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Protein

Guanine nucleotide exchange factor for Rab-3A

Gene

Rab3il1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activates RAB8A and RAB8B (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide exchange factor for Rab-3A
Alternative name(s):
Rab-3A-interacting-like protein 1
Short name:
Rab3A-interacting-like protein 1
Rabin3-like 1
Gene namesi
Name:Rab3il1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1922010 Rab3il1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003052961 – 383Guanine nucleotide exchange factor for Rab-3AAdd BLAST383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei169PhosphoserineCombined sources1
Modified residuei180PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8VDV3
PeptideAtlasiQ8VDV3
PRIDEiQ8VDV3

PTM databases

iPTMnetiQ8VDV3
PhosphoSitePlusiQ8VDV3

Expressioni

Gene expression databases

BgeeiENSMUSG00000024663 Expressed in 206 organ(s), highest expression level in testis
CleanExiMM_RAB3IL1
ExpressionAtlasiQ8VDV3 baseline and differential
GenevisibleiQ8VDV3 MM

Interactioni

Subunit structurei

Interacts with RAB3A and IHPK1 through the coiled-coil domain. This interaction is competitive. IHPK1 kinase activity is not required for this interaction (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi217000, 1 interactor
STRINGi10090.ENSMUSP00000108786

Structurei

3D structure databases

ProteinModelPortaliQ8VDV3
SMRiQ8VDV3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili77 – 128Sequence analysisAdd BLAST52

Sequence similaritiesi

Belongs to the SEC2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4324 Eukaryota
ENOG410XPSY LUCA
GeneTreeiENSGT00390000009036
HOGENOMiHOG000220814
HOVERGENiHBG057034
InParanoidiQ8VDV3
KOiK16779
OMAiTLFAEFQ
OrthoDBiEOG091G04MY
PhylomeDBiQ8VDV3
TreeFamiTF313748

Family and domain databases

InterProiView protein in InterPro
IPR009449 Sec2_N
PfamiView protein in Pfam
PF06428 Sec2p, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8VDV3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWSGQPQQDE GLPVGLSAIP VPWKNLGPSK SNRESSGGLV EASTSWEEAQ
60 70 80 90 100
GEEHPAPAPL DVSRLRSSSM EIREKGSEFL KEELYKAQKE LKLKDEECER
110 120 130 140 150
LCKVRAQLEQ ELEELTASLF EEAHKMVREA NMKQATSEKQ LKEAWGKIDM
160 170 180 190 200
LQAEVTALKT LVITSTPASP NRELHPQLLS PTKAGPRKGH SRQKSTSSSL
210 220 230 240 250
CPVVCPTAGH IPTPDKEGKE VDTTLFAEFQ AWRASPTLDK SCPFLERVYR
260 270 280 290 300
EDVGPCLDFT VQELSALVRT AVEDNTLTIE PVASQTLPAV KVPTVECNNT
310 320 330 340 350
NTCALSGLAR TCHHRIRLGD SDSHYYISPS SRARITAVCN FFTYIRYIQQ
360 370 380
GLVRQDAEPM FWEIMRLRKG MSLAKLGFFP QEA
Length:383
Mass (Da):42,713
Last modified:March 1, 2002 - v1
Checksum:i30B2F1C12495BF82
GO
Isoform 2 (identifier: Q8VDV3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Show »
Length:314
Mass (Da):35,420
Checksum:iEE1870D9F4F24584
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z585D3Z585_MOUSE
Guanine nucleotide exchange factor ...
Rab3il1
310Annotation score:
D3YXL8D3YXL8_MOUSE
Guanine nucleotide exchange factor ...
Rab3il1
86Annotation score:
D3YZ86D3YZ86_MOUSE
Guanine nucleotide exchange factor ...
Rab3il1
51Annotation score:
D3YZN2D3YZN2_MOUSE
Guanine nucleotide exchange factor ...
Rab3il1
57Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0283461 – 69Missing in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132764 mRNA Translation: BAE21345.1
AK161298 mRNA Translation: BAE36305.1
BC020147 mRNA Translation: AAH20147.1
CCDSiCCDS29569.1 [Q8VDV3-1]
CCDS84417.1 [Q8VDV3-2]
RefSeqiNP_001334358.1, NM_001347429.1 [Q8VDV3-2]
NP_653121.1, NM_144538.2 [Q8VDV3-1]
UniGeneiMm.281969

Genome annotation databases

EnsembliENSMUST00000113161; ENSMUSP00000108786; ENSMUSG00000024663 [Q8VDV3-1]
ENSMUST00000121418; ENSMUSP00000113828; ENSMUSG00000024663 [Q8VDV3-2]
ENSMUST00000144788; ENSMUSP00000121449; ENSMUSG00000024663 [Q8VDV3-1]
GeneIDi74760
KEGGimmu:74760
UCSCiuc008gov.1 mouse [Q8VDV3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132764 mRNA Translation: BAE21345.1
AK161298 mRNA Translation: BAE36305.1
BC020147 mRNA Translation: AAH20147.1
CCDSiCCDS29569.1 [Q8VDV3-1]
CCDS84417.1 [Q8VDV3-2]
RefSeqiNP_001334358.1, NM_001347429.1 [Q8VDV3-2]
NP_653121.1, NM_144538.2 [Q8VDV3-1]
UniGeneiMm.281969

3D structure databases

ProteinModelPortaliQ8VDV3
SMRiQ8VDV3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217000, 1 interactor
STRINGi10090.ENSMUSP00000108786

PTM databases

iPTMnetiQ8VDV3
PhosphoSitePlusiQ8VDV3

Proteomic databases

PaxDbiQ8VDV3
PeptideAtlasiQ8VDV3
PRIDEiQ8VDV3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113161; ENSMUSP00000108786; ENSMUSG00000024663 [Q8VDV3-1]
ENSMUST00000121418; ENSMUSP00000113828; ENSMUSG00000024663 [Q8VDV3-2]
ENSMUST00000144788; ENSMUSP00000121449; ENSMUSG00000024663 [Q8VDV3-1]
GeneIDi74760
KEGGimmu:74760
UCSCiuc008gov.1 mouse [Q8VDV3-1]

Organism-specific databases

CTDi5866
MGIiMGI:1922010 Rab3il1

Phylogenomic databases

eggNOGiKOG4324 Eukaryota
ENOG410XPSY LUCA
GeneTreeiENSGT00390000009036
HOGENOMiHOG000220814
HOVERGENiHBG057034
InParanoidiQ8VDV3
KOiK16779
OMAiTLFAEFQ
OrthoDBiEOG091G04MY
PhylomeDBiQ8VDV3
TreeFamiTF313748

Enzyme and pathway databases

ReactomeiR-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

PROiPR:Q8VDV3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024663 Expressed in 206 organ(s), highest expression level in testis
CleanExiMM_RAB3IL1
ExpressionAtlasiQ8VDV3 baseline and differential
GenevisibleiQ8VDV3 MM

Family and domain databases

InterProiView protein in InterPro
IPR009449 Sec2_N
PfamiView protein in Pfam
PF06428 Sec2p, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiR3GEF_MOUSE
AccessioniPrimary (citable) accession number: Q8VDV3
Secondary accession number(s): Q3TTM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 1, 2002
Last modified: September 12, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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