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Protein

Serine/arginine-rich splicing factor 4

Gene

Srsf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10 (By similarity).By similarity

GO - Molecular functioni

  • RNA binding Source: GO_Central
  • sequence-specific mRNA binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionRepressor, RNA-binding
Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/arginine-rich splicing factor 4
Alternative name(s):
Splicing factor, arginine/serine-rich 4
Gene namesi
Name:Srsf4
Synonyms:Sfrs4
ORF Names:MNCb-2616
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1890577 Srsf4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000819261 – 489Serine/arginine-rich splicing factor 4Add BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78PhosphoserineBy similarity1
Modified residuei84PhosphoserineBy similarity1
Modified residuei289PhosphoserineBy similarity1
Modified residuei291PhosphoserineBy similarity1
Modified residuei293PhosphoserineBy similarity1
Modified residuei441PhosphoserineBy similarity1
Modified residuei453PhosphoserineBy similarity1
Modified residuei455PhosphoserineBy similarity1

Post-translational modificationi

Extensively phosphorylated on serine residues in the RS domain.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VE97
MaxQBiQ8VE97
PaxDbiQ8VE97
PeptideAtlasiQ8VE97
PRIDEiQ8VE97

PTM databases

iPTMnetiQ8VE97
PhosphoSitePlusiQ8VE97

Expressioni

Gene expression databases

CleanExiMM_SFRS4

Interactioni

Subunit structurei

Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Interacts with PNN (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8VE97, 2 interactors
MINTiQ8VE97
STRINGi10090.ENSMUSP00000061474

Structurei

3D structure databases

ProteinModelPortaliQ8VE97
SMRiQ8VE97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 72RRM 1PROSITE-ProRule annotationAdd BLAST71
Domaini104 – 177RRM 2PROSITE-ProRule annotationAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi72 – 97Gly-rich (hinge region)Add BLAST26
Compositional biasi180 – 489Arg/Ser-rich (RS domain)Add BLAST310

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0106 Eukaryota
COG0724 LUCA
HOVERGENiHBG002295
InParanoidiQ8VE97

Family and domain databases

CDDicd12337 RRM1_SRSF4_like, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR035585 RRM1_SRSF4-like
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8VE97-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRVYIGRLS YQARERDVER FFKGYGKILE VDLKNGYGFV EFDDLRDADD
60 70 80 90 100
AVYELNGKDL CGERVIVEHA RGPRRDGSYG SGRSGYGYRR SGRDKYGPPT
110 120 130 140 150
RTEYRLIVEN LSSRCSWQDL KDYMRQAGEV TYADAHKGRK NEGVIEFVSY
160 170 180 190 200
SDMKRALEKL DGTEVNGRKI RLVEDKPGSR RRRSYSRSRS HSRSRSRSRH
210 220 230 240 250
SRKSRSRSGS SKSSHSKSRS RSRSGSHSRS KSRSRSQSRS RSKKEKSRSP
260 270 280 290 300
SKDNKSRSRS RSPDKSRSKS KDHAEDKLQN NDSAGKAKSH SPSRHDSKSR
310 320 330 340 350
SRSQERRAEE ERRRSVSRAR SQEKSRSQEK SLLKSRSRSR SRSRSRSKDK
360 370 380 390 400
RKGRKRSRDE SRSRSRSKSE RSRKHSSKRD SKVSSSSSSS KKKKDTDHSR
410 420 430 440 450
SPSRSVSKER EHAKAESGQR GSRAEGESEA PNPEPRARSR STSKSKPNVP
460 470 480
AESRSRSKSA SKTRSRSKSP SRSASRSPSR SRSRSHSRS
Length:489
Mass (Da):55,979
Last modified:March 1, 2002 - v1
Checksum:i8D5FE8D1EF4624B3
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q542V3Q542V3_MOUSE
Serine/arginine-rich-splicing facto...
Srsf4 Sfrs4, mCG_16265
491Annotation score:
A0A0A6YWA5A0A0A6YWA5_MOUSE
Serine/arginine-rich-splicing facto...
Srsf4
56Annotation score:
A0A0A6YXU8A0A0A6YXU8_MOUSE
Serine/arginine-rich-splicing facto...
Srsf4
31Annotation score:

Sequence cautioni

The sequence BAA95070 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti341S → SKVGS (Ref. 2) Curated1
Sequence conflicti389 – 390Missing (Ref. 2) Curated2
Sequence conflicti421G → E in BAA95070 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019437 mRNA Translation: AAH19437.1
AB041587 mRNA Translation: BAA95070.1 Different initiation.
UniGeneiMm.2478

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019437 mRNA Translation: AAH19437.1
AB041587 mRNA Translation: BAA95070.1 Different initiation.
UniGeneiMm.2478

3D structure databases

ProteinModelPortaliQ8VE97
SMRiQ8VE97
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VE97, 2 interactors
MINTiQ8VE97
STRINGi10090.ENSMUSP00000061474

PTM databases

iPTMnetiQ8VE97
PhosphoSitePlusiQ8VE97

Proteomic databases

EPDiQ8VE97
MaxQBiQ8VE97
PaxDbiQ8VE97
PeptideAtlasiQ8VE97
PRIDEiQ8VE97

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1890577 Srsf4

Phylogenomic databases

eggNOGiKOG0106 Eukaryota
COG0724 LUCA
HOVERGENiHBG002295
InParanoidiQ8VE97

Miscellaneous databases

ChiTaRSiSrsf4 mouse
PROiPR:Q8VE97
SOURCEiSearch...

Gene expression databases

CleanExiMM_SFRS4

Family and domain databases

CDDicd12337 RRM1_SRSF4_like, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR035585 RRM1_SRSF4-like
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSRSF4_MOUSE
AccessioniPrimary (citable) accession number: Q8VE97
Secondary accession number(s): Q9JJC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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