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Protein

Integrin beta-like protein 1

Gene

Itgbl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • integrin binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-like protein 1
Gene namesi
Name:Itgbl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2443439 Itgbl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000032302324 – 494Integrin beta-like protein 1Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi405N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VDV0
PRIDEiQ8VDV0

PTM databases

PhosphoSitePlusiQ8VDV0

Expressioni

Gene expression databases

BgeeiENSMUSG00000032925 Expressed in 160 organ(s), highest expression level in aorta
CleanExiMM_ITGBL1
ExpressionAtlasiQ8VDV0 baseline and differential
GenevisibleiQ8VDV0 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059019

Structurei

3D structure databases

ProteinModelPortaliQ8VDV0
SMRiQ8VDV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati51 – 95IAdd BLAST45
Repeati96 – 142IIAdd BLAST47
Repeati143 – 184IIIAdd BLAST42
Repeati185 – 230IVAdd BLAST46
Repeati231 – 275VAdd BLAST45
Repeati276 – 326VIAdd BLAST51
Repeati327 – 367VIIAdd BLAST41
Repeati368 – 414VIIIAdd BLAST47
Repeati415 – 454IXAdd BLAST40
Repeati455 – 494XAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 494Cysteine-rich tandem repeatsAdd BLAST444

Domaini

Contains ten tandem EGF-like repeats strikingly similar to those found in the cysteine rich 'stalk-like' structure of integrin beta-subunits.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
GeneTreeiENSGT00760000119064
HOGENOMiHOG000113115
HOVERGENiHBG052797
InParanoidiQ8VDV0
OMAiCQYPTHC
OrthoDBiEOG091G05SQ
PhylomeDBiQ8VDV0
TreeFamiTF332636

Family and domain databases

InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR027070 Integrin_b-like_p1
IPR015812 Integrin_bsu
PANTHERiPTHR10082 PTHR10082, 1 hit
PTHR10082:SF3 PTHR10082:SF3, 1 hit
PfamiView protein in Pfam
PF07974 EGF_2, 3 hits
SMARTiView protein in SMART
SM00181 EGF, 6 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 5 hits
PS00243 INTEGRIN_BETA, 9 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8VDV0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHPPGFRNFL LLVSSLLFIG LSAAPQSFLP SLRSLSGAPC RLSRAESERR
60 70 80 90 100
CRAPGQPPGS ALCHDRGRCE CGVCICHVTE PGTYFGPLCE CHEWICETYD
110 120 130 140 150
GKTCAGHGNC DCGKCKCDVG WSGEACQYPT KCDLTKKISN QMCKNSQDVI
160 170 180 190 200
CSNAGTCHCG RCKCDNSDGH GLIYGKFCEC DDRECIDDET EEVCGGHGKC
210 220 230 240 250
YCGNCYCEAG WHGDKCEFQC DITPWESKRR CTSPDGKVCS NRGTCVCGEC
260 270 280 290 300
SCHDVDPTGD WGDIHGDTCE CDERDCRAVY DRYSDDFCSG HGQCNCGRCD
310 320 330 340 350
CRAGWYGKKC EHPRNCPLSA EESTKKCQGS SDLPCSGRGR CECGRCTCYP
360 370 380 390 400
PGDSRVYGKT CECDDRRCED LDGVVCGGHG MCSCGRCVCE KGWFGKLCQH
410 420 430 440 450
LRKCNMTEEQ SRSLCESADG TLCSGKGSCH CGKCICSGEE WYISGEFCDC
460 470 480 490
DDRDCDKHDG LICTGNGICS CGNCECWDGW NGNACEIWLG TEYP
Length:494
Mass (Da):53,978
Last modified:March 18, 2008 - v2
Checksum:i6192CDC83E7F9005
GO
Isoform 2 (identifier: Q8VDV0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-210: HGKCYCGNCYCEAG → QGKGHIGCLICIII
     211-494: Missing.

Show »
Length:210
Mass (Da):22,689
Checksum:i9432859786AB8A22
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1B1E3B1B1E3_MOUSE
Integrin beta-like protein 1
Itgbl1
370Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95I → V in AAH20152 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032005197 – 210HGKCY…YCEAG → QGKGHIGCLICIII in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_032006211 – 494Missing in isoform 2. 1 PublicationAdd BLAST284

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029068 mRNA Translation: BAC26275.1
AK051773 mRNA Translation: BAC34761.1
CT033773
, AC154590, AC160988, AC161001 Genomic DNA Translation: CAP19194.1
BC020152 mRNA Translation: AAH20152.1
CCDSiCCDS27354.1 [Q8VDV0-1]
RefSeqiNP_663442.2, NM_145467.2 [Q8VDV0-1]
UniGeneiMm.383176

Genome annotation databases

EnsembliENSMUST00000049681; ENSMUSP00000059019; ENSMUSG00000032925 [Q8VDV0-1]
ENSMUST00000142161; ENSMUSP00000121659; ENSMUSG00000032925 [Q8VDV0-2]
GeneIDi223272
KEGGimmu:223272
UCSCiuc007vbu.2 mouse [Q8VDV0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029068 mRNA Translation: BAC26275.1
AK051773 mRNA Translation: BAC34761.1
CT033773
, AC154590, AC160988, AC161001 Genomic DNA Translation: CAP19194.1
BC020152 mRNA Translation: AAH20152.1
CCDSiCCDS27354.1 [Q8VDV0-1]
RefSeqiNP_663442.2, NM_145467.2 [Q8VDV0-1]
UniGeneiMm.383176

3D structure databases

ProteinModelPortaliQ8VDV0
SMRiQ8VDV0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059019

PTM databases

PhosphoSitePlusiQ8VDV0

Proteomic databases

PaxDbiQ8VDV0
PRIDEiQ8VDV0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049681; ENSMUSP00000059019; ENSMUSG00000032925 [Q8VDV0-1]
ENSMUST00000142161; ENSMUSP00000121659; ENSMUSG00000032925 [Q8VDV0-2]
GeneIDi223272
KEGGimmu:223272
UCSCiuc007vbu.2 mouse [Q8VDV0-1]

Organism-specific databases

CTDi9358
MGIiMGI:2443439 Itgbl1

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
GeneTreeiENSGT00760000119064
HOGENOMiHOG000113115
HOVERGENiHBG052797
InParanoidiQ8VDV0
OMAiCQYPTHC
OrthoDBiEOG091G05SQ
PhylomeDBiQ8VDV0
TreeFamiTF332636

Miscellaneous databases

PROiPR:Q8VDV0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032925 Expressed in 160 organ(s), highest expression level in aorta
CleanExiMM_ITGBL1
ExpressionAtlasiQ8VDV0 baseline and differential
GenevisibleiQ8VDV0 MM

Family and domain databases

InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR027070 Integrin_b-like_p1
IPR015812 Integrin_bsu
PANTHERiPTHR10082 PTHR10082, 1 hit
PTHR10082:SF3 PTHR10082:SF3, 1 hit
PfamiView protein in Pfam
PF07974 EGF_2, 3 hits
SMARTiView protein in SMART
SM00181 EGF, 6 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 5 hits
PS00243 INTEGRIN_BETA, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiITGBL_MOUSE
AccessioniPrimary (citable) accession number: Q8VDV0
Secondary accession number(s): Q8BKJ4, Q8BMS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 7, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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