Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website soon. Please explore and share your feedback. Take me to the new website.

UniProtKB - Q8VE73 (CUL7_MOUSE)

Entry version 159 (23 Feb 2022)
Sequence version 2 (09 Jan 2007)
Previous versions | rss
Add a publicationFeedback
Protein

Cullin-7

Gene

Cul7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1. Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain. Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation. Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development. Does not promote polyubiquitination and proteasomal degradation of p53/TP53. While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions (By similarity).

Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation.

By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-8951664, Neddylation
R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cullin-7
Short name:
CUL-7
Alternative name(s):
p185
p193
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cul7
Synonyms:Kiaa0076
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1913765, Cul7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000038545

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are neonatal lethal and show vascular defects in both the embryo and the placenta.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001198031 – 1689Cullin-7Add BLAST1689

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1567Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)Sequence analysis

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8VE73

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8VE73

PRoteomics IDEntifications database

More...PRIDEi		Q8VE73

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		285435 [Q8VE73-1]
285436 [Q8VE73-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8VE73

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8VE73

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000038545, Expressed in membranous labyrinth and 290 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8VE73, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8VE73, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 3M complex, composed of core components CUL7, CCDC8 and OBSL1.

Part of a Cul7-RING complex consisting of CUL7, RBX1, SKP1 and FBXW8.

Interacts with a complex of SKP1 and FBXW8, but not with SKP1 alone.

Interacts with CUL9; leading to inhibit CUL9 activity.

Interacts with FBXW8; interaction is mutually exclusive of binding to CUL9 or p53/TP53.

Interacts with p53/TP53; the interaction preferentially involves tetrameric and dimeric p53/TP53. The CUL7-CUL9 heterodimer seems to interact specifically with p53/TP53.

Interacts with OBSL1 (By similarity).

Interacts with CUL1; the interactions seems to be mediated by FBXW8.

Interacts (as part of the 3M complex) with HDAC4 and HDAC5; it is negatively regulated by ANKRA2 (By similarity).

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		211530, 13 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8VE73

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000049128

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8VE73, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8VE73

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini793 – 972DOCPROSITE-ProRule annotationAdd BLAST180

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni349 – 449Interaction with TP53By similarityAdd BLAST101
Regioni1321 – 1371DisorderedSequence analysisAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1321 – 1338Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1353 – 1368Acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cullin family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RDJD, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153954

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001067_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8VE73

Identification of Orthologs from Complete Genome Data

More...OMAi		NCLVVRI

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8VE73

TreeFam database of animal gene trees

More...TreeFami		TF101154

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit
2.30.30.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004939, APC_su10/DOC_dom
IPR016024, ARM-type_fold
IPR021097, CPH_domain
IPR031223, CUL7
IPR016157, Cullin_CS
IPR016158, Cullin_homology
IPR036317, Cullin_homology_sf
IPR001373, Cullin_N
IPR019559, Cullin_neddylation_domain
IPR008979, Galactose-bd-like_sf
IPR014722, Rib_L2_dom2
IPR036388, WH-like_DNA-bd_sf

