Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 123 (12 Aug 2020)
Sequence version 2 (16 Sep 2015)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Reticulophagy regulator 1

Gene

Retreg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed:26040720). Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed:19838196, PubMed:26040720).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Reticulophagy regulator 1
Alternative name(s):
Reticulophagy receptor 1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Retreg1
Synonyms:Fam134b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1913520, Retreg1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 42CytoplasmicBy similarityAdd BLAST42
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei43 – 64HelicalSequence analysisAdd BLAST22
Topological domaini65 – 75LumenalCuratedAdd BLAST11
Transmembranei76 – 93HelicalSequence analysisAdd BLAST18
Topological domaini94 – 98CytoplasmicCurated5
Transmembranei99 – 116HelicalSequence analysisAdd BLAST18
Topological domaini117 – 191LumenalCuratedAdd BLAST75
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 480CytoplasmicBy similarityAdd BLAST268

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Leads to an expanded endoplasmic reticulum.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002884671 – 480Reticulophagy regulator 1Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei340PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8VE91

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8VE91

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8VE91

PeptideAtlas

More...
PeptideAtlasi
Q8VE91

PRoteomics IDEntifications database

More...
PRIDEi
Q8VE91

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8VE91

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8VE91

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in sensory and autonomic ganglia has demonstrated by in situ hybridizations of embryonic day 14.5 mouse embryo sections. Detected specifically in organelle-like intracellular structures of the small and large neurons of dorsal root ganglia (DRG) and in Neuro-2a cells, a tumor cell line that is related to autonomic ganglion neurons (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022270, Expressed in gastrocnemius medialis and 304 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8VE91, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8VE91, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2.

By similarity

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-61579N

Protein interaction database and analysis system

More...
IntActi
Q8VE91, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000022881

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8VE91, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni67 – 216Reticulon homology domain1 PublicationAdd BLAST150

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi436 – 441LIR motifBy similarity6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The LIR motif interacts with ATG8 family proteins and is necessary to target the ER fragments to autophagosomes for lysosomal degradation.1 Publication
The reticulon homology domain provides capacity to bend the membrane and promotes ER scission (PubMed:26040720). This domain does not show relevant similarities with reticulon domains, preventing any domain predictions within the protein sequence.Curated1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RETREG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPW8, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160746

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_036265_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8VE91

KEGG Orthology (KO)

More...
KOi
K23880

Identification of Orthologs from Complete Genome Data

More...
OMAi
PRINQCI

Database of Orthologous Groups

More...
OrthoDBi
901531at2759

TreeFam database of animal gene trees

More...
TreeFami
TF329111

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033358, RETREG1
IPR043384, RETREG1/3

The PANTHER Classification System

More...
PANTHERi
PTHR28659, PTHR28659, 1 hit
PTHR28659:SF3, PTHR28659:SF3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: Q8VE91-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASPAPEEHA TQGCPATEEQ PPRPGVPGEE AGPEGAGPQV EEAAGRVAAA
60 70 80 90 100
LTWLLGEPVL WLGWRADELL SWKRPLRSLL TFLGANLLFW FLALTPWRVY
110 120 130 140 150
HLISVMILGR VIMQIIKEMV LSRTRGAQLW RSLTESWEVI NSKPDERARL
160 170 180 190 200
SQCIAESWMN FSMFLQEMSL FKQQSPGKFC LLVCSVCTFF TILGSYIPGV
210 220 230 240 250
ILSYLLLLFA FLCPLFKCND IGQKIYSKVK SILLKLDFGI GEYINQKKRE
260 270 280 290 300
RSEADKEKSH KDDSELDFSA LCPKISLTVA AKELSVSDTD VSEVSWTDNG
310 320 330 340 350
TFNLSEGYTP QTDTSDDLDR PSEEVFSRDL SDFPSLENGT GTNDEDELSL
360 370 380 390 400
GLPTELKRKK QQLDSAHRPS KERQSAAGLS LPLKSDQALH LMSNLAGDVI
410 420 430 440 450
TAAMTAAIKD QLEGARQALT QVAPTAGEDT DTEEGDDFEL LDQAELDQIE
460 470 480
SELGLTQDQG AEAQQSKKSS GFLSNLLGGH
Note: Predicted by similarity to human,.
Length:480
Mass (Da):52,967
Last modified:September 16, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6181AF418CBCC29A
GO
Isoform 1 (identifier: Q8VE91-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: MASPAPEEHA...RGAQLWRSLT → MLGDWAALLPSCLSRCWS

Show »
Length:364
Mass (Da):40,142
Checksum:iF9CABAA6944E3510
GO
Isoform 2 (identifier: Q8VE91-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: MASPAPEEHA...GAQLWRSLTE → MPAGGGCGPGR

Show »
Length:356
Mass (Da):38,963
Checksum:i94B899C82D774FA9
GO
Isoform 3 (identifier: Q8VE91-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: MASPAPEEHA...GAQLWRSLTE → M

Show »
Length:346
Mass (Da):38,153
Checksum:iA49678F437BB1459
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BQZ7A0A2I3BQZ7_MOUSE
Reticulophagy regulator 1
Retreg1
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BR09A0A2I3BR09_MOUSE
Reticulophagy regulator 1
Retreg1
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BS06A0A2I3BS06_MOUSE
Reticulophagy regulator 1
Retreg1
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0578361 – 135MASPA…RSLTE → MPAGGGCGPGR in isoform 2. Add BLAST135
Alternative sequenceiVSP_0578371 – 135MASPA…RSLTE → M in isoform 3. Add BLAST135
Alternative sequenceiVSP_0578381 – 134MASPA…WRSLT → MLGDWAALLPSCLSRCWS in isoform 1. Add BLAST134

