UniProtKB - Q8VDU4 (Q8VDU4_MOUSE)
Protein
Submitted name:
Proto-oncogene vav
Gene
Vav1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- small GTPase mediated signal transduction Source: InterPro
Keywordsi
Molecular function | Guanine-nucleotide releasing factorARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Proto-oncogene vavImportedSubmitted name: Vav1 proteinImported |
Gene namesi | Name:Vav1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98923, Vav1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000034116, Expressed in frontal cortex and 191 other tissues |
ExpressionAtlasi | Q8VDU4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 119 | Calponin-homology (CH)InterPro annotationAdd BLAST | 119 | |
Domaini | 194 – 373 | DHInterPro annotationAdd BLAST | 180 | |
Domaini | 402 – 504 | PHInterPro annotationAdd BLAST | 103 | |
Domaini | 515 – 564 | Phorbol-ester/DAG-typeInterPro annotationAdd BLAST | 50 | |
Domaini | 592 – 660 | SH3InterPro annotationAdd BLAST | 69 | |
Domaini | 619 – 726 | SH2InterPro annotationAdd BLAST | 108 | |
Domaini | 743 – 803 | SH3InterPro annotationAdd BLAST | 61 |
Keywords - Domaini
SH2 domainPROSITE-ProRule annotationARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation, Zinc-fingerARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000159125 |
OMAi | QPYISRP |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd01223, PH_Vav, 1 hit cd00160, RhoGEF, 1 hit cd11979, SH3_VAV1_1, 1 hit cd11976, SH3_VAV1_2, 1 hit |
Gene3Di | 1.10.418.10, 1 hit 1.20.900.10, 1 hit 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR022613, CAMSAP_CH IPR001715, CH-domain IPR036872, CH_dom_sf IPR035899, DBL_dom_sf IPR000219, DH-domain IPR001331, GDS_CDC24_CS IPR002219, PE/DAG-bd IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR037832, PH_Vav IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR003096, SM22_calponin IPR028530, Vav1 IPR035730, VAV1_SH3_1 IPR035729, VAV1_SH3_2 |
PANTHERi | PTHR45818:SF2, PTHR45818:SF2, 2 hits |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF11971, CAMSAP_CH, 1 hit PF00169, PH, 1 hit PF00621, RhoGEF, 1 hit PF00018, SH3_1, 2 hits |
PRINTSi | PR00452, SH3DOMAIN PR00888, SM22CALPONIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00033, CH, 1 hit SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit SM00326, SH3, 2 hits |
SUPFAMi | SSF47576, SSF47576, 1 hit SSF48065, SSF48065, 1 hit SSF50044, SSF50044, 2 hits SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50021, CH, 1 hit PS00741, DH_1, 1 hit PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 2 hits PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8VDU4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELWRQCTHW LIQCRVLPPS HRVTWEGAQV CELAQALRDG VLLCQLLNNL
60 70 80 90 100
LPQAINLREV NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF
110 120 130 140 150
DVQDFGKVIY TLSALSWTPI AQNKGIMPFP TEDSALNDED IYSGLSDQID
160 170 180 190 200
DTAEEDEDLY DCVENEEAEG DEIYEDLMRL ESVPTPPKMT EYDKRCCCLR
210 220 230 240 250
EIQQTEEKYT DTLGSIQQHF MKPLQRFLKP QDMETIFVNI EELFSVHTHF
260 270 280 290 300
LKELKDALAG PGATTLYQVF IKYKERFLVY GRYCSQVESA SKHLDQVATA
310 320 330 340 350
REDVQMKLEE CSQRANNGRF TLRDLLMVPM QRVLKYHLLL QELVKHTQDA
360 370 380 390 400
TEKENLRLAL DAMRDLAQCV NEVKRDNETL RQITNFQLSI ENLDQSLANY
410 420 430 440 450
GRPKIDGELK ITSVERRSKT DRYAFLLDKA LLICKRRGDS YDLKASVNLH
460 470 480 490 500
SFQVRDDSSG ERDNKKWSHM FLLIEDQGAQ GYELFFKTRE LKKKWMEQFE
510 520 530 540 550
MAISNIYPEN ATANGHDFQM FSFEETTSCK ACQMLLRGTF YQGYRCYRCR