The PANTHER Classification System

More...PANTHERi		PTHR22771:SF3, PTHR22771:SF3, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03256, ANAPC10, 1 hit
PF11515, Cul7, 1 hit
PF00888, Cullin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01337, APC10, 1 hit
SM00884, Cullin_Nedd8, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit
SSF49785, SSF49785, 1 hit
SSF75632, SSF75632, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01256, CULLIN_1, 1 hit
PS50069, CULLIN_2, 1 hit
PS51284, DOC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8VE73-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVGELRYREF RVPLGPGLHA YPDELIRQRV GHNGHPEYQI RWLILRRGDD 
        60         70         80         90        100
GDRDSTVDCK AEHILLWMSD DEIYANCHKM LGENGQVIAP SRESTEAGAL 
       110        120        130        140        150
DKSVLGEMET DVKSLIQRAL RQLEECVGTV PPAPLLHTVH VLSAYASIEP 
       160        170        180        190        200
LTGIFKDRRV VNLLMHMLSS PDYQIRWSAG RMIQALSSHD AGTRTQILLS 
       210        220        230        240        250
LSQQEAIEKH LDFDSRCALL ALFAQATLTE HPMSFEGVQL PQVPGRLLFS 
       260        270        280        290        300
LVKRYLHVTF LLDRLNGDAG DQGAQNNFIP EELNVGRGRL ELEFSMAMGT 
       310        320        330        340        350
LISELVQAMR WDGASSRPES SSSSTFQPRP AQFRPYTQRF RRSRRFRPRA 
       360        370        380        390        400
SFASFNTYAL YVRDTLRPGM RVRMLENYEE IAAGDEGQFR QSNDGVPPAQ 
       410        420        430        440        450
VLWDSTGHTY WVHWHMLEIL GFEEDIEDVI DIEELQELGA NGALSIVPPS 
       460        470        480        490        500
QRWKPITQLF AEPYVVPEEE DREESENLTQ AEWWELLFFI RQLSEAERLH 
       510        520        530        540        550
IVDLLQDHLE EERVLDYDML PELTVPVDLA QDLLLSLPQQ LEDSALRDLF 
       560        570        580        590        600
SCSVYRKYGP EVLVGHLSYP FVPGAQPNLF GANEESEAKD PPLQSASPAL 
       610        620        630        640        650
QRLVESLGPE GEVLVELEQA LGSEAPQETE VKSCLLQLQE QPQPFLALMR 
       660        670        680        690        700
SLDTSASNKT LHLTVLRILM QLVNFPEALL LPWHEAMDAC VTCLRSPNTD 
       710        720        730        740        750
REVLQELIFF LHRLTTTSRD YAVILNQLGA RDAISKVLEK HRGKLELAQE 
       760        770        780        790        800
LRDMVSKCEK HAHLYRKLTT NILGGCIQMV LGQIEDHRRT HRPIQIPFFD 
       810        820        830        840        850
VFLRYLCQGS SEEMKKNRYW EKVEVSSNPQ RASRLTDRNP KTYWESSGRA 
       860        870        880        890        900
GSHFITLHMR PGVIIRQLTL LVAGEDSSYM PAWVVVCGGN SIKSVNKELN 
       910        920        930        940        950
TVNVMPSASR VTLLENLTRF WPIIQIRIKR CQQGGINTRI RGLEVLGPKP 
       960        970        980        990       1000
TFWPVFREQL CRHTRLFYMV RAQAWSQDIA EDRRSLLHLS SRLNGALRHE 
      1010       1020       1030       1040       1050
QNFAERFLPD MEAAQALSKT CWEALVSPLV QNITSPDEDS TSSLGWLLDQ 
      1060       1070       1080       1090       1100
YLGCREAAYN PQSRAAAFSS RVRRLTHLLV HVEPREAAPP VVAIPRSKGR 
      1110       1120       1130       1140       1150
NRIHDWSYLI TRGLPSSIMK NLTRCWRSVV EEQMNKFLTA SWKDDDFVPR 
      1160       1170       1180       1190       1200
YCERYYVLQK SSSELFGPRA AFLLAMRNGC ADAVLRLPFL RAAHVSEQFA 
      1210       1220       1230       1240       1250
RHIDQRIQGS RMGGARGMEM LAQLQRCLES VLIFSPLEIA TTFEHYYQHY 
      1260       1270       1280       1290       1300
MADRLLSVGS SWLEGAVLEQ IGPCFPSRLP QQMLQSLNVS EELQRQFHVY 
      1310       1320       1330       1340       1350
QLQQLDQELL KLEDTEKKIQ VAHEDSGRED KSKKEEAIGE AAAVAMAEEE 
      1360       1370       1380       1390       1400
DQGKKEEGEE EGEGEDEEEE RYYKGTMPEV CVLVVTPRFW PVASVCQMLN 
      1410       1420       1430       1440       1450
PATCLPAYLR GTINHYTNFY SKSQSRSSLE KEPQRRLQWT WQGRAEVQFG 
      1460       1470       1480       1490       1500
GQILHVSTVQ MWLLLHLNNQ KEVSVESLQA ISELPPDVLH RAIGPLTSSR 
      1510       1520       1530       1540       1550
GPLDLQEQKN VPGGVLKIRD DSEEPRPRRG NVWLIPPQTY LQAEAEEGRN 
      1560       1570       1580       1590       1600
MEKRRNLLNC LVVRILKAHG DEGLHVDRLV YLVLEAWEKG PCPARGLVSS 
      1610       1620       1630       1640       1650
LGRGATCRSS DVLSCILHLL VKGTLRRHDD RPQVLYYAVP VTVMEPHMES 
      1660       1670       1680 
LNPGSAGPNP PLTFHTLQIR SRGVPYASCT DNHTFSTFR
Length:1,689
Mass (Da):192,292
Last modified:January 9, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6ED4641B577E53CD
GO
Isoform 2 (identifier: Q8VE73-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1472-1472: Missing.