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK007506 mRNA Translation: BAB25077.1
AK146972 mRNA Translation: BAE27577.1
AK015887 mRNA Translation: BAB30019.1
AK167327 mRNA Translation: BAE39429.1
AC131178 Genomic DNA No translation available.
AC162303 Genomic DNA No translation available.
BC019494 mRNA Translation: AAH19494.1
BC054415 mRNA Translation: AAH54415.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37050.1 [Q8VE91-4]
CCDS37051.1 [Q8VE91-2]
CCDS88741.1 [Q8VE91-1]
CCDS88742.1 [Q8VE91-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001030023.1, NM_001034851.2 [Q8VE91-4]
NP_001264244.1, NM_001277315.1 [Q8VE91-2]
NP_001264245.1, NM_001277316.1 [Q8VE91-1]
NP_001264246.1, NM_001277317.1 [Q8VE91-3]
NP_079735.2, NM_025459.3 [Q8VE91-2]
XP_006520197.1, XM_006520134.3 [Q8VE91-2]
XP_017172209.1, XM_017316720.1 [Q8VE91-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000022881; ENSMUSP00000022881; ENSMUSG00000022270 [Q8VE91-4]
ENSMUST00000110438; ENSMUSP00000106068; ENSMUSG00000022270 [Q8VE91-2]
ENSMUST00000226438; ENSMUSP00000154765; ENSMUSG00000022270 [Q8VE91-1]
ENSMUST00000227275; ENSMUSP00000154471; ENSMUSG00000022270 [Q8VE91-2]
ENSMUST00000228306; ENSMUSP00000154070; ENSMUSG00000022270 [Q8VE91-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
66270

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:66270

UCSC genome browser

More...
UCSCi
uc007vjf.2, mouse
uc007vjg.2, mouse [Q8VE91-4]
uc007vji.2, mouse [Q8VE91-2]
uc033gth.1, mouse [Q8VE91-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007506 mRNA Translation: BAB25077.1
AK146972 mRNA Translation: BAE27577.1
AK015887 mRNA Translation: BAB30019.1
AK167327 mRNA Translation: BAE39429.1
AC131178 Genomic DNA No translation available.
AC162303 Genomic DNA No translation available.
BC019494 mRNA Translation: AAH19494.1
BC054415 mRNA Translation: AAH54415.1
CCDSiCCDS37050.1 [Q8VE91-4]
CCDS37051.1 [Q8VE91-2]
CCDS88741.1 [Q8VE91-1]
CCDS88742.1 [Q8VE91-3]
RefSeqiNP_001030023.1, NM_001034851.2 [Q8VE91-4]
NP_001264244.1, NM_001277315.1 [Q8VE91-2]
NP_001264245.1, NM_001277316.1 [Q8VE91-1]
NP_001264246.1, NM_001277317.1 [Q8VE91-3]
NP_079735.2, NM_025459.3 [Q8VE91-2]
XP_006520197.1, XM_006520134.3 [Q8VE91-2]
XP_017172209.1, XM_017316720.1 [Q8VE91-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

DIPiDIP-61579N
IntActiQ8VE91, 1 interactor
STRINGi10090.ENSMUSP00000022881

PTM databases

iPTMnetiQ8VE91
PhosphoSitePlusiQ8VE91

Proteomic databases

EPDiQ8VE91
MaxQBiQ8VE91
PaxDbiQ8VE91
PeptideAtlasiQ8VE91
PRIDEiQ8VE91

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
5201, 133 antibodies

Genome annotation databases

EnsembliENSMUST00000022881; ENSMUSP00000022881; ENSMUSG00000022270 [Q8VE91-4]
ENSMUST00000110438; ENSMUSP00000106068; ENSMUSG00000022270 [Q8VE91-2]
ENSMUST00000226438; ENSMUSP00000154765; ENSMUSG00000022270 [Q8VE91-1]
ENSMUST00000227275; ENSMUSP00000154471; ENSMUSG00000022270 [Q8VE91-2]
ENSMUST00000228306; ENSMUSP00000154070; ENSMUSG00000022270 [Q8VE91-3]
GeneIDi66270
KEGGimmu:66270
UCSCiuc007vjf.2, mouse
uc007vjg.2, mouse [Q8VE91-4]
uc007vji.2, mouse [Q8VE91-2]
uc033gth.1, mouse [Q8VE91-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54463
MGIiMGI:1913520, Retreg1

Phylogenomic databases

eggNOGiENOG502QPW8, Eukaryota
GeneTreeiENSGT00940000160746
HOGENOMiCLU_036265_0_0_1
InParanoidiQ8VE91
KOiK23880
OMAiPRINQCI
OrthoDBi901531at2759
TreeFamiTF329111

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
66270, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Fam134b, mouse

Protein Ontology

More...
PROi
PR:Q8VE91
RNActiQ8VE91, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000022270, Expressed in gastrocnemius medialis and 304 other tissues
ExpressionAtlasiQ8VE91, baseline and differential
GenevisibleiQ8VE91, MM

Family and domain databases

InterProiView protein in InterPro
IPR033358, RETREG1
IPR043384, RETREG1/3
PANTHERiPTHR28659, PTHR28659, 1 hit
PTHR28659:SF3, PTHR28659:SF3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRETR1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VE91
Secondary accession number(s): E9QPM1
, Q7TMY5, Q9CUJ4, Q9D8Z5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 16, 2015
Last modified: August 12, 2020
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again