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Protein

Ras-related protein Rab-7b

Gene

Rab7b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22GTPBy similarity8
Nucleotide bindingi34 – 40GTPBy similarity7
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi124 – 127GTPBy similarity4
Nucleotide bindingi154 – 155GTPBy similarity2

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-8854214 TBC/RABGAPs
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-7b
Gene namesi
Name:Rab7b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2442295 Rab7b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211261 – 199Ras-related protein Rab-7bAdd BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186PhosphoserineCombined sources1
Lipidationi198S-geranylgeranyl cysteineBy similarity1
Lipidationi199S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ8VEA8
PRIDEiQ8VEA8

PTM databases

iPTMnetiQ8VEA8
PhosphoSitePlusiQ8VEA8
SwissPalmiQ8VEA8

Expressioni

Gene expression databases

BgeeiENSMUSG00000052688 Expressed in 186 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_5430435G22RIK
ExpressionAtlasiQ8VEA8 baseline and differential
GenevisibleiQ8VEA8 MM

Interactioni

Protein-protein interaction databases

BioGridi230511, 1 interactor
STRINGi10090.ENSMUSP00000065456

Structurei

3D structure databases

ProteinModelPortaliQ8VEA8
SMRiQ8VEA8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0394 Eukaryota
ENOG410XNZV LUCA
GeneTreeiENSGT00760000119125
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ8VEA8
KOiK07898
OMAiDYRTTLG
OrthoDBiEOG091G0MVE
PhylomeDBiQ8VEA8
TreeFamiTF326442

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8VEA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNPRKKVDLK LIIVGALGVG KTSLLHQYVH KTFFEEYQTT LGASILSKII
60 70 80 90 100
ILDDTTLKLQ IWDTGGQERF RSMVSTFYKG SDGCILAFDV TDPESFEALD
110 120 130 140 150
IWRDDVLAKI IPMEQSYPMV VLGNKIDLED RKVSQEVVHG WCKEKDMPYF
160 170 180 190
EVSAKNDINV VQAFEVLASR ALLRYQGTAE NHLIDSIKLS PGQPKSRCC
Length:199
Mass (Da):22,502
Last modified:March 1, 2002 - v1
Checksum:i33353842079CF6FC
GO
Isoform 2 (identifier: Q8VEA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-174: Missing.

Show »
Length:157
Mass (Da):17,712
Checksum:i7B31B49C7A169AD9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YZQ6D3YZQ6_MOUSE
Ras-related protein Rab-7b
Rab7b 5430435G22Rik
106Annotation score:
D3Z4X4D3Z4X4_MOUSE
RIKEN cDNA 5430435G22, isoform CRA_...
Rab7b 5430435G22Rik, mCG_2613
85Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187I → V in BAC29291 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011108133 – 174Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB232641 mRNA Translation: BAF02903.1
AK030688 mRNA Translation: BAC27078.1
AK036056 mRNA Translation: BAC29291.1
AK079999 mRNA Translation: BAC37802.1
CH466520 Genomic DNA Translation: EDL39704.1
CCDSiCCDS15272.1 [Q8VEA8-1]
CCDS78677.1 [Q8VEA8-2]
RefSeqiNP_001298025.1, NM_001311096.1 [Q8VEA8-2]
NP_663484.1, NM_145509.3 [Q8VEA8-1]
XP_006529493.1, XM_006529430.2 [Q8VEA8-1]
UniGeneiMm.44508

Genome annotation databases

EnsembliENSMUST00000064664; ENSMUSP00000066452; ENSMUSG00000052688 [Q8VEA8-2]
ENSMUST00000064679; ENSMUSP00000065456; ENSMUSG00000052688 [Q8VEA8-1]
GeneIDi226421
KEGGimmu:226421
UCSCiuc007cnp.1 mouse [Q8VEA8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB232641 mRNA Translation: BAF02903.1
AK030688 mRNA Translation: BAC27078.1
AK036056 mRNA Translation: BAC29291.1
AK079999 mRNA Translation: BAC37802.1
CH466520 Genomic DNA Translation: EDL39704.1
CCDSiCCDS15272.1 [Q8VEA8-1]
CCDS78677.1 [Q8VEA8-2]
RefSeqiNP_001298025.1, NM_001311096.1 [Q8VEA8-2]
NP_663484.1, NM_145509.3 [Q8VEA8-1]
XP_006529493.1, XM_006529430.2 [Q8VEA8-1]
UniGeneiMm.44508

3D structure databases

ProteinModelPortaliQ8VEA8
SMRiQ8VEA8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230511, 1 interactor
STRINGi10090.ENSMUSP00000065456

PTM databases

iPTMnetiQ8VEA8
PhosphoSitePlusiQ8VEA8
SwissPalmiQ8VEA8

Proteomic databases

PaxDbiQ8VEA8
PRIDEiQ8VEA8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064664; ENSMUSP00000066452; ENSMUSG00000052688 [Q8VEA8-2]
ENSMUST00000064679; ENSMUSP00000065456; ENSMUSG00000052688 [Q8VEA8-1]
GeneIDi226421
KEGGimmu:226421
UCSCiuc007cnp.1 mouse [Q8VEA8-1]

Organism-specific databases

CTDi338382
MGIiMGI:2442295 Rab7b

Phylogenomic databases

eggNOGiKOG0394 Eukaryota
ENOG410XNZV LUCA
GeneTreeiENSGT00760000119125
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ8VEA8
KOiK07898
OMAiDYRTTLG
OrthoDBiEOG091G0MVE
PhylomeDBiQ8VEA8
TreeFamiTF326442

Enzyme and pathway databases

ReactomeiR-MMU-8854214 TBC/RABGAPs
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

PROiPR:Q8VEA8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052688 Expressed in 186 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_5430435G22RIK
ExpressionAtlasiQ8VEA8 baseline and differential
GenevisibleiQ8VEA8 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB7B_MOUSE
AccessioniPrimary (citable) accession number: Q8VEA8
Secondary accession number(s): Q0PD09, Q8BJT0, Q8BZB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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