560 570 580 590 600
APAHKECLGR VPPCGRHGQD FAGTMKKDKL HRRAQDKKRN ELGLPKMEVF
610 620 630 640 650
QEYYGIPPPP GAFGPFLRLN PGDIVELTKA EAEHNWWEGR NTATNEVGWF
660 670 680 690 700
PCNRVHPYVH GPPQDLSVHL WYNVEVKHIK IMTSEGLYRI TEKKAFRGLL
710 720 730 740 750
ELVEFYQQNS LKDCFKSLDT TLQFPYKEPE RRAISKPPAG STKYFGTAKA
760 770 780 790 800
RYDFCARDRS ELSLKEGDII KILNKKGQQG WWRGEIYGRI GWFPSNYVEE
DYSEYC
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP27870 | VAV_MOUSE | Proto-oncogene vav | Vav1 Vav | 845 | Annotation score: | ||
E9PXI0 | E9PXI0_MOUSE | Proto-oncogene vav | Vav1 | 821 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CT010434 Genomic DNA No translation available. CT025692 Genomic DNA No translation available. BC020487 mRNA Translation: AAH20487.1 CT010321 mRNA Translation: CAJ18529.1 |
RefSeqi | NP_001157288.1, NM_001163816.1 |
Genome annotation databases
Ensembli | ENSMUST00000112870; ENSMUSP00000108491; ENSMUSG00000034116 |
GeneIDi | 22324 |
UCSCi | uc008deq.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CT010434 Genomic DNA No translation available. CT025692 Genomic DNA No translation available. BC020487 mRNA Translation: AAH20487.1 CT010321 mRNA Translation: CAJ18529.1 |
RefSeqi | NP_001157288.1, NM_001163816.1 |
3D structure databases
SMRi | Q8VDU4 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q8VDU4 |
Protocols and materials databases
Antibodypediai | 665, 729 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000112870; ENSMUSP00000108491; ENSMUSG00000034116 |
GeneIDi | 22324 |
UCSCi | uc008deq.2, mouse |
Organism-specific databases
CTDi | 7409 |
MGIi | MGI:98923, Vav1 |
Phylogenomic databases
GeneTreei | ENSGT00940000159125 |
OMAi | QPYISRP |
Miscellaneous databases
BioGRID-ORCSi | 22324, 2 hits in 17 CRISPR screens |
ChiTaRSi | Vav1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000034116, Expressed in frontal cortex and 191 other tissues |
ExpressionAtlasi | Q8VDU4, baseline and differential |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd01223, PH_Vav, 1 hit cd00160, RhoGEF, 1 hit cd11979, SH3_VAV1_1, 1 hit cd11976, SH3_VAV1_2, 1 hit |
Gene3Di | 1.10.418.10, 1 hit 1.20.900.10, 1 hit 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR022613, CAMSAP_CH IPR001715, CH-domain IPR036872, CH_dom_sf IPR035899, DBL_dom_sf IPR000219, DH-domain IPR001331, GDS_CDC24_CS IPR002219, PE/DAG-bd IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR037832, PH_Vav IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR003096, SM22_calponin IPR028530, Vav1 IPR035730, VAV1_SH3_1 IPR035729, VAV1_SH3_2 |
PANTHERi | PTHR45818:SF2, PTHR45818:SF2, 2 hits |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF11971, CAMSAP_CH, 1 hit PF00169, PH, 1 hit PF00621, RhoGEF, 1 hit PF00018, SH3_1, 2 hits |
PRINTSi | PR00452, SH3DOMAIN PR00888, SM22CALPONIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00033, CH, 1 hit SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit SM00326, SH3, 2 hits |
SUPFAMi | SSF47576, SSF47576, 1 hit SSF48065, SSF48065, 1 hit SSF50044, SSF50044, 2 hits SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50021, CH, 1 hit PS00741, DH_1, 1 hit PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 2 hits PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8VDU4_MOUSE | |
Accessioni | Q8VDU4Primary (citable) accession number: Q8VDU4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2002 |
Last sequence update: | March 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |