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Protein

Transcription initiation factor TFIID subunit 12

Gene

Taf12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 12
Alternative name(s):
Transcription initiation factor TFIID 20 kDa subunits
Short name:
TAFII-20
Short name:
TAFII20
Gene namesi
Name:Taf12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913714 Taf12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001189081 – 161Transcription initiation factor TFIID subunit 12Add BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki19Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei43PhosphothreonineBy similarity1
Modified residuei51PhosphoserineCombined sources1
Modified residuei59PhosphothreonineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8VE65
PaxDbiQ8VE65
PeptideAtlasiQ8VE65
PRIDEiQ8VE65

PTM databases

iPTMnetiQ8VE65
PhosphoSitePlusiQ8VE65

Expressioni

Gene expression databases

BgeeiENSMUSG00000028899 Expressed in 252 organ(s), highest expression level in testis
ExpressionAtlasiQ8VE65 baseline and differential
GenevisibleiQ8VE65 MM

Interactioni

Subunit structurei

TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Interacts directly with TBP; additional interactions between TAFII20 and TAFII28 or TAFII30 were detected. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L, SUPT3H, TAF6L, TAF9, TAF10, TAF12 and TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Interacts with ATF7 (via its transactivation domain); the interaction promotes the transactivation of ATF7 and is prevented by sumoylation of ATF7 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-1024 PCAF histone acetylase complex
CPX-916 TFTC histone acetylation complex
CPX-920 SAGA complex
CPX-932 General transcription factor complex TFIID
CPX-959 General transcription factor complex TFIID, Taf4b variant
CORUMiQ8VE65
DIPiDIP-29178N
IntActiQ8VE65, 4 interactors
MINTiQ8VE65
STRINGi10090.ENSMUSP00000030731

Structurei

3D structure databases

ProteinModelPortaliQ8VE65
SMRiQ8VE65
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 128Histone-foldCuratedAdd BLAST73

Sequence similaritiesi

Belongs to the TAF12 family.Curated

Phylogenomic databases

eggNOGiKOG1142 Eukaryota
COG5624 LUCA
GeneTreeiENSGT00390000002144
HOVERGENiHBG055174
InParanoidiQ8VE65
KOiK03126
OMAiQASMANS
PhylomeDBiQ8VE65
TreeFamiTF323652

Family and domain databases

CDDicd07981 TAF12, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR037794 TAF12
IPR003228 TFIID_TAF12_dom
PANTHERiPTHR12264 PTHR12264, 1 hit
PfamiView protein in Pfam
PF03847 TFIID_20kDa, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD012998 PD012998, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8VE65-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNQFGPSALI NLSSFSSVKP EPASTPPQGS MANSTTVGKI AGTPGTGGRL
60 70 80 90 100
SPENNQVLTK KKLQDLVREV DPNEQLDEDV EEMLLQIADD FIESVVTAAC
110 120 130 140 150
QLARHRKSST LEVKDVQLHL ERQWNMWIPG FGSEEIRPYK KACTTEAHKQ
160
RMALIRKTTK K
Length:161
Mass (Da):17,875
Last modified:March 1, 2002 - v1
Checksum:iB3C11D70B6E94E35
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QNT5E9QNT5_MOUSE
Transcription initiation factor TFI...
Taf12
213Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77D → G in BAB28669 (PubMed:16141072).Curated1
Sequence conflicti126M → I in BAB28669 (PubMed:16141072).Curated1
Sequence conflicti157K → N in BAB25276 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007811 mRNA Translation: BAB25276.1
AK013133 mRNA Translation: BAB28669.1
AK132927 mRNA Translation: BAE21426.1
BC019668 mRNA Translation: AAH19668.1
CCDSiCCDS18721.1
RefSeqiNP_079855.2, NM_025579.3
XP_006539170.2, XM_006539107.3
XP_006539172.1, XM_006539109.1
XP_006539173.1, XM_006539110.1
XP_017175839.1, XM_017320350.1
UniGeneiMm.331926

Genome annotation databases

EnsembliENSMUST00000030731; ENSMUSP00000030731; ENSMUSG00000028899
GeneIDi66464
KEGGimmu:66464
UCSCiuc008vax.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007811 mRNA Translation: BAB25276.1
AK013133 mRNA Translation: BAB28669.1
AK132927 mRNA Translation: BAE21426.1
BC019668 mRNA Translation: AAH19668.1
CCDSiCCDS18721.1
RefSeqiNP_079855.2, NM_025579.3
XP_006539170.2, XM_006539107.3
XP_006539172.1, XM_006539109.1
XP_006539173.1, XM_006539110.1
XP_017175839.1, XM_017320350.1
UniGeneiMm.331926

3D structure databases

ProteinModelPortaliQ8VE65
SMRiQ8VE65
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-1024 PCAF histone acetylase complex
CPX-916 TFTC histone acetylation complex
CPX-920 SAGA complex
CPX-932 General transcription factor complex TFIID
CPX-959 General transcription factor complex TFIID, Taf4b variant
CORUMiQ8VE65
DIPiDIP-29178N
IntActiQ8VE65, 4 interactors
MINTiQ8VE65
STRINGi10090.ENSMUSP00000030731

PTM databases

iPTMnetiQ8VE65
PhosphoSitePlusiQ8VE65

Proteomic databases

MaxQBiQ8VE65
PaxDbiQ8VE65
PeptideAtlasiQ8VE65
PRIDEiQ8VE65

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030731; ENSMUSP00000030731; ENSMUSG00000028899
GeneIDi66464
KEGGimmu:66464
UCSCiuc008vax.3 mouse

Organism-specific databases

CTDi6883
MGIiMGI:1913714 Taf12

Phylogenomic databases

eggNOGiKOG1142 Eukaryota
COG5624 LUCA
GeneTreeiENSGT00390000002144
HOVERGENiHBG055174
InParanoidiQ8VE65
KOiK03126
OMAiQASMANS
PhylomeDBiQ8VE65
TreeFamiTF323652

Enzyme and pathway databases

ReactomeiR-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Miscellaneous databases

PROiPR:Q8VE65
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028899 Expressed in 252 organ(s), highest expression level in testis
ExpressionAtlasiQ8VE65 baseline and differential
GenevisibleiQ8VE65 MM

Family and domain databases

CDDicd07981 TAF12, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR037794 TAF12
IPR003228 TFIID_TAF12_dom
PANTHERiPTHR12264 PTHR12264, 1 hit
PfamiView protein in Pfam
PF03847 TFIID_20kDa, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD012998 PD012998, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAF12_MOUSE
AccessioniPrimary (citable) accession number: Q8VE65
Secondary accession number(s): Q3V0S7, Q9CZ11, Q9D8Q0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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