Show »
Length:1,688
Mass (Da):192,163
Checksum:i8AD13BBC66EAA8A5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q6H4E9Q6H4_MOUSE
Cullin-7
Cul7
649Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Q1R4F6Q1R4_MOUSE
Cullin-7
Cul7
577Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti395G → V in BAE27723 (PubMed:16141072).Curated1
Sequence conflicti518D → E in BAD32160 (PubMed:15368895).Curated1
Sequence conflicti777 – 779IQM → DAW in AAH19645 (PubMed:15489334).Curated3
Sequence conflicti855 – 922Missing in AAH59865 (PubMed:15489334).CuratedAdd BLAST68
Sequence conflicti888G → R in BAE27723 (PubMed:16141072).Curated1
Sequence conflicti959Q → E in AAH59865 (PubMed:15489334).Curated1
Sequence conflicti1482S → L in BAB25811 (PubMed:16141072).Curated1
Sequence conflicti1495P → L in BAB25811 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0383311472Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK008655 mRNA Translation: BAB25811.1
AK147156 mRNA Translation: BAE27723.1
CT030702 Genomic DNA No translation available.
BC019645 mRNA Translation: AAH19645.1
BC026946 mRNA Translation: AAH26946.2
BC059865 mRNA Translation: AAH59865.1
BC100544 mRNA Translation: AAI00545.1
AK172882 mRNA Translation: BAD32160.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS28833.1 [Q8VE73-1]

NCBI Reference Sequences

More...RefSeqi		NP_079887.3, NM_025611.5 [Q8VE73-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000043464; ENSMUSP00000049128; ENSMUSG00000038545 [Q8VE73-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		66515

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:66515

UCSC genome browser

More...UCSCi		uc008ctp.1, mouse [Q8VE73-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008655 mRNA Translation: BAB25811.1
AK147156 mRNA Translation: BAE27723.1
CT030702 Genomic DNA No translation available.
BC019645 mRNA Translation: AAH19645.1
BC026946 mRNA Translation: AAH26946.2
BC059865 mRNA Translation: AAH59865.1
BC100544 mRNA Translation: AAI00545.1
AK172882 mRNA Translation: BAD32160.1
CCDSiCCDS28833.1 [Q8VE73-1]
RefSeqiNP_079887.3, NM_025611.5 [Q8VE73-1]

3D structure databases

SMRiQ8VE73
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi211530, 13 interactors
CORUMiQ8VE73
STRINGi10090.ENSMUSP00000049128

PTM databases

iPTMnetiQ8VE73
PhosphoSitePlusiQ8VE73

Proteomic databases

MaxQBiQ8VE73
PaxDbiQ8VE73
PRIDEiQ8VE73
ProteomicsDBi285435 [Q8VE73-1]
285436 [Q8VE73-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4223, 196 antibodies from 37 providers

The DNASU plasmid repository

More...DNASUi		66515

Genome annotation databases

EnsembliENSMUST00000043464; ENSMUSP00000049128; ENSMUSG00000038545 [Q8VE73-1]
GeneIDi66515
KEGGimmu:66515
UCSCiuc008ctp.1, mouse [Q8VE73-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9820
MGIiMGI:1913765, Cul7
VEuPathDBiHostDB:ENSMUSG00000038545

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiENOG502RDJD, Eukaryota
GeneTreeiENSGT00940000153954
HOGENOMiCLU_001067_1_0_1
InParanoidiQ8VE73
OMAiNCLVVRI
PhylomeDBiQ8VE73
TreeFamiTF101154

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-MMU-8951664, Neddylation
R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		66515, 1 hit in 63 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Cul7, mouse

Protein Ontology

More...PROi		PR:Q8VE73
RNActiQ8VE73, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000038545, Expressed in membranous labyrinth and 290 other tissues
ExpressionAtlasiQ8VE73, baseline and differential
GenevisibleiQ8VE73, MM

Family and domain databases

Gene3Di1.10.10.10, 1 hit
2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR004939, APC_su10/DOC_dom
IPR016024, ARM-type_fold
IPR021097, CPH_domain
IPR031223, CUL7
IPR016157, Cullin_CS
IPR016158, Cullin_homology
IPR036317, Cullin_homology_sf
IPR001373, Cullin_N
IPR019559, Cullin_neddylation_domain
IPR008979, Galactose-bd-like_sf
IPR014722, Rib_L2_dom2
IPR036388, WH-like_DNA-bd_sf
PANTHERiPTHR22771:SF3, PTHR22771:SF3, 1 hit
PfamiView protein in Pfam
PF03256, ANAPC10, 1 hit
PF11515, Cul7, 1 hit
PF00888, Cullin, 1 hit
SMARTiView protein in SMART
SM01337, APC10, 1 hit
SM00884, Cullin_Nedd8, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF49785, SSF49785, 1 hit
SSF75632, SSF75632, 1 hit
PROSITEiView protein in PROSITE
PS01256, CULLIN_1, 1 hit
PS50069, CULLIN_2, 1 hit
PS51284, DOC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCUL7_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VE73
Secondary accession number(s): Q3UHY3
, Q497I2, Q6A0D6, Q6PB63, Q8R3W4, Q9CVD5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: January 9, 2007
Last modified: February 23, 2022
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again