi | 828056at2759 |
PhylomeDBi | Q8VEB4 |
TreeFami | TF313258 |
Enzyme and pathway databases
Reactomei | R-MMU-1483115, Hydrolysis of LPC |
Miscellaneous databases
BioGRID-ORCSi | 192654, 3 hits in 19 CRISPR screens |
ChiTaRSi | Pla2g15, mouse |
PROi | PR:Q8VEB4 |
RNActi | Q8VEB4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031903, Expressed in stroma of bone marrow and 261 other tissues |
ExpressionAtlasi | Q8VEB4, baseline and differential |
Genevisiblei | Q8VEB4, MM |
Family and domain databases
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR003386, LACT/PDAT_acylTrfase |
Pfami | View protein in Pfam PF02450, LCAT, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PAG15_MOUSE | |
Accessioni | Q8VEB4Primary (citable) accession number: Q8VEB4 Secondary accession number(s): Q3TCB1, Q3U303 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2004 |
Last sequence update: | March 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families