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Entry version 111 (29 Sep 2021)
Sequence version 2 (06 Feb 2007)
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Protein

Protein FAM114A2

Gene

Fam114a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM114A2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1917629, Fam114a2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000020523

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002745651 – 497Protein FAM114A2Add BLAST497

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei84PhosphoserineBy similarity1
Modified residuei205PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8VE88

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8VE88

PeptideAtlas

More...
PeptideAtlasi
Q8VE88

PRoteomics IDEntifications database

More...
PRIDEi
Q8VE88

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
275814 [Q8VE88-1]
275815 [Q8VE88-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8VE88

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8VE88

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8VE88

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020523, Expressed in seminal vesicle and 319 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8VE88, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Molecular INTeraction database

More...
MINTi
Q8VE88

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000104478

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8VE88, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 54DisorderedSequence analysisAdd BLAST54
Regioni344 – 364DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 49Basic and acidic residuesSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM114 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QS74, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010054

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_035724_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8VE88

Identification of Orthologs from Complete Genome Data

More...
OMAi
KKDADQM

Database of Orthologous Groups

More...
OrthoDBi
947469at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8VE88

TreeFam database of animal gene trees

More...
TreeFami
TF324360

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007998, DUF719

The PANTHER Classification System

More...
PANTHERi
PTHR12842, PTHR12842, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05334, DUF719, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8VE88-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDKDPPESP VVTGVASTLK DENCEPVEKP EDKSQPVVST RKRPETKPSS
60 70 80 90 100
DLEASALPAQ VSLAVAKETA SKDVPQTGWG YWGSWGKSLL SSASATVATV
110 120 130 140 150
GQGISNVIEK AETSLGIPSP TEISAEVKQA AGEKNAGENG SLLVAAPFGM
160 170 180 190 200
LSTISTAVQS TGKSVISGGL DALEFIGKKT MDVIAEGDPG FKRTKGLMNR
210 220 230 240 250
TSTLSQVLRE AKDKEEQRPS NEVTMETDKK THYGLLFDEF QGLSHLEALE
260 270 280 290 300
MLSRESEIKV KSILSSLSGE ELQTTRLELE QLKEVFSLAE FCEEEEEERQ
310 320 330 340 350
GDDNFTKEIT DLFAQLHVSS RPEKLARARN TAYKWIRTSL ARPVAEKEEG
360 370 380 390 400
EKESEAGNTE EAQKHSIEDI HAFAIRSLAE LTACSIELFH KTAALVLHGQ
410 420 430 440 450
KQEVTALERS QTLSQMTVML CKDLASLSKE FTTCLTTAGV REKADVLNPV
460 470 480 490
ITAVFLEASN SASYIQDAFQ LLLPVLQISL IESKTESSTC EPQSRDL
Length:497
Mass (Da):54,045
Last modified:February 6, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9346964631460F6D
GO
Isoform 2 (identifier: Q8VE88-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-67: Missing.

Show »
Length:490
Mass (Da):53,376
Checksum:iEFD0D0464955F95E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14G → E in AAH19518 (PubMed:15489334).Curated1
Sequence conflicti304N → D in AAH19518 (PubMed:15489334).Curated1
Sequence conflicti318V → I in AAH19518 (PubMed:15489334).Curated1
Sequence conflicti438A → V in AAH19518 (PubMed:15489334).Curated1
Sequence conflicti488S → P in BAE29069 (PubMed:16141072).Curated1
Sequence conflicti494S → P in AAH19518 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02279661 – 67Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK018570 mRNA Translation: BAB31282.1
AK149763 mRNA Translation: BAE29069.1
AL672236 Genomic DNA No translation available.
BC019518 mRNA Translation: AAH19518.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24717.1 [Q8VE88-2]
CCDS48801.1 [Q8VE88-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001162138.1, NM_001168667.1 [Q8VE88-2]
NP_001162139.1, NM_001168668.1 [Q8VE88-1]
NP_080618.1, NM_026342.3 [Q8VE88-2]
XP_006534079.1, XM_006534016.3 [Q8VE88-1]
XP_011247496.1, XM_011249194.2 [Q8VE88-1]
XP_011247497.1, XM_011249195.2 [Q8VE88-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000020831; ENSMUSP00000020831; ENSMUSG00000020523 [Q8VE88-2]
ENSMUST00000108850; ENSMUSP00000104478; ENSMUSG00000020523 [Q8VE88-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
67726

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:67726

UCSC genome browser

More...
UCSCi
uc007izt.2, mouse [Q8VE88-1]
uc007izu.2, mouse [Q8VE88-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018570 mRNA Translation: BAB31282.1
AK149763 mRNA Translation: BAE29069.1
AL672236 Genomic DNA No translation available.
BC019518 mRNA Translation: AAH19518.1
CCDSiCCDS24717.1 [Q8VE88-2]
CCDS48801.1 [Q8VE88-1]
RefSeqiNP_001162138.1, NM_001168667.1 [Q8VE88-2]
NP_001162139.1, NM_001168668.1 [Q8VE88-1]
NP_080618.1, NM_026342.3 [Q8VE88-2]
XP_006534079.1, XM_006534016.3 [Q8VE88-1]
XP_011247496.1, XM_011249194.2 [Q8VE88-1]
XP_011247497.1, XM_011249195.2 [Q8VE88-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

MINTiQ8VE88
STRINGi10090.ENSMUSP00000104478

PTM databases

iPTMnetiQ8VE88
PhosphoSitePlusiQ8VE88
SwissPalmiQ8VE88

Proteomic databases

jPOSTiQ8VE88
PaxDbiQ8VE88
PeptideAtlasiQ8VE88
PRIDEiQ8VE88
ProteomicsDBi275814 [Q8VE88-1]
275815 [Q8VE88-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
48470, 69 antibodies

The DNASU plasmid repository

More...
DNASUi
67726

Genome annotation databases

EnsembliENSMUST00000020831; ENSMUSP00000020831; ENSMUSG00000020523 [Q8VE88-2]
ENSMUST00000108850; ENSMUSP00000104478; ENSMUSG00000020523 [Q8VE88-1]
GeneIDi67726
KEGGimmu:67726
UCSCiuc007izt.2, mouse [Q8VE88-1]
uc007izu.2, mouse [Q8VE88-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10827
MGIiMGI:1917629, Fam114a2
VEuPathDBiHostDB:ENSMUSG00000020523

Phylogenomic databases

eggNOGiENOG502QS74, Eukaryota
GeneTreeiENSGT00390000010054
HOGENOMiCLU_035724_1_0_1
InParanoidiQ8VE88
OMAiKKDADQM
OrthoDBi947469at2759
PhylomeDBiQ8VE88
TreeFamiTF324360

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
67726, 3 hits in 64 CRISPR screens

Protein Ontology

More...
PROi
PR:Q8VE88
RNActiQ8VE88, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020523, Expressed in seminal vesicle and 319 other tissues
GenevisibleiQ8VE88, MM

Family and domain databases

InterProiView protein in InterPro
IPR007998, DUF719
PANTHERiPTHR12842, PTHR12842, 1 hit
PfamiView protein in Pfam
PF05334, DUF719, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1142_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VE88
Secondary accession number(s): Q3UE42, Q5QNR1, Q9D310
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 29, 2021
This is version 111 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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