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Protein

SNF-related serine/threonine-protein kinase

Gene

Snrk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by phosphorylation on Thr-173.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45ATPPROSITE-ProRule annotationBy similarity1
Active sitei139Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 30ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SNF-related serine/threonine-protein kinase (EC:2.7.11.1)
Alternative name(s):
SNF1-related kinase
Gene namesi
Name:SnrkImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:108104 Snrk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002256061 – 748SNF-related serine/threonine-protein kinaseCuratedAdd BLAST748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei162PhosphoserineCombined sources1
Modified residuei173Phosphothreonine; by LKB1By similarity1
Modified residuei362PhosphoserineCombined sources1
Modified residuei390PhosphoserineBy similarity1
Modified residuei482PhosphoserineCombined sources1
Modified residuei495PhosphoserineBy similarity1
Modified residuei518PhosphoserineBy similarity1
Modified residuei534Omega-N-methylarginineCombined sources1
Modified residuei606PhosphoserineBy similarity1

Post-translational modificationi

Autophosphorylated. Phosphorylation on Thr-173 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39 (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ8VDU5
PaxDbiQ8VDU5
PeptideAtlasiQ8VDU5
PRIDEiQ8VDU5

PTM databases

iPTMnetiQ8VDU5
PhosphoSitePlusiQ8VDU5
SwissPalmiQ8VDU5

Expressioni

Tissue specificityi

Ubiquitously expressed in all tissues examined.1 Publication

Developmental stagei

Expressed from day 8 dpc along the epithelium of the differentiating neural tube. Expression persists along the dorsal axis until 12.5 dpc, but becomes progressively restricted to the more caudal part of the neural tube with much stronger intensity in the caudal neuropore. Also observed in the endoderm of the primitive gut between 8.5 and 11.5 dpc, at 10.5 dpc, in the endocardium and pericardium of the developing heart, and in both the endothelium and blood cells clustered at the ventral part of the dorsal aorta. Later in development (12.5 dpc), expressed in the endocardium and the interventricular septum of the heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000038145
CleanExiMM_SNRK
ExpressionAtlasiQ8VDU5 baseline and differential
GenevisibleiQ8VDU5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112919

Structurei

3D structure databases

ProteinModelPortaliQ8VDU5
SMRiQ8VDU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 269Protein kinasePROSITE-ProRule annotationAdd BLAST254
Domaini291 – 334UBAPROSITE-ProRule annotationAdd BLAST44

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4717 Eukaryota
ENOG410XR6N LUCA
GeneTreeiENSGT00900000140806
HOGENOMiHOG000059616
HOVERGENiHBG093970
InParanoidiQ8VDU5
KOiK08802
OMAiNVLNGHR
OrthoDBiEOG091G08XV
PhylomeDBiQ8VDU5
TreeFamiTF351991

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR015940 UBA
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50030 UBA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VDU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGFKRGYDG KIAGLYDLDK TLGRGHFAVV KLARHVFTGE KVAVKVIDKT
60 70 80 90 100
KLDTLATGHL FQEVRCMKLV QHPNIVRLYE VIDTQTKLYL ILELGDGGDM
110 120 130 140 150
FDYIMKHEEG LNEDLAKKYF AQIVHAISYC HKLHVVHRDL KPENVVFFEK
160 170 180 190 200
QGLVKLTDFG FSNKFQPGKK LTTSCGSLAY SAPEILLGDE YDAPAVDIWS
210 220 230 240 250
LGVILFMLVC GQPPFQEAND SETLTMIMDC KYTVPPRVSA GCRDLITRML
260 270 280 290 300
QRDPKRRASL EEIESHPWLQ GVDPSPATKY NIPLVSYKNL SEEEHNSIIQ
310 320 330 340 350
RMVLGDIADR DAIVEALETN RYNHITATYF LLAERILREK QEKEIQTRSA
360 370 380 390 400
SPSNIKAQFR QSWPTKIDVP QDLEDDLTAT PLSHATVPQS PARAGDNVLN
410 420 430 440 450
GHRSKGLCDP AKKDELPELA GPALSTVPPA SMKPAASGRK CLFRVEEDEE
460 470 480 490 500
EDEEDKKPVS LSTQVVLRRK PSVTNRLTSR KSAPVLNQIF EEGESDDEFD
510 520 530 540 550
MDENLPPKLS RLKMNIASPG TVHKRYHRRK SQGRGSSCSS SETSDDDSES
560 570 580 590 600
RRRLDKDSGF AYSWHRRDSS EGPPGSEGDG GGQSKPSSGG GVDKASPGEQ
610 620 630 640 650
GTGGGSQGGS GGTPSGTAGS SRRCAGPDSS SPSPASASAA PRGAELVQSL
660 670 680 690 700
KLVSLCLGSQ LHGAKYILDP QKALFSSVKV QEKSTWKMCI SAPGPSPSAD
710 720 730 740
LDPVRTKKLR NNALQLPLCE KTISVNIQRS RKEGLLCASS PASCCHVI
Length:748
Mass (Da):81,913
Last modified:March 1, 2002 - v1
Checksum:i9E3F7EA90136FCDA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5K → R in AAK97440 (PubMed:12234663).Curated1
Sequence conflicti112N → D in AAK97440 (PubMed:12234663).Curated1
Sequence conflicti549E → K in AAK97440 (PubMed:12234663).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF387809 mRNA Translation: AAK97440.1
BC020189 mRNA Translation: AAH20189.1
BC094658 mRNA Translation: AAH94658.1
CCDSiCCDS23644.1
RefSeqiNP_001158044.1, NM_001164572.1
NP_598502.2, NM_133741.2
XP_006512061.1, XM_006511998.3
XP_006512062.1, XM_006511999.3
XP_006512063.1, XM_006512000.3
XP_006512065.1, XM_006512002.3
XP_006512066.1, XM_006512003.3
UniGeneiMm.257989

Genome annotation databases

EnsembliENSMUST00000118886; ENSMUSP00000114132; ENSMUSG00000038145
ENSMUST00000120173; ENSMUSP00000112919; ENSMUSG00000038145
GeneIDi20623
KEGGimmu:20623
UCSCiuc009sen.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSNRK_MOUSE
AccessioniPrimary (citable) accession number: Q8VDU5
Secondary accession number(s): Q91WX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

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