UniProtKB - Q8VE42 (ANR49_MOUSE)
Protein
Ankyrin repeat domain-containing protein 49
Gene
Ankrd49
Organism
Mus musculus (Mouse)
Status
Functioni
May have a role in spermatogenesis where it promotes autophagy in response to serum starvation, via the NF-kappaB pathway.1 Publication
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- positive regulation of transcription, DNA-templated Source: MGI
- spermatogenesis Source: UniProtKB-KW
Keywordsi
Biological process | Differentiation, Spermatogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Ankyrin repeat domain-containing protein 49Alternative name(s): Fetal globin-increasing factor Fetal globin-inducing factor |
Gene namesi | Name:Ankrd49 Synonyms:Fgif, Gbif |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1930842, Ankrd49 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000244586 | 1 – 238 | Ankyrin repeat domain-containing protein 49Add BLAST | 238 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 48 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8VE42 |
MaxQBi | Q8VE42 |
PaxDbi | Q8VE42 |
PeptideAtlasi | Q8VE42 |
PRIDEi | Q8VE42 |
PTM databases
iPTMneti | Q8VE42 |
PhosphoSitePlusi | Q8VE42 |
Expressioni
Tissue specificityi
Expressed in spermatogonia, spermatocytes and round spermatids.1 Publication
Developmental stagei
Expressed in liver at embryonic stage 13 dpc, and in liver, brain and lung at 16 dpc (PubMed:11162141). In testis, expression levels steadily increase from 1 week after birth and plateau by 8 weeks after birth (PubMed:26043108).2 Publications
Gene expression databases
Bgeei | ENSMUSG00000031931, Expressed in forelimb bud and 286 other tissues |
ExpressionAtlasi | Q8VE42, baseline and differential |
Genevisiblei | Q8VE42, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 208022, 3 interactors |
STRINGi | 10090.ENSMUSP00000034406 |
Miscellaneous databases
RNActi | Q8VE42, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 72 – 105 | ANK 1Add BLAST | 34 | |
Repeati | 106 – 135 | ANK 2Add BLAST | 30 | |
Repeati | 139 – 168 | ANK 3Add BLAST | 30 | |
Repeati | 172 – 205 | ANK 4Add BLAST | 34 |
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG0512, Eukaryota |
GeneTreei | ENSGT00390000003919 |
HOGENOMi | CLU_000134_19_1_1 |
InParanoidi | Q8VE42 |
OMAi | EEWYEMQ |
OrthoDBi | 1546307at2759 |
PhylomeDBi | Q8VE42 |
TreeFami | TF351259 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8VE42-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKEKKDDEK PDLENSVDFS EQFNQLELLK THGHLIPTGT QSLWVGNSDE
60 70 80 90 100
DEEQEEKNEE WYQLQEKKME KDPSKLLLWA AEKNRLATVQ RLLSEKAAEV
110 120 130 140 150
NTRDEDEYTP LHRAAYSGHI DVVRELVAKG ADVHAVTVDG WTPLHSACKW
160 170 180 190 200
NNTKVASFLL QHDADINAQT KGLLTPLHLA AGNRDSRDTL ELLLMNRYIK
210 220 230
PELKNNSQET ASDIARRTSI YHYLFEIAEG CTNSSPPS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ3U523 | Q3U523_MOUSE | Ankyrin repeat domain-containing pr... | Ankrd49 | 120 | Annotation score: | ||
A0A1L1SUI8 | A0A1L1SUI8_MOUSE | Ankyrin repeat domain-containing pr... | Ankrd49 | 13 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 | L → Q in AAD04809 (PubMed:11162141).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF028722 mRNA Translation: AAD04809.1 AK132850 mRNA Translation: BAE21393.1 BC019777 mRNA Translation: AAH19777.1 |
CCDSi | CCDS22826.1 |
RefSeqi | NP_001335189.1, NM_001348260.1 NP_062657.2, NM_019683.4 XP_006510566.1, XM_006510503.2 |
Genome annotation databases
Ensembli | ENSMUST00000034406; ENSMUSP00000034406; ENSMUSG00000031931 ENSMUST00000216037; ENSMUSP00000149874; ENSMUSG00000031931 ENSMUST00000216372; ENSMUSP00000151079; ENSMUSG00000031931 |
GeneIDi | 56503 |
KEGGi | mmu:56503 |
UCSCi | uc009ofa.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF028722 mRNA Translation: AAD04809.1 AK132850 mRNA Translation: BAE21393.1 BC019777 mRNA Translation: AAH19777.1 |
CCDSi | CCDS22826.1 |
RefSeqi | NP_001335189.1, NM_001348260.1 NP_062657.2, NM_019683.4 XP_006510566.1, XM_006510503.2 |
3D structure databases
SMRi | Q8VE42 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 208022, 3 interactors |
STRINGi | 10090.ENSMUSP00000034406 |
PTM databases
iPTMneti | Q8VE42 |
PhosphoSitePlusi | Q8VE42 |
Proteomic databases
EPDi | Q8VE42 |
MaxQBi | Q8VE42 |
PaxDbi | Q8VE42 |
PeptideAtlasi | Q8VE42 |
PRIDEi | Q8VE42 |
Protocols and materials databases
Antibodypediai | 51056, 120 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000034406; ENSMUSP00000034406; ENSMUSG00000031931 ENSMUST00000216037; ENSMUSP00000149874; ENSMUSG00000031931 ENSMUST00000216372; ENSMUSP00000151079; ENSMUSG00000031931 |
GeneIDi | 56503 |
KEGGi | mmu:56503 |
UCSCi | uc009ofa.1, mouse |
Organism-specific databases
CTDi | 54851 |
MGIi | MGI:1930842, Ankrd49 |
Phylogenomic databases
eggNOGi | KOG0512, Eukaryota |
GeneTreei | ENSGT00390000003919 |
HOGENOMi | CLU_000134_19_1_1 |
InParanoidi | Q8VE42 |
OMAi | EEWYEMQ |
OrthoDBi | 1546307at2759 |
PhylomeDBi | Q8VE42 |
TreeFami | TF351259 |
Miscellaneous databases
BioGRID-ORCSi | 56503, 8 hits in 16 CRISPR screens |
ChiTaRSi | Ankrd49, mouse |
PROi | PR:Q8VE42 |
RNActi | Q8VE42, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031931, Expressed in forelimb bud and 286 other tissues |
ExpressionAtlasi | Q8VE42, baseline and differential |
Genevisiblei | Q8VE42, MM |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANR49_MOUSE | |
Accessioni | Q8VE42Primary (citable) accession number: Q8VE42 Secondary accession number(s): Q9Z2S1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | March 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot