Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rho-related GTP-binding protein RhoV

Gene

Rhov

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.By similarity

Cofactori

Mg2+By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 45GTPBy similarity8
Nucleotide bindingi85 – 89GTPBy similarity5
Nucleotide bindingi143 – 146GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoV
Gene namesi
Name:RhovImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2444227 Rhov

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003264391 – 236Rho-related GTP-binding protein RhoVAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineBy similarity1
Lipidationi234S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ8VDU1
PRIDEiQ8VDU1

PTM databases

PhosphoSitePlusiQ8VDU1

Expressioni

Gene expression databases

BgeeiENSMUSG00000034226 Expressed in 126 organ(s), highest expression level in urinary bladder
CleanExiMM_RHOV
GenevisibleiQ8VDU1 MM

Interactioni

Subunit structurei

Interacts with PAK2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041411

Structurei

3D structure databases

ProteinModelPortaliQ8VDU1
SMRiQ8VDU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.By similarity

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118978
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiQ8VDU1
KOiK07866
OMAiPPQMDYF
OrthoDBiEOG091G0E4F
PhylomeDBiQ8VDU1
TreeFamiTF321839

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VDU1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPRELSEAE PPPLPASTPP PRRRSAPPEL GIKCVLVGDG AVGKSSLIVS
60 70 80 90 100
YTCNGYPARY RPTALDTFSV QVLVDGAPVR IELWDTAGQE DFDRLRSLCY
110 120 130 140 150
PDTDVFLACF SVVQPSSFQN ITEKWLPEIR THNPQAPVLL VGTQADLRDD
160 170 180 190 200
VNVLIQLDQG GREGPVPQPQ AQGLAEKIRA CCYLECSALT QKNLKEVFDS
210 220 230
AILSAIEHKA RLEKKLNAKG VRTLSRCRWK KFFCFV
Length:236
Mass (Da):26,148
Last modified:March 1, 2002 - v1
Checksum:i36121B1A9CDA1627
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036775 mRNA Translation: BAC29571.1
AK037170 mRNA Translation: BAC29732.1
AL929318 Genomic DNA No translation available.
BC021307 mRNA Translation: AAH21307.1
CCDSiCCDS16598.1
RefSeqiNP_663505.1, NM_145530.2
UniGeneiMm.120274

Genome annotation databases

EnsembliENSMUST00000037360; ENSMUSP00000041411; ENSMUSG00000034226
GeneIDi228543
KEGGimmu:228543
UCSCiuc008ltm.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036775 mRNA Translation: BAC29571.1
AK037170 mRNA Translation: BAC29732.1
AL929318 Genomic DNA No translation available.
BC021307 mRNA Translation: AAH21307.1
CCDSiCCDS16598.1
RefSeqiNP_663505.1, NM_145530.2
UniGeneiMm.120274

3D structure databases

ProteinModelPortaliQ8VDU1
SMRiQ8VDU1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041411

PTM databases

PhosphoSitePlusiQ8VDU1

Proteomic databases

PaxDbiQ8VDU1
PRIDEiQ8VDU1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037360; ENSMUSP00000041411; ENSMUSG00000034226
GeneIDi228543
KEGGimmu:228543
UCSCiuc008ltm.2 mouse

Organism-specific databases

CTDi171177
MGIiMGI:2444227 Rhov

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118978
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiQ8VDU1
KOiK07866
OMAiPPQMDYF
OrthoDBiEOG091G0E4F
PhylomeDBiQ8VDU1
TreeFamiTF321839

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Miscellaneous databases

PROiPR:Q8VDU1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034226 Expressed in 126 organ(s), highest expression level in urinary bladder
CleanExiMM_RHOV
GenevisibleiQ8VDU1 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRHOV_MOUSE
AccessioniPrimary (citable) accession number: Q8VDU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2002
Last modified: September 12, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again